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The map label for this gene is map [H]

Identifier: 238916455

GI number: 238916455

Start: 520026

End: 520898

Strand: Direct

Name: map [H]

Synonym: EUBELI_00512

Alternate gene names: 238916455

Gene position: 520026-520898 (Clockwise)

Preceding gene: 238916454

Following gene: 238916456

Centisome position: 24.25

GC content: 38.49

Gene sequence:

>873_bases
ATGAAGGCATTACGAAAAGATGATCCCTGCTGGTGTAACAGTGGGAAAAAATATTGTGACTGTCACATGGAATTTGATAG
AAAATTAGATAATTTCAAGAGAAAGTTTCATAAGGTACCACCAAGAAATATTATTAAGAATGAAGAACAGCTTGCAGGAA
TGAGAGAAAGCAGCAAGATTAATATTGCTGTGCTTGATTATGTTGCAGAGAATATTCATGCAGGAATGACAACTCAGGAT
ATAGATGATTTGGTATACAAGAAAACAACCGAGATGGGTGGAATACCTGCACCACTTAATTATGAAGGATTTCCAAAGAG
TGTGTGTACTTCAATTAATGAGCAGGTATGTCATGGAATACCATCCAAGAATATCCAGCTTCTTGATGGTGATATAATTA
ATGTTGACTGTTCAACGATATTAAACGGATATTTTTCGGATTCATCAAGAATGTTCTGTATAGGTAATGTTGCACCAGAA
CATAAGAAGCTGGTGGATGTTGCAAAAGAATGTGTTGAGTTAGGTCTTGCACAGGTTAAGCCATGGGGACATCTTGGAGA
TGTTGCGGCGGCAATAAATGAACATGCAAAGGCTAATGGATATTCAGTAGTAAGAGAAGTTGGTGGACATGGAATAGGTC
TTGAATTTCACGAAACCCCATTTGTAAGTTATGTAATTAAGAAGGGAACAGGAATGGTCATGGCACCGGGCATGGTATTC
ACAATTGAGCCAATGATTAATGCGGGACTTCCGGACATATATATAGACGAGGGCAACAACTGGACAATATATACAGATGA
CGATTCGTACTCAGCACAGTGGGAAATAATGGTTCATGTGACTGAGGACGGATATGAGGTGATGTCGTATTAA

Upstream 100 bases:

>100_bases
GCAGGATACATATATACTAAAGAATGTTGTTTCAAGAAAGAAACAGTTCCTCCCGGCCATTATGGAAGCTATGGAGCAGT
AGAGAAAATGGAGAATAGTG

Downstream 100 bases:

>100_bases
GATAGATGTAGCCACGATTATGTAGTGTAGGTGACTCCGGCATTGGTGTATAAAAACATGGCTACAGCTATCTTGATAGG
ACATACAACAATAAGTGAAA

Product: methionyl aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MKALRKDDPCWCNSGKKYCDCHMEFDRKLDNFKRKFHKVPPRNIIKNEEQLAGMRESSKINIAVLDYVAENIHAGMTTQD
IDDLVYKKTTEMGGIPAPLNYEGFPKSVCTSINEQVCHGIPSKNIQLLDGDIINVDCSTILNGYFSDSSRMFCIGNVAPE
HKKLVDVAKECVELGLAQVKPWGHLGDVAAAINEHAKANGYSVVREVGGHGIGLEFHETPFVSYVIKKGTGMVMAPGMVF
TIEPMINAGLPDIYIDEGNNWTIYTDDDSYSAQWEIMVHVTEDGYEVMSY

Sequences:

>Translated_290_residues
MKALRKDDPCWCNSGKKYCDCHMEFDRKLDNFKRKFHKVPPRNIIKNEEQLAGMRESSKINIAVLDYVAENIHAGMTTQD
IDDLVYKKTTEMGGIPAPLNYEGFPKSVCTSINEQVCHGIPSKNIQLLDGDIINVDCSTILNGYFSDSSRMFCIGNVAPE
HKKLVDVAKECVELGLAQVKPWGHLGDVAAAINEHAKANGYSVVREVGGHGIGLEFHETPFVSYVIKKGTGMVMAPGMVF
TIEPMINAGLPDIYIDEGNNWTIYTDDDSYSAQWEIMVHVTEDGYEVMSY
>Mature_290_residues
MKALRKDDPCWCNSGKKYCDCHMEFDRKLDNFKRKFHKVPPRNIIKNEEQLAGMRESSKINIAVLDYVAENIHAGMTTQD
IDDLVYKKTTEMGGIPAPLNYEGFPKSVCTSINEQVCHGIPSKNIQLLDGDIINVDCSTILNGYFSDSSRMFCIGNVAPE
HKKLVDVAKECVELGLAQVKPWGHLGDVAAAINEHAKANGYSVVREVGGHGIGLEFHETPFVSYVIKKGTGMVMAPGMVF
TIEPMINAGLPDIYIDEGNNWTIYTDDDSYSAQWEIMVHVTEDGYEVMSY

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=244, Percent_Identity=41.3934426229508, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI40385867, Length=245, Percent_Identity=37.5510204081633, Blast_Score=171, Evalue=5e-43,
Organism=Escherichia coli, GI1786364, Length=246, Percent_Identity=40.650406504065, Blast_Score=188, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI71996291, Length=248, Percent_Identity=39.1129032258064, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323273, Length=252, Percent_Identity=38.8888888888889, Blast_Score=186, Evalue=5e-48,
Organism=Drosophila melanogaster, GI21355531, Length=247, Percent_Identity=39.2712550607287, Blast_Score=181, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24583427, Length=259, Percent_Identity=35.5212355212355, Blast_Score=164, Evalue=8e-41,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467
- InterPro:   IPR004027 [H]

Pfam domain/function: PF00557 Peptidase_M24; PF02810 SEC-C [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 32352; Mature: 32352

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALRKDDPCWCNSGKKYCDCHMEFDRKLDNFKRKFHKVPPRNIIKNEEQLAGMRESSKI
CCCCCCCCCCEECCCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHCCHHHHHCCCCCCEE
NIAVLDYVAENIHAGMTTQDIDDLVYKKTTEMGGIPAPLNYEGFPKSVCTSINEQVCHGI
EEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
PSKNIQLLDGDIINVDCSTILNGYFSDSSRMFCIGNVAPEHKKLVDVAKECVELGLAQVK
CCCCEEEECCCEEEEEHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
PWGHLGDVAAAINEHAKANGYSVVREVGGHGIGLEFHETPFVSYVIKKGTGMVMAPGMVF
CCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEECCCCCEEHHHHCCCCEEEECCEEE
TIEPMINAGLPDIYIDEGNNWTIYTDDDSYSAQWEIMVHVTEDGYEVMSY
EEEHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEEEEEEECCCEEECCC
>Mature Secondary Structure
MKALRKDDPCWCNSGKKYCDCHMEFDRKLDNFKRKFHKVPPRNIIKNEEQLAGMRESSKI
CCCCCCCCCCEECCCCCEEEECCHHHHHHHHHHHHHHCCCCHHHHCCHHHHHCCCCCCEE
NIAVLDYVAENIHAGMTTQDIDDLVYKKTTEMGGIPAPLNYEGFPKSVCTSINEQVCHGI
EEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
PSKNIQLLDGDIINVDCSTILNGYFSDSSRMFCIGNVAPEHKKLVDVAKECVELGLAQVK
CCCCEEEECCCEEEEEHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
PWGHLGDVAAAINEHAKANGYSVVREVGGHGIGLEFHETPFVSYVIKKGTGMVMAPGMVF
CCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEECCCCCEEHHHHCCCCEEEECCEEE
TIEPMINAGLPDIYIDEGNNWTIYTDDDSYSAQWEIMVHVTEDGYEVMSY
EEEHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEEEEEEECCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]