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The map label for this gene is vanRB [H]

Identifier: 238917433

GI number: 238917433

Start: 1565708

End: 1566361

Strand: Reverse

Name: vanRB [H]

Synonym: EUBELI_01511

Alternate gene names: 238917433

Gene position: 1566361-1565708 (Counterclockwise)

Preceding gene: 238917434

Following gene: 238917432

Centisome position: 73.05

GC content: 27.37

Gene sequence:

>654_bases
ATGAAAATATTAACTGTTGAAGATGATAATATGATAAGAGAGGGATTAAGTGAATATCTTTCAGAATTTGGATATACTGT
TATTCAAGCTAAAGATGGAAGAGAAGCCTTGTCAGAATTTAATAGCGATATAAATCTGGTTATCTTAGACATACAGATAC
CTTTTATAAATGGTTTAGAAGTATTGAAAGAAATTAGAAAGAAAAGCAATTTACCAATTCTAATCCTGACTGCATTTAGT
GATGAAGAATATAAAATTGATGCGTTTACTAATCTGGCAGATGGATATATAGAAAAGCCATTTTCATTGCCTGTCTTAAA
GGCTAGAATAGATTCTTTAATTAAGAAGAATTATGGACATTTAGAGAAGTTTGAATATAAGGATCTATCGGTTAATTTTA
ATAGCTATACAGCTAAAATAAATGGTGAAGAAATAGATGTAAATGCAAAAGAACTAGAAGTATTAAAATGTTTATTGGAT
AATAATGGACAAGTGTTAACAAGAATGCAAATTATTGATTATGTATGGAAAGATAGCGAAGAAACTCCTTATGATCGAGT
AATAGATGTATATATAAAAGAACTTAGAAAAAAATTACAATTAGACTGTATAACTACTATAAGAAATGTAGGATATAAAT
TGGAGAGAAAATGA

Upstream 100 bases:

>100_bases
TAAAATTTTTGGTGCTTTTTAGCACCAAAAATTTTTTTGCTTTTAAATATCCAATAATATGCTGTACAATATAAGCGAAT
AGGCTTAAGTGGAGGTATAC

Downstream 100 bases:

>100_bases
AAAAATTAAAGATATTTCCCAAAATGTTCATACAAATATTTTCTGTTCTTGGAATAATAATTATATTAGTTCATTCATTA
GTTTTTTTTATCTTTCCTAA

Product: two-component system OmpR family response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MKILTVEDDNMIREGLSEYLSEFGYTVIQAKDGREALSEFNSDINLVILDIQIPFINGLEVLKEIRKKSNLPILILTAFS
DEEYKIDAFTNLADGYIEKPFSLPVLKARIDSLIKKNYGHLEKFEYKDLSVNFNSYTAKINGEEIDVNAKELEVLKCLLD
NNGQVLTRMQIIDYVWKDSEETPYDRVIDVYIKELRKKLQLDCITTIRNVGYKLERK

Sequences:

>Translated_217_residues
MKILTVEDDNMIREGLSEYLSEFGYTVIQAKDGREALSEFNSDINLVILDIQIPFINGLEVLKEIRKKSNLPILILTAFS
DEEYKIDAFTNLADGYIEKPFSLPVLKARIDSLIKKNYGHLEKFEYKDLSVNFNSYTAKINGEEIDVNAKELEVLKCLLD
NNGQVLTRMQIIDYVWKDSEETPYDRVIDVYIKELRKKLQLDCITTIRNVGYKLERK
>Mature_217_residues
MKILTVEDDNMIREGLSEYLSEFGYTVIQAKDGREALSEFNSDINLVILDIQIPFINGLEVLKEIRKKSNLPILILTAFS
DEEYKIDAFTNLADGYIEKPFSLPVLKARIDSLIKKNYGHLEKFEYKDLSVNFNSYTAKINGEEIDVNAKELEVLKCLLD
NNGQVLTRMQIIDYVWKDSEETPYDRVIDVYIKELRKKLQLDCITTIRNVGYKLERK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=33.0357142857143, Blast_Score=121, Evalue=3e-29,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=33.6322869955157, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=31.0810810810811, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1786599, Length=226, Percent_Identity=28.7610619469027, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=29.2792792792793, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=30.0448430493274, Blast_Score=102, Evalue=1e-23,
Organism=Escherichia coli, GI1787229, Length=223, Percent_Identity=29.5964125560538, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=32.1739130434783, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=31.4159292035398, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=34.2465753424658, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=29.9107142857143, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=31.1111111111111, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=28.1938325991189, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1790299, Length=143, Percent_Identity=31.4685314685315, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1788550, Length=105, Percent_Identity=34.2857142857143, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=34.7107438016529, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25186; Mature: 25186

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILTVEDDNMIREGLSEYLSEFGYTVIQAKDGREALSEFNSDINLVILDIQIPFINGLE
CEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCCEEEEEEEEECCCCHHH
VLKEIRKKSNLPILILTAFSDEEYKIDAFTNLADGYIEKPFSLPVLKARIDSLIKKNYGH
HHHHHHHHCCCCEEEEEECCCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
LEKFEYKDLSVNFNSYTAKINGEEIDVNAKELEVLKCLLDNNGQVLTRMQIIDYVWKDSE
CHHCCCCEEEEEECCEEEEECCCEECCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCC
ETPYDRVIDVYIKELRKKLQLDCITTIRNVGYKLERK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCC
>Mature Secondary Structure
MKILTVEDDNMIREGLSEYLSEFGYTVIQAKDGREALSEFNSDINLVILDIQIPFINGLE
CEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCCEEEEEEEEECCCCHHH
VLKEIRKKSNLPILILTAFSDEEYKIDAFTNLADGYIEKPFSLPVLKARIDSLIKKNYGH
HHHHHHHHCCCCEEEEEECCCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCC
LEKFEYKDLSVNFNSYTAKINGEEIDVNAKELEVLKCLLDNNGQVLTRMQIIDYVWKDSE
CHHCCCCEEEEEECCEEEEECCCEECCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCC
ETPYDRVIDVYIKELRKKLQLDCITTIRNVGYKLERK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631706; 12663927 [H]