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The map label for this gene is uvrC

Identifier: 238917912

GI number: 238917912

Start: 2062015

End: 2063853

Strand: Reverse

Name: uvrC

Synonym: EUBELI_01999

Alternate gene names: 238917912

Gene position: 2063853-2062015 (Counterclockwise)

Preceding gene: 238917913

Following gene: 238917911

Centisome position: 96.25

GC content: 42.14

Gene sequence:

>1839_bases
ATGTTTAATTTAGAAGAAGAGCTTAAGAAACTCCCGGCAAAACCGGGAGTTTATATTATGCATGATAAGTGGGACAACAT
AATATATATAGGTAAGGCGAAGGTTTTAAAGAATCGTGTAAGACAGTATTTCCAGAGCAACAGGAATAAGTCTGCCAAGA
TTGTGCAGATGGTGTCACATATTCAGTACTTTGAGTATATTATCACAGATTCTGAACTTGAGGCGCTTGTTTTGGAGTGC
AATCTTATCAAGGAGCACAGGCCTAAGTACAATACCATGCTAAAGGATGACAAGAGTTATCCTTTTATTAAGATTACCGT
TGGTGAAGAGTATCCAAGGGTACTTTTTGCAAGAAAGATGAAGCATGGAGCAGGTAAGTATTTCGGTCCTTACACTTCTG
CGGCAGCAGTCAAGGACACTATTGAACTTCTATGCAAGCTGTATAAGGTAAGAACCTGTAACAGAAATCTGCCTAAAGAT
GAGGGCAGGGACAGGCCGTGTCTTAATTATCATATCGGACAGTGTGATGCACCATGTCAGGGATATGTAAGCGGTGAGGA
ATACAGAAGAAGAATTGATGAGGTTGTAGCTTTCTTAAATGGTGATTACAAGAAGATTATGGACAGGCTTACAACGCAGA
TGCAGGAAGCGTCTGAGAAGATGGAATACGAGGAAGCTGCAAGATACAGAGACTTGTTAATGAGTGTCAAGCAGGTTGCA
CAGAAGCAGAAGATTACAGCAGATGATGTTAATGACAGAGATGTCATTGCGTGTGCAAGTGACGGTCAGGACGCAGTTGT
GCAGGTGTTCTTTATCAGGCAGGGCAAGCTTCTTGGAAGAGATCATTTTCATATGAAGGTTGCCGAAGGTGACTCTAAGA
GCGACATAATTTCTGAATTTATGAAACAGTATTACGGCGGAACTCCATTTATACCTAATATTATTATGGTGCAGTACGAG
ATAGAGGATGCGGATACAATAGCACAGTGGCTTAGTGCAAGAAAGAGTCGCAAGGTAAGTATTGTCACACCTAAGAAGGG
CGACAAGGAAAAGATGGTTGAGCTTGCATATAAGAATGCCCAGCTTGTTCTTACACAGGATGCGGAGAAGATTAAGCGTG
AGGAGAGCAGGACAACAGGAGCTATGAAAGAGATTGCCGGCTGGCTTGGACTTGGGACACTTCACAGAGCAGAGGCTTAC
GATATATCTAATACAAATGGCGTTGAAAGTGTTGGCTCAATGGTCGTTTTTGAGGATGGAAAACCAAAGAAGAACGATTA
TCGCAAGTTCAGGATAAGAACAGTAAAGGGGCCGGATGATTATAAGAGCATGCGTGAGGTTCTGACAAGACGTTTTACAA
GGGGTATGCGTGAGCGGGAAGGACTCGAGGATAGTCACGGATTTTCGAGATATCCAGACCTTATTATGATGGATGGCGGA
CGCGGCCAGGTGAATATTGCACTTGATGTACTTAAGGAACTGGGACTTAATATTCCTGTGTGTGGTATGGTAAAAGATGA
TACCCACAGCACAAGGGGTCTGTATTATAACAATATTGAGATACCGATAGATAAGCACAGCGAGGGCTTTAAGCTGATTA
CAAGGGTGCAGGATGAGGCACACAGATTTGCAATAACTTATCACAGAAGCTTAAGAGATAAGGCACAGGTATCTTCTGTA
CTTGATTCGATTGAAGGAATCGGCCCTGTAAGAAGAAAGGCACTTATGAAGCATTTTCTTGATATAGAAAAGATACGGCA
GGCATCAGTGGATGAGCTTATGAAGGCTGATGGTATTACTGAAAATGTGGCAGAGAATATATACAAATTCTTTCATTGA

Upstream 100 bases:

>100_bases
AATGTGTTGACAAAGCTGACATAACTGGGATAATAAATACTATAAGACAGGTGCGAAGATACGCACTTAAGAAAGCCAGA
GGATTGAAGAAGCTTATAGT

Downstream 100 bases:

>100_bases
TAATACTTTTATAATAGCATTTAGAGCTTGTCTGTGATAAACTTAGGATATATGAAATCGTAAATATGAGTTTGGAGGCA
GAGAATATATGAATAATGGT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MFNLEEELKKLPAKPGVYIMHDKWDNIIYIGKAKVLKNRVRQYFQSNRNKSAKIVQMVSHIQYFEYIITDSELEALVLEC
NLIKEHRPKYNTMLKDDKSYPFIKITVGEEYPRVLFARKMKHGAGKYFGPYTSAAAVKDTIELLCKLYKVRTCNRNLPKD
EGRDRPCLNYHIGQCDAPCQGYVSGEEYRRRIDEVVAFLNGDYKKIMDRLTTQMQEASEKMEYEEAARYRDLLMSVKQVA
QKQKITADDVNDRDVIACASDGQDAVVQVFFIRQGKLLGRDHFHMKVAEGDSKSDIISEFMKQYYGGTPFIPNIIMVQYE
IEDADTIAQWLSARKSRKVSIVTPKKGDKEKMVELAYKNAQLVLTQDAEKIKREESRTTGAMKEIAGWLGLGTLHRAEAY
DISNTNGVESVGSMVVFEDGKPKKNDYRKFRIRTVKGPDDYKSMREVLTRRFTRGMREREGLEDSHGFSRYPDLIMMDGG
RGQVNIALDVLKELGLNIPVCGMVKDDTHSTRGLYYNNIEIPIDKHSEGFKLITRVQDEAHRFAITYHRSLRDKAQVSSV
LDSIEGIGPVRRKALMKHFLDIEKIRQASVDELMKADGITENVAENIYKFFH

Sequences:

>Translated_612_residues
MFNLEEELKKLPAKPGVYIMHDKWDNIIYIGKAKVLKNRVRQYFQSNRNKSAKIVQMVSHIQYFEYIITDSELEALVLEC
NLIKEHRPKYNTMLKDDKSYPFIKITVGEEYPRVLFARKMKHGAGKYFGPYTSAAAVKDTIELLCKLYKVRTCNRNLPKD
EGRDRPCLNYHIGQCDAPCQGYVSGEEYRRRIDEVVAFLNGDYKKIMDRLTTQMQEASEKMEYEEAARYRDLLMSVKQVA
QKQKITADDVNDRDVIACASDGQDAVVQVFFIRQGKLLGRDHFHMKVAEGDSKSDIISEFMKQYYGGTPFIPNIIMVQYE
IEDADTIAQWLSARKSRKVSIVTPKKGDKEKMVELAYKNAQLVLTQDAEKIKREESRTTGAMKEIAGWLGLGTLHRAEAY
DISNTNGVESVGSMVVFEDGKPKKNDYRKFRIRTVKGPDDYKSMREVLTRRFTRGMREREGLEDSHGFSRYPDLIMMDGG
RGQVNIALDVLKELGLNIPVCGMVKDDTHSTRGLYYNNIEIPIDKHSEGFKLITRVQDEAHRFAITYHRSLRDKAQVSSV
LDSIEGIGPVRRKALMKHFLDIEKIRQASVDELMKADGITENVAENIYKFFH
>Mature_612_residues
MFNLEEELKKLPAKPGVYIMHDKWDNIIYIGKAKVLKNRVRQYFQSNRNKSAKIVQMVSHIQYFEYIITDSELEALVLEC
NLIKEHRPKYNTMLKDDKSYPFIKITVGEEYPRVLFARKMKHGAGKYFGPYTSAAAVKDTIELLCKLYKVRTCNRNLPKD
EGRDRPCLNYHIGQCDAPCQGYVSGEEYRRRIDEVVAFLNGDYKKIMDRLTTQMQEASEKMEYEEAARYRDLLMSVKQVA
QKQKITADDVNDRDVIACASDGQDAVVQVFFIRQGKLLGRDHFHMKVAEGDSKSDIISEFMKQYYGGTPFIPNIIMVQYE
IEDADTIAQWLSARKSRKVSIVTPKKGDKEKMVELAYKNAQLVLTQDAEKIKREESRTTGAMKEIAGWLGLGTLHRAEAY
DISNTNGVESVGSMVVFEDGKPKKNDYRKFRIRTVKGPDDYKSMREVLTRRFTRGMREREGLEDSHGFSRYPDLIMMDGG
RGQVNIALDVLKELGLNIPVCGMVKDDTHSTRGLYYNNIEIPIDKHSEGFKLITRVQDEAHRFAITYHRSLRDKAQVSSV
LDSIEGIGPVRRKALMKHFLDIEKIRQASVDELMKADGITENVAENIYKFFH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=622, Percent_Identity=36.9774919614148, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1788037, Length=195, Percent_Identity=26.1538461538462, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_EUBE2 (C4Z4U3)

Other databases:

- EMBL:   CP001104
- RefSeq:   YP_002931429.1
- GeneID:   7957016
- GenomeReviews:   CP001104_GR
- KEGG:   eel:EUBELI_01999
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 70475; Mature: 70475

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNLEEELKKLPAKPGVYIMHDKWDNIIYIGKAKVLKNRVRQYFQSNRNKSAKIVQMVSH
CCCHHHHHHHCCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IQYFEYIITDSELEALVLECNLIKEHRPKYNTMLKDDKSYPFIKITVGEEYPRVLFARKM
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEEEECCCCHHHHHHHHH
KHGAGKYFGPYTSAAAVKDTIELLCKLYKVRTCNRNLPKDEGRDRPCLNYHIGQCDAPCQ
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GYVSGEEYRRRIDEVVAFLNGDYKKIMDRLTTQMQEASEKMEYEEAARYRDLLMSVKQVA
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKQKITADDVNDRDVIACASDGQDAVVQVFFIRQGKLLGRDHFHMKVAEGDSKSDIISEF
HHHCCCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHH
MKQYYGGTPFIPNIIMVQYEIEDADTIAQWLSARKSRKVSIVTPKKGDKEKMVELAYKNA
HHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCC
QLVLTQDAEKIKREESRTTGAMKEIAGWLGLGTLHRAEAYDISNTNGVESVGSMVVFEDG
EEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHCCEEEEECC
KPKKNDYRKFRIRTVKGPDDYKSMREVLTRRFTRGMREREGLEDSHGFSRYPDLIMMDGG
CCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCC
RGQVNIALDVLKELGLNIPVCGMVKDDTHSTRGLYYNNIEIPIDKHSEGFKLITRVQDEA
CCEEEHHHHHHHHCCCCCCEEEEEECCCCCCCCEEECCEEEECCCCCCCHHHHHHHHHHH
HRFAITYHRSLRDKAQVSSVLDSIEGIGPVRRKALMKHFLDIEKIRQASVDELMKADGIT
HHEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
ENVAENIYKFFH
HHHHHHHHHHCC
>Mature Secondary Structure
MFNLEEELKKLPAKPGVYIMHDKWDNIIYIGKAKVLKNRVRQYFQSNRNKSAKIVQMVSH
CCCHHHHHHHCCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IQYFEYIITDSELEALVLECNLIKEHRPKYNTMLKDDKSYPFIKITVGEEYPRVLFARKM
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEEEECCCCHHHHHHHHH
KHGAGKYFGPYTSAAAVKDTIELLCKLYKVRTCNRNLPKDEGRDRPCLNYHIGQCDAPCQ
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GYVSGEEYRRRIDEVVAFLNGDYKKIMDRLTTQMQEASEKMEYEEAARYRDLLMSVKQVA
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKQKITADDVNDRDVIACASDGQDAVVQVFFIRQGKLLGRDHFHMKVAEGDSKSDIISEF
HHHCCCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHH
MKQYYGGTPFIPNIIMVQYEIEDADTIAQWLSARKSRKVSIVTPKKGDKEKMVELAYKNA
HHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCC
QLVLTQDAEKIKREESRTTGAMKEIAGWLGLGTLHRAEAYDISNTNGVESVGSMVVFEDG
EEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHHHCCEEEEECC
KPKKNDYRKFRIRTVKGPDDYKSMREVLTRRFTRGMREREGLEDSHGFSRYPDLIMMDGG
CCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCC
RGQVNIALDVLKELGLNIPVCGMVKDDTHSTRGLYYNNIEIPIDKHSEGFKLITRVQDEA
CCEEEHHHHHHHHCCCCCCEEEEEECCCCCCCCEEECCEEEECCCCCCCHHHHHHHHHHH
HRFAITYHRSLRDKAQVSSVLDSIEGIGPVRRKALMKHFLDIEKIRQASVDELMKADGIT
HHEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
ENVAENIYKFFH
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA