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The map label for this gene is dnaX [H]

Identifier: 238917931

GI number: 238917931

Start: 2088498

End: 2090183

Strand: Reverse

Name: dnaX [H]

Synonym: EUBELI_02018

Alternate gene names: 238917931

Gene position: 2090183-2088498 (Counterclockwise)

Preceding gene: 238917932

Following gene: 238917930

Centisome position: 97.48

GC content: 40.63

Gene sequence:

>1686_bases
ATGAGGTTAAGGGCTGCGAAAGTAAAGACAGCGCAGAGGGAGGTAACCATGTCATATCAGGCTTTATACAGAAAATGGCG
TCCAGACAATTTCAATGATGTAAAAGGACAGGATACAATAGTAACAACTCTGCGAAATCAGATTAATGCAGACAGAATAG
GCCATGCATATCTGTTCTGCGGAACAAGAGGAACTGGTAAGACATCAGTTGCCAAGATATTTGCGAAGGCAGTTAATTGT
GAGCATCCGGTTGACGGCAACCCTTGTGGAGAGTGCCCGACATGCAAGGCGATTGCGGCTGGAACAAGCATGAATGTAAT
AGAGATAGATGCGGCATCTAACAATGGTGTCGATAATATAAGACAGATAAGAGAAGAAGTACAGTACTCACCGACAGAAG
GAAGATTCAAAGTCTATATAATTGATGAGGTTCATATGCTTTCAATAGGAGCGTTCAATGCATTGTTAAAGACATTGGAA
GAACCTCCGGCATATGTAATATTTATACTGGCTACTACAGAAGTGGCGAAGATTCCTATTACAATCCTTTCAAGATGTCA
GAGATATGACTTCCACAGGATAACAATAGAGACAATTGCAGGCAGGCTGTCAGAACTTATGAAGGCGGAGGGACTGAATG
TAGAGGATAAGGCAATAAAATATGTTGCCAAAGCTGCAGATGGTTCTATGCGAGATGCGTTAAGTCTGTTAGACCAGTGT
CTGGCATTCTATCTGGGGAAAGACCTTAAGTATGAAAATGTATTAGATGTTCTTGGGGCAGTTGACACGGCGGTATTTAG
TAAAATGCTTTCAACAATCCTGTCAGGAGATGTTGCTGTGTGCATGTCACTTATGGAAGACCTGATAATGCAGGGAAGAG
ACCTTTCACAATTTGTTACAGACTTTATATGGTATCTTAGAAATCTGCTTCTTATTAAGACAACCAAAGATGCAGAAAGA
ATTGAGGACGTAATAGAAGTATCAGCAGATAATCTTGAAGACCTGAAGAAAGATGCACAGAATGTAGATATAGATACACT
TATGTATTATATAAGAGTGTTGTCAGAATTATCGAATGACCTGAAGTTTTCTACACAGAAAAGAGTTAAGACAGAGATAA
CATTTATAAAGCTGATGCGTCCGGCAATGGATAACAGTCAGGATATCGGCGATGTTGTAAGCCGTGTGACAATGCTTGAA
GGGCAGTTACAGAAAGTACTTGATGATATTAAAAGCGGTAAACTTGTAAGCACAGCAGGTATGGCTGGTGGCGCTGCGGG
CAGTCAGGCAGCAGTACAGCAGCAGACCTCAAAGAAGCCTGTAGTTAAGCGTGTATATGATGCAGTTCCAGAAGATGTTA
AGGCAATAGCGGCAGGCTGGAAGGATATCATAGCAACGATAGATGACCCTGTTAATCAGACATTTTTACAGGCTGCACAT
GTTACATTAGCAGAAGATGGAATTAGTCTTGAAATTATGGTAGAATCACTTAGTGCCTATAATTCACTCAGCAGACAGGA
AGTTATGGAAAGCATAGAGAATGTAATTGAGGAGAGAACAGGAGTAAGGGTTTCAATTAAAGTGACTAAGCTTAACGATG
ATGAAGATTTCCACAGCAGATTCGTGGATCTTAAGGAACTCGTAGGCATAGATATAGAAGTAGATGATAAGGAGGAACTT
ATATAA

Upstream 100 bases:

>100_bases
TGATATTCCTAAATTATCCTGCGAAGCAGGAACTTAACCGACATAAGTAAAACATAAGCTGCGAAGCAGCGGCAGACGCC
GGAGGCGGATGGTTTTACGC

Downstream 100 bases:

>100_bases
TGGCTAAAAGAGGTGGTTTTCCAGGAGGAATGCCTGGTAATATGAATAATCTGATGAAGCAGGCACAGAGAATGCAGCGT
CAGATGGAGGAGCAGCAGGC

Product: DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MRLRAAKVKTAQREVTMSYQALYRKWRPDNFNDVKGQDTIVTTLRNQINADRIGHAYLFCGTRGTGKTSVAKIFAKAVNC
EHPVDGNPCGECPTCKAIAAGTSMNVIEIDAASNNGVDNIRQIREEVQYSPTEGRFKVYIIDEVHMLSIGAFNALLKTLE
EPPAYVIFILATTEVAKIPITILSRCQRYDFHRITIETIAGRLSELMKAEGLNVEDKAIKYVAKAADGSMRDALSLLDQC
LAFYLGKDLKYENVLDVLGAVDTAVFSKMLSTILSGDVAVCMSLMEDLIMQGRDLSQFVTDFIWYLRNLLLIKTTKDAER
IEDVIEVSADNLEDLKKDAQNVDIDTLMYYIRVLSELSNDLKFSTQKRVKTEITFIKLMRPAMDNSQDIGDVVSRVTMLE
GQLQKVLDDIKSGKLVSTAGMAGGAAGSQAAVQQQTSKKPVVKRVYDAVPEDVKAIAAGWKDIIATIDDPVNQTFLQAAH
VTLAEDGISLEIMVESLSAYNSLSRQEVMESIENVIEERTGVRVSIKVTKLNDDEDFHSRFVDLKELVGIDIEVDDKEEL
I

Sequences:

>Translated_561_residues
MRLRAAKVKTAQREVTMSYQALYRKWRPDNFNDVKGQDTIVTTLRNQINADRIGHAYLFCGTRGTGKTSVAKIFAKAVNC
EHPVDGNPCGECPTCKAIAAGTSMNVIEIDAASNNGVDNIRQIREEVQYSPTEGRFKVYIIDEVHMLSIGAFNALLKTLE
EPPAYVIFILATTEVAKIPITILSRCQRYDFHRITIETIAGRLSELMKAEGLNVEDKAIKYVAKAADGSMRDALSLLDQC
LAFYLGKDLKYENVLDVLGAVDTAVFSKMLSTILSGDVAVCMSLMEDLIMQGRDLSQFVTDFIWYLRNLLLIKTTKDAER
IEDVIEVSADNLEDLKKDAQNVDIDTLMYYIRVLSELSNDLKFSTQKRVKTEITFIKLMRPAMDNSQDIGDVVSRVTMLE
GQLQKVLDDIKSGKLVSTAGMAGGAAGSQAAVQQQTSKKPVVKRVYDAVPEDVKAIAAGWKDIIATIDDPVNQTFLQAAH
VTLAEDGISLEIMVESLSAYNSLSRQEVMESIENVIEERTGVRVSIKVTKLNDDEDFHSRFVDLKELVGIDIEVDDKEEL
I
>Mature_561_residues
MRLRAAKVKTAQREVTMSYQALYRKWRPDNFNDVKGQDTIVTTLRNQINADRIGHAYLFCGTRGTGKTSVAKIFAKAVNC
EHPVDGNPCGECPTCKAIAAGTSMNVIEIDAASNNGVDNIRQIREEVQYSPTEGRFKVYIIDEVHMLSIGAFNALLKTLE
EPPAYVIFILATTEVAKIPITILSRCQRYDFHRITIETIAGRLSELMKAEGLNVEDKAIKYVAKAADGSMRDALSLLDQC
LAFYLGKDLKYENVLDVLGAVDTAVFSKMLSTILSGDVAVCMSLMEDLIMQGRDLSQFVTDFIWYLRNLLLIKTTKDAER
IEDVIEVSADNLEDLKKDAQNVDIDTLMYYIRVLSELSNDLKFSTQKRVKTEITFIKLMRPAMDNSQDIGDVVSRVTMLE
GQLQKVLDDIKSGKLVSTAGMAGGAAGSQAAVQQQTSKKPVVKRVYDAVPEDVKAIAAGWKDIIATIDDPVNQTFLQAAH
VTLAEDGISLEIMVESLSAYNSLSRQEVMESIENVIEERTGVRVSIKVTKLNDDEDFHSRFVDLKELVGIDIEVDDKEEL
I

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=287, Percent_Identity=24.390243902439, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI31881687, Length=287, Percent_Identity=24.390243902439, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI194306571, Length=215, Percent_Identity=29.3023255813954, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI194306567, Length=215, Percent_Identity=29.3023255813954, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI6677723, Length=215, Percent_Identity=29.3023255813954, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1786676, Length=363, Percent_Identity=38.2920110192837, Blast_Score=272, Evalue=4e-74,
Organism=Escherichia coli, GI1787341, Length=142, Percent_Identity=33.0985915492958, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1787119, Length=232, Percent_Identity=25, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554730, Length=274, Percent_Identity=25.5474452554745, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17541988, Length=254, Percent_Identity=27.9527559055118, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71986063, Length=300, Percent_Identity=25.6666666666667, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324039, Length=258, Percent_Identity=26.3565891472868, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322528, Length=288, Percent_Identity=22.5694444444444, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6324478, Length=316, Percent_Identity=25, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859927, Length=292, Percent_Identity=22.6027397260274, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17647857, Length=283, Percent_Identity=26.8551236749117, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19921076, Length=257, Percent_Identity=26.0700389105058, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 62352; Mature: 62352

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRAAKVKTAQREVTMSYQALYRKWRPDNFNDVKGQDTIVTTLRNQINADRIGHAYLFC
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCEEEEE
GTRGTGKTSVAKIFAKAVNCEHPVDGNPCGECPTCKAIAAGTSMNVIEIDAASNNGVDNI
ECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEECCCCCCHHHH
RQIREEVQYSPTEGRFKVYIIDEVHMLSIGAFNALLKTLEEPPAYVIFILATTEVAKIPI
HHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHH
TILSRCQRYDFHRITIETIAGRLSELMKAEGLNVEDKAIKYVAKAADGSMRDALSLLDQC
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
LAFYLGKDLKYENVLDVLGAVDTAVFSKMLSTILSGDVAVCMSLMEDLIMQGRDLSQFVT
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHH
DFIWYLRNLLLIKTTKDAERIEDVIEVSADNLEDLKKDAQNVDIDTLMYYIRVLSELSND
HHHHHHHHHEEEEECCHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LKFSTQKRVKTEITFIKLMRPAMDNSQDIGDVVSRVTMLEGQLQKVLDDIKSGKLVSTAG
HCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
MAGGAAGSQAAVQQQTSKKPVVKRVYDAVPEDVKAIAAGWKDIIATIDDPVNQTFLQAAH
CCCCCCCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VTLAEDGISLEIMVESLSAYNSLSRQEVMESIENVIEERTGVRVSIKVTKLNDDEDFHSR
HEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHH
FVDLKELVGIDIEVDDKEELI
HHHHHHHHCCCEEECCHHCCC
>Mature Secondary Structure
MRLRAAKVKTAQREVTMSYQALYRKWRPDNFNDVKGQDTIVTTLRNQINADRIGHAYLFC
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCEEEEE
GTRGTGKTSVAKIFAKAVNCEHPVDGNPCGECPTCKAIAAGTSMNVIEIDAASNNGVDNI
ECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEECCCCCCHHHH
RQIREEVQYSPTEGRFKVYIIDEVHMLSIGAFNALLKTLEEPPAYVIFILATTEVAKIPI
HHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHH
TILSRCQRYDFHRITIETIAGRLSELMKAEGLNVEDKAIKYVAKAADGSMRDALSLLDQC
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHH
LAFYLGKDLKYENVLDVLGAVDTAVFSKMLSTILSGDVAVCMSLMEDLIMQGRDLSQFVT
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHH
DFIWYLRNLLLIKTTKDAERIEDVIEVSADNLEDLKKDAQNVDIDTLMYYIRVLSELSND
HHHHHHHHHEEEEECCHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LKFSTQKRVKTEITFIKLMRPAMDNSQDIGDVVSRVTMLEGQLQKVLDDIKSGKLVSTAG
HCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECC
MAGGAAGSQAAVQQQTSKKPVVKRVYDAVPEDVKAIAAGWKDIIATIDDPVNQTFLQAAH
CCCCCCCCHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VTLAEDGISLEIMVESLSAYNSLSRQEVMESIENVIEERTGVRVSIKVTKLNDDEDFHSR
HEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHH
FVDLKELVGIDIEVDDKEELI
HHHHHHHHCCCEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]