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The map label for this gene is ffh [H]

Identifier: 238916984

GI number: 238916984

Start: 1062492

End: 1063838

Strand: Reverse

Name: ffh [H]

Synonym: EUBELI_01053

Alternate gene names: 238916984

Gene position: 1063838-1062492 (Counterclockwise)

Preceding gene: 238916985

Following gene: 238916983

Centisome position: 49.61

GC content: 39.27

Gene sequence:

>1347_bases
ATGGCATTCGATAGTTTATCAGAGAAATTGCAGAATATTTTTAAGAATCTTCGTGGTAAGGGCCGTTTATCAGAAGCTGA
TGTTAAGGCTGCTCTTAAGGAAGTTAAGCTTGCCCTGCTTGAAGCTGATGTTAACTTTAAGGTGGTTAAGCAGTTTATCA
AGTCTGTAGAAGAAAGAGCAATTGGTCAGGATGTTATGTCAAGTCTTACACCTGGTCAGATGGTTATCAAGATTGTTAAT
GAAGAGATGGTATCTCTTATGGGATCTGAGACAACTGAGATTGCCTTGAAACCTGGCTCTGAGATTACTGTTATCATGAT
GGCAGGTCTTCAGGGTGCTGGTAAGACAACTACTACAGCAAAGCTTGCTGGTAAATTCAAGGCGAAGGGAAGAAAACCTC
TTTTAGTTGCCTGTGATGTATACAGACCAGCAGCCATTGAACAGCTTACTATTAATGGTAATAAACAGGGCGTTGAAGTA
TTCTCTATGGGAACTAACCAGAAGCCTGTTGATATTGCCAAAGCTGCTATAGCCCATGCTAAGAATAATGATTTTAATAC
AGTTATTCTTGATACAGCAGGACGACTTCATGTTGATGAAGACATGATGAATGAGCTTATAGACATTAAAGCTAATGTAT
CAGTTGACCAGACAATTCTTGTAGTTGACTCCATGACAGGTCAGGATGCTGTTAATGTTGCTTCATCATTTAACGAGAAG
GTTGGCATTGACGGAGTTATCCTTACTAAGTTAGATGGTGATACAAGAGGTGGTGCTGCACTTTCAATTAAGGCAGTTAC
CGGAAAGCCAATTCTTTATGTTGGTATGGGGGAAAAGCTTTCAGATCTTGAACAGTTTTATCCAGACCGTATGGCATCAA
GAATACTTGGTATGGGAGATGTCCTTACCCTTATTGAGAAGGCTGAAGCACAGCTTGATGCTGATAAAGCAAAAGCTATG
GAAGAAAAGCTTAAGAAAGCAGAATTTGATTTTAATGACTTTCTTGAGTATATGGGACAGATTAAGAATATGGGTGGTAT
CAGTTCAATTATGAGCATGATGCCAGGACTGTCGGGTCAGATGAAGAATGTTTCAATCGATGATGATGAAGCAGAGAAGA
ATATGAGAAGAACCGAATCTATCATATATTCAATGACTAAGGCAGAAAGAAGTAATCCGGACATACTTAATCCTTCAAGG
AAGAACAGAATTGCAAGAGGTGCAGGTGTTGATATTGCTGATGTTAACAGACTTGTAAAGCAGTTTGAACAGATGAAGAA
GATGATGAAGCAGATGCCGGGAATGATGAAAGGTGCTAAAAAGGGACGTTTCAAGTTACCTTTTTAA

Upstream 100 bases:

>100_bases
CTTTAGTTGATGATTACATGGAAAGTCAGGATATATCTGATATTCATGAAATCAAGAAGTTATCCAATGAGATTCTTGAA
GAATTTTAAGGAGAGATATT

Downstream 100 bases:

>100_bases
CATAGATTAATTTTTAAGAATAATACAGGAGGTGAATGTAATGGCAGTAAAGATTAGATTAAAGAGATTAGGTGAGAAGA
AAAATCCTTTCTATAGAATT

Product: signal recognition particle, subunit SRP54

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MAFDSLSEKLQNIFKNLRGKGRLSEADVKAALKEVKLALLEADVNFKVVKQFIKSVEERAIGQDVMSSLTPGQMVIKIVN
EEMVSLMGSETTEIALKPGSEITVIMMAGLQGAGKTTTTAKLAGKFKAKGRKPLLVACDVYRPAAIEQLTINGNKQGVEV
FSMGTNQKPVDIAKAAIAHAKNNDFNTVILDTAGRLHVDEDMMNELIDIKANVSVDQTILVVDSMTGQDAVNVASSFNEK
VGIDGVILTKLDGDTRGGAALSIKAVTGKPILYVGMGEKLSDLEQFYPDRMASRILGMGDVLTLIEKAEAQLDADKAKAM
EEKLKKAEFDFNDFLEYMGQIKNMGGISSIMSMMPGLSGQMKNVSIDDDEAEKNMRRTESIIYSMTKAERSNPDILNPSR
KNRIARGAGVDIADVNRLVKQFEQMKKMMKQMPGMMKGAKKGRFKLPF

Sequences:

>Translated_448_residues
MAFDSLSEKLQNIFKNLRGKGRLSEADVKAALKEVKLALLEADVNFKVVKQFIKSVEERAIGQDVMSSLTPGQMVIKIVN
EEMVSLMGSETTEIALKPGSEITVIMMAGLQGAGKTTTTAKLAGKFKAKGRKPLLVACDVYRPAAIEQLTINGNKQGVEV
FSMGTNQKPVDIAKAAIAHAKNNDFNTVILDTAGRLHVDEDMMNELIDIKANVSVDQTILVVDSMTGQDAVNVASSFNEK
VGIDGVILTKLDGDTRGGAALSIKAVTGKPILYVGMGEKLSDLEQFYPDRMASRILGMGDVLTLIEKAEAQLDADKAKAM
EEKLKKAEFDFNDFLEYMGQIKNMGGISSIMSMMPGLSGQMKNVSIDDDEAEKNMRRTESIIYSMTKAERSNPDILNPSR
KNRIARGAGVDIADVNRLVKQFEQMKKMMKQMPGMMKGAKKGRFKLPF
>Mature_447_residues
AFDSLSEKLQNIFKNLRGKGRLSEADVKAALKEVKLALLEADVNFKVVKQFIKSVEERAIGQDVMSSLTPGQMVIKIVNE
EMVSLMGSETTEIALKPGSEITVIMMAGLQGAGKTTTTAKLAGKFKAKGRKPLLVACDVYRPAAIEQLTINGNKQGVEVF
SMGTNQKPVDIAKAAIAHAKNNDFNTVILDTAGRLHVDEDMMNELIDIKANVSVDQTILVVDSMTGQDAVNVASSFNEKV
GIDGVILTKLDGDTRGGAALSIKAVTGKPILYVGMGEKLSDLEQFYPDRMASRILGMGDVLTLIEKAEAQLDADKAKAME
EKLKKAEFDFNDFLEYMGQIKNMGGISSIMSMMPGLSGQMKNVSIDDDEAEKNMRRTESIIYSMTKAERSNPDILNPSRK
NRIARGAGVDIADVNRLVKQFEQMKKMMKQMPGMMKGAKKGRFKLPF

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=447, Percent_Identity=34.675615212528, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI226371618, Length=385, Percent_Identity=34.2857142857143, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI23308697, Length=301, Percent_Identity=27.906976744186, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI295424842, Length=304, Percent_Identity=27.6315789473684, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI89061728, Length=162, Percent_Identity=37.6543209876543, Blast_Score=112, Evalue=1e-24,
Organism=Escherichia coli, GI1788963, Length=458, Percent_Identity=50, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1789874, Length=206, Percent_Identity=37.8640776699029, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17539958, Length=448, Percent_Identity=29.6875, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI193206261, Length=296, Percent_Identity=29.7297297297297, Blast_Score=111, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6325345, Length=429, Percent_Identity=32.8671328671329, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6320498, Length=312, Percent_Identity=27.5641025641026, Blast_Score=106, Evalue=7e-24,
Organism=Drosophila melanogaster, GI17647949, Length=454, Percent_Identity=33.4801762114537, Blast_Score=221, Evalue=9e-58,
Organism=Drosophila melanogaster, GI24641198, Length=306, Percent_Identity=26.797385620915, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 48934; Mature: 48803

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFDSLSEKLQNIFKNLRGKGRLSEADVKAALKEVKLALLEADVNFKVVKQFIKSVEERA
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IGQDVMSSLTPGQMVIKIVNEEMVSLMGSETTEIALKPGSEITVIMMAGLQGAGKTTTTA
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCCCCCHHH
KLAGKFKAKGRKPLLVACDVYRPAAIEQLTINGNKQGVEVFSMGTNQKPVDIAKAAIAHA
HHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHC
KNNDFNTVILDTAGRLHVDEDMMNELIDIKANVSVDQTILVVDSMTGQDAVNVASSFNEK
CCCCCCEEEEECCCCEEECHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCC
VGIDGVILTKLDGDTRGGAALSIKAVTGKPILYVGMGEKLSDLEQFYPDRMASRILGMGD
CCCCEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCHH
VLTLIEKAEAQLDADKAKAMEEKLKKAEFDFNDFLEYMGQIKNMGGISSIMSMMPGLSGQ
HHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
MKNVSIDDDEAEKNMRRTESIIYSMTKAERSNPDILNPSRKNRIARGAGVDIADVNRLVK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHH
QFEQMKKMMKQMPGMMKGAKKGRFKLPF
HHHHHHHHHHHCCHHHHCCCCCCEECCC
>Mature Secondary Structure 
AFDSLSEKLQNIFKNLRGKGRLSEADVKAALKEVKLALLEADVNFKVVKQFIKSVEERA
CHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IGQDVMSSLTPGQMVIKIVNEEMVSLMGSETTEIALKPGSEITVIMMAGLQGAGKTTTTA
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCCCCCCHHH
KLAGKFKAKGRKPLLVACDVYRPAAIEQLTINGNKQGVEVFSMGTNQKPVDIAKAAIAHA
HHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHC
KNNDFNTVILDTAGRLHVDEDMMNELIDIKANVSVDQTILVVDSMTGQDAVNVASSFNEK
CCCCCCEEEEECCCCEEECHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCC
VGIDGVILTKLDGDTRGGAALSIKAVTGKPILYVGMGEKLSDLEQFYPDRMASRILGMGD
CCCCEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCHH
VLTLIEKAEAQLDADKAKAMEEKLKKAEFDFNDFLEYMGQIKNMGGISSIMSMMPGLSGQ
HHHHHHHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCC
MKNVSIDDDEAEKNMRRTESIIYSMTKAERSNPDILNPSRKNRIARGAGVDIADVNRLVK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHH
QFEQMKKMMKQMPGMMKGAKKGRFKLPF
HHHHHHHHHHHCCHHHHCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8335643; 9384377; 7511896 [H]