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The map label for this gene is edd [H]

Identifier: 238919513

GI number: 238919513

Start: 1571708

End: 1573528

Strand: Direct

Name: edd [H]

Synonym: NT01EI_1609

Alternate gene names: 238919513

Gene position: 1571708-1573528 (Clockwise)

Preceding gene: 238919512

Following gene: 238919514

Centisome position: 41.23

GC content: 63.37

Gene sequence:

>1821_bases
ATGAATCCAATCGTAGAACGTGTTACCCAACGCATTATTGAACGCTCCCGCGCCACTCGTGTGGCGTATCTGGCTAAGAT
TGAGCGGGCGCGCAGCACACGTGTGCAGCGCGCCCAGCTGGCGTGTGGCAACCTGGCGCACGGCTTCGCCTCCTGTACTC
AGCAGGATAAGGCATCGCTGAAGAGCATGACCAAAAGTGATATCGCGATCATCACCTCGTATAACGATATGCTTTCCGCC
CACCAGCCCTATGAAAGCTATCCGGAACAGATTAAGCAGGCGCTGCATCAGGTGGGGGCAGTCGGTCAGGTAGCCGGTGG
CGTGCCGGCGATGTGTGACGGGGTGACTCAGGGTCAGGATGGCATGGAGCTGTCGCTGATGAGTCGCGAAGTGATAGCCA
TGTCCGCCGCGGTCGGGCTGTCGCATAACATGTTCGACGGCGCGCTGTACCTGGGCGTCTGTGACAAGATCGTGCCGGGG
CTGTTCATGGCAGCGATGTCCTTTGGCCATCTGCCGACCCTGTTCGTGCCGGCCGGGCCGATGGCCAGCGGTCTGCCGAA
CAAGGAGAAGGTACGCATCCGTCAGCTGTTTGCGGAGGGCAAGGTCGGGCGTGACGCCCTGCTGGAGTCAGAGGCTGCCT
CCTACCATGCGCCGGGCACCTGTACATTCTATGGCACGGCCAACTCCAACCAGATGGTGATGGAGGTGATGGGGATGCAC
CTGCCGGGCGCCTCTTTCGTTCAGCCGGACTGTGCGCTGCGTCATGCGCTGACTGACGCGGCGGCACGTCAGGTGACGCG
GATGACCGAGAGCAGTGGCAGCTATCTGCCGGTCGGGCGGATGGTGGATGAAAAGGTCGTGGTTAACGGCATTGTCGCCC
TGCTGGCGACCGGCGGCTCGACCAATCTCACCATGCACCTGGTGGCGATGGCGCGTGCCGCGGGCATCCTGATCAACTGG
GATGACTTCTCCGAGCTCTCAGAGGCGGTTCCGCTGCTGTGCCGTATTTACCCCAACGGTCCGGCGGATATCAACCACTT
CCAGGCGGCCGGCGGCGTGGCGCTGCTGGTGCGAGAACTGCTGAAGGGCGGGCTGCTGCATGACGATGTCGACACCGTGG
CGGGTCACGGCCTGCACCGTTACACCCAGGAGCCGTTCCTGGAGAACGGGCAGCTGGTGTACCGCGAAGGCACCGGGCGT
TCCTACGATACGGCAGTGATCGCCAGCATTGAGGCGCCATTTGCCCCTCACGGCGGCACCAAAGTGCTGTCCGGTAACCT
GGGGCGCGCGGTGATGAAGACCTCGGCGGTACCGGAGGAGAACCAGATTATTGAAGCACCGGCAGTGGTGTTTAACAGCC
AGCATGACGTGCTGCCGGCCTTTGAAGCGGGCGCGCTGGATCGTGACTGCGTGGTGGTGGTGCGCTATCAGGGACCGCGG
GCCATCGGGATGCCGGAGCTGCACAAGCTGATGCCGCCGCTGGGTGTGCTGATGGATCGCGGGCTGAAGGTGGCGCTGGT
GACGGATGGTCGTCTCTCCGGCGCCTCGGGTAAAGTGCCGTCGGCGATTCACGTGACGCCGGAGGCCTGCGCCGGTGGCC
TGCTGGCCAAGGTATGCAACGGCGACATGATCCGGGTTGATGGGCGCAGCGGCGAGCTGACCCTGCTGGTGGATCAGGCG
GAACTGGCGGCGCGCGATGCATTCCAGCCGGACCTCTCCGCGCTGCACGACGGTTGTGGCCGTGAGCTGTTCAACGCGTT
GCGTGAACAGTTGTCCGGTGCCGAAGAGGGCGCCAGTTGCATCCCGTTTTACCGTTCCTGA

Upstream 100 bases:

>100_bases
CAGGCCGCCGGCGGAGCGGAGGTGAATGAGATGCCGATCCGCGCCGTGCTCCAGCAGAGCATGACGCCGGTCGACGTCTA
CTGGACGGCATGAGGCTGTA

Downstream 100 bases:

>100_bases
TAGGCGAGGCGACGTATACCGCCTCAATAGCTGTGACCGATCCCGGGCGCAGGCCCAGGCGTCAGACCGGCAGGGAATGC
CGGTGCTCGGGGTCACTTAT

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MNPIVERVTQRIIERSRATRVAYLAKIERARSTRVQRAQLACGNLAHGFASCTQQDKASLKSMTKSDIAIITSYNDMLSA
HQPYESYPEQIKQALHQVGAVGQVAGGVPAMCDGVTQGQDGMELSLMSREVIAMSAAVGLSHNMFDGALYLGVCDKIVPG
LFMAAMSFGHLPTLFVPAGPMASGLPNKEKVRIRQLFAEGKVGRDALLESEAASYHAPGTCTFYGTANSNQMVMEVMGMH
LPGASFVQPDCALRHALTDAAARQVTRMTESSGSYLPVGRMVDEKVVVNGIVALLATGGSTNLTMHLVAMARAAGILINW
DDFSELSEAVPLLCRIYPNGPADINHFQAAGGVALLVRELLKGGLLHDDVDTVAGHGLHRYTQEPFLENGQLVYREGTGR
SYDTAVIASIEAPFAPHGGTKVLSGNLGRAVMKTSAVPEENQIIEAPAVVFNSQHDVLPAFEAGALDRDCVVVVRYQGPR
AIGMPELHKLMPPLGVLMDRGLKVALVTDGRLSGASGKVPSAIHVTPEACAGGLLAKVCNGDMIRVDGRSGELTLLVDQA
ELAARDAFQPDLSALHDGCGRELFNALREQLSGAEEGASCIPFYRS

Sequences:

>Translated_606_residues
MNPIVERVTQRIIERSRATRVAYLAKIERARSTRVQRAQLACGNLAHGFASCTQQDKASLKSMTKSDIAIITSYNDMLSA
HQPYESYPEQIKQALHQVGAVGQVAGGVPAMCDGVTQGQDGMELSLMSREVIAMSAAVGLSHNMFDGALYLGVCDKIVPG
LFMAAMSFGHLPTLFVPAGPMASGLPNKEKVRIRQLFAEGKVGRDALLESEAASYHAPGTCTFYGTANSNQMVMEVMGMH
LPGASFVQPDCALRHALTDAAARQVTRMTESSGSYLPVGRMVDEKVVVNGIVALLATGGSTNLTMHLVAMARAAGILINW
DDFSELSEAVPLLCRIYPNGPADINHFQAAGGVALLVRELLKGGLLHDDVDTVAGHGLHRYTQEPFLENGQLVYREGTGR
SYDTAVIASIEAPFAPHGGTKVLSGNLGRAVMKTSAVPEENQIIEAPAVVFNSQHDVLPAFEAGALDRDCVVVVRYQGPR
AIGMPELHKLMPPLGVLMDRGLKVALVTDGRLSGASGKVPSAIHVTPEACAGGLLAKVCNGDMIRVDGRSGELTLLVDQA
ELAARDAFQPDLSALHDGCGRELFNALREQLSGAEEGASCIPFYRS
>Mature_606_residues
MNPIVERVTQRIIERSRATRVAYLAKIERARSTRVQRAQLACGNLAHGFASCTQQDKASLKSMTKSDIAIITSYNDMLSA
HQPYESYPEQIKQALHQVGAVGQVAGGVPAMCDGVTQGQDGMELSLMSREVIAMSAAVGLSHNMFDGALYLGVCDKIVPG
LFMAAMSFGHLPTLFVPAGPMASGLPNKEKVRIRQLFAEGKVGRDALLESEAASYHAPGTCTFYGTANSNQMVMEVMGMH
LPGASFVQPDCALRHALTDAAARQVTRMTESSGSYLPVGRMVDEKVVVNGIVALLATGGSTNLTMHLVAMARAAGILINW
DDFSELSEAVPLLCRIYPNGPADINHFQAAGGVALLVRELLKGGLLHDDVDTVAGHGLHRYTQEPFLENGQLVYREGTGR
SYDTAVIASIEAPFAPHGGTKVLSGNLGRAVMKTSAVPEENQIIEAPAVVFNSQHDVLPAFEAGALDRDCVVVVRYQGPR
AIGMPELHKLMPPLGVLMDRGLKVALVTDGRLSGASGKVPSAIHVTPEACAGGLLAKVCNGDMIRVDGRSGELTLLVDQA
ELAARDAFQPDLSALHDGCGRELFNALREQLSGAEEGASCIPFYRS

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=603, Percent_Identity=79.4361525704809, Blast_Score=987, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=557, Percent_Identity=30.8797127468582, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI2367371, Length=482, Percent_Identity=30.0829875518672, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1786464, Length=478, Percent_Identity=28.4518828451883, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6322476, Length=475, Percent_Identity=32.2105263157895, Blast_Score=186, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64527; Mature: 64527

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIVERVTQRIIERSRATRVAYLAKIERARSTRVQRAQLACGNLAHGFASCTQQDKASL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSMTKSDIAIITSYNDMLSAHQPYESYPEQIKQALHQVGAVGQVAGGVPAMCDGVTQGQD
HHHCCCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCCCCCC
GMELSLMSREVIAMSAAVGLSHNMFDGALYLGVCDKIVPGLFMAAMSFGHLPTLFVPAGP
CCEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MASGLPNKEKVRIRQLFAEGKVGRDALLESEAASYHAPGTCTFYGTANSNQMVMEVMGMH
HHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHCCC
LPGASFVQPDCALRHALTDAAARQVTRMTESSGSYLPVGRMVDEKVVVNGIVALLATGGS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TNLTMHLVAMARAAGILINWDDFSELSEAVPLLCRIYPNGPADINHFQAAGGVALLVREL
CCHHHHHHHHHHHCCEEEECCCHHHHHHHHCEEEEECCCCCCCCCHHHHCCCHHHHHHHH
LKGGLLHDDVDTVAGHGLHRYTQEPFLENGQLVYREGTGRSYDTAVIASIEAPFAPHGGT
HHCCCCCCCHHHHHCCCHHHHCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCC
KVLSGNLGRAVMKTSAVPEENQIIEAPAVVFNSQHDVLPAFEAGALDRDCVVVVRYQGPR
EEECCCCCHHHHHHCCCCCCCCEEECCHHEECCCCCCCCCHHCCCCCCCEEEEEEECCCC
AIGMPELHKLMPPLGVLMDRGLKVALVTDGRLSGASGKVPSAIHVTPEACAGGLLAKVCN
CCCCHHHHHHCCHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEECHHHHHHHHHHHHCC
GDMIRVDGRSGELTLLVDQAELAARDAFQPDLSALHDGCGRELFNALREQLSGAEEGASC
CCEEEEECCCCCEEEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
IPFYRS
CCCCCC
>Mature Secondary Structure
MNPIVERVTQRIIERSRATRVAYLAKIERARSTRVQRAQLACGNLAHGFASCTQQDKASL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSMTKSDIAIITSYNDMLSAHQPYESYPEQIKQALHQVGAVGQVAGGVPAMCDGVTQGQD
HHHCCCCEEEEEECHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHCCCCCCCC
GMELSLMSREVIAMSAAVGLSHNMFDGALYLGVCDKIVPGLFMAAMSFGHLPTLFVPAGP
CCEEHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
MASGLPNKEKVRIRQLFAEGKVGRDALLESEAASYHAPGTCTFYGTANSNQMVMEVMGMH
HHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHCCC
LPGASFVQPDCALRHALTDAAARQVTRMTESSGSYLPVGRMVDEKVVVNGIVALLATGGS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TNLTMHLVAMARAAGILINWDDFSELSEAVPLLCRIYPNGPADINHFQAAGGVALLVREL
CCHHHHHHHHHHHCCEEEECCCHHHHHHHHCEEEEECCCCCCCCCHHHHCCCHHHHHHHH
LKGGLLHDDVDTVAGHGLHRYTQEPFLENGQLVYREGTGRSYDTAVIASIEAPFAPHGGT
HHCCCCCCCHHHHHCCCHHHHCCCCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCC
KVLSGNLGRAVMKTSAVPEENQIIEAPAVVFNSQHDVLPAFEAGALDRDCVVVVRYQGPR
EEECCCCCHHHHHHCCCCCCCCEEECCHHEECCCCCCCCCHHCCCCCCCEEEEEEECCCC
AIGMPELHKLMPPLGVLMDRGLKVALVTDGRLSGASGKVPSAIHVTPEACAGGLLAKVCN
CCCCHHHHHHCCHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEECHHHHHHHHHHHHCC
GDMIRVDGRSGELTLLVDQAELAARDAFQPDLSALHDGCGRELFNALREQLSGAEEGASC
CCEEEEECCCCCEEEEECCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
IPFYRS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]