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The map label for this gene is uppS [H]

Identifier: 238916788

GI number: 238916788

Start: 861745

End: 862479

Strand: Direct

Name: uppS [H]

Synonym: EUBELI_00850

Alternate gene names: 238916788

Gene position: 861745-862479 (Clockwise)

Preceding gene: 238916787

Following gene: 238916789

Centisome position: 40.19

GC content: 36.6

Gene sequence:

>735_bases
ATGGATACATTTAACGAGAGTCTCGGATTAAAGATTCCGGGGCATGTTGCCGTTATTCTTGATGGTAATGGAAGATGGGC
TAAGAAAAGACATCTCCCAAGAACAATGGGACATGTGCAGGGAAGCAAAGTTGTTGAAGATATGCTTTATGTCGTAGATG
AGCTTGGTGTAAAGTATTTTACTGTATATGCTTTTTCAACAGAGAACTGGAAACGTTCAACAGAAGAAGTAAGTACTCTT
ATGGGAATCTTAAGAACTTATCTTAAGGATTGTGTTAAGAAATCCATGAAGAATAATGTGCGATGCAGGGTTATTGGAAG
AAAAGATGAACTCAGCCAGGATATTATAGACAGTATCAATAATCTTGAAGAGAAAACCAGGAATAATACAGGGCTTAATT
TTACTATAGCCATTAATTATGGTGGAAGAGATGAGATAACAAGAGCGGTAAGAAAGATTGCCGGCAAGGTATCAGAAGGA
AGTCTTAAGCCTGAAGATATAGATGAAGATACAATAAGTAATAATCTTGATACTTGGGAATTGCCAGATCCAGATTTACT
TATAAGAACAAGCGGTGAGCAGAGATTATCTAATTATCTGTGCTGGCAGCTTGCTTATACAGAATTTTATTTCACAGATA
TTTATTGGCCTGATTTTGACAGGGAAGAACTTATTAAAGCATTTGAGAAATATAATAAGACGGAAAGAAGATTCGGCGGA
GTTAAGGAGGAGTAG

Upstream 100 bases:

>100_bases
AGACAAAAGAGATACTTACAGTTTAAGAAAATGTCAGGGCTGTTGGATATTTTACAACAGCCTTTTTGTAATTGAATGAA
TTGCGAGAGGAATCATAGAT

Downstream 100 bases:

>100_bases
ATTATGCGTACAAGAATTATGAGCGGAGCTGTGCTCATAGTCATACTTTTCACATGCCTGTATTTTGGAGGCTGGGTTAC
ATTCGGGTTCAGTCTGTTTA

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MDTFNESLGLKIPGHVAVILDGNGRWAKKRHLPRTMGHVQGSKVVEDMLYVVDELGVKYFTVYAFSTENWKRSTEEVSTL
MGILRTYLKDCVKKSMKNNVRCRVIGRKDELSQDIIDSINNLEEKTRNNTGLNFTIAINYGGRDEITRAVRKIAGKVSEG
SLKPEDIDEDTISNNLDTWELPDPDLLIRTSGEQRLSNYLCWQLAYTEFYFTDIYWPDFDREELIKAFEKYNKTERRFGG
VKEE

Sequences:

>Translated_244_residues
MDTFNESLGLKIPGHVAVILDGNGRWAKKRHLPRTMGHVQGSKVVEDMLYVVDELGVKYFTVYAFSTENWKRSTEEVSTL
MGILRTYLKDCVKKSMKNNVRCRVIGRKDELSQDIIDSINNLEEKTRNNTGLNFTIAINYGGRDEITRAVRKIAGKVSEG
SLKPEDIDEDTISNNLDTWELPDPDLLIRTSGEQRLSNYLCWQLAYTEFYFTDIYWPDFDREELIKAFEKYNKTERRFGG
VKEE
>Mature_244_residues
MDTFNESLGLKIPGHVAVILDGNGRWAKKRHLPRTMGHVQGSKVVEDMLYVVDELGVKYFTVYAFSTENWKRSTEEVSTL
MGILRTYLKDCVKKSMKNNVRCRVIGRKDELSQDIIDSINNLEEKTRNNTGLNFTIAINYGGRDEITRAVRKIAGKVSEG
SLKPEDIDEDTISNNLDTWELPDPDLLIRTSGEQRLSNYLCWQLAYTEFYFTDIYWPDFDREELIKAFEKYNKTERRFGG
VKEE

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=37.9464285714286, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=37.9464285714286, Blast_Score=149, Evalue=3e-36,
Organism=Escherichia coli, GI1786371, Length=246, Percent_Identity=43.4959349593496, Blast_Score=216, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=37.7777777777778, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=35.2112676056338, Blast_Score=125, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=218, Percent_Identity=34.4036697247706, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI18857969, Length=225, Percent_Identity=35.1111111111111, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28254; Mature: 28254

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTFNESLGLKIPGHVAVILDGNGRWAKKRHLPRTMGHVQGSKVVEDMLYVVDELGVKYF
CCCCCCCCCCCCCCEEEEEECCCCCCHHHHCCCHHHHHCCHHHHHHHHHHHHHHCCCEEE
TVYAFSTENWKRSTEEVSTLMGILRTYLKDCVKKSMKNNVRCRVIGRKDELSQDIIDSIN
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHH
NLEEKTRNNTGLNFTIAINYGGRDEITRAVRKIAGKVSEGSLKPEDIDEDTISNNLDTWE
HHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCC
LPDPDLLIRTSGEQRLSNYLCWQLAYTEFYFTDIYWPDFDREELIKAFEKYNKTERRFGG
CCCCCEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHCHHHHHCCC
VKEE
CCCC
>Mature Secondary Structure
MDTFNESLGLKIPGHVAVILDGNGRWAKKRHLPRTMGHVQGSKVVEDMLYVVDELGVKYF
CCCCCCCCCCCCCCEEEEEECCCCCCHHHHCCCHHHHHCCHHHHHHHHHHHHHHCCCEEE
TVYAFSTENWKRSTEEVSTLMGILRTYLKDCVKKSMKNNVRCRVIGRKDELSQDIIDSIN
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHH
NLEEKTRNNTGLNFTIAINYGGRDEITRAVRKIAGKVSEGSLKPEDIDEDTISNNLDTWE
HHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCC
LPDPDLLIRTSGEQRLSNYLCWQLAYTEFYFTDIYWPDFDREELIKAFEKYNKTERRFGG
CCCCCEEEECCCHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHCHHHHHCCC
VKEE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]