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The map label for this gene is pyrG [H]

Identifier: 238917605

GI number: 238917605

Start: 1746934

End: 1748619

Strand: Direct

Name: pyrG [H]

Synonym: EUBELI_01684

Alternate gene names: 238917605

Gene position: 1746934-1748619 (Clockwise)

Preceding gene: 238917603

Following gene: 238917617

Centisome position: 81.47

GC content: 39.38

Gene sequence:

>1686_bases
ATGGAAATTTATAATACAGGGCTGTATAATATTGCATATTTTTTTGATTACACATTCAGATTGGAGGAAAAGATGGCTGT
TAAATATGTATTTGTAACAGGTGGTGTTGTTTCCGGTTTAGGAAAAGGTATCACTGCCGCATCTTTAGGCAGACTGCTTA
AAGCCCGTGGTTTTTCTGTAACCATGCAGAAGTTTGACCCTTATATTAATATTGATCCAGGTACTATGAACCCTATCCAG
CACGGAGAAGTTTTCGTAACTGACGATGGTGCTGAGACAGACCTTGACCTTGGTCACTATGAAAGATTTATTGATGAGAG
CCTTAATAAGAATTCTAATGTAACTACCGGTAAAGTATACTGGTCAGTATTACAGAAGGAACGCCGTGGAGATTTCGGTG
GAGGCACAGTCCAGGTAATCCCTCATATTACTAATGAAATAAAGAGCCGTTTTTTCAGAGATTATTCAACTGATGAAACT
AAGATTGCAATTATAGAAGTCGGTGGTACTGTTGGAGATATCGAGAGTCAGCCTTTCCTTGAGGCAATCAGACAATTTCA
GCATGAAGTAGGACATGAAAACGCAATTCTTATTCACGTAACACTTATTCCTTATCTTAAGGCATCTGGTGAGATGAAGA
CTAAGCCTACACAGGCAAGCGTTAAGGAACTCCAGGGAATGGGAATCCGTCCGGATATTCTTGTATGCCGTACAGAGCAT
CCTCTTGAGGCAGGTATCAAGGATAAGATAGCACTTTTCTGTAATGTACCTAAGTCTCATGTACTTCAGAACTTAGATGT
TGAGATTCTTTATGATGCACCTCTTGCAATGGAAGAAGAACATCTTGCACAGGTAGCATGTGAATGTTTACACCTTGACT
GTCCAGAACCAGATCTTGATGAATGGAGAGCAATGTGCAAAGCCTGGAAGAATCCTACCAAGAAGGTAACTGTTGCATTA
GTCGGTAAATATATCCAGCTTCATGATGCTTATATCAGTGTTGTAGAAGCATTAAAGCATGGTGGTGTATATAATTCATG
TGATGTAACTATCAAATGGATTGATTCAGAAACTGTAACTCCTGAAACTGCTGATGAACTTCTCTCTGACGTATCCGGTA
TATTAGTTCCAGGCGGATTCGGAGACAGAGGTACAGAAGGAAAGATTGAAGCTATCCGTTATGCAAGAGAGCATAATATT
CCATTCTTAGGATTGTGCCTGGGAATGCAGCTTTCAATTGTTGAATTTGCAAGAAATGTTATAGGATATGACGACGCACA
CAGTGTTGAACTTAATCCTAACACAACCCACCCTGTTATACATCTTATGCCAGATCAGGAAGGCATTGATGATATCGGCG
GTACATTAAGACTTGGTTCTTATCCTTGTGTACTTGATAAAACAAGTAAGGCTTATGAACTTTATGGTGAAGAGCTTATA
CATGAACGTCACAGACACAGATATGAAGTAAATAATGATTATAGAAAAGTTCTTACCGAGAACGGTATGATGCTTTCAGG
AATATCTCCTGATGGAAGAATTGTTGAGATGATAGAATTAAAGAATCACCCATGGTTTGTTGCCACACAGGCACATCCGG
AATTAAAGTCAAGACCTAACCGTCCACATCCATTATTCAGAGGCTTTATAACAGCAGCCCTTGAATATCAGGATAAGAAC
CATTAA

Upstream 100 bases:

>100_bases
TTTTCATTATAAAGAAGGAAAAAATATAAATCAACCAAAATCTAAGTGTTTAATAAGATGTTTATATTTACTTTATATTC
TTAGTTTTTTTCTTTAAACT

Downstream 100 bases:

>100_bases
TTATATATACACATAATAAAAACATCACCTGACGAATCCGACTTTCGTATCAGGTGATGTTTTTATTGCTTTTGCTTATA
AAATTATTACTTATTAAGAC

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MEIYNTGLYNIAYFFDYTFRLEEKMAVKYVFVTGGVVSGLGKGITAASLGRLLKARGFSVTMQKFDPYINIDPGTMNPIQ
HGEVFVTDDGAETDLDLGHYERFIDESLNKNSNVTTGKVYWSVLQKERRGDFGGGTVQVIPHITNEIKSRFFRDYSTDET
KIAIIEVGGTVGDIESQPFLEAIRQFQHEVGHENAILIHVTLIPYLKASGEMKTKPTQASVKELQGMGIRPDILVCRTEH
PLEAGIKDKIALFCNVPKSHVLQNLDVEILYDAPLAMEEEHLAQVACECLHLDCPEPDLDEWRAMCKAWKNPTKKVTVAL
VGKYIQLHDAYISVVEALKHGGVYNSCDVTIKWIDSETVTPETADELLSDVSGILVPGGFGDRGTEGKIEAIRYAREHNI
PFLGLCLGMQLSIVEFARNVIGYDDAHSVELNPNTTHPVIHLMPDQEGIDDIGGTLRLGSYPCVLDKTSKAYELYGEELI
HERHRHRYEVNNDYRKVLTENGMMLSGISPDGRIVEMIELKNHPWFVATQAHPELKSRPNRPHPLFRGFITAALEYQDKN
H

Sequences:

>Translated_561_residues
MEIYNTGLYNIAYFFDYTFRLEEKMAVKYVFVTGGVVSGLGKGITAASLGRLLKARGFSVTMQKFDPYINIDPGTMNPIQ
HGEVFVTDDGAETDLDLGHYERFIDESLNKNSNVTTGKVYWSVLQKERRGDFGGGTVQVIPHITNEIKSRFFRDYSTDET
KIAIIEVGGTVGDIESQPFLEAIRQFQHEVGHENAILIHVTLIPYLKASGEMKTKPTQASVKELQGMGIRPDILVCRTEH
PLEAGIKDKIALFCNVPKSHVLQNLDVEILYDAPLAMEEEHLAQVACECLHLDCPEPDLDEWRAMCKAWKNPTKKVTVAL
VGKYIQLHDAYISVVEALKHGGVYNSCDVTIKWIDSETVTPETADELLSDVSGILVPGGFGDRGTEGKIEAIRYAREHNI
PFLGLCLGMQLSIVEFARNVIGYDDAHSVELNPNTTHPVIHLMPDQEGIDDIGGTLRLGSYPCVLDKTSKAYELYGEELI
HERHRHRYEVNNDYRKVLTENGMMLSGISPDGRIVEMIELKNHPWFVATQAHPELKSRPNRPHPLFRGFITAALEYQDKN
H
>Mature_561_residues
MEIYNTGLYNIAYFFDYTFRLEEKMAVKYVFVTGGVVSGLGKGITAASLGRLLKARGFSVTMQKFDPYINIDPGTMNPIQ
HGEVFVTDDGAETDLDLGHYERFIDESLNKNSNVTTGKVYWSVLQKERRGDFGGGTVQVIPHITNEIKSRFFRDYSTDET
KIAIIEVGGTVGDIESQPFLEAIRQFQHEVGHENAILIHVTLIPYLKASGEMKTKPTQASVKELQGMGIRPDILVCRTEH
PLEAGIKDKIALFCNVPKSHVLQNLDVEILYDAPLAMEEEHLAQVACECLHLDCPEPDLDEWRAMCKAWKNPTKKVTVAL
VGKYIQLHDAYISVVEALKHGGVYNSCDVTIKWIDSETVTPETADELLSDVSGILVPGGFGDRGTEGKIEAIRYAREHNI
PFLGLCLGMQLSIVEFARNVIGYDDAHSVELNPNTTHPVIHLMPDQEGIDDIGGTLRLGSYPCVLDKTSKAYELYGEELI
HERHRHRYEVNNDYRKVLTENGMMLSGISPDGRIVEMIELKNHPWFVATQAHPELKSRPNRPHPLFRGFITAALEYQDKN
H

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=549, Percent_Identity=47.3588342440801, Blast_Score=509, Evalue=1e-144,
Organism=Homo sapiens, GI28559085, Length=549, Percent_Identity=47.3588342440801, Blast_Score=496, Evalue=1e-140,
Organism=Homo sapiens, GI28559083, Length=549, Percent_Identity=47.3588342440801, Blast_Score=496, Evalue=1e-140,
Organism=Homo sapiens, GI221316689, Length=549, Percent_Identity=47.3588342440801, Blast_Score=496, Evalue=1e-140,
Organism=Escherichia coli, GI1789142, Length=546, Percent_Identity=52.9304029304029, Blast_Score=570, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI25148299, Length=601, Percent_Identity=37.1048252911814, Blast_Score=396, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6319432, Length=559, Percent_Identity=44.0071556350626, Blast_Score=469, Evalue=1e-133,
Organism=Saccharomyces cerevisiae, GI6322563, Length=561, Percent_Identity=44.7415329768271, Blast_Score=456, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24664469, Length=550, Percent_Identity=46.5454545454545, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI21357815, Length=494, Percent_Identity=44.9392712550607, Blast_Score=416, Evalue=1e-116,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 62971; Mature: 62971

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIYNTGLYNIAYFFDYTFRLEEKMAVKYVFVTGGVVSGLGKGITAASLGRLLKARGFSV
CCEECCCHHEEEEEEEEEEEECCCEEEEEEEEECHHHHHHCCCCHHHHHHHHHHHCCCEE
TMQKFDPYINIDPGTMNPIQHGEVFVTDDGAETDLDLGHYERFIDESLNKNSNVTTGKVY
EHHHCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHH
WSVLQKERRGDFGGGTVQVIPHITNEIKSRFFRDYSTDETKIAIIEVGGTVGDIESQPFL
HHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHH
EAIRQFQHEVGHENAILIHVTLIPYLKASGEMKTKPTQASVKELQGMGIRPDILVCRTEH
HHHHHHHHHHCCCCEEEEEEEEEEHHCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCC
PLEAGIKDKIALFCNVPKSHVLQNLDVEILYDAPLAMEEEHLAQVACECLHLDCPEPDLD
CHHCCCCCCEEEEECCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCHH
EWRAMCKAWKNPTKKVTVALVGKYIQLHDAYISVVEALKHGGVYNSCDVTIKWIDSETVT
HHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCC
PETADELLSDVSGILVPGGFGDRGTEGKIEAIRYAREHNIPFLGLCLGMQLSIVEFARNV
CHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEHHHCCHHHHHHHHHHH
IGYDDAHSVELNPNTTHPVIHLMPDQEGIDDIGGTLRLGSYPCVLDKTSKAYELYGEELI
CCCCCCCEEEECCCCCCCEEEECCCCCCHHHCCCEEEECCCCEEECCCCHHHHHHHHHHH
HERHRHRYEVNNDYRKVLTENGMMLSGISPDGRIVEMIELKNHPWFVATQAHPELKSRPN
HHHHHCCCCCCCHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCEEEEECCCCHHHCCCC
RPHPLFRGFITAALEYQDKNH
CCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEIYNTGLYNIAYFFDYTFRLEEKMAVKYVFVTGGVVSGLGKGITAASLGRLLKARGFSV
CCEECCCHHEEEEEEEEEEEECCCEEEEEEEEECHHHHHHCCCCHHHHHHHHHHHCCCEE
TMQKFDPYINIDPGTMNPIQHGEVFVTDDGAETDLDLGHYERFIDESLNKNSNVTTGKVY
EHHHCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHH
WSVLQKERRGDFGGGTVQVIPHITNEIKSRFFRDYSTDETKIAIIEVGGTVGDIESQPFL
HHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCHHH
EAIRQFQHEVGHENAILIHVTLIPYLKASGEMKTKPTQASVKELQGMGIRPDILVCRTEH
HHHHHHHHHHCCCCEEEEEEEEEEHHCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEECCC
PLEAGIKDKIALFCNVPKSHVLQNLDVEILYDAPLAMEEEHLAQVACECLHLDCPEPDLD
CHHCCCCCCEEEEECCCHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCHH
EWRAMCKAWKNPTKKVTVALVGKYIQLHDAYISVVEALKHGGVYNSCDVTIKWIDSETVT
HHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCC
PETADELLSDVSGILVPGGFGDRGTEGKIEAIRYAREHNIPFLGLCLGMQLSIVEFARNV
CHHHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEHHHCCHHHHHHHHHHH
IGYDDAHSVELNPNTTHPVIHLMPDQEGIDDIGGTLRLGSYPCVLDKTSKAYELYGEELI
CCCCCCCEEEECCCCCCCEEEECCCCCCHHHCCCEEEECCCCEEECCCCHHHHHHHHHHH
HERHRHRYEVNNDYRKVLTENGMMLSGISPDGRIVEMIELKNHPWFVATQAHPELKSRPN
HHHHHCCCCCCCHHHHHHHCCCEEEECCCCCCCEEEEEEECCCCEEEEECCCCHHHCCCC
RPHPLFRGFITAALEYQDKNH
CCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA