Click here to switch to the map view.

The map label for this gene is acrR [H]

Identifier: 238919032

GI number: 238919032

Start: 1095979

End: 1096692

Strand: Direct

Name: acrR [H]

Synonym: NT01EI_1100

Alternate gene names: 238919032

Gene position: 1095979-1096692 (Clockwise)

Preceding gene: 238919027

Following gene: 238919033

Centisome position: 28.75

GC content: 53.64

Gene sequence:

>714_bases
ATGGCACGAAAAACCAAACAGCAGGCCCAAGAGACCCGACAGCAAATCCTTGACGCTGCCATACGTGAGTTTTCCGCACG
CGGTGTCGCCGCCACCTCATTAAACGATATCGCTAACGCTGCAGGGGTTACCCGTGGGGCCATTTACTGGCATTTTAAGA
ACAAAACTGACATTTTTCACGCCGTCTGGGAGTTTATGGAGTCCAGGCTCAGTGAGCTTGAGCTAGAGTATCAGACAAAG
TTTCCGGATGATCCACTGCGTATATTGCGTGAGCTCCTAATTTTTATTTTGGTCGCGACGGTGGTGGATCCGCAGCGACG
GGCGATGATGGAAATTCTGTACCATAAGTGCGAGTTCGTCGGCGAGATGCGGGCGCTGGGCGAACGGCGTAAACTGATGT
ATCTGGAGAGCTACACGCGCATTGAACGGGTTCTGCAGCACTGTGTCTTTCGGGAGCAGCTGCCGTCGAATCTGGATATG
CTGCGCAGTGCCATCGCCCTGCGCAGCTATATTACCGGTATCATGGAGAGCTGGCTGTTTACCCCGGAGCGCTTCGATCT
GCAACAGCAGGCGATACCGCTGGTGGATAACGTGATCGCCATGCTACAGCACAGCCCGTTTTTACGCCGTGATGCGGCGT
GTGCGCCCAATGATACCTCTGTATGGGAAAGCGGTTTCCCAGCCATGCTAAACAGTGTTGATAAAGACGAGTAG

Upstream 100 bases:

>100_bases
CACTGGTAAAAAACCCATTGCTGCGCTATCAAAAAACGCATGTTATGGTACATACATTCATCAATGTATGTAAGTCTTGA
TACTTTAAAAAAATAACGCC

Downstream 100 bases:

>100_bases
ATAACAATGCAAAAAATTGTCGTGATTGCCAATGGGGCCGGTTATGGCCATGAATCTCTGTTCAATGCGCTGCGCCTGGC
GCTGGCGATGAAGGAGCAGG

Product: DNA-binding transcriptional repressor AcrR

Products: NA

Alternate protein names: Potential acrAB operon repressor [H]

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MARKTKQQAQETRQQILDAAIREFSARGVAATSLNDIANAAGVTRGAIYWHFKNKTDIFHAVWEFMESRLSELELEYQTK
FPDDPLRILRELLIFILVATVVDPQRRAMMEILYHKCEFVGEMRALGERRKLMYLESYTRIERVLQHCVFREQLPSNLDM
LRSAIALRSYITGIMESWLFTPERFDLQQQAIPLVDNVIAMLQHSPFLRRDAACAPNDTSVWESGFPAMLNSVDKDE

Sequences:

>Translated_237_residues
MARKTKQQAQETRQQILDAAIREFSARGVAATSLNDIANAAGVTRGAIYWHFKNKTDIFHAVWEFMESRLSELELEYQTK
FPDDPLRILRELLIFILVATVVDPQRRAMMEILYHKCEFVGEMRALGERRKLMYLESYTRIERVLQHCVFREQLPSNLDM
LRSAIALRSYITGIMESWLFTPERFDLQQQAIPLVDNVIAMLQHSPFLRRDAACAPNDTSVWESGFPAMLNSVDKDE
>Mature_236_residues
ARKTKQQAQETRQQILDAAIREFSARGVAATSLNDIANAAGVTRGAIYWHFKNKTDIFHAVWEFMESRLSELELEYQTKF
PDDPLRILRELLIFILVATVVDPQRRAMMEILYHKCEFVGEMRALGERRKLMYLESYTRIERVLQHCVFREQLPSNLDML
RSAIALRSYITGIMESWLFTPERFDLQQQAIPLVDNVIAMLQHSPFLRRDAACAPNDTSVWESGFPAMLNSVDKDE

Specific function: Potential regulator protein for the acrAB genes [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=212, Percent_Identity=56.1320754716981, Blast_Score=254, Evalue=3e-69,
Organism=Escherichia coli, GI1789664, Length=203, Percent_Identity=43.3497536945813, Blast_Score=156, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 27502; Mature: 27371

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKTKQQAQETRQQILDAAIREFSARGVAATSLNDIANAAGVTRGAIYWHFKNKTDIFH
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHCEEEEEECCCHHHHH
AVWEFMESRLSELELEYQTKFPDDPLRILRELLIFILVATVVDPQRRAMMEILYHKCEFV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
GEMRALGERRKLMYLESYTRIERVLQHCVFREQLPSNLDMLRSAIALRSYITGIMESWLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
TPERFDLQQQAIPLVDNVIAMLQHSPFLRRDAACAPNDTSVWESGFPAMLNSVDKDE
CCHHHCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHCCCHHHHHCCCCCC
>Mature Secondary Structure 
ARKTKQQAQETRQQILDAAIREFSARGVAATSLNDIANAAGVTRGAIYWHFKNKTDIFH
CCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHCEEEEEECCCHHHHH
AVWEFMESRLSELELEYQTKFPDDPLRILRELLIFILVATVVDPQRRAMMEILYHKCEFV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
GEMRALGERRKLMYLESYTRIERVLQHCVFREQLPSNLDMLRSAIALRSYITGIMESWLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
TPERFDLQQQAIPLVDNVIAMLQHSPFLRRDAACAPNDTSVWESGFPAMLNSVDKDE
CCHHHCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]