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The map label for this gene is zwf [H]

Identifier: 238919511

GI number: 238919511

Start: 1569478

End: 1570950

Strand: Direct

Name: zwf [H]

Synonym: NT01EI_1607

Alternate gene names: 238919511

Gene position: 1569478-1570950 (Clockwise)

Preceding gene: 238919508

Following gene: 238919512

Centisome position: 41.17

GC content: 58.32

Gene sequence:

>1473_bases
ATGGCGGTAACGTCAACGGCACAGGCTTGCGACCTGATTATTTTTGGCGCCAAGGGCGATCTGGCCCGGCGCAAGCTGCT
GCCTTCCCTGTATCAACTGGAAAAAGCTGGCCATATTCACCCCGAGACGCGCATTATCGGCGTCGGCCGCGCCGAGTGGG
ATGCCGCGGCCTACCGTAAGGTGGTGCGTGAGGCGCTGGATACCTTTTTGAAGGAGCCGCTTGACGATGCACTGTGGCAG
CGTCTGAGTGCCCGCCTCGACTTTTGCAACCTGGACGTCAACGATACCGAGCATTTTCAGCGTCTGGCGGAGAGGGTGGA
GCCCCAGCAGCGGGTGACCATTAACTATTTTGCCATGCCGCCGAGTACCTTTGGCGCGATTTGCCAGGGGCTGGGACATG
CGGGGATGAACCTCCAGCCCAGCCGTATCGTCATGGAGAAGCCGCTGGGGACCGATCTGGCCTCATCGCAGGCGATTAAC
GATCAGGTAGCGCGCTATTTTGATGAAAATCAGGTATACCGCATCGACCATTATCTGGGTAAGGAGACGGTGCTGAACCT
GCTGGCGCTGCGTTTTGCCAACGCGCTGTTTGCCAATAACTGGGACAACAGCATGATCGACCACGTGCAGATCACCGTGG
CGGAAGAGGTCGGCATCGAAGGGCGCTGGGGCTATTTTGATCAGGCAGGACAGATGCGCGACATGGTACAGAACCATCTG
CTGCAGATCCTGACCATGATCGCCATGGATCCGCCAGCGGACCTCTCCACCGACCGTATCCGCGATGAGAAGGTCAAGGT
GCTGCGATCCCTACGCCGCATCAACCACAGCAACGTACGTGAGACAACGGTGCGCGGCCAGTACACCGCCGGCTTCGTGC
AGGGACAGAAGGTGCCGGGATACCTGGAAGAAGAGGGGGCGAACAAGTGCAGCAATACGGAAACCTTTATTGCCATTCGC
GTCGATATTGACAACTGGCGCTGGGCAGGGGTGCCGTTTTATCTGCGTACCGGTAAGCGCCTGCCGAGCAAGTGCTCTGA
AGTGGTCATCTATTTCAAAAATCCACCGCTGAACCTGTTCAGCGACTCCTATCAGGCGCTGCCGCAGAATAAGTTGACCA
TTCGCCTGCAGCCGGATGAAGGGGTACAGATCGATATTCTGAATAAGGTGCCGGGGCTGGAGCATAAACACCGTCTGCAG
ACCACTAAGCTGGATCTGAGCTTCTCCGATACCTTCCATCAGGAGCATCTGGCAGACGCCTATGAACGCCTGCTGCTGGA
GGCAATGCGCGGTATTCAGGCGCTGTTTGTCCGCCGCGATGAAGTGGAAGAGGCCTGGAAGTGGGTCGACTCCATCATGA
CGGCCTGGGCCGACGACAACGACGCGCCGAAGCCTTATCAGGCGGGTACCTGGGGGCCGGTATCTTCGGTGGCGCTGATC
ACCCGCGACGGCCGTTGCTGGAACGAATTCTGA

Upstream 100 bases:

>100_bases
TATGGAAAGCGCAACGGAAAAGTCGTTTTTCTCGCTACAATCAGGATCATCAGAATGATTCTGTAAAAAAATTACAAGTA
ACCTGCACGAGGAGAGAGAT

Downstream 100 bases:

>100_bases
GTGGACTGTGCGGGGTGCAGGCCGCCCCGCGCAACGCGAGAGGAGCAGATATAAATGGCACACCTTATCGAATTTGGCAG
CGCGGACGCGCTGAACATCC

Product: glucose-6-phosphate dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MAVTSTAQACDLIIFGAKGDLARRKLLPSLYQLEKAGHIHPETRIIGVGRAEWDAAAYRKVVREALDTFLKEPLDDALWQ
RLSARLDFCNLDVNDTEHFQRLAERVEPQQRVTINYFAMPPSTFGAICQGLGHAGMNLQPSRIVMEKPLGTDLASSQAIN
DQVARYFDENQVYRIDHYLGKETVLNLLALRFANALFANNWDNSMIDHVQITVAEEVGIEGRWGYFDQAGQMRDMVQNHL
LQILTMIAMDPPADLSTDRIRDEKVKVLRSLRRINHSNVRETTVRGQYTAGFVQGQKVPGYLEEEGANKCSNTETFIAIR
VDIDNWRWAGVPFYLRTGKRLPSKCSEVVIYFKNPPLNLFSDSYQALPQNKLTIRLQPDEGVQIDILNKVPGLEHKHRLQ
TTKLDLSFSDTFHQEHLADAYERLLLEAMRGIQALFVRRDEVEEAWKWVDSIMTAWADDNDAPKPYQAGTWGPVSSVALI
TRDGRCWNEF

Sequences:

>Translated_490_residues
MAVTSTAQACDLIIFGAKGDLARRKLLPSLYQLEKAGHIHPETRIIGVGRAEWDAAAYRKVVREALDTFLKEPLDDALWQ
RLSARLDFCNLDVNDTEHFQRLAERVEPQQRVTINYFAMPPSTFGAICQGLGHAGMNLQPSRIVMEKPLGTDLASSQAIN
DQVARYFDENQVYRIDHYLGKETVLNLLALRFANALFANNWDNSMIDHVQITVAEEVGIEGRWGYFDQAGQMRDMVQNHL
LQILTMIAMDPPADLSTDRIRDEKVKVLRSLRRINHSNVRETTVRGQYTAGFVQGQKVPGYLEEEGANKCSNTETFIAIR
VDIDNWRWAGVPFYLRTGKRLPSKCSEVVIYFKNPPLNLFSDSYQALPQNKLTIRLQPDEGVQIDILNKVPGLEHKHRLQ
TTKLDLSFSDTFHQEHLADAYERLLLEAMRGIQALFVRRDEVEEAWKWVDSIMTAWADDNDAPKPYQAGTWGPVSSVALI
TRDGRCWNEF
>Mature_489_residues
AVTSTAQACDLIIFGAKGDLARRKLLPSLYQLEKAGHIHPETRIIGVGRAEWDAAAYRKVVREALDTFLKEPLDDALWQR
LSARLDFCNLDVNDTEHFQRLAERVEPQQRVTINYFAMPPSTFGAICQGLGHAGMNLQPSRIVMEKPLGTDLASSQAIND
QVARYFDENQVYRIDHYLGKETVLNLLALRFANALFANNWDNSMIDHVQITVAEEVGIEGRWGYFDQAGQMRDMVQNHLL
QILTMIAMDPPADLSTDRIRDEKVKVLRSLRRINHSNVRETTVRGQYTAGFVQGQKVPGYLEEEGANKCSNTETFIAIRV
DIDNWRWAGVPFYLRTGKRLPSKCSEVVIYFKNPPLNLFSDSYQALPQNKLTIRLQPDEGVQIDILNKVPGLEHKHRLQT
TKLDLSFSDTFHQEHLADAYERLLLEAMRGIQALFVRRDEVEEAWKWVDSIMTAWADDNDAPKPYQAGTWGPVSSVALIT
RDGRCWNEF

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=479, Percent_Identity=36.5344467640919, Blast_Score=307, Evalue=2e-83,
Organism=Homo sapiens, GI108773793, Length=479, Percent_Identity=36.5344467640919, Blast_Score=307, Evalue=2e-83,
Organism=Homo sapiens, GI52145310, Length=500, Percent_Identity=27.6, Blast_Score=159, Evalue=6e-39,
Organism=Escherichia coli, GI1788158, Length=490, Percent_Identity=81.8367346938776, Blast_Score=858, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17538218, Length=494, Percent_Identity=36.4372469635627, Blast_Score=305, Evalue=3e-83,
Organism=Saccharomyces cerevisiae, GI6324088, Length=476, Percent_Identity=33.8235294117647, Blast_Score=275, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24643350, Length=471, Percent_Identity=36.3057324840764, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24643352, Length=471, Percent_Identity=36.3057324840764, Blast_Score=293, Evalue=1e-79,
Organism=Drosophila melanogaster, GI221513548, Length=488, Percent_Identity=29.0983606557377, Blast_Score=183, Evalue=3e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 55849; Mature: 55718

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTSTAQACDLIIFGAKGDLARRKLLPSLYQLEKAGHIHPETRIIGVGRAEWDAAAYRK
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHH
VVREALDTFLKEPLDDALWQRLSARLDFCNLDVNDTEHFQRLAERVEPQQRVTINYFAMP
HHHHHHHHHHHCCHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHCCCCCEEEEEEEECC
PSTFGAICQGLGHAGMNLQPSRIVMEKPLGTDLASSQAINDQVARYFDENQVYRIDHYLG
CHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHC
KETVLNLLALRFANALFANNWDNSMIDHVQITVAEEVGIEGRWGYFDQAGQMRDMVQNHL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCCCCCCCHHCCHHHHHHHHHHH
LQILTMIAMDPPADLSTDRIRDEKVKVLRSLRRINHSNVRETTVRGQYTAGFVQGQKVPG
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEECCCEEEHEEECCCCCC
YLEEEGANKCSNTETFIAIRVDIDNWRWAGVPFYLRTGKRLPSKCSEVVIYFKNPPLNLF
CHHHHCCCCCCCCCEEEEEEEEECCCEECCCCCEECCCCCCCCCCCEEEEEECCCCCCHH
SDSYQALPQNKLTIRLQPDEGVQIDILNKVPGLEHKHRLQTTKLDLSFSDTFHQEHLADA
CCHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHEEEEEEHHHHHHHHHHHHH
YERLLLEAMRGIQALFVRRDEVEEAWKWVDSIMTAWADDNDAPKPYQAGTWGPVSSVALI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEE
TRDGRCWNEF
EECCCCCCCC
>Mature Secondary Structure 
AVTSTAQACDLIIFGAKGDLARRKLLPSLYQLEKAGHIHPETRIIGVGRAEWDAAAYRK
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHH
VVREALDTFLKEPLDDALWQRLSARLDFCNLDVNDTEHFQRLAERVEPQQRVTINYFAMP
HHHHHHHHHHHCCHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHCCCCCEEEEEEEECC
PSTFGAICQGLGHAGMNLQPSRIVMEKPLGTDLASSQAINDQVARYFDENQVYRIDHYLG
CHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEHHHHHC
KETVLNLLALRFANALFANNWDNSMIDHVQITVAEEVGIEGRWGYFDQAGQMRDMVQNHL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHCCCCCCCCCHHCCHHHHHHHHHHH
LQILTMIAMDPPADLSTDRIRDEKVKVLRSLRRINHSNVRETTVRGQYTAGFVQGQKVPG
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEECCCEEEHEEECCCCCC
YLEEEGANKCSNTETFIAIRVDIDNWRWAGVPFYLRTGKRLPSKCSEVVIYFKNPPLNLF
CHHHHCCCCCCCCCEEEEEEEEECCCEECCCCCEECCCCCCCCCCCEEEEEECCCCCCHH
SDSYQALPQNKLTIRLQPDEGVQIDILNKVPGLEHKHRLQTTKLDLSFSDTFHQEHLADA
CCHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHEEEEEEHHHHHHHHHHHHH
YERLLLEAMRGIQALFVRRDEVEEAWKWVDSIMTAWADDNDAPKPYQAGTWGPVSSVALI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEE
TRDGRCWNEF
EECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8145647 [H]