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The map label for this gene is dxr

Identifier: 238916790

GI number: 238916790

Start: 863301

End: 864443

Strand: Direct

Name: dxr

Synonym: EUBELI_00852

Alternate gene names: 238916790

Gene position: 863301-864443 (Clockwise)

Preceding gene: 238916789

Following gene: 238916791

Centisome position: 40.26

GC content: 40.59

Gene sequence:

>1143_bases
ATGAAGAACGTTTCTATACTTGGTTCAACTGGTTCAATTGGAACACAGACATTAGATGTTATTAGAAGAAATGCTGATAT
TAATGTAGTTGCACTTGCAGCAGGTACAAGGGTTTCTGACCTTGCAGAACAGGTCCGTGAATTCAAGCCACAGCTTGTAT
GTATAGGTAAAGAAGAACTTGTTCCAGAGTTAAAGACTCTTATCGGTGATATGGATGTTAAGATTGTAAGTGGTGACGAA
GGTCTTATTGAGGCTGCAACAATTGAGAGTGCAGAAATTGTTGTCACAGCGGTTGTAGGTATGATGGGAATTACACCTAC
AGTTGAAGCTATCAAGGCACATAAGGACATTGCACTTGCCAATAAAGAGACACTTGTGTGTGCTGGTCATATTATTATGA
GTCTTGCTAAGGAATGCAATGTTAATATATATCCTGTTGACAGCGAACATTCAGCAATATTCCAGTGCCTTAACGGTGAG
AGACGTGGTGAGATAGAGAAGATTCTTCTTACAGCTTCTGGTGGTCCATTCAGAGGAAAGAAAAGAGCTGACCTTGAAAA
TGTACAGTTAGAGGATGCACTTAAGCATCCTAACTGGGCTATGGGACGCAAGATAACAATAGATTCTTCTACTATGGTTA
ATAAAGGGCTTGAGGTGATGGAGGCACAGTGGCTTTTTGGAGTACCTGCCGAGAAGGTTCAGGTTATAGTCCAGCCACAG
AGCATAATCCATTCAATGGTTGAATTCAAGGACGGAGCTGTTATGGCACAGCTTGGAAGTCCTGATATGAGACTTCCTAT
ACAGTATGCTCTTTATTATCCTGAAAGAAGAAAACTTAACACAGAAAGACTTGATTTCTATGAACTGGCTAAGATTACAT
TTGAAAAGCCGGATATGGAGACTTTCAAGGGACTTAAGCTTGCTTACGAGGCAGCAGCACGCGGGGGAAATATCCCGACT
GCGCTTAATGCAGCTAACGAAGTAGCTGTAGCAAGATTTTTAGACAGAAAGATAAAATATCTGGATATTCCGGATATTAT
AGAATACGCCATGAATGAAGTGGATTATATCAATAATCCAACAGTAGAGCAGATTCTCTCTACACAGAAGATAGTAACAG
ACATGATAGAAAGCAGGTGGTAG

Upstream 100 bases:

>100_bases
GACATGGCGGAATTATGGACAGATTCGACAGTGCTATATTCACTGCACCTGTTGTTTACTGGTCAATAGAGGTTATTAAC
AAAGTCTTTGGAGGTTGATA

Downstream 100 bases:

>100_bases
GAGTTGGTTCTTAATGTTATTCTGGCGATTCTTGTACTTAGTATAATTGTTATTGTCCATGAATTCGGACATTTTATAAT
AGCTAAGGCTAATGGCATAA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKNVSILGSTGSIGTQTLDVIRRNADINVVALAAGTRVSDLAEQVREFKPQLVCIGKEELVPELKTLIGDMDVKIVSGDE
GLIEAATIESAEIVVTAVVGMMGITPTVEAIKAHKDIALANKETLVCAGHIIMSLAKECNVNIYPVDSEHSAIFQCLNGE
RRGEIEKILLTASGGPFRGKKRADLENVQLEDALKHPNWAMGRKITIDSSTMVNKGLEVMEAQWLFGVPAEKVQVIVQPQ
SIIHSMVEFKDGAVMAQLGSPDMRLPIQYALYYPERRKLNTERLDFYELAKITFEKPDMETFKGLKLAYEAAARGGNIPT
ALNAANEVAVARFLDRKIKYLDIPDIIEYAMNEVDYINNPTVEQILSTQKIVTDMIESRW

Sequences:

>Translated_380_residues
MKNVSILGSTGSIGTQTLDVIRRNADINVVALAAGTRVSDLAEQVREFKPQLVCIGKEELVPELKTLIGDMDVKIVSGDE
GLIEAATIESAEIVVTAVVGMMGITPTVEAIKAHKDIALANKETLVCAGHIIMSLAKECNVNIYPVDSEHSAIFQCLNGE
RRGEIEKILLTASGGPFRGKKRADLENVQLEDALKHPNWAMGRKITIDSSTMVNKGLEVMEAQWLFGVPAEKVQVIVQPQ
SIIHSMVEFKDGAVMAQLGSPDMRLPIQYALYYPERRKLNTERLDFYELAKITFEKPDMETFKGLKLAYEAAARGGNIPT
ALNAANEVAVARFLDRKIKYLDIPDIIEYAMNEVDYINNPTVEQILSTQKIVTDMIESRW
>Mature_380_residues
MKNVSILGSTGSIGTQTLDVIRRNADINVVALAAGTRVSDLAEQVREFKPQLVCIGKEELVPELKTLIGDMDVKIVSGDE
GLIEAATIESAEIVVTAVVGMMGITPTVEAIKAHKDIALANKETLVCAGHIIMSLAKECNVNIYPVDSEHSAIFQCLNGE
RRGEIEKILLTASGGPFRGKKRADLENVQLEDALKHPNWAMGRKITIDSSTMVNKGLEVMEAQWLFGVPAEKVQVIVQPQ
SIIHSMVEFKDGAVMAQLGSPDMRLPIQYALYYPERRKLNTERLDFYELAKITFEKPDMETFKGLKLAYEAAARGGNIPT
ALNAANEVAVARFLDRKIKYLDIPDIIEYAMNEVDYINNPTVEQILSTQKIVTDMIESRW

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=381, Percent_Identity=43.8320209973753, Blast_Score=305, Evalue=3e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_EUBE2 (C4Z5K1)

Other databases:

- EMBL:   CP001104
- RefSeq:   YP_002930307.1
- GeneID:   7958352
- GenomeReviews:   CP001104_GR
- KEGG:   eel:EUBELI_00852
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 41974; Mature: 41974

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: BINDING 122-122 BINDING 149-149 BINDING 173-173 BINDING 196-196 BINDING 218-218

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNVSILGSTGSIGTQTLDVIRRNADINVVALAAGTRVSDLAEQVREFKPQLVCIGKEEL
CCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEECHHHH
VPELKTLIGDMDVKIVSGDEGLIEAATIESAEIVVTAVVGMMGITPTVEAIKAHKDIALA
HHHHHHHHCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHCCEEEC
NKETLVCAGHIIMSLAKECNVNIYPVDSEHSAIFQCLNGERRGEIEKILLTASGGPFRGK
CCCEEEEHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCC
KRADLENVQLEDALKHPNWAMGRKITIDSSTMVNKGLEVMEAQWLFGVPAEKVQVIVQPQ
CCCCCCCCCHHHHHCCCCCCCCCEEEECCHHHHHCCHHHHHHHHHCCCCHHHEEEEECCH
SIIHSMVEFKDGAVMAQLGSPDMRLPIQYALYYPERRKLNTERLDFYELAKITFEKPDME
HHHHHHHHHCCCEEEEECCCCCCCCCEEEEEECCHHHCCCCHHCCHHHHHHHEECCCCHH
TFKGLKLAYEAAARGGNIPTALNAANEVAVARFLDRKIKYLDIPDIIEYAMNEVDYINNP
HHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
TVEQILSTQKIVTDMIESRW
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNVSILGSTGSIGTQTLDVIRRNADINVVALAAGTRVSDLAEQVREFKPQLVCIGKEEL
CCCEEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEECHHHH
VPELKTLIGDMDVKIVSGDEGLIEAATIESAEIVVTAVVGMMGITPTVEAIKAHKDIALA
HHHHHHHHCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHCCEEEC
NKETLVCAGHIIMSLAKECNVNIYPVDSEHSAIFQCLNGERRGEIEKILLTASGGPFRGK
CCCEEEEHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCC
KRADLENVQLEDALKHPNWAMGRKITIDSSTMVNKGLEVMEAQWLFGVPAEKVQVIVQPQ
CCCCCCCCCHHHHHCCCCCCCCCEEEECCHHHHHCCHHHHHHHHHCCCCHHHEEEEECCH
SIIHSMVEFKDGAVMAQLGSPDMRLPIQYALYYPERRKLNTERLDFYELAKITFEKPDME
HHHHHHHHHCCCEEEEECCCCCCCCCEEEEEECCHHHCCCCHHCCHHHHHHHEECCCCHH
TFKGLKLAYEAAARGGNIPTALNAANEVAVARFLDRKIKYLDIPDIIEYAMNEVDYINNP
HHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
TVEQILSTQKIVTDMIESRW
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA