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The map label for this gene is pyrD [H]

Identifier: 238916477

GI number: 238916477

Start: 540871

End: 541782

Strand: Direct

Name: pyrD [H]

Synonym: EUBELI_00534

Alternate gene names: 238916477

Gene position: 540871-541782 (Clockwise)

Preceding gene: 238916476

Following gene: 238916478

Centisome position: 25.22

GC content: 40.68

Gene sequence:

>912_bases
ATGAGCGATATTAATATGTCAGTCAATATTGCAGGAGTTGAATTAAAGAATCCTGTGACAGTTGCTTCCGGAACATTCGG
ATCAGGCATGGAGTATGGGGAATATGTTGACCTTAACAGACTTGGTGCGGTAACAACAAAGGGCGTTGCCAATATTCCAT
GGCCGGGCAATCCTACACCAAGAATTGCTGAGACTTACGGTGGAATGATGAATGCTATCGGATTACAGAATCCGGGACTT
GATACATTTGTAAAAAGAGATATTCCATTTCTTAAACAGTACGATACTAAGATTATTGTTAATGTTTGTGGAAAATCTGA
GGCAGATTATGTGGATGCTGTTGAAAAGCTTGGTGAACAGCCAGTTGACCTTCTTGAAATTAATATCTCATGCCCTAATG
TCAAAGAGGGTGGAATTGCTTTCGGACAGGTTCCATCTTCTGCAGAGGCTATTACTAAGGCGGTTAAGAAGGTTGCAAAG
CAGCCGGTTATTATGAAGTTAAGTCCTAATGTTACTGATATCACAGAGATGGCAAAGGCTGTAGAGGCAGGTGGTGCTGA
CGCAGTTTCGCTTATCAATACTCTTACAGGTATGAAGATTGATGTGAACAGAAGAACATTTGCAGTAGCTAACAAGACTG
CGGGTGTATCAGGACCTGCTATTCATCCAATCGCAGTAAGAATGGTTTATCAGGTTGCCAATGCAATTAACCTTCCTATA
ATCGGAATGGGTGGAATCAGAACAGCAGAGGATGCACTTGAAATGATTATGGTTGGTGCAAGTGCAGTTGCTGTTGGAAC
AGCGAATTTTAATGATCCATATACAACTATTAAGGTTATTGATGGAATCAGGGAATATATGGAAAAGAATAATGTAGCAG
ATATTAAGGAGCTGATTGGTTGTGTCAGATAG

Upstream 100 bases:

>100_bases
GTGTATGTAAATCAACTGGGATTGACGACCATTCTCAGGTTAAGAATAAGAGAGTGTGCAAGGAAGGTCCGGTATTTAAT
GTTAAGGAGGTAGAACTGTA

Downstream 100 bases:

>100_bases
AATACTTTTCTTAAGTAATGGTTCTATATGCTATGACTCAACAACTTACTTTATTGACTGTATAAGTGAAGAATTAAAAG
CTATGGGCTGGGAAGTCATG

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSDINMSVNIAGVELKNPVTVASGTFGSGMEYGEYVDLNRLGAVTTKGVANIPWPGNPTPRIAETYGGMMNAIGLQNPGL
DTFVKRDIPFLKQYDTKIIVNVCGKSEADYVDAVEKLGEQPVDLLEINISCPNVKEGGIAFGQVPSSAEAITKAVKKVAK
QPVIMKLSPNVTDITEMAKAVEAGGADAVSLINTLTGMKIDVNRRTFAVANKTAGVSGPAIHPIAVRMVYQVANAINLPI
IGMGGIRTAEDALEMIMVGASAVAVGTANFNDPYTTIKVIDGIREYMEKNNVADIKELIGCVR

Sequences:

>Translated_303_residues
MSDINMSVNIAGVELKNPVTVASGTFGSGMEYGEYVDLNRLGAVTTKGVANIPWPGNPTPRIAETYGGMMNAIGLQNPGL
DTFVKRDIPFLKQYDTKIIVNVCGKSEADYVDAVEKLGEQPVDLLEINISCPNVKEGGIAFGQVPSSAEAITKAVKKVAK
QPVIMKLSPNVTDITEMAKAVEAGGADAVSLINTLTGMKIDVNRRTFAVANKTAGVSGPAIHPIAVRMVYQVANAINLPI
IGMGGIRTAEDALEMIMVGASAVAVGTANFNDPYTTIKVIDGIREYMEKNNVADIKELIGCVR
>Mature_302_residues
SDINMSVNIAGVELKNPVTVASGTFGSGMEYGEYVDLNRLGAVTTKGVANIPWPGNPTPRIAETYGGMMNAIGLQNPGLD
TFVKRDIPFLKQYDTKIIVNVCGKSEADYVDAVEKLGEQPVDLLEINISCPNVKEGGIAFGQVPSSAEAITKAVKKVAKQ
PVIMKLSPNVTDITEMAKAVEAGGADAVSLINTLTGMKIDVNRRTFAVANKTAGVSGPAIHPIAVRMVYQVANAINLPII
GMGGIRTAEDALEMIMVGASAVAVGTANFNDPYTTIKVIDGIREYMEKNNVADIKELIGCVR

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=333, Percent_Identity=30.03003003003, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI45006951, Length=330, Percent_Identity=26.969696969697, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI87082059, Length=319, Percent_Identity=27.5862068965517, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1787177, Length=280, Percent_Identity=25, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71984108, Length=306, Percent_Identity=30.3921568627451, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322633, Length=266, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24640763, Length=298, Percent_Identity=28.8590604026846, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI18858217, Length=298, Percent_Identity=28.8590604026846, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281361352, Length=289, Percent_Identity=26.9896193771626, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17137316, Length=289, Percent_Identity=26.9896193771626, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32058; Mature: 31927

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDINMSVNIAGVELKNPVTVASGTFGSGMEYGEYVDLNRLGAVTTKGVANIPWPGNPTP
CCCCCEEEEEEEEEECCCEEEECCCCCCCCCCCCEECHHHCCCCCCCCCEECCCCCCCCC
RIAETYGGMMNAIGLQNPGLDTFVKRDIPFLKQYDTKIIVNVCGKSEADYVDAVEKLGEQ
HHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHCCCEEEEEECCCCCCHHHHHHHHHCCC
PVDLLEINISCPNVKEGGIAFGQVPSSAEAITKAVKKVAKQPVIMKLSPNVTDITEMAKA
CCEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHH
VEAGGADAVSLINTLTGMKIDVNRRTFAVANKTAGVSGPAIHPIAVRMVYQVANAINLPI
HHCCCCHHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
IGMGGIRTAEDALEMIMVGASAVAVGTANFNDPYTTIKVIDGIREYMEKNNVADIKELIG
EECCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
CVR
HCC
>Mature Secondary Structure 
SDINMSVNIAGVELKNPVTVASGTFGSGMEYGEYVDLNRLGAVTTKGVANIPWPGNPTP
CCCCEEEEEEEEEECCCEEEECCCCCCCCCCCCEECHHHCCCCCCCCCEECCCCCCCCC
RIAETYGGMMNAIGLQNPGLDTFVKRDIPFLKQYDTKIIVNVCGKSEADYVDAVEKLGEQ
HHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHCCCEEEEEECCCCCCHHHHHHHHHCCC
PVDLLEINISCPNVKEGGIAFGQVPSSAEAITKAVKKVAKQPVIMKLSPNVTDITEMAKA
CCEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHH
VEAGGADAVSLINTLTGMKIDVNRRTFAVANKTAGVSGPAIHPIAVRMVYQVANAINLPI
HHCCCCHHHHHHHHHCCCEEEECCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCE
IGMGGIRTAEDALEMIMVGASAVAVGTANFNDPYTTIKVIDGIREYMEKNNVADIKELIG
EECCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHH
CVR
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA