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The map label for this gene is prs [H]

Identifier: 238917841

GI number: 238917841

Start: 1990326

End: 1991510

Strand: Direct

Name: prs [H]

Synonym: EUBELI_01922

Alternate gene names: 238917841

Gene position: 1990326-1991510 (Clockwise)

Preceding gene: 238917840

Following gene: 238917856

Centisome position: 92.82

GC content: 39.58

Gene sequence:

>1185_bases
ATGCCACGTGATGAAAGACACACAGAAACTATTCCCTACGGAACTTTAGGTATTATCCCATTAGCAAGCTGCACTGAAAT
GGGTAAGAAAGTTGACGAGTACCTTGTAAAGTGGAGAGAGCAGCGTCAGAATGAGAATACTTCTACCCTTAATTTTGCAG
GATATAAGAGAGACAGTTACATTGTAAACGCTAAGACTCCTAGATTCGGTTCAGGAGAAGGAAAGGGCGTTCTTGTAGAT
TCTGTCCGTGGTCATGACTTATATATTATGCTTGATGTCTGCAACTACAGCCTTGAATACACTGTATGTGGTTTCAAGAA
TCATATGTCTCCTGATGATCACTATGCTGACCTCAAGAGAGTTATTGCTGCTGCAGGTGGTAAGGCAAGAAGAATTAATG
TAATCATGCCTTTCCTTTATGAATCAAGACAGCACAAGAGAACAGGAAGAGAATCTCTTGACTGTGCACTTATGCTTCAG
GAACTTACAGATATGGGTGTCGAGAATATTATTACTTTTGATGCTCACGACCCTAGAGTTCACAATGCAATTCCTCTTAA
GGGATTTGAATCTGTATCATGCACATATCAGTTTATCAAGTATCTTCTTCTTAATGTAGATGACCTTCATATTGACAGCG
AGCATATGATGGTTATCAGCCCTGATGAAGGTGGTATGGGACGTGCTGTTTACTTTGCCAATGTTCTTGGTCTTGACATG
GGTATGTTCTACAAGAGAAGAGATTACACTAGGATTGTTAATGGTCGAAATCCTATCGTTGCACATGAGTTCCTTGGAAC
TAATGTTGAGGGCAAGGATGTTATCATCATTGATGATATGATTTCTTCTGGTGAAAGTATGATTGATGTTGCTTCTGAGC
TTAAGAAGCGTGGCGCAAGCAGAGTATTCTGTGCTACTACATTCGGTCTTTTCACTAACGGCTTTAAGAAGTTTGATGAG
GCATATGAGAATGGCATTATTGACAGAATCCTTACAACTAACCTTGTATACCAGCCATCAGAACTTCTCTCTAAGCCTTG
GTACATCAATGTTGATATGAGCAAATATATGGCTCTTCTTATTGATACACTTAACCATGATTCTTCAATCAGCAATCTCT
TAAGCCCGGTTGAAAGAATCCAGCAGAGAGTTAAGGAATATAACGAACTTCATTACGGAAAGTAA

Upstream 100 bases:

>100_bases
CGATTATTTATGTCAAATATATCATTGACTTATTTCGCGTCAATGTTTATATTTTTATATGTATGTTTAATTATTATACT
TTTATGGAGGATTATTTATT

Downstream 100 bases:

>100_bases
TTAATAACAGAAATGGAATCTGACACATTTAAGCCAGATTCCATTTTTTAATTTCTTATTGCAGCATCATTCTTTGTTTC
CGCTGGTCTGTCTGTACCAG

Product: phosphoribosylpyrophosphate synthetase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MPRDERHTETIPYGTLGIIPLASCTEMGKKVDEYLVKWREQRQNENTSTLNFAGYKRDSYIVNAKTPRFGSGEGKGVLVD
SVRGHDLYIMLDVCNYSLEYTVCGFKNHMSPDDHYADLKRVIAAAGGKARRINVIMPFLYESRQHKRTGRESLDCALMLQ
ELTDMGVENIITFDAHDPRVHNAIPLKGFESVSCTYQFIKYLLLNVDDLHIDSEHMMVISPDEGGMGRAVYFANVLGLDM
GMFYKRRDYTRIVNGRNPIVAHEFLGTNVEGKDVIIIDDMISSGESMIDVASELKKRGASRVFCATTFGLFTNGFKKFDE
AYENGIIDRILTTNLVYQPSELLSKPWYINVDMSKYMALLIDTLNHDSSISNLLSPVERIQQRVKEYNELHYGK

Sequences:

>Translated_394_residues
MPRDERHTETIPYGTLGIIPLASCTEMGKKVDEYLVKWREQRQNENTSTLNFAGYKRDSYIVNAKTPRFGSGEGKGVLVD
SVRGHDLYIMLDVCNYSLEYTVCGFKNHMSPDDHYADLKRVIAAAGGKARRINVIMPFLYESRQHKRTGRESLDCALMLQ
ELTDMGVENIITFDAHDPRVHNAIPLKGFESVSCTYQFIKYLLLNVDDLHIDSEHMMVISPDEGGMGRAVYFANVLGLDM
GMFYKRRDYTRIVNGRNPIVAHEFLGTNVEGKDVIIIDDMISSGESMIDVASELKKRGASRVFCATTFGLFTNGFKKFDE
AYENGIIDRILTTNLVYQPSELLSKPWYINVDMSKYMALLIDTLNHDSSISNLLSPVERIQQRVKEYNELHYGK
>Mature_393_residues
PRDERHTETIPYGTLGIIPLASCTEMGKKVDEYLVKWREQRQNENTSTLNFAGYKRDSYIVNAKTPRFGSGEGKGVLVDS
VRGHDLYIMLDVCNYSLEYTVCGFKNHMSPDDHYADLKRVIAAAGGKARRINVIMPFLYESRQHKRTGRESLDCALMLQE
LTDMGVENIITFDAHDPRVHNAIPLKGFESVSCTYQFIKYLLLNVDDLHIDSEHMMVISPDEGGMGRAVYFANVLGLDMG
MFYKRRDYTRIVNGRNPIVAHEFLGTNVEGKDVIIIDDMISSGESMIDVASELKKRGASRVFCATTFGLFTNGFKKFDEA
YENGIIDRILTTNLVYQPSELLSKPWYINVDMSKYMALLIDTLNHDSSISNLLSPVERIQQRVKEYNELHYGK

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=317, Percent_Identity=23.9747634069401, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI4506129, Length=317, Percent_Identity=23.3438485804416, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI28557709, Length=317, Percent_Identity=24.6056782334385, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI84875539, Length=320, Percent_Identity=23.125, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI194018537, Length=382, Percent_Identity=21.9895287958115, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787458, Length=316, Percent_Identity=27.2151898734177, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17554702, Length=322, Percent_Identity=23.2919254658385, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71989924, Length=322, Percent_Identity=23.2919254658385, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25149168, Length=322, Percent_Identity=23.2919254658385, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17554704, Length=322, Percent_Identity=23.2919254658385, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17570245, Length=279, Percent_Identity=20.7885304659498, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321776, Length=318, Percent_Identity=27.3584905660377, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320946, Length=309, Percent_Identity=24.5954692556634, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319403, Length=251, Percent_Identity=25.4980079681275, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21355239, Length=317, Percent_Identity=23.9747634069401, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI45551540, Length=340, Percent_Identity=22.3529411764706, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 44825; Mature: 44694

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRDERHTETIPYGTLGIIPLASCTEMGKKVDEYLVKWREQRQNENTSTLNFAGYKRDSY
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCE
IVNAKTPRFGSGEGKGVLVDSVRGHDLYIMLDVCNYSLEYTVCGFKNHMSPDDHYADLKR
EEECCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHH
VIAAAGGKARRINVIMPFLYESRQHKRTGRESLDCALMLQELTDMGVENIITFDAHDPRV
HHHHCCCCCEEEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHEEEECCCCCCC
HNAIPLKGFESVSCTYQFIKYLLLNVDDLHIDSEHMMVISPDEGGMGRAVYFANVLGLDM
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCCCCHHHHHHHHHHHHH
GMFYKRRDYTRIVNGRNPIVAHEFLGTNVEGKDVIIIDDMISSGESMIDVASELKKRGAS
HHHHHHCCHHHHCCCCCCEEEHHHHCCCCCCCEEEEEEHHHHCCHHHHHHHHHHHHCCCC
RVFCATTFGLFTNGFKKFDEAYENGIIDRILTTNLVYQPSELLSKPWYINVDMSKYMALL
EEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCHHHHCCCCEEEECHHHHHHHH
IDTLNHDSSISNLLSPVERIQQRVKEYNELHYGK
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PRDERHTETIPYGTLGIIPLASCTEMGKKVDEYLVKWREQRQNENTSTLNFAGYKRDSY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCE
IVNAKTPRFGSGEGKGVLVDSVRGHDLYIMLDVCNYSLEYTVCGFKNHMSPDDHYADLKR
EEECCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHH
VIAAAGGKARRINVIMPFLYESRQHKRTGRESLDCALMLQELTDMGVENIITFDAHDPRV
HHHHCCCCCEEEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHEEEECCCCCCC
HNAIPLKGFESVSCTYQFIKYLLLNVDDLHIDSEHMMVISPDEGGMGRAVYFANVLGLDM
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCCCCHHHHHHHHHHHHH
GMFYKRRDYTRIVNGRNPIVAHEFLGTNVEGKDVIIIDDMISSGESMIDVASELKKRGAS
HHHHHHCCHHHHCCCCCCEEEHHHHCCCCCCCEEEEEEHHHHCCHHHHHHHHHHHHCCCC
RVFCATTFGLFTNGFKKFDEAYENGIIDRILTTNLVYQPSELLSKPWYINVDMSKYMALL
EEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEECCHHHHCCCCEEEECHHHHHHHH
IDTLNHDSSISNLLSPVERIQQRVKEYNELHYGK
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]