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The map label for this gene is pepQ [H]

Identifier: 238916720

GI number: 238916720

Start: 791332

End: 793149

Strand: Direct

Name: pepQ [H]

Synonym: EUBELI_00782

Alternate gene names: 238916720

Gene position: 791332-793149 (Clockwise)

Preceding gene: 238916719

Following gene: 238916721

Centisome position: 36.91

GC content: 39.93

Gene sequence:

>1818_bases
ATGCAGATTACAGATGCAAAGGTAATAGCAGGCAGATTATCTAAGGTAAGGGATATCATGAAATCAGAAGGCGTTGATAT
ATATGTAGTCGTAACAGGTGATTACCATATATCGGAGTATGCAGGAGATTATTTTAAGGAAAGAGAATTCATTACAGGAT
TCACAGGCTCTGCCGGAACGGCTGTTATAACACAGGATGATGCAAGGCTTTTCACTGACGGAAGATATTTCGTGCAGGCT
GAAAAGCAGATTGAAGGGACAGGCTTTTCACTGATGAAGGTCGGTGCTCCGGGTGTTATGAATGTGGCACAGTACTGTGA
GAGTATAGTTAAAGATGGAATGAGCATGGGATTTGATGGAAGAACCATGCCGGCTGAAGAAGGAATTGAGCTGTCTGATA
TATGTAAAAAAGCAGGAGCAGGCTGTTTGTATGATTTTGATGCAATTGAGAATATATATGAGGACAGGGCAGAGTTTCCA
CACAGCAAAGCATTTTATCTTGATGAAGAGTACTCAGGAGAAAGCATAATAAGCAAGCTTTCAAGAATAAGAAAGTATAT
GGATAATAAAAATGCTGATATACATATTATGGCAACGCTTGACGACATATGCTGGACATTCAATATAAGAGGATGCGATG
TTGAGTGCAACCCTGTTATTATGGCATATTCAGTGATAACTAAGGATAAAGCATACATATATACTGATAAGGACAGGTTT
GATGATAAGACGCTGGCCAAATTCGGAGAGGCATGTGTAAAGGTGCTGCCATATGACAGCATATATGGAGACATTACCAG
AATGAATGGAAAAGTGCTTATTGATAAGAGACGTGTGAATATGCGTATATATGAGCTTATACAGTCTGGAAGAGATGTGG
AAGCGGTACTGTCTGACAATCCGGCAATGCATTTTAAGGCAATAAAGAATGAGACAGAGATAAGGAATCTATATGGCATA
CATGTTGACGATGGCGTGGCTGTAACAAAATTCATATTCTGGCTTAAGAAAAATGTTGCATCAGGTAATTTAACAGAAGC
AGATGCAGCGGCATATCTTGATAATTTAAGAAGCAATATAAAAGATTACATAGAACTAAGCTTTGACACAATCAGTGCGT
ATAATGCAAATGCAGCGATGATGCATTACCATGCAGATGAAACCAATGCGGCTGTCTTAAAGCCGGAAGGCATGCTGCTT
GTGGATTCAGGCGGACAGTATATGCGTGGAACAACTGATATAACAAGAACAATAGCACTTGGATCTGTGACTGATGAGAT
GAAGATGTATTACACACTTACACTTAAAGGCATGTTAAGCCTGGCAAATGCAAAATTCTTAAAAGGCTGTAACGGTTTCA
GTCTTGATATTCTTGCCAGAGCACCACTGTGGAATGTCGGAATGGACTACCGATGCGGAACAGGCCATGGCATAGGATAC
CTTTTAAATGTGCATGAGAGTCCTAACGGGTTTCGATGGAAGCACAATCCGGGTAAGAATGACCTTGCAGTTATTGAAGA
GGGCATGGTTACATCTGATGAGCCGGGGGTATATATTGAGGGCAGGTTCGGTATAAGAATTGAAAATGAGATTGTGTGCC
AGAAAGATTTCGACAATGAATATGGCACATTTTTAAAGTTTGACATGCTTACAGTTGTTCCGATAGACTTAGAACTTGTT
GATGTAAATTATCTTGATGCTGTTGATATTGAGCGGCTCAATAAGTATCAGGAAAGAGTATATAAGACGCTTGAACCGTA
TTTTGAAGGTGAAGAAAAGGATATGTTAAGAGAGGCAACCAGACCAATAGGAGGTTGA

Upstream 100 bases:

>100_bases
GAAGCTATGTGAGCAGAATAGAGAAAAAGGCACTTGGTAAATTAAGAGAAGTGCTTATTGAGTGGAAACTTATATGATAA
TATAGTCAGGAGGACATGAA

Downstream 100 bases:

>100_bases
GATGGAGTTAAAGGAATTTTCGCATAAGGGCGAAGCAATTGAAAAGGAGATTAAGAAGGAGTTCCAGTTCATGGGACGGA
CAATTAAGAAACGCCGCGTA

Product: X-Pro aminopeptidase

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MQITDAKVIAGRLSKVRDIMKSEGVDIYVVVTGDYHISEYAGDYFKEREFITGFTGSAGTAVITQDDARLFTDGRYFVQA
EKQIEGTGFSLMKVGAPGVMNVAQYCESIVKDGMSMGFDGRTMPAEEGIELSDICKKAGAGCLYDFDAIENIYEDRAEFP
HSKAFYLDEEYSGESIISKLSRIRKYMDNKNADIHIMATLDDICWTFNIRGCDVECNPVIMAYSVITKDKAYIYTDKDRF
DDKTLAKFGEACVKVLPYDSIYGDITRMNGKVLIDKRRVNMRIYELIQSGRDVEAVLSDNPAMHFKAIKNETEIRNLYGI
HVDDGVAVTKFIFWLKKNVASGNLTEADAAAYLDNLRSNIKDYIELSFDTISAYNANAAMMHYHADETNAAVLKPEGMLL
VDSGGQYMRGTTDITRTIALGSVTDEMKMYYTLTLKGMLSLANAKFLKGCNGFSLDILARAPLWNVGMDYRCGTGHGIGY
LLNVHESPNGFRWKHNPGKNDLAVIEEGMVTSDEPGVYIEGRFGIRIENEIVCQKDFDNEYGTFLKFDMLTVVPIDLELV
DVNYLDAVDIERLNKYQERVYKTLEPYFEGEEKDMLREATRPIGG

Sequences:

>Translated_605_residues
MQITDAKVIAGRLSKVRDIMKSEGVDIYVVVTGDYHISEYAGDYFKEREFITGFTGSAGTAVITQDDARLFTDGRYFVQA
EKQIEGTGFSLMKVGAPGVMNVAQYCESIVKDGMSMGFDGRTMPAEEGIELSDICKKAGAGCLYDFDAIENIYEDRAEFP
HSKAFYLDEEYSGESIISKLSRIRKYMDNKNADIHIMATLDDICWTFNIRGCDVECNPVIMAYSVITKDKAYIYTDKDRF
DDKTLAKFGEACVKVLPYDSIYGDITRMNGKVLIDKRRVNMRIYELIQSGRDVEAVLSDNPAMHFKAIKNETEIRNLYGI
HVDDGVAVTKFIFWLKKNVASGNLTEADAAAYLDNLRSNIKDYIELSFDTISAYNANAAMMHYHADETNAAVLKPEGMLL
VDSGGQYMRGTTDITRTIALGSVTDEMKMYYTLTLKGMLSLANAKFLKGCNGFSLDILARAPLWNVGMDYRCGTGHGIGY
LLNVHESPNGFRWKHNPGKNDLAVIEEGMVTSDEPGVYIEGRFGIRIENEIVCQKDFDNEYGTFLKFDMLTVVPIDLELV
DVNYLDAVDIERLNKYQERVYKTLEPYFEGEEKDMLREATRPIGG
>Mature_605_residues
MQITDAKVIAGRLSKVRDIMKSEGVDIYVVVTGDYHISEYAGDYFKEREFITGFTGSAGTAVITQDDARLFTDGRYFVQA
EKQIEGTGFSLMKVGAPGVMNVAQYCESIVKDGMSMGFDGRTMPAEEGIELSDICKKAGAGCLYDFDAIENIYEDRAEFP
HSKAFYLDEEYSGESIISKLSRIRKYMDNKNADIHIMATLDDICWTFNIRGCDVECNPVIMAYSVITKDKAYIYTDKDRF
DDKTLAKFGEACVKVLPYDSIYGDITRMNGKVLIDKRRVNMRIYELIQSGRDVEAVLSDNPAMHFKAIKNETEIRNLYGI
HVDDGVAVTKFIFWLKKNVASGNLTEADAAAYLDNLRSNIKDYIELSFDTISAYNANAAMMHYHADETNAAVLKPEGMLL
VDSGGQYMRGTTDITRTIALGSVTDEMKMYYTLTLKGMLSLANAKFLKGCNGFSLDILARAPLWNVGMDYRCGTGHGIGY
LLNVHESPNGFRWKHNPGKNDLAVIEEGMVTSDEPGVYIEGRFGIRIENEIVCQKDFDNEYGTFLKFDMLTVVPIDLELV
DVNYLDAVDIERLNKYQERVYKTLEPYFEGEEKDMLREATRPIGG

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=627, Percent_Identity=32.8548644338118, Blast_Score=342, Evalue=5e-94,
Organism=Homo sapiens, GI264681565, Length=627, Percent_Identity=32.0574162679426, Blast_Score=320, Evalue=2e-87,
Organism=Homo sapiens, GI93141226, Length=610, Percent_Identity=31.9672131147541, Blast_Score=313, Evalue=3e-85,
Organism=Caenorhabditis elegans, GI17509539, Length=620, Percent_Identity=32.5806451612903, Blast_Score=318, Evalue=4e-87,
Organism=Caenorhabditis elegans, GI25149105, Length=599, Percent_Identity=27.5459098497496, Blast_Score=207, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6322999, Length=650, Percent_Identity=31.2307692307692, Blast_Score=285, Evalue=1e-77,
Organism=Drosophila melanogaster, GI17137632, Length=619, Percent_Identity=34.4103392568659, Blast_Score=313, Evalue=3e-85,
Organism=Drosophila melanogaster, GI161078230, Length=600, Percent_Identity=27.1666666666667, Blast_Score=216, Evalue=5e-56,
Organism=Drosophila melanogaster, GI21357287, Length=600, Percent_Identity=27.1666666666667, Blast_Score=216, Evalue=5e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 68041; Mature: 68041

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQITDAKVIAGRLSKVRDIMKSEGVDIYVVVTGDYHISEYAGDYFKEREFITGFTGSAGT
CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEHHHHHHHHHHCCCCEEEECCCCCE
AVITQDDARLFTDGRYFVQAEKQIEGTGFSLMKVGAPGVMNVAQYCESIVKDGMSMGFDG
EEEEECCCEEEECCEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHCCCCC
RTMPAEEGIELSDICKKAGAGCLYDFDAIENIYEDRAEFPHSKAFYLDEEYSGESIISKL
CCCCHHCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHH
SRIRKYMDNKNADIHIMATLDDICWTFNIRGCDVECNPVIMAYSVITKDKAYIYTDKDRF
HHHHHHHCCCCCCEEEEEEECCEEEEEEEECCCCCCCCEEEEEEEEECCCEEEEECCCCC
DDKTLAKFGEACVKVLPYDSIYGDITRMNGKVLIDKRRVNMRIYELIQSGRDVEAVLSDN
CHHHHHHHHHHHHHHCCCCHHHCCCEECCCEEEEEECCCCHHHHHHHHCCCCEEEEECCC
PAMHFKAIKNETEIRNLYGIHVDDGVAVTKFIFWLKKNVASGNLTEADAAAYLDNLRSNI
CCEEEEECCCCHHHHHEEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
KDYIELSFDTISAYNANAAMMHYHADETNAAVLKPEGMLLVDSGGQYMRGTTDITRTIAL
HHHHEEEEHEEEECCCCEEEEEEECCCCCEEEECCCCEEEEECCCCEECCCCHHHHEEEE
GSVTDEMKMYYTLTLKGMLSLANAKFLKGCNGFSLDILARAPLWNVGMDYRCGTGHGIGY
CCCCCCEEEEEEEEEHHHHHHHHHHHHCCCCCCEEEEEEECCEECCCCCEECCCCCCCEE
LLNVHESPNGFRWKHNPGKNDLAVIEEGMVTSDEPGVYIEGRFGIRIENEIVCQKDFDNE
EEEECCCCCCCEECCCCCCCCHHEEECCCCCCCCCCEEEEEEEEEEECCEEEEECCCCCC
YGTFLKFDMLTVVPIDLELVDVNYLDAVDIERLNKYQERVYKTLEPYFEGEEKDMLREAT
CCCEEEEEEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
RPIGG
CCCCC
>Mature Secondary Structure
MQITDAKVIAGRLSKVRDIMKSEGVDIYVVVTGDYHISEYAGDYFKEREFITGFTGSAGT
CCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEHHHHHHHHHHCCCCEEEECCCCCE
AVITQDDARLFTDGRYFVQAEKQIEGTGFSLMKVGAPGVMNVAQYCESIVKDGMSMGFDG
EEEEECCCEEEECCEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCHHCCCCC
RTMPAEEGIELSDICKKAGAGCLYDFDAIENIYEDRAEFPHSKAFYLDEEYSGESIISKL
CCCCHHCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHH
SRIRKYMDNKNADIHIMATLDDICWTFNIRGCDVECNPVIMAYSVITKDKAYIYTDKDRF
HHHHHHHCCCCCCEEEEEEECCEEEEEEEECCCCCCCCEEEEEEEEECCCEEEEECCCCC
DDKTLAKFGEACVKVLPYDSIYGDITRMNGKVLIDKRRVNMRIYELIQSGRDVEAVLSDN
CHHHHHHHHHHHHHHCCCCHHHCCCEECCCEEEEEECCCCHHHHHHHHCCCCEEEEECCC
PAMHFKAIKNETEIRNLYGIHVDDGVAVTKFIFWLKKNVASGNLTEADAAAYLDNLRSNI
CCEEEEECCCCHHHHHEEEEEECCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
KDYIELSFDTISAYNANAAMMHYHADETNAAVLKPEGMLLVDSGGQYMRGTTDITRTIAL
HHHHEEEEHEEEECCCCEEEEEEECCCCCEEEECCCCEEEEECCCCEECCCCHHHHEEEE
GSVTDEMKMYYTLTLKGMLSLANAKFLKGCNGFSLDILARAPLWNVGMDYRCGTGHGIGY
CCCCCCEEEEEEEEEHHHHHHHHHHHHCCCCCCEEEEEEECCEECCCCCEECCCCCCCEE
LLNVHESPNGFRWKHNPGKNDLAVIEEGMVTSDEPGVYIEGRFGIRIENEIVCQKDFDNE
EEEECCCCCCCEECCCCCCCCHHEEECCCCCCCCCCEEEEEEEEEEECCEEEEECCCCCC
YGTFLKFDMLTVVPIDLELVDVNYLDAVDIERLNKYQERVYKTLEPYFEGEEKDMLREAT
CCCEEEEEEEEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
RPIGG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]