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The map label for this gene is argD [H]

Identifier: 238916539

GI number: 238916539

Start: 608704

End: 609921

Strand: Direct

Name: argD [H]

Synonym: EUBELI_00596

Alternate gene names: 238916539

Gene position: 608704-609921 (Clockwise)

Preceding gene: 238916538

Following gene: 238916540

Centisome position: 28.39

GC content: 39.41

Gene sequence:

>1218_bases
ATGTGTGCTCATAAGAATAGGAAAGTGAGAGTAATCATGAATACACAGCAGATTATAGAAACAGCAGAAGAGAAGCTGAT
TCATACATACAACCGTTACCAGATAGTACTTGATAAGGGTGACGGAGTAAGACTTTACGATACAGATGGTAAAGAATATC
TTGATTTTGGAGCAGGTATAGCAGTATTTGCACTTGGTTATAACAATAAAGAATATAATGATGCATTAAAGGCACAGATT
GATAAGCTTATACACACATCTAATTATTTCTACAATGAACCGGCTGTAGAGGCTGCAACAGCACTTACAAAGGCTTCAGG
AATGGACAGAGTATTCTTTACTAACAGTGGTACAGAGGCTATTGAAGGTGCAGTTAAGCTTGCAAAGAAATATTATTATG
TCAAGAACGGAAAGGCTGATGCAGAGATTATTGCAATGCAGCATTCATTCCATGGAAGAAGTATGGGAGCACTTGCAGTA
ACTGGAAATAAGCATTATCAGGAAGCATTCGGACCTATGATACCGGGAATTAAGTTTGCACAGTATAACGACCTTGACAG
TGTAAAGGAACTTGTTAATGACAAAACATGTGCTATAATATTTGAGACAGTACAGGGTGAAGGAGGAATTTATCCTGCTA
CTAAAGAATTTATTGAAGGTGTAAGAAAGTTATGCGATGAGAAGGGAATCCTTCTTATACTTGATGAGATTCAGTGCGGA
ATGGGAAGAACAGGAAGTATGTTTGCATTCCAGCAGTATGGCGTTAAGCCTGATATCCTTACAGTTGCCAAGGCTCTTGG
CTGTGGAGTTCCTGTAGGTGCATTTGCAGCGACAGAGGAAGTTGCGAAGGCATTAGTTCCAGGAGACCATGGAACAACAT
ACGGTGGTAATCCACTTGCATGTGCAGCAGCAACCAAGGTGTTCGAACTTTTTGAGAAGCAGCATGTATTAGATAATGTC
AAGGAAGTATCTGCTTACTTTGAAGAAAAGCTTGATGAGCTTGTTGAGACAATAGATGTTGTTGTCGAGAGACGAGGAAT
GGGACTTATGCAGGGACTTGAGTTATCAGTTAATCCTAAGGACGTAATTGCCAAAGCACTTGATAATGGACTTATTCTTT
TCTCAGCAGGAACTAATGTTATAAGATTTGTTCCACCACTTGTAATCACTAAGGCAGATGTAGATGAATGCATAGCTAAG
CTTAAGAAATCCTTCTAG

Upstream 100 bases:

>100_bases
CAGCTATTCTTTCAGATGATGCAGAAAAATTCTTTGATTCAGATAAATAATTGCGAACCGTAAGCTTTGAGGTTATAATA
TTATATTAGCTCATGTGAAA

Downstream 100 bases:

>100_bases
AATCAGGAGTTTACTTTATGAAATTAAGAAGATTTATCAGTATGATGCTGATTGTTACCATGCTGACAGTCTTTGCAGGC
TGTGGTAATAAAGATGACAG

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MCAHKNRKVRVIMNTQQIIETAEEKLIHTYNRYQIVLDKGDGVRLYDTDGKEYLDFGAGIAVFALGYNNKEYNDALKAQI
DKLIHTSNYFYNEPAVEAATALTKASGMDRVFFTNSGTEAIEGAVKLAKKYYYVKNGKADAEIIAMQHSFHGRSMGALAV
TGNKHYQEAFGPMIPGIKFAQYNDLDSVKELVNDKTCAIIFETVQGEGGIYPATKEFIEGVRKLCDEKGILLILDEIQCG
MGRTGSMFAFQQYGVKPDILTVAKALGCGVPVGAFAATEEVAKALVPGDHGTTYGGNPLACAAATKVFELFEKQHVLDNV
KEVSAYFEEKLDELVETIDVVVERRGMGLMQGLELSVNPKDVIAKALDNGLILFSAGTNVIRFVPPLVITKADVDECIAK
LKKSF

Sequences:

>Translated_405_residues
MCAHKNRKVRVIMNTQQIIETAEEKLIHTYNRYQIVLDKGDGVRLYDTDGKEYLDFGAGIAVFALGYNNKEYNDALKAQI
DKLIHTSNYFYNEPAVEAATALTKASGMDRVFFTNSGTEAIEGAVKLAKKYYYVKNGKADAEIIAMQHSFHGRSMGALAV
TGNKHYQEAFGPMIPGIKFAQYNDLDSVKELVNDKTCAIIFETVQGEGGIYPATKEFIEGVRKLCDEKGILLILDEIQCG
MGRTGSMFAFQQYGVKPDILTVAKALGCGVPVGAFAATEEVAKALVPGDHGTTYGGNPLACAAATKVFELFEKQHVLDNV
KEVSAYFEEKLDELVETIDVVVERRGMGLMQGLELSVNPKDVIAKALDNGLILFSAGTNVIRFVPPLVITKADVDECIAK
LKKSF
>Mature_405_residues
MCAHKNRKVRVIMNTQQIIETAEEKLIHTYNRYQIVLDKGDGVRLYDTDGKEYLDFGAGIAVFALGYNNKEYNDALKAQI
DKLIHTSNYFYNEPAVEAATALTKASGMDRVFFTNSGTEAIEGAVKLAKKYYYVKNGKADAEIIAMQHSFHGRSMGALAV
TGNKHYQEAFGPMIPGIKFAQYNDLDSVKELVNDKTCAIIFETVQGEGGIYPATKEFIEGVRKLCDEKGILLILDEIQCG
MGRTGSMFAFQQYGVKPDILTVAKALGCGVPVGAFAATEEVAKALVPGDHGTTYGGNPLACAAATKVFELFEKQHVLDNV
KEVSAYFEEKLDELVETIDVVVERRGMGLMQGLELSVNPKDVIAKALDNGLILFSAGTNVIRFVPPLVITKADVDECIAK
LKKSF

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=385, Percent_Identity=34.025974025974, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI284507298, Length=299, Percent_Identity=34.4481605351171, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI13994255, Length=437, Percent_Identity=27.9176201372998, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI37574042, Length=402, Percent_Identity=26.865671641791, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI226442705, Length=404, Percent_Identity=26.4851485148515, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI226442709, Length=365, Percent_Identity=27.1232876712329, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI24119277, Length=445, Percent_Identity=25.6179775280899, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI188536080, Length=442, Percent_Identity=24.4343891402715, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI38679950, Length=442, Percent_Identity=24.4343891402715, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI38679946, Length=442, Percent_Identity=24.4343891402715, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1789759, Length=388, Percent_Identity=43.5567010309278, Blast_Score=340, Evalue=6e-95,
Organism=Escherichia coli, GI1788044, Length=379, Percent_Identity=43.5356200527704, Blast_Score=334, Evalue=5e-93,
Organism=Escherichia coli, GI145693181, Length=377, Percent_Identity=36.0742705570292, Blast_Score=218, Evalue=4e-58,
Organism=Escherichia coli, GI1789016, Length=405, Percent_Identity=33.3333333333333, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1787560, Length=392, Percent_Identity=34.1836734693878, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1786991, Length=400, Percent_Identity=28.75, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1786349, Length=334, Percent_Identity=31.7365269461078, Blast_Score=130, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI25144271, Length=390, Percent_Identity=33.5897435897436, Blast_Score=230, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI32564660, Length=432, Percent_Identity=30.5555555555556, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI25144274, Length=261, Percent_Identity=34.0996168582375, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71992977, Length=409, Percent_Identity=27.1393643031785, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17541228, Length=439, Percent_Identity=25.2847380410023, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI71981843, Length=185, Percent_Identity=31.3513513513514, Blast_Score=106, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324432, Length=394, Percent_Identity=39.8477157360406, Blast_Score=281, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6323470, Length=418, Percent_Identity=31.1004784688995, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6324386, Length=460, Percent_Identity=25.4347826086956, Blast_Score=116, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6321456, Length=427, Percent_Identity=23.1850117096019, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21357415, Length=383, Percent_Identity=33.6814621409922, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI161085790, Length=452, Percent_Identity=28.7610619469027, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI28574759, Length=440, Percent_Identity=29.5454545454545, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI21356575, Length=406, Percent_Identity=29.064039408867, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI281366494, Length=421, Percent_Identity=23.7529691211401, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24667139, Length=421, Percent_Identity=23.7529691211401, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24667143, Length=421, Percent_Identity=23.7529691211401, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 44372; Mature: 44372

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCAHKNRKVRVIMNTQQIIETAEEKLIHTYNRYQIVLDKGDGVRLYDTDGKEYLDFGAGI
CCCCCCCEEEEEECHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEECCCHHHHHHCCCE
AVFALGYNNKEYNDALKAQIDKLIHTSNYFYNEPAVEAATALTKASGMDRVFFTNSGTEA
EEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHH
IEGAVKLAKKYYYVKNGKADAEIIAMQHSFHGRSMGALAVTGNKHYQEAFGPMIPGIKFA
HHHHHHHHHHHEEEECCCCCEEEEEEECCCCCCCCCEEEEECCCHHHHHHHCCCCCCEEE
QYNDLDSVKELVNDKTCAIIFETVQGEGGIYPATKEFIEGVRKLCDEKGILLILDEIQCG
CCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCC
MGRTGSMFAFQQYGVKPDILTVAKALGCGVPVGAFAATEEVAKALVPGDHGTTYGGNPLA
CCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCH
CAAATKVFELFEKQHVLDNVKEVSAYFEEKLDELVETIDVVVERRGMGLMQGLELSVNPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCEECCCHH
DVIAKALDNGLILFSAGTNVIRFVPPLVITKADVDECIAKLKKSF
HHHHHHHCCCEEEEECCCCCEECCCCCEEEECCHHHHHHHHHHCC
>Mature Secondary Structure
MCAHKNRKVRVIMNTQQIIETAEEKLIHTYNRYQIVLDKGDGVRLYDTDGKEYLDFGAGI
CCCCCCCEEEEEECHHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEECCCHHHHHHCCCE
AVFALGYNNKEYNDALKAQIDKLIHTSNYFYNEPAVEAATALTKASGMDRVFFTNSGTEA
EEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCHHH
IEGAVKLAKKYYYVKNGKADAEIIAMQHSFHGRSMGALAVTGNKHYQEAFGPMIPGIKFA
HHHHHHHHHHHEEEECCCCCEEEEEEECCCCCCCCCEEEEECCCHHHHHHHCCCCCCEEE
QYNDLDSVKELVNDKTCAIIFETVQGEGGIYPATKEFIEGVRKLCDEKGILLILDEIQCG
CCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCC
MGRTGSMFAFQQYGVKPDILTVAKALGCGVPVGAFAATEEVAKALVPGDHGTTYGGNPLA
CCCCCCCHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCH
CAAATKVFELFEKQHVLDNVKEVSAYFEEKLDELVETIDVVVERRGMGLMQGLELSVNPK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCEECCCHH
DVIAKALDNGLILFSAGTNVIRFVPPLVITKADVDECIAKLKKSF
HHHHHHHCCCEEEEECCCCCEECCCCCEEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10588044; 10688204 [H]