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The map label for this gene is ribD [H]

Identifier: 238918989

GI number: 238918989

Start: 1053573

End: 1054694

Strand: Direct

Name: ribD [H]

Synonym: NT01EI_1056

Alternate gene names: 238918989

Gene position: 1053573-1054694 (Clockwise)

Preceding gene: 238918988

Following gene: 238918990

Centisome position: 27.64

GC content: 63.81

Gene sequence:

>1122_bases
ATGATGATGTCTGCAGTCCATTCCGATGAATTTTACATGGCGCGCGCCTTTGAGCTGGCGCGCCGTGGCCGCTTTACCAC
CACCCCCAATCCTAATGTCGGTTGCGTACTGGTACGCGACGATCGCATCGTGGGCGAAGGGTTTCACCTGCGCGCCGGTG
AGCCTCATGCCGAGGTTCTTGCTCTGCGGATGGCCGGTGAGCAGGCCCGTGGTGCGACGGCCTATGTCACCCTGGAGCCG
TGCAGCCACCATGGCCGTACGCCCCCCTGCGCAGATGCGCTGGTGGCCGCCGGTGTCAGCCGGGTGGTCGCAGCAATGCA
AGACCCGAATCCCCACGTGGCCGGACGGGGGCTATACCGTCTGCAGCAGGCGGGGATCGCGGTGCAACATGGACTGATGC
TGGCCGAGGCTGAAGCCATCAATAAAGGCTTTCTGAAGCGTATGCGTACCGGCTTTCCCTATGTACAGCTGAAGCTGGGT
GCTTCTCTCGATGGGCGTACCGCCATGGCCTCCGGCGAAAGTCAGTGGATCACCTCTGCTGCCGCTCGCGCCGATGTTCA
GCGTTACCGGGCGCAGAGCTCGGCGATTTTAAGCAGTAGCGCGACGGTGCTGGCGGACGATCCGGCACTGACGGTGCGCT
GGGATTCGCTGGATGAGGATACCCAGCGTCTGTATCCGCGTGAGCACCTGCGCCAGCCGCTGCGGGTGATCGTGGACAGC
CATAACCGGGTGACGCCGCAGCACGGGCTGGTCGCACAGCCCGGTGAGACGCTACTGGCACGGATTGATCCCGATACGCA
GGACTGGCCGCCATCGGTGAGCCAGCTGGCTGTACCGCGTCACGGCGAGGGGCTGGATCTGGTGCTGCTGATGATGCAGC
TGGGTAAAATGCAGCTGAACAGCGTGTGGGTTGAGGCAGGGCCACGCCTGGCCGGTGCCCTGCTGCAGGCTGGCCTGGTT
GATGAGCTGATTGTTTATCTGGCGCCGATGCTGTTGGGCGATGCGGCGCGCGGACTGTGCCATCTGCCTGGGTTGGAGCG
CCTGGGCGATGCCCCGGCCCTGACGTTTAGCGATGTTACCCGGGTTGGCAACGATTTGCGTCTGACGCTGCGCATGGTCT
AG

Upstream 100 bases:

>100_bases
ATTCGTTTTGCCTCTGTATATCGCAGTTTTGAGGATGTACGGGAGTTTGGCGAAGAGATCGCCCGTTTGCAGGAGTAGCG
CATTCAGCGTAGGAACCGTG

Downstream 100 bases:

>100_bases
GCGACCTAATTCCGCCCCGGCAGCGTGCCGTGCCGGGTTGGGCACAGCCGCCGAAATGACAATGGATCTGAGCAGAAGTG
CAAAGAGTATGATAGAATCC

Product: riboflavin biosynthesis protein RibD

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MMMSAVHSDEFYMARAFELARRGRFTTTPNPNVGCVLVRDDRIVGEGFHLRAGEPHAEVLALRMAGEQARGATAYVTLEP
CSHHGRTPPCADALVAAGVSRVVAAMQDPNPHVAGRGLYRLQQAGIAVQHGLMLAEAEAINKGFLKRMRTGFPYVQLKLG
ASLDGRTAMASGESQWITSAAARADVQRYRAQSSAILSSSATVLADDPALTVRWDSLDEDTQRLYPREHLRQPLRVIVDS
HNRVTPQHGLVAQPGETLLARIDPDTQDWPPSVSQLAVPRHGEGLDLVLLMMQLGKMQLNSVWVEAGPRLAGALLQAGLV
DELIVYLAPMLLGDAARGLCHLPGLERLGDAPALTFSDVTRVGNDLRLTLRMV

Sequences:

>Translated_373_residues
MMMSAVHSDEFYMARAFELARRGRFTTTPNPNVGCVLVRDDRIVGEGFHLRAGEPHAEVLALRMAGEQARGATAYVTLEP
CSHHGRTPPCADALVAAGVSRVVAAMQDPNPHVAGRGLYRLQQAGIAVQHGLMLAEAEAINKGFLKRMRTGFPYVQLKLG
ASLDGRTAMASGESQWITSAAARADVQRYRAQSSAILSSSATVLADDPALTVRWDSLDEDTQRLYPREHLRQPLRVIVDS
HNRVTPQHGLVAQPGETLLARIDPDTQDWPPSVSQLAVPRHGEGLDLVLLMMQLGKMQLNSVWVEAGPRLAGALLQAGLV
DELIVYLAPMLLGDAARGLCHLPGLERLGDAPALTFSDVTRVGNDLRLTLRMV
>Mature_373_residues
MMMSAVHSDEFYMARAFELARRGRFTTTPNPNVGCVLVRDDRIVGEGFHLRAGEPHAEVLALRMAGEQARGATAYVTLEP
CSHHGRTPPCADALVAAGVSRVVAAMQDPNPHVAGRGLYRLQQAGIAVQHGLMLAEAEAINKGFLKRMRTGFPYVQLKLG
ASLDGRTAMASGESQWITSAAARADVQRYRAQSSAILSSSATVLADDPALTVRWDSLDEDTQRLYPREHLRQPLRVIVDS
HNRVTPQHGLVAQPGETLLARIDPDTQDWPPSVSQLAVPRHGEGLDLVLLMMQLGKMQLNSVWVEAGPRLAGALLQAGLV
DELIVYLAPMLLGDAARGLCHLPGLERLGDAPALTFSDVTRVGNDLRLTLRMV

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=362, Percent_Identity=74.8618784530387, Blast_Score=566, Evalue=1e-163,
Organism=Escherichia coli, GI145693172, Length=170, Percent_Identity=33.5294117647059, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 40460; Mature: 40460

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMMSAVHSDEFYMARAFELARRGRFTTTPNPNVGCVLVRDDRIVGEGFHLRAGEPHAEVL
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEECCCEEECCCCCHHHEE
ALRMAGEQARGATAYVTLEPCSHHGRTPPCADALVAAGVSRVVAAMQDPNPHVAGRGLYR
EEHHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LQQAGIAVQHGLMLAEAEAINKGFLKRMRTGFPYVQLKLGASLDGRTAMASGESQWITSA
HHHCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCCHHHHHHH
AARADVQRYRAQSSAILSSSATVLADDPALTVRWDSLDEDTQRLYPREHLRQPLRVIVDS
HHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCCCHHHHCCCHHHHHHHHHHHHCC
HNRVTPQHGLVAQPGETLLARIDPDTQDWPPSVSQLAVPRHGEGLDLVLLMMQLGKMQLN
CCCCCCCCCEEECCCCCEEEEECCCCCCCCCCHHHEECCCCCCCHHHHHHHHHHCCHHHH
SVWVEAGPRLAGALLQAGLVDELIVYLAPMLLGDAARGLCHLPGLERLGDAPALTFSDVT
HEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEHHHHH
RVGNDLRLTLRMV
HCCCCEEEEEEEC
>Mature Secondary Structure
MMMSAVHSDEFYMARAFELARRGRFTTTPNPNVGCVLVRDDRIVGEGFHLRAGEPHAEVL
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCEEECCCEEECCCCCHHHEE
ALRMAGEQARGATAYVTLEPCSHHGRTPPCADALVAAGVSRVVAAMQDPNPHVAGRGLYR
EEHHCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LQQAGIAVQHGLMLAEAEAINKGFLKRMRTGFPYVQLKLGASLDGRTAMASGESQWITSA
HHHCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCCHHHHHHH
AARADVQRYRAQSSAILSSSATVLADDPALTVRWDSLDEDTQRLYPREHLRQPLRVIVDS
HHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCCCHHHHCCCHHHHHHHHHHHHCC
HNRVTPQHGLVAQPGETLLARIDPDTQDWPPSVSQLAVPRHGEGLDLVLLMMQLGKMQLN
CCCCCCCCCEEECCCCCEEEEECCCCCCCCCCHHHEECCCCCCCHHHHHHHHHHCCHHHH
SVWVEAGPRLAGALLQAGLVDELIVYLAPMLLGDAARGLCHLPGLERLGDAPALTFSDVT
HEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEHHHHH
RVGNDLRLTLRMV
HCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1406588; 9278503; 9068650 [H]