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The map label for this gene is arnA [H]

Identifier: 238919324

GI number: 238919324

Start: 1402208

End: 1404187

Strand: Direct

Name: arnA [H]

Synonym: NT01EI_1415

Alternate gene names: 238919324

Gene position: 1402208-1404187 (Clockwise)

Preceding gene: 238919323

Following gene: 238919325

Centisome position: 36.78

GC content: 58.54

Gene sequence:

>1980_bases
ATGAAAGCTGTTGTCTTTGCCTATCACGATATGGGCTGTGCCGGTGTGCAGTCATTGATTGATGCCGGTTACGAAATCGC
TGCCATCGTTACCCACCAGGATGCTCCCGGTGAAAATCTGTTCTTTGGCTCGGTCGCCCGCCTTGCGGCCCAGCATAATA
TTCCGGTATTTGCGCCGGATGATGTGAATCATCCGCTGTGGGTTGAGCGCCTGCGGGCGCTGCAGCCGCAGGTGATCTTC
TCTTTCTACTATCGCCATCTGCTGAACGATGAGATTTTGGCGCTGGCACCGCAGGGCGCGTTTAACCTGCATGGTTCGCT
GCTGCCGGCCTACCGTGGCCGTGCGCCGCTGAACTGGGTATTGGTCAACGGCGAGACGGAGAGCGGGGTGACGCTGCACC
GTATGGAGAAGCGTGCGGATGCCGGGAATATTATCGCTCAGCATCGTATCGCGATCGCCGAAGAGGATACGGCGCTGACG
CTGCACCACAAGCTGTGCCAGTGCGCCCGCGTGCTGCTGGCTGAGGCATTGCCACAGATCCGCAGCGGCAGCTATGCTGA
ATTCCCGCAGGATGAAAGCGCCGCGACCTACGTAGGTCGCCGTACTCCGGCCGATGGCCGCCTGGAGTGGAGCAAACCGG
CGCGGGAGCTGTATAACCTGGTTCGCGCGGTGACAGAGCCTTGGCCGGGTGCCTTTAGCTATGCCGGTAACCGTCAGTTT
ACGGTCTGGCAGGCACGGGTACGCCGCGATCTGCCTGCTGCACGCCCCGGCACGGTGCTTTTGGCATCGCCGCTGACGAT
CGCCTGTGGCGAAGGGGCGCTGGAGATCGTGGCCGGTCAGCCGCAGGACGGCCTGTATATGCAGGGCAGCCAGCTGGCGG
AAAGCCTGGGGCTGGTTGAAGGCGCCATTCTGAACAGTTCGCTGAATTTTGGCGCCCGCCGGGCGACCCGGGTACTGATC
CTGGGCGTTAACGGCTTTATCGGTAACCATTTGACCGAGCGTCTGCTGGCGGAAGATAACTATGAAATCTACGGCCTGGA
TATCGGCTCCGACGCCATTTCACGGTTTATCGGCCACCCGCGCTTCCACTTTGTCGAAGGGGATATCAGTATTCACTCCG
AATGGATCGAGTATCACATTAAGAAGTGTGATGTGGTGCTGCCGCTGGTGGCGATCGCCACGCCGATCGAATATACCCGT
AATCCGCTGCGCGTTTTTGAGCTCGACTTTGAAGAGAACCTGAAGATTGTGCGCGACTGCGTAAAATACAAGAAGCGCAT
CATCTTCCCGTCCACCTCTGAAGTCTACGGTATGTGCAGCGATCCGCAGTTTGATGAGGATAGCTCTAACCTGATCGTCG
GGCCGATCAACAAACAGCGCTGGATCTACTCCGTATCCAAACAGCTGCTGGACCGCATCATCTGGGCCTACGGTGCCAAG
GATGAACTGCGCTTCACGCTGTTCCGCCCCTTCAACTGGATGGGGCCGCGTCTGGACAACCTGAATGCGGCGCGCATCGG
CAGTTCCCGCGCCATTACCCAGCTGATCCTGAATCTGGTGGAAGGGTCGCCGATCAAGCTGGTGGACGGTGGACGCCAGA
AGCGCTGCTTTACCGATATTAAAGAAGGGGTTGAGGCACTGTTCCGCATTATCGAAAACAAAGACAATCTGTGTGACGGG
CAGATTATCAACATCGGTAACCCGGATAACGAAGCCAGCATCCGTGAACTGGCTGAGCAGCTGCTGGTGTGCTTTGAGCA
GCACCCGCTGCGCGATCGCTTCCCGCCTTTCGCCGGTTTCCGCGAAGTGGAGAGCAGCAGCTACTATGGCAAAGGCTATC
AGGACGTGGAGCACCGTAAGCCGAGCATCCGCAACGCACAGCGTCTGCTGGGCTGGCAGCCGGTGATCCCGATGGAGAGC
ACTATCGAGGATACCCTGGACTTCTTCCTGCAGACCTTTGACGGTACGGAGCAGGAATGA

Upstream 100 bases:

>100_bases
ATATCGGCCGCATCTATAACGACGTGCGCGCCCGCCCCCGCTATTTTATTCAGAATGTCGTCCGCGCTAACCAGCCGGAC
GAAGAACAGGAAAAATGATC

Downstream 100 bases:

>100_bases
AACGGGTTGGTCTGCGCATTGACGTAGACACCTGGCGCGGCACGCGTGATGGCGTGCCGGCGCTGGTGTCGCTGCTGCGC
CGGCACGGGATCCGGGCGAC

Product: bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase

Products: NA

Alternate protein names: UDP-4-amino-4-deoxy-L-arabinose formyltransferase; ArnAFT; UDP-L-Ara4N formyltransferase; UDP-glucuronic acid oxidase, UDP-4-keto-hexauronic acid decarboxylating; ArnADH; UDP-GlcUA decarboxylase; UDP-glucuronic acid dehydrogenase [H]

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MKAVVFAYHDMGCAGVQSLIDAGYEIAAIVTHQDAPGENLFFGSVARLAAQHNIPVFAPDDVNHPLWVERLRALQPQVIF
SFYYRHLLNDEILALAPQGAFNLHGSLLPAYRGRAPLNWVLVNGETESGVTLHRMEKRADAGNIIAQHRIAIAEEDTALT
LHHKLCQCARVLLAEALPQIRSGSYAEFPQDESAATYVGRRTPADGRLEWSKPARELYNLVRAVTEPWPGAFSYAGNRQF
TVWQARVRRDLPAARPGTVLLASPLTIACGEGALEIVAGQPQDGLYMQGSQLAESLGLVEGAILNSSLNFGARRATRVLI
LGVNGFIGNHLTERLLAEDNYEIYGLDIGSDAISRFIGHPRFHFVEGDISIHSEWIEYHIKKCDVVLPLVAIATPIEYTR
NPLRVFELDFEENLKIVRDCVKYKKRIIFPSTSEVYGMCSDPQFDEDSSNLIVGPINKQRWIYSVSKQLLDRIIWAYGAK
DELRFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLVDGGRQKRCFTDIKEGVEALFRIIENKDNLCDG
QIINIGNPDNEASIRELAEQLLVCFEQHPLRDRFPPFAGFREVESSSYYGKGYQDVEHRKPSIRNAQRLLGWQPVIPMES
TIEDTLDFFLQTFDGTEQE

Sequences:

>Translated_659_residues
MKAVVFAYHDMGCAGVQSLIDAGYEIAAIVTHQDAPGENLFFGSVARLAAQHNIPVFAPDDVNHPLWVERLRALQPQVIF
SFYYRHLLNDEILALAPQGAFNLHGSLLPAYRGRAPLNWVLVNGETESGVTLHRMEKRADAGNIIAQHRIAIAEEDTALT
LHHKLCQCARVLLAEALPQIRSGSYAEFPQDESAATYVGRRTPADGRLEWSKPARELYNLVRAVTEPWPGAFSYAGNRQF
TVWQARVRRDLPAARPGTVLLASPLTIACGEGALEIVAGQPQDGLYMQGSQLAESLGLVEGAILNSSLNFGARRATRVLI
LGVNGFIGNHLTERLLAEDNYEIYGLDIGSDAISRFIGHPRFHFVEGDISIHSEWIEYHIKKCDVVLPLVAIATPIEYTR
NPLRVFELDFEENLKIVRDCVKYKKRIIFPSTSEVYGMCSDPQFDEDSSNLIVGPINKQRWIYSVSKQLLDRIIWAYGAK
DELRFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLVDGGRQKRCFTDIKEGVEALFRIIENKDNLCDG
QIINIGNPDNEASIRELAEQLLVCFEQHPLRDRFPPFAGFREVESSSYYGKGYQDVEHRKPSIRNAQRLLGWQPVIPMES
TIEDTLDFFLQTFDGTEQE
>Mature_659_residues
MKAVVFAYHDMGCAGVQSLIDAGYEIAAIVTHQDAPGENLFFGSVARLAAQHNIPVFAPDDVNHPLWVERLRALQPQVIF
SFYYRHLLNDEILALAPQGAFNLHGSLLPAYRGRAPLNWVLVNGETESGVTLHRMEKRADAGNIIAQHRIAIAEEDTALT
LHHKLCQCARVLLAEALPQIRSGSYAEFPQDESAATYVGRRTPADGRLEWSKPARELYNLVRAVTEPWPGAFSYAGNRQF
TVWQARVRRDLPAARPGTVLLASPLTIACGEGALEIVAGQPQDGLYMQGSQLAESLGLVEGAILNSSLNFGARRATRVLI
LGVNGFIGNHLTERLLAEDNYEIYGLDIGSDAISRFIGHPRFHFVEGDISIHSEWIEYHIKKCDVVLPLVAIATPIEYTR
NPLRVFELDFEENLKIVRDCVKYKKRIIFPSTSEVYGMCSDPQFDEDSSNLIVGPINKQRWIYSVSKQLLDRIIWAYGAK
DELRFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLVDGGRQKRCFTDIKEGVEALFRIIENKDNLCDG
QIINIGNPDNEASIRELAEQLLVCFEQHPLRDRFPPFAGFREVESSSYYGKGYQDVEHRKPSIRNAQRLLGWQPVIPMES
TIEDTLDFFLQTFDGTEQE

Specific function: Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabin

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the sugar epimerase family. UDP-glucuronic acid decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=344, Percent_Identity=26.7441860465116, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI21614513, Length=315, Percent_Identity=23.8095238095238, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI238814322, Length=290, Percent_Identity=22.4137931034483, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1788589, Length=658, Percent_Identity=75.9878419452888, Blast_Score=1051, Evalue=0.0,
Organism=Escherichia coli, GI1789683, Length=298, Percent_Identity=30.2013422818792, Blast_Score=135, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17539532, Length=348, Percent_Identity=25.5747126436782, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI133930964, Length=262, Percent_Identity=24.8091603053435, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356223, Length=348, Percent_Identity=25.2873563218391, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI28571984, Length=207, Percent_Identity=28.5024154589372, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45550868, Length=207, Percent_Identity=28.5024154589372, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR021168
- InterPro:   IPR001509
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase; PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.13; =1.1.1.305 [H]

Molecular weight: Translated: 74001; Mature: 74001

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVFAYHDMGCAGVQSLIDAGYEIAAIVTHQDAPGENLFFGSVARLAAQHNIPVFAPD
CCEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEECCC
DVNHPLWVERLRALQPQVIFSFYYRHLLNDEILALAPQGAFNLHGSLLPAYRGRAPLNWV
CCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHCCCCCEEEE
LVNGETESGVTLHRMEKRADAGNIIAQHRIAIAEEDTALTLHHKLCQCARVLLAEALPQI
EEECCCCCCCHHHHHHHHCCCCCHHHHHEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHH
RSGSYAEFPQDESAATYVGRRTPADGRLEWSKPARELYNLVRAVTEPWPGAFSYAGNRQF
HCCCCCCCCCCCCHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCEECCCCCEE
TVWQARVRRDLPAARPGTVLLASPLTIACGEGALEIVAGQPQDGLYMQGSQLAESLGLVE
EHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCEEEEECCCCCCCEECHHHHHHHHHHHH
GAILNSSLNFGARRATRVLILGVNGFIGNHLTERLLAEDNYEIYGLDIGSDAISRFIGHP
HHHHCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCC
RFHFVEGDISIHSEWIEYHIKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLKIVRDC
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEECHHHCHHHHHHH
VKYKKRIIFPSTSEVYGMCSDPQFDEDSSNLIVGPINKQRWIYSVSKQLLDRIIWAYGAK
HHHHHEEECCCCHHHEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCC
DELRFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLVDGGRQKRCFTDI
CCEEEEEECCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
KEGVEALFRIIENKDNLCDGQIINIGNPDNEASIRELAEQLLVCFEQHPLRDRFPPFAGF
HHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCCCH
REVESSSYYGKGYQDVEHRKPSIRNAQRLLGWQPVIPMESTIEDTLDFFLQTFDGTEQE
HHHCCCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKAVVFAYHDMGCAGVQSLIDAGYEIAAIVTHQDAPGENLFFGSVARLAAQHNIPVFAPD
CCEEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEECCC
DVNHPLWVERLRALQPQVIFSFYYRHLLNDEILALAPQGAFNLHGSLLPAYRGRAPLNWV
CCCCCHHHHHHHHHCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHCCCCCEEEE
LVNGETESGVTLHRMEKRADAGNIIAQHRIAIAEEDTALTLHHKLCQCARVLLAEALPQI
EEECCCCCCCHHHHHHHHCCCCCHHHHHEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHH
RSGSYAEFPQDESAATYVGRRTPADGRLEWSKPARELYNLVRAVTEPWPGAFSYAGNRQF
HCCCCCCCCCCCCHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHCCCCCCCEECCCCCEE
TVWQARVRRDLPAARPGTVLLASPLTIACGEGALEIVAGQPQDGLYMQGSQLAESLGLVE
EHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCEEEEECCCCCCCEECHHHHHHHHHHHH
GAILNSSLNFGARRATRVLILGVNGFIGNHLTERLLAEDNYEIYGLDIGSDAISRFIGHP
HHHHCCCCCCCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCC
RFHFVEGDISIHSEWIEYHIKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLKIVRDC
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCEEEEEECHHHCHHHHHHH
VKYKKRIIFPSTSEVYGMCSDPQFDEDSSNLIVGPINKQRWIYSVSKQLLDRIIWAYGAK
HHHHHEEECCCCHHHEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCC
DELRFTLFRPFNWMGPRLDNLNAARIGSSRAITQLILNLVEGSPIKLVDGGRQKRCFTDI
CCEEEEEECCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
KEGVEALFRIIENKDNLCDGQIINIGNPDNEASIRELAEQLLVCFEQHPLRDRFPPFAGF
HHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHCCCCCCCH
REVESSSYYGKGYQDVEHRKPSIRNAQRLLGWQPVIPMESTIEDTLDFFLQTFDGTEQE
HHHCCCCCCCCCCCHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA