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The map label for this gene is 238916461

Identifier: 238916461

GI number: 238916461

Start: 524097

End: 524960

Strand: Direct

Name: 238916461

Synonym: EUBELI_00518

Alternate gene names: NA

Gene position: 524097-524960 (Clockwise)

Preceding gene: 238916459

Following gene: 238916462

Centisome position: 24.44

GC content: 36.23

Gene sequence:

>864_bases
ATGGCAGATTATAAATTAAAAAATGTATGTGATTTCGATCTGGCACAGACATTGGAATGTGGACAGTGTTTTCATTTTGT
AAAGCTCGATGAAGAGGATTATGTACTGACGGCAAAGGGGTATGTATTACATGTTTCACAGGAGGCTGATACCGTTACAT
TTTATGATACAGACAAAGATGAATATGTAAATGTATGGAAAGATTATTTCGATATGGACAGGGATTATTCAGCAATTAAG
AAAAAGCTGCTGGAAAAAGATGATAAGTTAAAGGATGCAATTGAAAGCATGTGGGGAGTGAGGATTCTTAATCAGGATTT
TTTTGAAACACTTATATCATTCATTATATCGCAGAATAAGCAGATACCTCATATTAAGAAGATAGTAGCTGATATATCTG
CAAAGTTTGGTACATATAAGGGAACATATGGTGGAGCGGATATGTATACATTTCCAACACTTGAACAGCTTGCCAATGCA
AGTGAAGAGGACTTTAAAGAGTTAAAGACAGGATTCCGTGCGCCATATATTATGGATGCAATAAGAAGGAATATGGCAGG
CCAGTTTGATATAAATGAACTTAAGAGCATGGATTATGATTCGTGCATTAAGGAACTTATGACAATAAAAGGTGTTGGAG
AGAAGGTTGCCAACTGCGTAAGCCTTTTCGGACTTGGAAAGAAAGAAGCATTTCCTGTTGATGTGTGGATTAAAAGAATT
ATGGAGACAATGTATTTTGACGGTGTGGACACTCCAAAGGATAAGATTGCTGCTTTTGCAAAGGAACAGTTTGGGGAACT
GGGGGGATTTGCACAGCAGTATCTGTTTTATTATGGAAAATCAATAAAAATGGGTGTTAAATAA

Upstream 100 bases:

>100_bases
GAATTTCATGTGTTGTCTCCTATTGATTAAATTATATATAATTGTATAACGGGGTTGTTATAAATGTAAAGCAAAATGAT
AAGAAATATGGAGGATAATT

Downstream 100 bases:

>100_bases
TAATTATTAATAAAATCTAAAAAATATAATATATTTGAATTAGCTGTTGACAAATAAAAGCATGAAGTGTTACATTATGT
GCAGTGGTTAGCACTCGAAA

Product: N-glycosylase/DNA lyase

Products: NA

Alternate protein names: 8-oxoguanine DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase; AP lyase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MADYKLKNVCDFDLAQTLECGQCFHFVKLDEEDYVLTAKGYVLHVSQEADTVTFYDTDKDEYVNVWKDYFDMDRDYSAIK
KKLLEKDDKLKDAIESMWGVRILNQDFFETLISFIISQNKQIPHIKKIVADISAKFGTYKGTYGGADMYTFPTLEQLANA
SEEDFKELKTGFRAPYIMDAIRRNMAGQFDINELKSMDYDSCIKELMTIKGVGEKVANCVSLFGLGKKEAFPVDVWIKRI
METMYFDGVDTPKDKIAAFAKEQFGELGGFAQQYLFYYGKSIKMGVK

Sequences:

>Translated_287_residues
MADYKLKNVCDFDLAQTLECGQCFHFVKLDEEDYVLTAKGYVLHVSQEADTVTFYDTDKDEYVNVWKDYFDMDRDYSAIK
KKLLEKDDKLKDAIESMWGVRILNQDFFETLISFIISQNKQIPHIKKIVADISAKFGTYKGTYGGADMYTFPTLEQLANA
SEEDFKELKTGFRAPYIMDAIRRNMAGQFDINELKSMDYDSCIKELMTIKGVGEKVANCVSLFGLGKKEAFPVDVWIKRI
METMYFDGVDTPKDKIAAFAKEQFGELGGFAQQYLFYYGKSIKMGVK
>Mature_286_residues
ADYKLKNVCDFDLAQTLECGQCFHFVKLDEEDYVLTAKGYVLHVSQEADTVTFYDTDKDEYVNVWKDYFDMDRDYSAIKK
KLLEKDDKLKDAIESMWGVRILNQDFFETLISFIISQNKQIPHIKKIVADISAKFGTYKGTYGGADMYTFPTLEQLANAS
EEDFKELKTGFRAPYIMDAIRRNMAGQFDINELKSMDYDSCIKELMTIKGVGEKVANCVSLFGLGKKEAFPVDVWIKRIM
ETMYFDGVDTPKDKIAAFAKEQFGELGGFAQQYLFYYGKSIKMGVK

Specific function: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type-1 OGG1 family [H]

Homologues:

Organism=Homo sapiens, GI4505495, Length=281, Percent_Identity=28.1138790035587, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI8670540, Length=277, Percent_Identity=27.7978339350181, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI8670534, Length=281, Percent_Identity=27.7580071174377, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI8670530, Length=284, Percent_Identity=27.4647887323944, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI8670542, Length=277, Percent_Identity=27.7978339350181, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI8670532, Length=284, Percent_Identity=27.4647887323944, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI8670536, Length=218, Percent_Identity=26.605504587156, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323580, Length=273, Percent_Identity=32.2344322344322, Blast_Score=101, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24640654, Length=286, Percent_Identity=30.4195804195804, Blast_Score=123, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR004577
- InterPro:   IPR012904 [H]

Pfam domain/function: PF00730 HhH-GPD; PF07934 OGG_N [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 33001; Mature: 32870

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADYKLKNVCDFDLAQTLECGQCFHFVKLDEEDYVLTAKGYVLHVSQEADTVTFYDTDKD
CCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEECCEEEEEECCCCEEEEEECCHH
EYVNVWKDYFDMDRDYSAIKKKLLEKDDKLKDAIESMWGVRILNQDFFETLISFIISQNK
HHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QIPHIKKIVADISAKFGTYKGTYGGADMYTFPTLEQLANASEEDFKELKTGFRAPYIMDA
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCHHHHHH
IRRNMAGQFDINELKSMDYDSCIKELMTIKGVGEKVANCVSLFGLGKKEAFPVDVWIKRI
HHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
METMYFDGVDTPKDKIAAFAKEQFGELGGFAQQYLFYYGKSIKMGVK
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ADYKLKNVCDFDLAQTLECGQCFHFVKLDEEDYVLTAKGYVLHVSQEADTVTFYDTDKD
CCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCEEEEECCEEEEEECCCCEEEEEECCHH
EYVNVWKDYFDMDRDYSAIKKKLLEKDDKLKDAIESMWGVRILNQDFFETLISFIISQNK
HHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QIPHIKKIVADISAKFGTYKGTYGGADMYTFPTLEQLANASEEDFKELKTGFRAPYIMDA
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHCCCHHHHHH
IRRNMAGQFDINELKSMDYDSCIKELMTIKGVGEKVANCVSLFGLGKKEAFPVDVWIKRI
HHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
METMYFDGVDTPKDKIAAFAKEQFGELGGFAQQYLFYYGKSIKMGVK
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]