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The map label for this gene is ansA [H]

Identifier: 238919549

GI number: 238919549

Start: 1606398

End: 1607414

Strand: Reverse

Name: ansA [H]

Synonym: NT01EI_1645

Alternate gene names: 238919549

Gene position: 1607414-1606398 (Counterclockwise)

Preceding gene: 238919550

Following gene: 238919548

Centisome position: 42.16

GC content: 59.49

Gene sequence:

>1017_bases
ATGCAAAAAAAATCTATCTATGTGGCCTACACCGGCGGCACCATCGGCATGCAACGCTCCGCACAGGGCTACATCCCCGT
CTCCGGGCACCTGCAGCGTCAGTTGGCGTTGATGCCGGAGTTTCACCGCCCCGAGATGCCGGACTTTACCATCCATGAGT
ATCAGCCGCTGATCGACTCTTCCGATACCACGCCCGCCGACTGGCAGTACATCGCCGACGATATTCAGGCCAGCTACGCC
GACTATGACGGCTTTGTGATCCTGCATGGCACCGATACCATGGCATTTACCGCCTCAGCGCTCTCATTTATGTTCGAGAA
CCTGGCAAAACCGGTGATCGTCACCGGCTCACAGATCCCACTCGCCGAGCTGCGCTCCGACGGGCAGACCAACCTGCTGA
ACGCCCTCTATCTGGCGGCCAATTATCCCATTAATGAAGTCTCATTGTTCTTCAATAACCAGCTGTTCCGCGGCAACCGG
ACCACCAAGGCGCACGCCGATGGCTTTGATGCCTTCGCCTCGCCCAACTATCCCATACTGCTGGAGGCAGGGATCAACAT
TCGCCGTATCGCACCGCTGGTAACGCCGCTGCATCAGGCGCCGTTCCGGGTTCATCCCATCACGCCGCAGCCGATCGGGG
TGGTGACCCTCTATCCCGGGATCTCGGCCAATGTGGTGCGCAACTTCCTGCGTCAACCGGTGCGGGCGCTGATCCTACGC
TCCTACGGCGTCGGCAACGCGCCACAGAATCCTGAACTGCTCGATGAGCTGATCCGCGCCTCACAGCGCGGTATCGTTGT
CGTCAACCTGACGCAATGCTTCTCCGGGCGGGTCAACATGGAAGGCTATGCCACCGGCAACGCCCTGGCCCACGCCGGGG
TAATCAGCGGTTTTGACATGACGGTTGAGGCGGCGTTGACTAAACTGCATTATCTATTGAGCCAATCGCTGAGCGCAGAC
CAAATCCGCCGCCTGATGCAGCAGGATCTGCGCGGAGAGCTGAGCGAGACCCCCTAA

Upstream 100 bases:

>100_bases
TTCATGGCTGTTGGCCCGGCGGTCTTTTTTTCTTTTGTATTATCCCTATAATCCCCGCATATTTGCGCATCAGCGCCCCA
GCTACGGCGAACTTTCTGTC

Downstream 100 bases:

>100_bases
GCGTAATATCTCACCGCGACAACGTCGGGAGAGACAACCTAGCCATACAACCACGGGAGGACGACGGATGTCCGCTGCAC
TTTTGCTGATCGATCTACAG

Product: cytoplasmic asparaginase I

Products: NA

Alternate protein names: L-asparaginase I; L-ASNase I; L-asparagine amidohydrolase I [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MQKKSIYVAYTGGTIGMQRSAQGYIPVSGHLQRQLALMPEFHRPEMPDFTIHEYQPLIDSSDTTPADWQYIADDIQASYA
DYDGFVILHGTDTMAFTASALSFMFENLAKPVIVTGSQIPLAELRSDGQTNLLNALYLAANYPINEVSLFFNNQLFRGNR
TTKAHADGFDAFASPNYPILLEAGINIRRIAPLVTPLHQAPFRVHPITPQPIGVVTLYPGISANVVRNFLRQPVRALILR
SYGVGNAPQNPELLDELIRASQRGIVVVNLTQCFSGRVNMEGYATGNALAHAGVISGFDMTVEAALTKLHYLLSQSLSAD
QIRRLMQQDLRGELSETP

Sequences:

>Translated_338_residues
MQKKSIYVAYTGGTIGMQRSAQGYIPVSGHLQRQLALMPEFHRPEMPDFTIHEYQPLIDSSDTTPADWQYIADDIQASYA
DYDGFVILHGTDTMAFTASALSFMFENLAKPVIVTGSQIPLAELRSDGQTNLLNALYLAANYPINEVSLFFNNQLFRGNR
TTKAHADGFDAFASPNYPILLEAGINIRRIAPLVTPLHQAPFRVHPITPQPIGVVTLYPGISANVVRNFLRQPVRALILR
SYGVGNAPQNPELLDELIRASQRGIVVVNLTQCFSGRVNMEGYATGNALAHAGVISGFDMTVEAALTKLHYLLSQSLSAD
QIRRLMQQDLRGELSETP
>Mature_338_residues
MQKKSIYVAYTGGTIGMQRSAQGYIPVSGHLQRQLALMPEFHRPEMPDFTIHEYQPLIDSSDTTPADWQYIADDIQASYA
DYDGFVILHGTDTMAFTASALSFMFENLAKPVIVTGSQIPLAELRSDGQTNLLNALYLAANYPINEVSLFFNNQLFRGNR
TTKAHADGFDAFASPNYPILLEAGINIRRIAPLVTPLHQAPFRVHPITPQPIGVVTLYPGISANVVRNFLRQPVRALILR
SYGVGNAPQNPELLDELIRASQRGIVVVNLTQCFSGRVNMEGYATGNALAHAGVISGFDMTVEAALTKLHYLLSQSLSAD
QIRRLMQQDLRGELSETP

Specific function: Unknown

COG id: COG0252

COG function: function code EJ; L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the asparaginase 1 family [H]

Homologues:

Organism=Homo sapiens, GI122937331, Length=356, Percent_Identity=46.9101123595506, Blast_Score=283, Evalue=1e-76,
Organism=Escherichia coli, GI1788065, Length=335, Percent_Identity=82.089552238806, Blast_Score=566, Evalue=1e-163,
Organism=Escherichia coli, GI1789327, Length=283, Percent_Identity=27.5618374558304, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17558280, Length=357, Percent_Identity=43.6974789915966, Blast_Score=276, Evalue=9e-75,
Organism=Caenorhabditis elegans, GI193207372, Length=357, Percent_Identity=43.6974789915966, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17558278, Length=357, Percent_Identity=43.6974789915966, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI193207374, Length=357, Percent_Identity=43.6974789915966, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24639609, Length=364, Percent_Identity=43.956043956044, Blast_Score=288, Evalue=3e-78,
Organism=Drosophila melanogaster, GI24645530, Length=359, Percent_Identity=42.0612813370474, Blast_Score=275, Evalue=3e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006033
- InterPro:   IPR006034
- InterPro:   IPR020827 [H]

Pfam domain/function: PF00710 Asparaginase [H]

EC number: =3.5.1.1 [H]

Molecular weight: Translated: 37278; Mature: 37278

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00144 ASN_GLN_ASE_1 ; PS00917 ASN_GLN_ASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKKSIYVAYTGGTIGMQRSAQGYIPVSGHLQRQLALMPEFHRPEMPDFTIHEYQPLIDS
CCCCEEEEEEECCCEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCC
SDTTPADWQYIADDIQASYADYDGFVILHGTDTMAFTASALSFMFENLAKPVIVTGSQIP
CCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCC
LAELRSDGQTNLLNALYLAANYPINEVSLFFNNQLFRGNRTTKAHADGFDAFASPNYPIL
HHHHHCCCCHHHHHHHHHHCCCCCCCEEEEECCEEECCCCCCCCCCCCCHHCCCCCCCEE
LEAGINIRRIAPLVTPLHQAPFRVHPITPQPIGVVTLYPGISANVVRNFLRQPVRALILR
EECCCCHHHHHHHHHHHHHCCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
SYGVGNAPQNPELLDELIRASQRGIVVVNLTQCFSGRVNMEGYATGNALAHAGVISGFDM
HCCCCCCCCCHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCEEECCCHHHHHHHHCCCCH
TVEAALTKLHYLLSQSLSADQIRRLMQQDLRGELSETP
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQKKSIYVAYTGGTIGMQRSAQGYIPVSGHLQRQLALMPEFHRPEMPDFTIHEYQPLIDS
CCCCEEEEEEECCCEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCC
SDTTPADWQYIADDIQASYADYDGFVILHGTDTMAFTASALSFMFENLAKPVIVTGSQIP
CCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEEECCCCC
LAELRSDGQTNLLNALYLAANYPINEVSLFFNNQLFRGNRTTKAHADGFDAFASPNYPIL
HHHHHCCCCHHHHHHHHHHCCCCCCCEEEEECCEEECCCCCCCCCCCCCHHCCCCCCCEE
LEAGINIRRIAPLVTPLHQAPFRVHPITPQPIGVVTLYPGISANVVRNFLRQPVRALILR
EECCCCHHHHHHHHHHHHHCCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHH
SYGVGNAPQNPELLDELIRASQRGIVVVNLTQCFSGRVNMEGYATGNALAHAGVISGFDM
HCCCCCCCCCHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCEEECCCHHHHHHHHCCCCH
TVEAALTKLHYLLSQSLSADQIRRLMQQDLRGELSETP
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]