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The map label for this gene is pknB [H]

Identifier: 238917865

GI number: 238917865

Start: 2012059

End: 2013555

Strand: Reverse

Name: pknB [H]

Synonym: EUBELI_01946

Alternate gene names: 238917865

Gene position: 2013555-2012059 (Counterclockwise)

Preceding gene: 238917867

Following gene: 238917864

Centisome position: 93.91

GC content: 34.07

Gene sequence:

>1497_bases
GTGGATAACCGATTTTACGAGAAATATGAAATCATTAAGGAACTTGCAAGTTCCAATCATTCTAAAATTTATCTGGTAAG
GCATGTTATACTAGATGTATATCGTGTAGCCAAGATATTTACGGGCAGTCATGAGGAATCAGAACGACTTCTGAATGAGG
CCCATCTTATTAAGAATTTGAAACATCCCCACATTCCTGTAATTTATGATATTGAACAGAATATTGGAGAAGATAATGAT
AGTATCTGCATTATCGAAGAATATATTGATGGTAAATCTTTGCGGCAATATGTTAATGATGAAACAGAGACTAATGGCTG
CCTGGATATCCATGAAATATGCCGTATTGGCATAGAATTGTGTTGTATACTGGAATATCTTCACAGCTTTAATGGTGAAG
GAATATTACATATGGATATTAAGCCTGATAATATTATGCTTGATAATTACGGAAAAGTTAAACTTATAGATTTTGACAAT
GCAGTCATTGCAGGATGCGGTATGCAGGTAAATAATGGAAGTCTGTTATTTGCAGCACCTGAACAATACTCAGGTGAAGA
TGCCGTGGAGCAGTCAGATATATATAGTGTGGGAATGGTCATCCTATTTATGATTTCTCATGGAAAAATCAGGACATATG
AGAATCATAACTTATCAGGAGCAGCTGAAAGATATTCAGTATTGTATCACTTAATTAACAAATCACTGCATCATCAATGG
GGATTGAGGTATGAAAGTGTTACATTGGTTCGTGAAGAACTGGAATCTATAATGAAAATGGGTGGCGGTACATTTGAAAA
ACTCTCTTATGTCATTCAGGTTGCAGGAGAAAAACCCGGTATAGGTGTTACTAATGCAGTTATGAGTATGGCACATTTTT
TTCGGAATAATCAATATGATTGTGTTGTTGTTGATAAATCTGGTAACGATTATCTGCACAGGGAAATTGTGAGGAGCACA
TTAATGCCAGAAGGATTTTATCTTTATGATAATATAAAAGTTATACCGGATTATTATAATGCAATATCTGTAAATGGAGT
GAGAAGCAGAATTGTAATTATAGACTGCGGATGTGATTTTAATAAGAGCAGAGAGGTTAAAATTACGGATATTACTGGGG
ATAATTATACATGTATACGGGTTTTTATAGTTGGAAAGGCTACACATTGCAGCGGGAAGAAGATGGATGATAAAGATATT
ATTATGCTGAACCTTGTAGGGGCAAGACAATTTTATGAACTTGTAAACAGTGTGTATAAAGGAAAGAAATGTTATAGAAT
ACCATGCATATATAACTGGAATGAAGCAAATCCTATATTTGACGAAACAATGAATGATTTCTTACAGGATAACCTTACAG
GGATAATGAAAGGTTACAGACCTCACAGAATAAAGGAGTGTATTGGAAGGCTATATGAAAAAGTTAGAAATTTCAGGGTT
ATTAAGTGGTTTAGAAAAAAGAAGAAAAAGCAGGAACACAGCTGTAATAAATTATAA

Upstream 100 bases:

>100_bases
AAAATAAATATAAATTTTTTGAAAAAATATATTGAAAATTAAATTATTATAGTGTATCCTATGTTTAGGAGATGTTTTTC
ATGTATCGTCGTAAGAGGAG

Downstream 100 bases:

>100_bases
GACTGTCGGACTGATTGGATTATGCAGCGGTGCCGGAACAACACAGCTTGGTGTTATGCTTGCAAATTATTTCTCTAATG
GACTTCATCTGAAAACAGCT

Product: serine/threonine protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MDNRFYEKYEIIKELASSNHSKIYLVRHVILDVYRVAKIFTGSHEESERLLNEAHLIKNLKHPHIPVIYDIEQNIGEDND
SICIIEEYIDGKSLRQYVNDETETNGCLDIHEICRIGIELCCILEYLHSFNGEGILHMDIKPDNIMLDNYGKVKLIDFDN
AVIAGCGMQVNNGSLLFAAPEQYSGEDAVEQSDIYSVGMVILFMISHGKIRTYENHNLSGAAERYSVLYHLINKSLHHQW
GLRYESVTLVREELESIMKMGGGTFEKLSYVIQVAGEKPGIGVTNAVMSMAHFFRNNQYDCVVVDKSGNDYLHREIVRST
LMPEGFYLYDNIKVIPDYYNAISVNGVRSRIVIIDCGCDFNKSREVKITDITGDNYTCIRVFIVGKATHCSGKKMDDKDI
IMLNLVGARQFYELVNSVYKGKKCYRIPCIYNWNEANPIFDETMNDFLQDNLTGIMKGYRPHRIKECIGRLYEKVRNFRV
IKWFRKKKKKQEHSCNKL

Sequences:

>Translated_498_residues
MDNRFYEKYEIIKELASSNHSKIYLVRHVILDVYRVAKIFTGSHEESERLLNEAHLIKNLKHPHIPVIYDIEQNIGEDND
SICIIEEYIDGKSLRQYVNDETETNGCLDIHEICRIGIELCCILEYLHSFNGEGILHMDIKPDNIMLDNYGKVKLIDFDN
AVIAGCGMQVNNGSLLFAAPEQYSGEDAVEQSDIYSVGMVILFMISHGKIRTYENHNLSGAAERYSVLYHLINKSLHHQW
GLRYESVTLVREELESIMKMGGGTFEKLSYVIQVAGEKPGIGVTNAVMSMAHFFRNNQYDCVVVDKSGNDYLHREIVRST
LMPEGFYLYDNIKVIPDYYNAISVNGVRSRIVIIDCGCDFNKSREVKITDITGDNYTCIRVFIVGKATHCSGKKMDDKDI
IMLNLVGARQFYELVNSVYKGKKCYRIPCIYNWNEANPIFDETMNDFLQDNLTGIMKGYRPHRIKECIGRLYEKVRNFRV
IKWFRKKKKKQEHSCNKL
>Mature_498_residues
MDNRFYEKYEIIKELASSNHSKIYLVRHVILDVYRVAKIFTGSHEESERLLNEAHLIKNLKHPHIPVIYDIEQNIGEDND
SICIIEEYIDGKSLRQYVNDETETNGCLDIHEICRIGIELCCILEYLHSFNGEGILHMDIKPDNIMLDNYGKVKLIDFDN
AVIAGCGMQVNNGSLLFAAPEQYSGEDAVEQSDIYSVGMVILFMISHGKIRTYENHNLSGAAERYSVLYHLINKSLHHQW
GLRYESVTLVREELESIMKMGGGTFEKLSYVIQVAGEKPGIGVTNAVMSMAHFFRNNQYDCVVVDKSGNDYLHREIVRST
LMPEGFYLYDNIKVIPDYYNAISVNGVRSRIVIIDCGCDFNKSREVKITDITGDNYTCIRVFIVGKATHCSGKKMDDKDI
IMLNLVGARQFYELVNSVYKGKKCYRIPCIYNWNEANPIFDETMNDFLQDNLTGIMKGYRPHRIKECIGRLYEKVRNFRV
IKWFRKKKKKQEHSCNKL

Specific function: Unknown

COG id: COG0515

COG function: function code RTKL; Serine/threonine protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI4505373, Length=167, Percent_Identity=32.9341317365269, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI116256471, Length=222, Percent_Identity=28.3783783783784, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI7661974, Length=204, Percent_Identity=26.9607843137255, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI33636756, Length=223, Percent_Identity=26.0089686098655, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4502023, Length=205, Percent_Identity=25.8536585365854, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI193083125, Length=223, Percent_Identity=26.0089686098655, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI254028237, Length=223, Percent_Identity=26.0089686098655, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI254028240, Length=223, Percent_Identity=26.0089686098655, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI193083127, Length=223, Percent_Identity=26.0089686098655, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI38569460, Length=203, Percent_Identity=28.0788177339901, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI254028232, Length=223, Percent_Identity=26.0089686098655, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI46852166, Length=223, Percent_Identity=26.0089686098655, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI86990441, Length=223, Percent_Identity=26.0089686098655, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI193083129, Length=223, Percent_Identity=26.0089686098655, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI254028234, Length=223, Percent_Identity=26.0089686098655, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI21735566, Length=176, Percent_Identity=28.9772727272727, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI21735564, Length=176, Percent_Identity=28.9772727272727, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI21735562, Length=176, Percent_Identity=28.9772727272727, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI4507361, Length=176, Percent_Identity=28.9772727272727, Blast_Score=67, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI115533246, Length=224, Percent_Identity=29.4642857142857, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71997537, Length=224, Percent_Identity=29.4642857142857, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193208263, Length=224, Percent_Identity=29.4642857142857, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71997531, Length=224, Percent_Identity=29.4642857142857, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71994328, Length=176, Percent_Identity=30.1136363636364, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193204599, Length=203, Percent_Identity=25.615763546798, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320685, Length=204, Percent_Identity=27.9411764705882, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324805, Length=205, Percent_Identity=27.3170731707317, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321780, Length=167, Percent_Identity=34.7305389221557, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323125, Length=248, Percent_Identity=27.4193548387097, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319328, Length=183, Percent_Identity=30.6010928961749, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6325117, Length=159, Percent_Identity=28.9308176100629, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320327, Length=179, Percent_Identity=30.1675977653631, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320715, Length=158, Percent_Identity=31.0126582278481, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI161077453, Length=210, Percent_Identity=29.0476190476191, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI161077455, Length=210, Percent_Identity=29.0476190476191, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI161077232, Length=203, Percent_Identity=27.0935960591133, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161077230, Length=203, Percent_Identity=27.0935960591133, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24655167, Length=203, Percent_Identity=27.0935960591133, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17137774, Length=152, Percent_Identity=29.6052631578947, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281361563, Length=207, Percent_Identity=26.0869565217391, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356423, Length=207, Percent_Identity=26.0869565217391, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR005543
- InterPro:   IPR000719
- InterPro:   IPR017441
- InterPro:   IPR017442
- InterPro:   IPR008271 [H]

Pfam domain/function: PF03793 PASTA; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 57485; Mature: 57485

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00108 PROTEIN_KINASE_ST ; PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNRFYEKYEIIKELASSNHSKIYLVRHVILDVYRVAKIFTGSHEESERLLNEAHLIKNL
CCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
KHPHIPVIYDIEQNIGEDNDSICIIEEYIDGKSLRQYVNDETETNGCLDIHEICRIGIEL
CCCCCCEEEECHHHCCCCCCCEEEEHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
CCILEYLHSFNGEGILHMDIKPDNIMLDNYGKVKLIDFDNAVIAGCGMQVNNGSLLFAAP
HHHHHHHHCCCCCEEEEEECCCCCEEEECCCEEEEEECCCCEEEECCEEECCCEEEEECC
EQYSGEDAVEQSDIYSVGMVILFMISHGKIRTYENHNLSGAAERYSVLYHLINKSLHHQW
CCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
GLRYESVTLVREELESIMKMGGGTFEKLSYVIQVAGEKPGIGVTNAVMSMAHFFRNNQYD
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCE
CVVVDKSGNDYLHREIVRSTLMPEGFYLYDNIKVIPDYYNAISVNGVRSRIVIIDCGCDF
EEEEECCCCHHHHHHHHHHHCCCCCEEEEECEEECCCCCCEEEECCCEEEEEEEECCCCC
NKSREVKITDITGDNYTCIRVFIVGKATHCSGKKMDDKDIIMLNLVGARQFYELVNSVYK
CCCCEEEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHC
GKKCYRIPCIYNWNEANPIFDETMNDFLQDNLTGIMKGYRPHRIKECIGRLYEKVRNFRV
CCCEEEECEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHH
IKWFRKKKKKQEHSCNKL
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDNRFYEKYEIIKELASSNHSKIYLVRHVILDVYRVAKIFTGSHEESERLLNEAHLIKNL
CCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHC
KHPHIPVIYDIEQNIGEDNDSICIIEEYIDGKSLRQYVNDETETNGCLDIHEICRIGIEL
CCCCCCEEEECHHHCCCCCCCEEEEHHHCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
CCILEYLHSFNGEGILHMDIKPDNIMLDNYGKVKLIDFDNAVIAGCGMQVNNGSLLFAAP
HHHHHHHHCCCCCEEEEEECCCCCEEEECCCEEEEEECCCCEEEECCEEECCCEEEEECC
EQYSGEDAVEQSDIYSVGMVILFMISHGKIRTYENHNLSGAAERYSVLYHLINKSLHHQW
CCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHH
GLRYESVTLVREELESIMKMGGGTFEKLSYVIQVAGEKPGIGVTNAVMSMAHFFRNNQYD
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCE
CVVVDKSGNDYLHREIVRSTLMPEGFYLYDNIKVIPDYYNAISVNGVRSRIVIIDCGCDF
EEEEECCCCHHHHHHHHHHHCCCCCEEEEECEEECCCCCCEEEECCCEEEEEEEECCCCC
NKSREVKITDITGDNYTCIRVFIVGKATHCSGKKMDDKDIIMLNLVGARQFYELVNSVYK
CCCCEEEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHC
GKKCYRIPCIYNWNEANPIFDETMNDFLQDNLTGIMKGYRPHRIKECIGRLYEKVRNFRV
CCCEEEECEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHH
IKWFRKKKKKQEHSCNKL
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]