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The map label for this gene is fadH [C]

Identifier: 238918983

GI number: 238918983

Start: 1045796

End: 1047862

Strand: Direct

Name: fadH [C]

Synonym: NT01EI_1050

Alternate gene names: 238918983

Gene position: 1045796-1047862 (Clockwise)

Preceding gene: 238918979

Following gene: 238918987

Centisome position: 27.43

GC content: 63.81

Gene sequence:

>2067_bases
ATGGCCGAATACTCACACCTGCTCTCACCGCTGGCGCTGACGCCGACGCTGTCGCTGAAAAACCGCATCATGAAGTCACC
GCAGTCCACCATGTACTGGGGAGAGGAGTATGCGATGAGCGATCGGGTGGTTGATTTTTATGAAAGTATTGCCCAGGGCG
GCGCGGGGATGATCGTGATCGCCGGGATCCTGTGGTATCCGGCCCACCCCGGAGGGGTCTATGGCGCGCTGTTTGACGAT
CGGTATATCGCCGGGATGAGGCGGCTGGTGGAGACCCTGCACCGCCACGACTGCGTGGTGTTTTGTCAGTTTCACCACAC
CGGCCCTTCGGCTCCCAGCGATGAGCACGGTGGGCGCCCCTTTGGCTCCTCCACGCTGGAACAGGCAGAGTTGTCCTCAC
CCACTCCCTATCTGCACGCCACCCGTGGCGTCACCCGAGAGGAGATCGCCCTGCATCGCGAGCGCTACATTGAGGCGGCG
GTACGCGCCTACCAGGCGGGGTTCGACGGGGTGGAGGTGCACGGTGCCCACGGCTATTTTCTGCAGAGTTTTTTGAGTCG
GGTGTGGAACCGGCGCGAGGACGAGTATGGCTGCCAGAGCATTGAAAACCGCACCCGCCTGATGGTGGAGATCATTCGGG
GTATCAAGGCCAGACTGGGGGAGGATTTCCCGGTCGGCGTGCGCATCAACGGCGAGGAGTTTATGGCGCAGGGTGCGATG
ACGCTGGAGGAGTCGATCCAGATTGCCCAGGCGCTGGAGCAGGCTGGAGCCTGCTATATCAGCGTCAGCGGCTATGGATT
TGGTCCGCTGCCGATGACCTATGTACCGGACTATTTTCCCTATCCTGAGCCGGAGCCGGCGATGTGCCCCTATATGGATC
GTTATCGCCAAGAGGGTGTCTATGCCTGGGGAGCTGCCGCGATCAAACCCCACGTACAGATCCCGGTGGTGGCGGTAGGG
CGGATGGATGAACAGCGCGGGGAGCGTCTGCTGCAAGAGGGTAAGGCGGATATTATCGCCTATGGCCGTATGCTGTGGGC
CGATCCGGCCTTTCCCAATAAGCTGCGGGAGGGGCGGCCTCTCGATATCGTGCGCTGTAACCGCTGTGCCACCTGTGAGG
ATCCGCCGCGCGCCGCGCGCCGCTGTCGGGTGAATCCGGCATTGGGCCGCGAGCGGGCGCTGGCGATCTACCCCGCAGTG
CAGGCCAGACGTATTCTGGTGATCGGTGCAGGCCCGGCTGGGATGGAGGCCGCGCGGGTGGCCGCGCTGCGTGGCCATAG
GGTGACGCTGTGCGATGCGGCACCGCGTCTGGGGGGACGGCTGTGGCTGGCCTCGATGATCAAGGGGTCCGCGGTGGAGA
ATGTGCGCCCGTTGGTGGATTACCTGATCCATCAGGTGCGTAGCATATCCGGGATTGAGATCTGCCTGAATCGAACGATG
AACGCCGAAGAGGTCATGACGCTGCAGCCGGATGCCGTGGTGGTGGCGACCGGGGGTAACTATGCGCTGCCGGACATTCC
CGGGATCCAGCGCTGGAATGTCCGGGGGGTCAAGTCATTGTCGCGTCTGGCGGCCTGGCCGCTGCGCGTGTTTGGGCCGG
ATCTGCTTAATCGGCTGAGCCGGATTGCGCTGCCGCTGGGATCGCGTATTGTGATTCTGGGCGGGCAGATCGAGGGTATC
CAAGGGGCTATCTTTCTTGCCAAGCGCGGCAAGCGGGTTACCGTGCTGGAGCCTTCGGTGCAGCTGGGCGAGGGAATACC
GCCCCGCTATCGGGAGCGGGCGCTGGCCTGGCTGCAGCAGCACCCGCGGGTCACTCTGCATACCGGCGTATGCTGGCAGC
GTATTGAGCGGGATGGTGCCCACTTCCTGACGGCGGAGGGGGAGGATCGGTGTGAGCCCTGTCATTCGGTGCTGGTGCTG
ACCCGGCAGAGCCCGGCGACCGAACTGGCCGATGTCCTGCGCGTGCGCGGGGCAGAGGTGCATGTGATAGGATCGGCCAA
CGGGGCGCAGCATAGCCTGATCGTCGATGCTATGGCGCAGGGACGGGAGGTCGGCGTCATGCTGTAG

Upstream 100 bases:

>100_bases
GGGCGGCCCCGCTGGCGTGGCGTATATATTGCATTCGTCTTAGCGCTGTCCGTGCGGGGTGGCACTCATATCGCCCGCTG
TTTACCGTAAGGGGAATTCC

Downstream 100 bases:

>100_bases
GGCGCAGTGATGCTAGGGAAAGCGCCCGCTTGGGGGGCGCAGTCGTGTCAGGTAGCGTTTACAGTATGCAGCCGGTACGG
CGTCCATCCAGTAACGCGTG

Product: NADH oxidase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 688; Mature: 687

Protein sequence:

>688_residues
MAEYSHLLSPLALTPTLSLKNRIMKSPQSTMYWGEEYAMSDRVVDFYESIAQGGAGMIVIAGILWYPAHPGGVYGALFDD
RYIAGMRRLVETLHRHDCVVFCQFHHTGPSAPSDEHGGRPFGSSTLEQAELSSPTPYLHATRGVTREEIALHRERYIEAA
VRAYQAGFDGVEVHGAHGYFLQSFLSRVWNRREDEYGCQSIENRTRLMVEIIRGIKARLGEDFPVGVRINGEEFMAQGAM
TLEESIQIAQALEQAGACYISVSGYGFGPLPMTYVPDYFPYPEPEPAMCPYMDRYRQEGVYAWGAAAIKPHVQIPVVAVG
RMDEQRGERLLQEGKADIIAYGRMLWADPAFPNKLREGRPLDIVRCNRCATCEDPPRAARRCRVNPALGRERALAIYPAV
QARRILVIGAGPAGMEAARVAALRGHRVTLCDAAPRLGGRLWLASMIKGSAVENVRPLVDYLIHQVRSISGIEICLNRTM
NAEEVMTLQPDAVVVATGGNYALPDIPGIQRWNVRGVKSLSRLAAWPLRVFGPDLLNRLSRIALPLGSRIVILGGQIEGI
QGAIFLAKRGKRVTVLEPSVQLGEGIPPRYRERALAWLQQHPRVTLHTGVCWQRIERDGAHFLTAEGEDRCEPCHSVLVL
TRQSPATELADVLRVRGAEVHVIGSANGAQHSLIVDAMAQGREVGVML

Sequences:

>Translated_688_residues
MAEYSHLLSPLALTPTLSLKNRIMKSPQSTMYWGEEYAMSDRVVDFYESIAQGGAGMIVIAGILWYPAHPGGVYGALFDD
RYIAGMRRLVETLHRHDCVVFCQFHHTGPSAPSDEHGGRPFGSSTLEQAELSSPTPYLHATRGVTREEIALHRERYIEAA
VRAYQAGFDGVEVHGAHGYFLQSFLSRVWNRREDEYGCQSIENRTRLMVEIIRGIKARLGEDFPVGVRINGEEFMAQGAM
TLEESIQIAQALEQAGACYISVSGYGFGPLPMTYVPDYFPYPEPEPAMCPYMDRYRQEGVYAWGAAAIKPHVQIPVVAVG
RMDEQRGERLLQEGKADIIAYGRMLWADPAFPNKLREGRPLDIVRCNRCATCEDPPRAARRCRVNPALGRERALAIYPAV
QARRILVIGAGPAGMEAARVAALRGHRVTLCDAAPRLGGRLWLASMIKGSAVENVRPLVDYLIHQVRSISGIEICLNRTM
NAEEVMTLQPDAVVVATGGNYALPDIPGIQRWNVRGVKSLSRLAAWPLRVFGPDLLNRLSRIALPLGSRIVILGGQIEGI
QGAIFLAKRGKRVTVLEPSVQLGEGIPPRYRERALAWLQQHPRVTLHTGVCWQRIERDGAHFLTAEGEDRCEPCHSVLVL
TRQSPATELADVLRVRGAEVHVIGSANGAQHSLIVDAMAQGREVGVML
>Mature_687_residues
AEYSHLLSPLALTPTLSLKNRIMKSPQSTMYWGEEYAMSDRVVDFYESIAQGGAGMIVIAGILWYPAHPGGVYGALFDDR
YIAGMRRLVETLHRHDCVVFCQFHHTGPSAPSDEHGGRPFGSSTLEQAELSSPTPYLHATRGVTREEIALHRERYIEAAV
RAYQAGFDGVEVHGAHGYFLQSFLSRVWNRREDEYGCQSIENRTRLMVEIIRGIKARLGEDFPVGVRINGEEFMAQGAMT
LEESIQIAQALEQAGACYISVSGYGFGPLPMTYVPDYFPYPEPEPAMCPYMDRYRQEGVYAWGAAAIKPHVQIPVVAVGR
MDEQRGERLLQEGKADIIAYGRMLWADPAFPNKLREGRPLDIVRCNRCATCEDPPRAARRCRVNPALGRERALAIYPAVQ
ARRILVIGAGPAGMEAARVAALRGHRVTLCDAAPRLGGRLWLASMIKGSAVENVRPLVDYLIHQVRSISGIEICLNRTMN
AEEVMTLQPDAVVVATGGNYALPDIPGIQRWNVRGVKSLSRLAAWPLRVFGPDLLNRLSRIALPLGSRIVILGGQIEGIQ
GAIFLAKRGKRVTVLEPSVQLGEGIPPRYRERALAWLQQHPRVTLHTGVCWQRIERDGAHFLTAEGEDRCEPCHSVLVLT
RQSPATELADVLRVRGAEVHVIGSANGAQHSLIVDAMAQGREVGVML

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=728, Percent_Identity=28.7087912087912, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1787939, Length=383, Percent_Identity=25.3263707571802, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17559804, Length=388, Percent_Identity=26.8041237113402, Blast_Score=113, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17564188, Length=385, Percent_Identity=26.2337662337662, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17559802, Length=209, Percent_Identity=33.0143540669856, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17565138, Length=366, Percent_Identity=24.8633879781421, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI72001454, Length=332, Percent_Identity=26.5060240963855, Blast_Score=100, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17540738, Length=263, Percent_Identity=27.3764258555133, Blast_Score=99, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17566914, Length=269, Percent_Identity=27.1375464684015, Blast_Score=96, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17566916, Length=261, Percent_Identity=24.5210727969349, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321973, Length=201, Percent_Identity=28.3582089552239, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6325086, Length=197, Percent_Identity=28.4263959390863, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 76057; Mature: 75925

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEYSHLLSPLALTPTLSLKNRIMKSPQSTMYWGEEYAMSDRVVDFYESIAQGGAGMIVI
CCCHHHHHCCHHCCCCHHHHHHHHCCCCHHEECCHHHHHHHHHHHHHHHHHCCCCCEEEE
AGILWYPAHPGGVYGALFDDRYIAGMRRLVETLHRHDCVVFCQFHHTGPSAPSDEHGGRP
EHHHHCCCCCCCEEEEHHCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCC
FGSSTLEQAELSSPTPYLHATRGVTREEIALHRERYIEAAVRAYQAGFDGVEVHGAHGYF
CCCCHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
LQSFLSRVWNRREDEYGCQSIENRTRLMVEIIRGIKARLGEDFPVGVRINGEEFMAQGAM
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHCCH
TLEESIQIAQALEQAGACYISVSGYGFGPLPMTYVPDYFPYPEPEPAMCPYMDRYRQEGV
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCC
YAWGAAAIKPHVQIPVVAVGRMDEQRGERLLQEGKADIIAYGRMLWADPAFPNKLREGRP
EEECHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEHHHHHCCCCCCCHHHCCCCC
LDIVRCNRCATCEDPPRAARRCRVNPALGRERALAIYPAVQARRILVIGAGPAGMEAARV
CCEEECCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHH
AALRGHRVTLCDAAPRLGGRLWLASMIKGSAVENVRPLVDYLIHQVRSISGIEICLNRTM
HHHCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC
NAEEVMTLQPDAVVVATGGNYALPDIPGIQRWNVRGVKSLSRLAAWPLRVFGPDLLNRLS
CHHHEEEECCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCHHHHHHHH
RIALPLGSRIVILGGQIEGIQGAIFLAKRGKRVTVLEPSVQLGEGIPPRYRERALAWLQQ
HHHCCCCCEEEEECCEECCCCEEEEEECCCCEEEEECCCHHHCCCCCHHHHHHHHHHHHH
HPRVTLHTGVCWQRIERDGAHFLTAEGEDRCEPCHSVLVLTRQSPATELADVLRVRGAEV
CCCEEEECCHHHHHHHCCCCEEEECCCCHHHHHHHHEEEEECCCCHHHHHHHHHHCCCEE
HVIGSANGAQHSLIVDAMAQGREVGVML
EEEECCCCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
AEYSHLLSPLALTPTLSLKNRIMKSPQSTMYWGEEYAMSDRVVDFYESIAQGGAGMIVI
CCHHHHHCCHHCCCCHHHHHHHHCCCCHHEECCHHHHHHHHHHHHHHHHHCCCCCEEEE
AGILWYPAHPGGVYGALFDDRYIAGMRRLVETLHRHDCVVFCQFHHTGPSAPSDEHGGRP
EHHHHCCCCCCCEEEEHHCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCC
FGSSTLEQAELSSPTPYLHATRGVTREEIALHRERYIEAAVRAYQAGFDGVEVHGAHGYF
CCCCHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
LQSFLSRVWNRREDEYGCQSIENRTRLMVEIIRGIKARLGEDFPVGVRINGEEFMAQGAM
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHCCH
TLEESIQIAQALEQAGACYISVSGYGFGPLPMTYVPDYFPYPEPEPAMCPYMDRYRQEGV
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCC
YAWGAAAIKPHVQIPVVAVGRMDEQRGERLLQEGKADIIAYGRMLWADPAFPNKLREGRP
EEECHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEHHHHHCCCCCCCHHHCCCCC
LDIVRCNRCATCEDPPRAARRCRVNPALGRERALAIYPAVQARRILVIGAGPAGMEAARV
CCEEECCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHH
AALRGHRVTLCDAAPRLGGRLWLASMIKGSAVENVRPLVDYLIHQVRSISGIEICLNRTM
HHHCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC
NAEEVMTLQPDAVVVATGGNYALPDIPGIQRWNVRGVKSLSRLAAWPLRVFGPDLLNRLS
CHHHEEEECCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCHHHHHHHH
RIALPLGSRIVILGGQIEGIQGAIFLAKRGKRVTVLEPSVQLGEGIPPRYRERALAWLQQ
HHHCCCCCEEEEECCEECCCCEEEEEECCCCEEEEECCCHHHCCCCCHHHHHHHHHHHHH
HPRVTLHTGVCWQRIERDGAHFLTAEGEDRCEPCHSVLVLTRQSPATELADVLRVRGAEV
CCCEEEECCHHHHHHHCCCCEEEECCCCHHHHHHHHEEEEECCCCHHHHHHHHHHCCCEE
HVIGSANGAQHSLIVDAMAQGREVGVML
EEEECCCCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]