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The map label for this gene is hemA

Identifier: 238919469

GI number: 238919469

Start: 1524299

End: 1525561

Strand: Direct

Name: hemA

Synonym: NT01EI_1563

Alternate gene names: 238919469

Gene position: 1524299-1525561 (Clockwise)

Preceding gene: 238919464

Following gene: 238919470

Centisome position: 39.98

GC content: 62.79

Gene sequence:

>1263_bases
ATGAGTCTTCTTGCACTTGGAATCAATCATAAAACGGCGCCGGTCTCCCTGCGGGAACGGGTAACGTTTTCGCCCGATAC
GCTGGATCGGGCCATTGAAAGCCTGCTGCGACAGCCGTCGGTGCAGGCCGGGGTAGTGCTGTCGACCTGTAACCGCACCG
AGCTGTATCTGAGCGTGGAGCAGCGGGCCGATCTGCGTCAGCAGATCGTCGACTGGCTGTGTAGCTACCATCAGCTGACG
CCAGAGGAGGTGAGCGACAGTCTCTATTGGCATCAGGATAACGAGGCGGTCAGCCATCTGATGCGGGTGGCCAGCGGCCT
GGACTCGCTGGTGCTGGGCGAGCCGCAAATACTGGGCCAGGTGAAGAAAGCCTTTTCGGAATCTCAACGTGAGCAGGCGC
TGTCTGCTGACCTGGAGCGTCTGTTTCAAAAGACTTTCTCGGTGGCCAAGCGGGTACGTACGGAAACCGAAATCGGCACC
AGCGCGGTGTCGGTGGCGTTTGCCGCCTGTACGCTGGCGCGCCAGATCTTTGAGTCGCTGGCCCGGCTTAACGTGCTGCT
GGTCGGGGCGGGTGAGACCATTGAGCTGGTGGCCCGCCATCTGCATCAGCACCAGGTACAGCATATGATGATCGCCAACC
GTACCCGTGAGCGTGCCCAGTCGCTGGCCGATGAGGTCGGGGCTGAGGTGATCCCGCTGGCGGATATCGATGCCCGCCTG
GCGGACGCCGATATCGTTATCAGCTCGACGGCCAGCCCGCTGCCGATCATCGGTAAAGGAATGGTCGAGCGCGCGCTGAA
GGCGCGCCGCAACAGGCCGATGCTGTTGGTCGATATCGCCGTTCCGCGCGACATTGAGCCGGAGGTCGGCGATCTGGCCA
ACGCCTATCTGTACAGCGTGGATGATCTGCATGCCATTATTCAGGGCAATATGGCCCAGCGGCAGGAGGCGGCGGTGCAG
GCCGAGCACATCGTGCAGCAGGAGTGTGCCAACTTTATGGCCTGGTTGCGCGCGCAGGGGGCCGTCGATACCATCCGTGA
ATACCGGGCTCAGGCGGAGCAGCGGCGGGCCGAGGCCGAATCCGAAGCGCTGGCGGCGCTGGCGCAGGGCGTTGAGGCAG
AGGCAGTGATCCGCCGCCTGGCGCATCGCCTGACCAACCGCCTGATCCATGCACCGACCAAATCCCTTCAGCAGGCCGCT
GGCAGCGGCGATGCACAGCGTCTGCAGATGCTGCGCGACAGCCTTGGGCTGGATCATAATTAG

Upstream 100 bases:

>100_bases
CGCTCCGGCGGTGCGGTGGCTTTTATTGCTTCGGTGCATCAAGTAGAATGCAGCGATAACCGATAACCCTAATGAAGTCG
CGACTACTTGACGGTTTTTC

Downstream 100 bases:

>100_bases
TTCTCTCCTTTCTTATATATTTACAGGTAAATAGCCACGCATGAAGCCCTCTATCGTTGCCAAACTAGAAGCATTACAGG
AGCGCCATGAAGAAGTTCAG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSLLALGINHKTAPVSLRERVTFSPDTLDRAIESLLRQPSVQAGVVLSTCNRTELYLSVEQRADLRQQIVDWLCSYHQLT
PEEVSDSLYWHQDNEAVSHLMRVASGLDSLVLGEPQILGQVKKAFSESQREQALSADLERLFQKTFSVAKRVRTETEIGT
SAVSVAFAACTLARQIFESLARLNVLLVGAGETIELVARHLHQHQVQHMMIANRTRERAQSLADEVGAEVIPLADIDARL
ADADIVISSTASPLPIIGKGMVERALKARRNRPMLLVDIAVPRDIEPEVGDLANAYLYSVDDLHAIIQGNMAQRQEAAVQ
AEHIVQQECANFMAWLRAQGAVDTIREYRAQAEQRRAEAESEALAALAQGVEAEAVIRRLAHRLTNRLIHAPTKSLQQAA
GSGDAQRLQMLRDSLGLDHN

Sequences:

>Translated_420_residues
MSLLALGINHKTAPVSLRERVTFSPDTLDRAIESLLRQPSVQAGVVLSTCNRTELYLSVEQRADLRQQIVDWLCSYHQLT
PEEVSDSLYWHQDNEAVSHLMRVASGLDSLVLGEPQILGQVKKAFSESQREQALSADLERLFQKTFSVAKRVRTETEIGT
SAVSVAFAACTLARQIFESLARLNVLLVGAGETIELVARHLHQHQVQHMMIANRTRERAQSLADEVGAEVIPLADIDARL
ADADIVISSTASPLPIIGKGMVERALKARRNRPMLLVDIAVPRDIEPEVGDLANAYLYSVDDLHAIIQGNMAQRQEAAVQ
AEHIVQQECANFMAWLRAQGAVDTIREYRAQAEQRRAEAESEALAALAQGVEAEAVIRRLAHRLTNRLIHAPTKSLQQAA
GSGDAQRLQMLRDSLGLDHN
>Mature_419_residues
SLLALGINHKTAPVSLRERVTFSPDTLDRAIESLLRQPSVQAGVVLSTCNRTELYLSVEQRADLRQQIVDWLCSYHQLTP
EEVSDSLYWHQDNEAVSHLMRVASGLDSLVLGEPQILGQVKKAFSESQREQALSADLERLFQKTFSVAKRVRTETEIGTS
AVSVAFAACTLARQIFESLARLNVLLVGAGETIELVARHLHQHQVQHMMIANRTRERAQSLADEVGAEVIPLADIDARLA
DADIVISSTASPLPIIGKGMVERALKARRNRPMLLVDIAVPRDIEPEVGDLANAYLYSVDDLHAIIQGNMAQRQEAAVQA
EHIVQQECANFMAWLRAQGAVDTIREYRAQAEQRRAEAESEALAALAQGVEAEAVIRRLAHRLTNRLIHAPTKSLQQAAG
SGDAQRLQMLRDSLGLDHN

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=418, Percent_Identity=75.5980861244019, Blast_Score=628, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_EDWI9 (C5B813)

Other databases:

- EMBL:   CP001600
- RefSeq:   YP_002932984.1
- ProteinModelPortal:   C5B813
- GeneID:   7961044
- GenomeReviews:   CP001600_GR
- KEGG:   eic:NT01EI_1563
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR003462
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR13812
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46408; Mature: 46277

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLALGINHKTAPVSLRERVTFSPDTLDRAIESLLRQPSVQAGVVLSTCNRTELYLSVE
CCEEEEECCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEEEHH
QRADLRQQIVDWLCSYHQLTPEEVSDSLYWHQDNEAVSHLMRVASGLDSLVLGEPQILGQ
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCHHHHHH
VKKAFSESQREQALSADLERLFQKTFSVAKRVRTETEIGTSAVSVAFAACTLARQIFESL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLNVLLVGAGETIELVARHLHQHQVQHMMIANRTRERAQSLADEVGAEVIPLADIDARL
HHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHH
ADADIVISSTASPLPIIGKGMVERALKARRNRPMLLVDIAVPRDIEPEVGDLANAYLYSV
CCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
DDLHAIIQGNMAQRQEAAVQAEHIVQQECANFMAWLRAQGAVDTIREYRAQAEQRRAEAE
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SEALAALAQGVEAEAVIRRLAHRLTNRLIHAPTKSLQQAAGSGDAQRLQMLRDSLGLDHN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SLLALGINHKTAPVSLRERVTFSPDTLDRAIESLLRQPSVQAGVVLSTCNRTELYLSVE
CEEEEECCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCEEEEEEHH
QRADLRQQIVDWLCSYHQLTPEEVSDSLYWHQDNEAVSHLMRVASGLDSLVLGEPQILGQ
HHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCHHHHHH
VKKAFSESQREQALSADLERLFQKTFSVAKRVRTETEIGTSAVSVAFAACTLARQIFESL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARLNVLLVGAGETIELVARHLHQHQVQHMMIANRTRERAQSLADEVGAEVIPLADIDARL
HHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHH
ADADIVISSTASPLPIIGKGMVERALKARRNRPMLLVDIAVPRDIEPEVGDLANAYLYSV
CCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
DDLHAIIQGNMAQRQEAAVQAEHIVQQECANFMAWLRAQGAVDTIREYRAQAEQRRAEAE
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SEALAALAQGVEAEAVIRRLAHRLTNRLIHAPTKSLQQAAGSGDAQRLQMLRDSLGLDHN
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA