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The map label for this gene is ywlC [H]

Identifier: 238917860

GI number: 238917860

Start: 2007659

End: 2008714

Strand: Reverse

Name: ywlC [H]

Synonym: EUBELI_01941

Alternate gene names: 238917860

Gene position: 2008714-2007659 (Counterclockwise)

Preceding gene: 238917861

Following gene: 238917859

Centisome position: 93.68

GC content: 40.15

Gene sequence:

>1056_bases
ATGGAAACAATAATAAAGAAGATAACACACACAGAAGAAGATAAGAAAATATATGAACAGGCAGGACAGATTCTAAGAGA
GGGAGGGCTTGTGGCATTTCCTACGGAGACTGTATACGGACTTGGTGCGGATGCACTTGATGCAAAAGCTTCAGCCAAAA
TATATGCAGCAAAGGGAAGACCTTCTGATAATCCGCTTATAGTGCATATTGCAGATGTTAATGCATTGTATGACTTAGCC
AAAGAGGTACCAGATAAGGCACTTGTGCTGGCAGAAAAATTCTGGCCGGGTCCGCTTACAATGATTCTTAAGAAAAAGGA
TAAAGTACCTGATTCTATAACAGGAGGTCTTGGAACGGTTGCTATAAGAATGCCAAGCCACCCTGTTGCGGCAGAACTTA
TAAGAAGCTCAGGAGTATATATAGCTGCACCAAGTGCCAATACATCAGGAAAGCCAAGCCCAACAAGGGCAGAGCATGTA
ATTAATGATTTATCTGGAAGAATAGATATGATTATTCAGGATGATACTGTAGATATAGGTGTGGAATCTACAATTATTGA
TTTGAGCGAGGAAGTTCCGACTATATTAAGACCTGGATATATCACACAGGCTATGTTTGAGGAAGCTATAGGAAAGACGA
TAATTGATCCTGCTATTATGGGAAGCCTTAAAGAAGGGGTTGTACCTAAAGCACCGGGAATGAAATACAAGCACTATGCA
CCTAATGCTGATGTGACTATTGTTGAAGGTCAGCATGAAAAGGTTGTTCAGTATATTAACGCCCAGATTGCAGAAAAGGA
AGCAGAAGGTCATAGATGTGCAGTTATGGCAACTGATGAGACAAAAGATAAATATATATGCAGTGATATTGTTTCAGCAG
GACATAAGGATGATGAGCTTAGTGTTGCAAGAAACCTGTATGCGATATTAAGGGACTTTGACAAGCAGAACATAGAGTTT
GTTTACTCAGAAAGCTTTGAGACAAAGAATGTGGGACAGGCTGTTATGAACAGACTTATCAAGGCAGCCGGGCACAAAAT
AGTTAAACTGGATTAA

Upstream 100 bases:

>100_bases
TACGGAAGAATATCAGGAAAAAGTGGCTGATGCTCTGTATTGTGGTATAATAGAATATCTGATGATGAATATGAAGTAAT
GAAAGCTGGCGAAAGGTTTT

Downstream 100 bases:

>100_bases
TATATTTTTAATTAATGAAGATATGAGGATTTCCTATGAACACATTTGACAAGGTGATATTCGTATGTAATGGAAATACA
TGCAGAAGTCCAATGGCGGC

Product: translation factor

Products: NA

Alternate protein names: t(6)A37 threonylcarbamoyladenosine biosynthesis protein YwlC [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
METIIKKITHTEEDKKIYEQAGQILREGGLVAFPTETVYGLGADALDAKASAKIYAAKGRPSDNPLIVHIADVNALYDLA
KEVPDKALVLAEKFWPGPLTMILKKKDKVPDSITGGLGTVAIRMPSHPVAAELIRSSGVYIAAPSANTSGKPSPTRAEHV
INDLSGRIDMIIQDDTVDIGVESTIIDLSEEVPTILRPGYITQAMFEEAIGKTIIDPAIMGSLKEGVVPKAPGMKYKHYA
PNADVTIVEGQHEKVVQYINAQIAEKEAEGHRCAVMATDETKDKYICSDIVSAGHKDDELSVARNLYAILRDFDKQNIEF
VYSESFETKNVGQAVMNRLIKAAGHKIVKLD

Sequences:

>Translated_351_residues
METIIKKITHTEEDKKIYEQAGQILREGGLVAFPTETVYGLGADALDAKASAKIYAAKGRPSDNPLIVHIADVNALYDLA
KEVPDKALVLAEKFWPGPLTMILKKKDKVPDSITGGLGTVAIRMPSHPVAAELIRSSGVYIAAPSANTSGKPSPTRAEHV
INDLSGRIDMIIQDDTVDIGVESTIIDLSEEVPTILRPGYITQAMFEEAIGKTIIDPAIMGSLKEGVVPKAPGMKYKHYA
PNADVTIVEGQHEKVVQYINAQIAEKEAEGHRCAVMATDETKDKYICSDIVSAGHKDDELSVARNLYAILRDFDKQNIEF
VYSESFETKNVGQAVMNRLIKAAGHKIVKLD
>Mature_351_residues
METIIKKITHTEEDKKIYEQAGQILREGGLVAFPTETVYGLGADALDAKASAKIYAAKGRPSDNPLIVHIADVNALYDLA
KEVPDKALVLAEKFWPGPLTMILKKKDKVPDSITGGLGTVAIRMPSHPVAAELIRSSGVYIAAPSANTSGKPSPTRAEHV
INDLSGRIDMIIQDDTVDIGVESTIIDLSEEVPTILRPGYITQAMFEEAIGKTIIDPAIMGSLKEGVVPKAPGMKYKHYA
PNADVTIVEGQHEKVVQYINAQIAEKEAEGHRCAVMATDETKDKYICSDIVSAGHKDDELSVARNLYAILRDFDKQNIEF
VYSESFETKNVGQAVMNRLIKAAGHKIVKLD

Specific function: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (Probable) [H]

COG id: COG0009

COG function: function code J; Putative translation factor (SUA5)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 YrdC-like domain [H]

Homologues:

Organism=Homo sapiens, GI58761510, Length=200, Percent_Identity=30, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87081864, Length=189, Percent_Identity=26.984126984127, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI2367210, Length=138, Percent_Identity=31.1594202898551, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17537239, Length=176, Percent_Identity=31.25, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321269, Length=394, Percent_Identity=32.994923857868, Blast_Score=183, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR005145
- InterPro:   IPR004388
- InterPro:   IPR006070
- InterPro:   IPR010923 [H]

Pfam domain/function: PF03481 SUA5; PF01300 Sua5_yciO_yrdC [H]

EC number: NA

Molecular weight: Translated: 38192; Mature: 38192

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS51163 YRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METIIKKITHTEEDKKIYEQAGQILREGGLVAFPTETVYGLGADALDAKASAKIYAAKGR
CHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEECCHHHHHCCCHHHCCCCCCEEEEECCC
PSDNPLIVHIADVNALYDLAKEVPDKALVLAEKFWPGPLTMILKKKDKVPDSITGGLGTV
CCCCCEEEEEECHHHHHHHHHHCCCHHEEEHHHCCCCCCEEEEECCCCCCCCCCCCCEEE
AIRMPSHPVAAELIRSSGVYIAAPSANTSGKPSPTRAEHVINDLSGRIDMIIQDDTVDIG
EEECCCCHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCEECC
VESTIIDLSEEVPTILRPGYITQAMFEEAIGKTIIDPAIMGSLKEGVVPKAPGMKYKHYA
CCHHEEECHHHCCHHHCCCHHHHHHHHHHHCHHHHCHHHHHHHHHCCCCCCCCCCEEEEC
PNADVTIVEGQHEKVVQYINAQIAEKEAEGHRCAVMATDETKDKYICSDIVSAGHKDDEL
CCCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCHH
SVARNLYAILRDFDKQNIEFVYSESFETKNVGQAVMNRLIKAAGHKIVKLD
HHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEC
>Mature Secondary Structure
METIIKKITHTEEDKKIYEQAGQILREGGLVAFPTETVYGLGADALDAKASAKIYAAKGR
CHHHHHHHHCCHHHHHHHHHHHHHHHHCCEEEECCHHHHHCCCHHHCCCCCCEEEEECCC
PSDNPLIVHIADVNALYDLAKEVPDKALVLAEKFWPGPLTMILKKKDKVPDSITGGLGTV
CCCCCEEEEEECHHHHHHHHHHCCCHHEEEHHHCCCCCCEEEEECCCCCCCCCCCCCEEE
AIRMPSHPVAAELIRSSGVYIAAPSANTSGKPSPTRAEHVINDLSGRIDMIIQDDTVDIG
EEECCCCHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCEECC
VESTIIDLSEEVPTILRPGYITQAMFEEAIGKTIIDPAIMGSLKEGVVPKAPGMKYKHYA
CCHHEEECHHHCCHHHCCCHHHHHHHHHHHCHHHHCHHHHHHHHHCCCCCCCCCCEEEEC
PNADVTIVEGQHEKVVQYINAQIAEKEAEGHRCAVMATDETKDKYICSDIVSAGHKDDEL
CCCCEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCHH
SVARNLYAILRDFDKQNIEFVYSESFETKNVGQAVMNRLIKAAGHKIVKLD
HHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]