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The map label for this gene is fba [H]

Identifier: 238917752

GI number: 238917752

Start: 1891739

End: 1892602

Strand: Direct

Name: fba [H]

Synonym: EUBELI_01833

Alternate gene names: 238917752

Gene position: 1891739-1892602 (Clockwise)

Preceding gene: 238917748

Following gene: 238917753

Centisome position: 88.23

GC content: 40.62

Gene sequence:

>864_bases
ATGTTAGTTTCAGCAAAAGAAATGTTAGACAATGCTCTTGCCGGCAAATATGCTGTCGGTCAGTTCAACATCAATAACCT
TGAATGGACTAAGTCTATTCTCCTTACTGCACAGGAGATGAATGCTCCTGTAATCCTTGGTGTATCTGAGGGCGCCGGTA
AGTATATGACAGGTTTTGAGACTGTTGCAGCCATGGTTAAAGCTATGGACAAGTCTCTTGGAATCACTGTTCCTGTTGCT
CTTCATCTTGACCACGGAACATACGAAGGATGCTACAAATGTATCAAAGCAGGCTTCACATCTATTATGTTTGATGGTTC
TCACTATCCAATTGACGAAAATATCAAGAAAACAACAGAACTTGTTAATGTAGCACACAATCTTGGTCTTTCTATTGAAG
CAGAAGTTGGTTCAATAGGTGGCGAGGAAGATGGTGTTATCGGAATGGGTGAATGTGCAGACCCTGATGAATGTAAATCT
ATTGCTGATCTTGGCGTAGATATGCTTGCAGCAGGTATTGGTAACATTCATGGAAAGTATCCGGCTAACTGGCCAGGATT
AAGCTTTGAAACACTTGCTGCAGTTAAGGAAAAGATTGGTGATATGCCATTAGTTCTTCACGGTGGTACAGGAATTCCAG
CAGATATGATTCAGAAGGCTATTTCTCTCGGTGTATCTAAGATTAATGTTAATACAGAATGCCAGCTTTCATTTGCTGAT
GCAACAAGAAAATATGTTGAAGCAGGCAAAGATCTTGAAGGAAAGGGCTTTGATCCTAGAAAACTTCTCGCTCCTGGATG
TGAAGCTATTAAAGAAACTGTACGTGAGAAGATTAATCTTTTCGGTTCAGCTGGAAAAGCATGA

Upstream 100 bases:

>100_bases
TATATTTATACATAAATATCAGTTAAATATTTCTTTTCATTTTTAATGATATGAGATATAATATTGTCATGCAAAAATCG
TGCAATGGAGGTAAAGAAAT

Downstream 100 bases:

>100_bases
TAAAAACTGATTGGAGATTATTATGAGTGATATTAAAACAGAGGATAATGATGATTTTATTGTGTCCTCCTCTGATTTAG
AAAAGGATGAAGCAGACATC

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MLVSAKEMLDNALAGKYAVGQFNINNLEWTKSILLTAQEMNAPVILGVSEGAGKYMTGFETVAAMVKAMDKSLGITVPVA
LHLDHGTYEGCYKCIKAGFTSIMFDGSHYPIDENIKKTTELVNVAHNLGLSIEAEVGSIGGEEDGVIGMGECADPDECKS
IADLGVDMLAAGIGNIHGKYPANWPGLSFETLAAVKEKIGDMPLVLHGGTGIPADMIQKAISLGVSKINVNTECQLSFAD
ATRKYVEAGKDLEGKGFDPRKLLAPGCEAIKETVREKINLFGSAGKA

Sequences:

>Translated_287_residues
MLVSAKEMLDNALAGKYAVGQFNINNLEWTKSILLTAQEMNAPVILGVSEGAGKYMTGFETVAAMVKAMDKSLGITVPVA
LHLDHGTYEGCYKCIKAGFTSIMFDGSHYPIDENIKKTTELVNVAHNLGLSIEAEVGSIGGEEDGVIGMGECADPDECKS
IADLGVDMLAAGIGNIHGKYPANWPGLSFETLAAVKEKIGDMPLVLHGGTGIPADMIQKAISLGVSKINVNTECQLSFAD
ATRKYVEAGKDLEGKGFDPRKLLAPGCEAIKETVREKINLFGSAGKA
>Mature_287_residues
MLVSAKEMLDNALAGKYAVGQFNINNLEWTKSILLTAQEMNAPVILGVSEGAGKYMTGFETVAAMVKAMDKSLGITVPVA
LHLDHGTYEGCYKCIKAGFTSIMFDGSHYPIDENIKKTTELVNVAHNLGLSIEAEVGSIGGEEDGVIGMGECADPDECKS
IADLGVDMLAAGIGNIHGKYPANWPGLSFETLAAVKEKIGDMPLVLHGGTGIPADMIQKAISLGVSKINVNTECQLSFAD
ATRKYVEAGKDLEGKGFDPRKLLAPGCEAIKETVREKINLFGSAGKA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=290, Percent_Identity=39.6551724137931, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI87082041, Length=292, Percent_Identity=36.986301369863, Blast_Score=181, Evalue=4e-47,
Organism=Escherichia coli, GI1788072, Length=294, Percent_Identity=36.734693877551, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1789293, Length=321, Percent_Identity=26.4797507788162, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322790, Length=328, Percent_Identity=25.609756097561, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 30341; Mature: 30341

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVSAKEMLDNALAGKYAVGQFNINNLEWTKSILLTAQEMNAPVILGVSEGAGKYMTGFE
CCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
TVAAMVKAMDKSLGITVPVALHLDHGTYEGCYKCIKAGFTSIMFDGSHYPIDENIKKTTE
HHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHH
LVNVAHNLGLSIEAEVGSIGGEEDGVIGMGECADPDECKSIADLGVDMLAAGIGNIHGKY
HHHHHHHCCCEEEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PANWPGLSFETLAAVKEKIGDMPLVLHGGTGIPADMIQKAISLGVSKINVNTECQLSFAD
CCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCHHEEECCCEEEEEHHH
ATRKYVEAGKDLEGKGFDPRKLLAPGCEAIKETVREKINLFGSAGKA
HHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLVSAKEMLDNALAGKYAVGQFNINNLEWTKSILLTAQEMNAPVILGVSEGAGKYMTGFE
CCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
TVAAMVKAMDKSLGITVPVALHLDHGTYEGCYKCIKAGFTSIMFDGSHYPIDENIKKTTE
HHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHH
LVNVAHNLGLSIEAEVGSIGGEEDGVIGMGECADPDECKSIADLGVDMLAAGIGNIHGKY
HHHHHHHCCCEEEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PANWPGLSFETLAAVKEKIGDMPLVLHGGTGIPADMIQKAISLGVSKINVNTECQLSFAD
CCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCHHEEECCCEEEEEHHH
ATRKYVEAGKDLEGKGFDPRKLLAPGCEAIKETVREKINLFGSAGKA
HHHHHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7569993 [H]