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The map label for this gene is prs [H]

Identifier: 238919466

GI number: 238919466

Start: 1521449

End: 1522396

Strand: Reverse

Name: prs [H]

Synonym: NT01EI_1560

Alternate gene names: 238919466

Gene position: 1522396-1521449 (Counterclockwise)

Preceding gene: 238919467

Following gene: 238919465

Centisome position: 39.93

GC content: 58.54

Gene sequence:

>948_bases
GTGCCTGATATGAAGCTTTTTGCTGGTAACGCTACCCCGGAACTAGCACAACGTATTGCCAACCGTTTGTACACCAGCCT
CGGCGACGCCGCTGTAGGCCGTTTTAGTGACGGCGAAGTGAGCGTGCAAATTAACGAAAATGTACGCGGTGGTGATATTT
TCATCATCCAGTCCACCTGTGCCCCGACCAACGATAACCTGATGGAGCTGGTTGTCATGGTTGACGCACTGCGCCGCGCC
TCTGCCGGTCGCATCACAGCGGTAATCCCTTACTTCGGCTATGCGCGTCAGGATCGCCGCGTGCGCTCCGCCCGTGTGCC
GATCACGGCAAAAGTCGTCGCGGACTTCCTCTCCAGCGTAGGGGTTGACCGCGTACTGACCGTGGACCTGCATGCAGAAC
AGATCCAGGGCTTCTTCGACGTACCGGTAGATAACGTATTCGGCAGCCCGATCCTGCTGGAAGACATGCTGCAGCAGAAG
CTGGAAAACCCGATCGTGGTCTCTCCGGACATCGGCGGCGTCGTACGTGCCCGCGCCATCGCCAAACTGCTCAACGATAC
CGACATGGCCATCATCGATAAGCGTCGTCCGCGCGCCAACGTCTCCCAGGTGATGCACATCATCGGTGACGTCGCCGATC
GCGACTGCGTCCTGGTCGACGACATGATCGATACCGGCGGCACCCTGTGCAAAGCGGCCGAAGCGCTGAAAGAGCGTGGC
GCCAAGCGCGTATTCGCCTATGCGACCCATCCGATCTTCTCCGGCAACGCCATTGACAACATCAAGAATTCCGTCATCGA
TGAGTTTGTGGTGTGTGACACCATTCCGCTGGCGCCGGAGATCAAGGCGCTGGACAAGGTGCGCAGCCTGACGCTGTCCG
GTATGTTGGCCGAAGCCATCCGCCGCATCAGCAACGAAGAGTCCATCTCTGCGATGTTTGAACACTGA

Upstream 100 bases:

>100_bases
GACTCAAACAATACCCGTAGGGTAATGCGGCGCGTCAGCCCACTCCCAGTTAGCGCGCCGTACTATCAACTTCTCTGGAC
GCAAGCCTGAGGTTCTTCTC

Downstream 100 bases:

>100_bases
TAGCTTGCGCCAGATAAAAACGGCGGATTTATCCGCCGTTTTTCGTTTCTGTCGCGCGGTGGACTGGGTAGAGTCCACCG
TCACCCGCCCCCGAGATACC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MPDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQQK
LENPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVADRDCVLVDDMIDTGGTLCKAAEALKERG
AKRVFAYATHPIFSGNAIDNIKNSVIDEFVVCDTIPLAPEIKALDKVRSLTLSGMLAEAIRRISNEESISAMFEH

Sequences:

>Translated_315_residues
MPDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRA
SAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQQK
LENPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVADRDCVLVDDMIDTGGTLCKAAEALKERG
AKRVFAYATHPIFSGNAIDNIKNSVIDEFVVCDTIPLAPEIKALDKVRSLTLSGMLAEAIRRISNEESISAMFEH
>Mature_314_residues
PDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTCAPTNDNLMELVVMVDALRRAS
AGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSVGVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQQKL
ENPIVVSPDIGGVVRARAIAKLLNDTDMAIIDKRRPRANVSQVMHIIGDVADRDCVLVDDMIDTGGTLCKAAEALKERGA
KRVFAYATHPIFSGNAIDNIKNSVIDEFVVCDTIPLAPEIKALDKVRSLTLSGMLAEAIRRISNEESISAMFEH

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=317, Percent_Identity=48.8958990536278, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI4506129, Length=317, Percent_Identity=48.8958990536278, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI84875539, Length=319, Percent_Identity=48.58934169279, Blast_Score=305, Evalue=3e-83,
Organism=Homo sapiens, GI28557709, Length=317, Percent_Identity=48.2649842271293, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI4506133, Length=343, Percent_Identity=35.2769679300292, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI194018537, Length=343, Percent_Identity=35.8600583090379, Blast_Score=184, Evalue=7e-47,
Organism=Homo sapiens, GI310128524, Length=153, Percent_Identity=32.6797385620915, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI310115209, Length=153, Percent_Identity=32.6797385620915, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI310118259, Length=153, Percent_Identity=32.6797385620915, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI310119946, Length=153, Percent_Identity=32.6797385620915, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1787458, Length=315, Percent_Identity=95.2380952380952, Blast_Score=605, Evalue=1e-174,
Organism=Caenorhabditis elegans, GI25149168, Length=317, Percent_Identity=45.7413249211356, Blast_Score=291, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI17554702, Length=317, Percent_Identity=45.7413249211356, Blast_Score=290, Evalue=5e-79,
Organism=Caenorhabditis elegans, GI71989924, Length=317, Percent_Identity=45.7413249211356, Blast_Score=288, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17554704, Length=312, Percent_Identity=45.5128205128205, Blast_Score=282, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17570245, Length=338, Percent_Identity=33.1360946745562, Blast_Score=188, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6321776, Length=319, Percent_Identity=47.6489028213166, Blast_Score=268, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6319403, Length=316, Percent_Identity=45.5696202531646, Blast_Score=268, Evalue=1e-72,
Organism=Saccharomyces cerevisiae, GI6320946, Length=315, Percent_Identity=45.7142857142857, Blast_Score=266, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6322667, Length=206, Percent_Identity=40.7766990291262, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324511, Length=115, Percent_Identity=41.7391304347826, Blast_Score=102, Evalue=7e-23,
Organism=Drosophila melanogaster, GI21355239, Length=317, Percent_Identity=47.6340694006309, Blast_Score=293, Evalue=7e-80,
Organism=Drosophila melanogaster, GI45551540, Length=339, Percent_Identity=44.5427728613569, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI24651458, Length=356, Percent_Identity=33.9887640449438, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24651456, Length=356, Percent_Identity=33.9887640449438, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI281362873, Length=356, Percent_Identity=33.9887640449438, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24651454, Length=356, Percent_Identity=33.9887640449438, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24651462, Length=375, Percent_Identity=32.2666666666667, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24651464, Length=375, Percent_Identity=32.2666666666667, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI45552010, Length=375, Percent_Identity=32.2666666666667, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34351; Mature: 34220

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTC
CCCCEEEECCCCHHHHHHHHHHHHHHHCHHHHCCCCCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
GVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQQKLENPIVVSPDIGGVVRARAI
CCCEEEEEEECHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHH
AKLLNDTDMAIIDKRRPRANVSQVMHIIGDVADRDCVLVDDMIDTGGTLCKAAEALKERG
HHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEHHHHHCCCHHHHHHHHHHHCC
AKRVFAYATHPIFSGNAIDNIKNSVIDEFVVCDTIPLAPEIKALDKVRSLTLSGMLAEAI
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RRISNEESISAMFEH
HHHCCHHHHHHHHCC
>Mature Secondary Structure 
PDMKLFAGNATPELAQRIANRLYTSLGDAAVGRFSDGEVSVQINENVRGGDIFIIQSTC
CCCEEEECCCCHHHHHHHHHHHHHHHCHHHHCCCCCCEEEEEECCCCCCCEEEEEECCC
APTNDNLMELVVMVDALRRASAGRITAVIPYFGYARQDRRVRSARVPITAKVVADFLSSV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHC
GVDRVLTVDLHAEQIQGFFDVPVDNVFGSPILLEDMLQQKLENPIVVSPDIGGVVRARAI
CCCEEEEEEECHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHH
AKLLNDTDMAIIDKRRPRANVSQVMHIIGDVADRDCVLVDDMIDTGGTLCKAAEALKERG
HHHHCCCCEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEHHHHHCCCHHHHHHHHHHHCC
AKRVFAYATHPIFSGNAIDNIKNSVIDEFVVCDTIPLAPEIKALDKVRSLTLSGMLAEAI
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RRISNEESISAMFEH
HHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]