Click here to switch to the map view.

The map label for this gene is dxs [H]

Identifier: 238916479

GI number: 238916479

Start: 543408

End: 545162

Strand: Reverse

Name: dxs [H]

Synonym: EUBELI_00536

Alternate gene names: 238916479

Gene position: 545162-543408 (Counterclockwise)

Preceding gene: 238916496

Following gene: 238916472

Centisome position: 25.43

GC content: 40.51

Gene sequence:

>1755_bases
ATGTATATTGAGAATATTAACAGTCCTGCTGATGTGAAGAAATTAAACATCATGCAGCTTAATGTCCTTGCAGAGGAAAT
GCGTCACGCCCTTCTTACAAGAGCCAGCAGACACGGTGGACATTTTGGTCCTAACTTCGGTATGGTAGAAGCAATCATTG
CCATGCATTATGTATTTGATTCGCCTAAAGATAAAATCGTATTTGATGTATCACACCAGTGTTATCCACACAAGATGCTC
ACTGGAAGAAAAGACGCATATCTTTATGAGGAGCATTATGATGATGTGTCAGGATACACTAATCCGAACGAAAGCGAACA
TGATTTCTTTACTGTAGGTCATACTTCAACTTCTATAAGTCTTGCCTGCGGTCTTGCCAAAGCAAGAGATTTAAACGGTG
AAGACGGCAATGTAATTGCTGTTATAGGTGATGGTTCTTTAAGCGGCGGTGAGGCTTTGGAAGGTCTTGATTTTGCTTCT
GAATTAAATAGCAACATGATTATCGTTGCTAACGATAACGACATGTCTATTGCTGAGAATCACGGTGGTCTTTATGCCAA
CTTAAAGCTTCTTCGTGAAACAAACGGACAGGCTGAATGTAATCTTTTTAAGGCAATGAACCTTGATTACATCTATGTTG
ATAAGGGTAATGATATTGCTTCTTTAATTGAAGCATTTGAAAAGGTTAAAGACACTAAAAAAGCTGTTGTTGTCCACATT
AATACGCTTAAAGGCAAGGGTTATGCACCTGCTGAACAGAACAAAGAAAAATGGCACTGGCATATGCCTTTTGATATCGC
AACCGGTGAATCTCTTTTCAAGGACGAAGAGCCTGATTTCTCTGACGCTTCTTTAGAATATCTGTTAAAGAAGATGGACG
AGGATAAGAGTGTTGTTGCAATCACAGCCGGAACTCCTACTGTTATGGGATTTACTGCTGACATGAGAGCTAAAGCAGGA
AAACAGTTTGTTGATGTTGGTATCGCAGAGGAAACTGCTGTTGCATTAGCTTCCGGTATCGCTGCTAACGGCGGAAAGCC
TGTATTTGGCGTTTACAGCTCATTTATACAGAGAGCCTATGACCAGATTACTCAGGATGTATGTATTAACGGCAATGCTG
TAACATTTGCAGTATTTGCAGGTTCTGTGTACGGGATGAATGATGTTACACATCTCGGACTTCAGGATATCCCTATGCTC
AACAGCATTCCGGGACTTATATATCTTGCACCTGTCACTAAGGAAGATTATATTGCTATGCTTGACTGGTCTTTAACTCA
GAATGAGTATCCTGTTGCTATTAAAGTTCCGGGCGGCAGAATGGTATCCACAGGCACACCTGTAACTAAAGATTTTGGCA
AGCTGGACACCTATGAGATTACTAAGAAAGGAAGCAAAGTTGCTATCCTCGGGCTTGGAACTTTCTATGAAAATGCTGTT
AAAGCCGCTGATATTCTTAAGGCTTCACACGGAATTGACGCAACTGTTATCAATCCTTACTATATCTCAGGTATTGACGC
AGACACTCTTAATGAATTAAAGAAAGACCACGCAGTAGTTGCAACTCTTGAGGACGGCTATCTTGAAGGCGGCTTCGGAG
CTAAGATTGCAGCATTCTATGGTTCTTCTGATATGAAGGTATTAAACTTCGGTATTAAGAAAGAATTTATCGACAGATAC
GATGTCGCAGAAGTATTAAAGGACAACCATCTTACTCCTGAACAGATTGCAGAAGATATCGCAGCAACATTATAA

Upstream 100 bases:

>100_bases
CCATTTGCAGATATAATACGAATTTCTCTTGACCTAAACCTGACTTTAGGTGTTATTATATAAAATGTATTAAAATCTAA
GATAAGGAGTATCAGAAAAC

Downstream 100 bases:

>100_bases
CTATATTGTTTCATTATAATCGAAAAGACATGGCAATCATTTTTATCAATGACTGTCATGTCTTTTTAGAATTTATCCCT
GTCTTTAGTTTCCATAATGG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MYIENINSPADVKKLNIMQLNVLAEEMRHALLTRASRHGGHFGPNFGMVEAIIAMHYVFDSPKDKIVFDVSHQCYPHKML
TGRKDAYLYEEHYDDVSGYTNPNESEHDFFTVGHTSTSISLACGLAKARDLNGEDGNVIAVIGDGSLSGGEALEGLDFAS
ELNSNMIIVANDNDMSIAENHGGLYANLKLLRETNGQAECNLFKAMNLDYIYVDKGNDIASLIEAFEKVKDTKKAVVVHI
NTLKGKGYAPAEQNKEKWHWHMPFDIATGESLFKDEEPDFSDASLEYLLKKMDEDKSVVAITAGTPTVMGFTADMRAKAG
KQFVDVGIAEETAVALASGIAANGGKPVFGVYSSFIQRAYDQITQDVCINGNAVTFAVFAGSVYGMNDVTHLGLQDIPML
NSIPGLIYLAPVTKEDYIAMLDWSLTQNEYPVAIKVPGGRMVSTGTPVTKDFGKLDTYEITKKGSKVAILGLGTFYENAV
KAADILKASHGIDATVINPYYISGIDADTLNELKKDHAVVATLEDGYLEGGFGAKIAAFYGSSDMKVLNFGIKKEFIDRY
DVAEVLKDNHLTPEQIAEDIAATL

Sequences:

>Translated_584_residues
MYIENINSPADVKKLNIMQLNVLAEEMRHALLTRASRHGGHFGPNFGMVEAIIAMHYVFDSPKDKIVFDVSHQCYPHKML
TGRKDAYLYEEHYDDVSGYTNPNESEHDFFTVGHTSTSISLACGLAKARDLNGEDGNVIAVIGDGSLSGGEALEGLDFAS
ELNSNMIIVANDNDMSIAENHGGLYANLKLLRETNGQAECNLFKAMNLDYIYVDKGNDIASLIEAFEKVKDTKKAVVVHI
NTLKGKGYAPAEQNKEKWHWHMPFDIATGESLFKDEEPDFSDASLEYLLKKMDEDKSVVAITAGTPTVMGFTADMRAKAG
KQFVDVGIAEETAVALASGIAANGGKPVFGVYSSFIQRAYDQITQDVCINGNAVTFAVFAGSVYGMNDVTHLGLQDIPML
NSIPGLIYLAPVTKEDYIAMLDWSLTQNEYPVAIKVPGGRMVSTGTPVTKDFGKLDTYEITKKGSKVAILGLGTFYENAV
KAADILKASHGIDATVINPYYISGIDADTLNELKKDHAVVATLEDGYLEGGFGAKIAAFYGSSDMKVLNFGIKKEFIDRY
DVAEVLKDNHLTPEQIAEDIAATL
>Mature_584_residues
MYIENINSPADVKKLNIMQLNVLAEEMRHALLTRASRHGGHFGPNFGMVEAIIAMHYVFDSPKDKIVFDVSHQCYPHKML
TGRKDAYLYEEHYDDVSGYTNPNESEHDFFTVGHTSTSISLACGLAKARDLNGEDGNVIAVIGDGSLSGGEALEGLDFAS
ELNSNMIIVANDNDMSIAENHGGLYANLKLLRETNGQAECNLFKAMNLDYIYVDKGNDIASLIEAFEKVKDTKKAVVVHI
NTLKGKGYAPAEQNKEKWHWHMPFDIATGESLFKDEEPDFSDASLEYLLKKMDEDKSVVAITAGTPTVMGFTADMRAKAG
KQFVDVGIAEETAVALASGIAANGGKPVFGVYSSFIQRAYDQITQDVCINGNAVTFAVFAGSVYGMNDVTHLGLQDIPML
NSIPGLIYLAPVTKEDYIAMLDWSLTQNEYPVAIKVPGGRMVSTGTPVTKDFGKLDTYEITKKGSKVAILGLGTFYENAV
KAADILKASHGIDATVINPYYISGIDADTLNELKKDHAVVATLEDGYLEGGFGAKIAAFYGSSDMKVLNFGIKKEFIDRY
DVAEVLKDNHLTPEQIAEDIAATL

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=501, Percent_Identity=24.3512974051896, Blast_Score=90, Evalue=6e-18,
Organism=Escherichia coli, GI1786622, Length=592, Percent_Identity=31.9256756756757, Blast_Score=295, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI17539652, Length=564, Percent_Identity=23.4042553191489, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 63652; Mature: 63652

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIENINSPADVKKLNIMQLNVLAEEMRHALLTRASRHGGHFGPNFGMVEAIIAMHYVFD
CCCCCCCCCCCHHEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHC
SPKDKIVFDVSHQCYPHKMLTGRKDAYLYEEHYDDVSGYTNPNESEHDFFTVGHTSTSIS
CCCCCEEEEECCCCCCCHHHCCCCCCEEEHHHCCCCCCCCCCCCCCCCEEEEECCCCEEE
LACGLAKARDLNGEDGNVIAVIGDGSLSGGEALEGLDFASELNSNMIIVANDNDMSIAEN
EEECCHHHCCCCCCCCCEEEEEECCCCCCCCHHHCCHHHHHCCCCEEEEECCCCCEEEEC
HGGLYANLKLLRETNGQAECNLFKAMNLDYIYVDKGNDIASLIEAFEKVKDTKKAVVVHI
CCCEEEEEEEEECCCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEE
NTLKGKGYAPAEQNKEKWHWHMPFDIATGESLFKDEEPDFSDASLEYLLKKMDEDKSVVA
EEECCCCCCCCCCCCCCEEEECCEEECCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCEEE
ITAGTPTVMGFTADMRAKAGKQFVDVGIAEETAVALASGIAANGGKPVFGVYSSFIQRAY
EECCCCEEEEEEHHHHHHCCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
DQITQDVCINGNAVTFAVFAGSVYGMNDVTHLGLQDIPMLNSIPGLIYLAPVTKEDYIAM
HHHHHHHEECCCEEEEEEEECCCCCCCCHHHCCCCCCCHHHCCCCEEEEEECCCCCEEEE
LDWSLTQNEYPVAIKVPGGRMVSTGTPVTKDFGKLDTYEITKKGSKVAILGLGTFYENAV
EEEEECCCCCCEEEECCCCEEEECCCCCCHHHCCCCCEEEECCCCEEEEEEECHHHHHHH
KAADILKASHGIDATVINPYYISGIDADTLNELKKDHAVVATLEDGYLEGGFGAKIAAFY
HHHHHHHHCCCCCEEEECCEEEECCCHHHHHHHHCCCEEEEEECCCCEECCCCCEEEEEE
GSSDMKVLNFGIKKEFIDRYDVAEVLKDNHLTPEQIAEDIAATL
CCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MYIENINSPADVKKLNIMQLNVLAEEMRHALLTRASRHGGHFGPNFGMVEAIIAMHYVFD
CCCCCCCCCCCHHEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHC
SPKDKIVFDVSHQCYPHKMLTGRKDAYLYEEHYDDVSGYTNPNESEHDFFTVGHTSTSIS
CCCCCEEEEECCCCCCCHHHCCCCCCEEEHHHCCCCCCCCCCCCCCCCEEEEECCCCEEE
LACGLAKARDLNGEDGNVIAVIGDGSLSGGEALEGLDFASELNSNMIIVANDNDMSIAEN
EEECCHHHCCCCCCCCCEEEEEECCCCCCCCHHHCCHHHHHCCCCEEEEECCCCCEEEEC
HGGLYANLKLLRETNGQAECNLFKAMNLDYIYVDKGNDIASLIEAFEKVKDTKKAVVVHI
CCCEEEEEEEEECCCCCCEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEE
NTLKGKGYAPAEQNKEKWHWHMPFDIATGESLFKDEEPDFSDASLEYLLKKMDEDKSVVA
EEECCCCCCCCCCCCCCEEEECCEEECCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCEEE
ITAGTPTVMGFTADMRAKAGKQFVDVGIAEETAVALASGIAANGGKPVFGVYSSFIQRAY
EECCCCEEEEEEHHHHHHCCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
DQITQDVCINGNAVTFAVFAGSVYGMNDVTHLGLQDIPMLNSIPGLIYLAPVTKEDYIAM
HHHHHHHEECCCEEEEEEEECCCCCCCCHHHCCCCCCCHHHCCCCEEEEEECCCCCEEEE
LDWSLTQNEYPVAIKVPGGRMVSTGTPVTKDFGKLDTYEITKKGSKVAILGLGTFYENAV
EEEEECCCCCCEEEECCCCEEEECCCCCCHHHCCCCCEEEECCCCEEEEEEECHHHHHHH
KAADILKASHGIDATVINPYYISGIDADTLNELKKDHAVVATLEDGYLEGGFGAKIAAFY
HHHHHHHHCCCCCEEEECCEEEECCCHHHHHHHHCCCEEEEEECCCCEECCCCCEEEEEE
GSSDMKVLNFGIKKEFIDRYDVAEVLKDNHLTPEQIAEDIAATL
CCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA