Click here to switch to the map view.

The map label for this gene is cobB [H]

Identifier: 238917877

GI number: 238917877

Start: 2021057

End: 2021773

Strand: Reverse

Name: cobB [H]

Synonym: EUBELI_01958

Alternate gene names: 238917877

Gene position: 2021773-2021057 (Counterclockwise)

Preceding gene: 238917878

Following gene: 238917876

Centisome position: 94.29

GC content: 36.12

Gene sequence:

>717_bases
ATGAATAATGTTGATAAGTTTATTAAATTAGTGCATGAATGTGATAATATTGTTTTTTTCGGTGGGGCGGGAGTATCTAC
AGAGAGTGGGATTCCTGATTTCAGAAGTCCGGACGGATTATATAACCAGAAATACAAATATCCACCAGAAACGATTATCA
GTCATTCTTTTTACCAGAGATATCCAGAGGAATTCTATAGATTTTACAAGGATAAAATGCTTTATCCTGACGCAAAGCCT
GGAATTACACATCTGGCATTGGCAAAGCTTGAAAAAGAAGGAAAGCTGAAAGCAGTTGTTACACAAAATATTGACGGACT
TCATCAGAAAGCTGGAAGCAGCAATGTAATTGAACTGCATGGATCAGTGCTTAGAAATTATTGTGAAAGATGTCATAAGT
TCTATGGTATCGATAAGATAATTAATTCTGAAGGCATTCCAATGTGTGACTGCGGTGGAAGGATAAAACCTGATGTTGTA
TTGTATGAAGAAGGCCTTGATGATAACAATGTAACAAATGCTGTGAATTGTATAAAACAAGCAGATATGCTTATAGTCGG
CGGTACATCTCTTGGTGTATATCCAGCGGCAGGACTTATAGATTATTATAGGGGAGACAAGCTTGTTCTTATTAATAAGT
CAGCAACACCTTATGACAACAGGGCTGATATTCTTATAAATGCACCACTTGCAGATGTATTTAAGAATTTTATGTGA

Upstream 100 bases:

>100_bases
GTCATTATCTACAACGAAAGTGAATTCGGTGAATATGCAGCACAGAATTACAAAAATGAGTTGGAAAGTAATAAATGTAA
TGTGTTAGGTGTGGTAATTA

Downstream 100 bases:

>100_bases
TTAATATATAACGGAGATTGTGAATGGCGGGTATTATTCCATACGAACCTGGTGATATTGTAGAAATGAAAAAAAAGCAC
CCATGTGGAAGCAGCGAATG

Product: hypothetical protein

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MNNVDKFIKLVHECDNIVFFGGAGVSTESGIPDFRSPDGLYNQKYKYPPETIISHSFYQRYPEEFYRFYKDKMLYPDAKP
GITHLALAKLEKEGKLKAVVTQNIDGLHQKAGSSNVIELHGSVLRNYCERCHKFYGIDKIINSEGIPMCDCGGRIKPDVV
LYEEGLDDNNVTNAVNCIKQADMLIVGGTSLGVYPAAGLIDYYRGDKLVLINKSATPYDNRADILINAPLADVFKNFM

Sequences:

>Translated_238_residues
MNNVDKFIKLVHECDNIVFFGGAGVSTESGIPDFRSPDGLYNQKYKYPPETIISHSFYQRYPEEFYRFYKDKMLYPDAKP
GITHLALAKLEKEGKLKAVVTQNIDGLHQKAGSSNVIELHGSVLRNYCERCHKFYGIDKIINSEGIPMCDCGGRIKPDVV
LYEEGLDDNNVTNAVNCIKQADMLIVGGTSLGVYPAAGLIDYYRGDKLVLINKSATPYDNRADILINAPLADVFKNFM
>Mature_238_residues
MNNVDKFIKLVHECDNIVFFGGAGVSTESGIPDFRSPDGLYNQKYKYPPETIISHSFYQRYPEEFYRFYKDKMLYPDAKP
GITHLALAKLEKEGKLKAVVTQNIDGLHQKAGSSNVIELHGSVLRNYCERCHKFYGIDKIINSEGIPMCDCGGRIKPDVV
LYEEGLDDNNVTNAVNCIKQADMLIVGGTSLGVYPAAGLIDYYRGDKLVLINKSATPYDNRADILINAPLADVFKNFM

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300797577, Length=254, Percent_Identity=30.3149606299213, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI6912660, Length=225, Percent_Identity=36.8888888888889, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI63054862, Length=204, Percent_Identity=38.7254901960784, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI13775602, Length=202, Percent_Identity=38.1188118811881, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI300795542, Length=245, Percent_Identity=30.2040816326531, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI13775600, Length=213, Percent_Identity=36.6197183098592, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI6912664, Length=267, Percent_Identity=29.2134831460674, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI300797597, Length=241, Percent_Identity=31.1203319502075, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI13787215, Length=254, Percent_Identity=30.3149606299213, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI6912662, Length=265, Percent_Identity=31.3207547169811, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI300797705, Length=198, Percent_Identity=37.3737373737374, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI7657575, Length=234, Percent_Identity=32.0512820512821, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI215982798, Length=173, Percent_Identity=30.0578034682081, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI308199517, Length=196, Percent_Identity=34.1836734693878, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71990482, Length=276, Percent_Identity=31.8840579710145, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17567771, Length=276, Percent_Identity=30.0724637681159, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI71990487, Length=278, Percent_Identity=31.6546762589928, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17541892, Length=248, Percent_Identity=30.6451612903226, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17505510, Length=238, Percent_Identity=26.0504201680672, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6325242, Length=225, Percent_Identity=36.4444444444444, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320163, Length=257, Percent_Identity=28.0155642023346, Blast_Score=86, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324504, Length=239, Percent_Identity=27.1966527196653, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24648389, Length=218, Percent_Identity=37.1559633027523, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17137536, Length=233, Percent_Identity=33.4763948497854, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28571445, Length=256, Percent_Identity=33.59375, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24645650, Length=242, Percent_Identity=27.6859504132231, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28571443, Length=217, Percent_Identity=31.3364055299539, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI28571441, Length=217, Percent_Identity=31.3364055299539, Blast_Score=77, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 26661; Mature: 26661

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNVDKFIKLVHECDNIVFFGGAGVSTESGIPDFRSPDGLYNQKYKYPPETIISHSFYQR
CCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
YPEEFYRFYKDKMLYPDAKPGITHLALAKLEKEGKLKAVVTQNIDGLHQKAGSSNVIELH
CHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCEEEHH
GSVLRNYCERCHKFYGIDKIINSEGIPMCDCGGRIKPDVVLYEEGLDDNNVTNAVNCIKQ
HHHHHHHHHHHHHHHCHHHHHCCCCCEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHH
ADMLIVGGTSLGVYPAAGLIDYYRGDKLVLINKSATPYDNRADILINAPLADVFKNFM
CCEEEECCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCHHHHHHHCC
>Mature Secondary Structure
MNNVDKFIKLVHECDNIVFFGGAGVSTESGIPDFRSPDGLYNQKYKYPPETIISHSFYQR
CCCHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
YPEEFYRFYKDKMLYPDAKPGITHLALAKLEKEGKLKAVVTQNIDGLHQKAGSSNVIELH
CHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCEEEHH
GSVLRNYCERCHKFYGIDKIINSEGIPMCDCGGRIKPDVVLYEEGLDDNNVTNAVNCIKQ
HHHHHHHHHHHHHHHCHHHHHCCCCCEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHH
ADMLIVGGTSLGVYPAAGLIDYYRGDKLVLINKSATPYDNRADILINAPLADVFKNFM
CCEEEECCCCCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCCEEEECCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]