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The map label for this gene is aroK [H]

Identifier: 238916445

GI number: 238916445

Start: 506811

End: 507335

Strand: Direct

Name: aroK [H]

Synonym: EUBELI_00502

Alternate gene names: 238916445

Gene position: 506811-507335 (Clockwise)

Preceding gene: 238916444

Following gene: 238916446

Centisome position: 23.64

GC content: 38.1

Gene sequence:

>525_bases
ATGGAGGTACACATGAATAATATTATACTTATAGGAATGCCGGGAAGCGGAAAAAGTTCGCTTGGAGTAGTACTTGCCAA
GAAGATAGGATTTGGATTCATTGATTCGGATCTTGTTATTCAGCAAAGAGAGGGAATGACTCTTGAAAGAATAATTGAAA
AGCATGGAGATGCAGGATTTATACAGATTGAAAATGAAGTGAATTGTTCAATCAGTCCGCACCACACGGTTATTGCAACT
GGTGGGAGTGCTGTATATGGAAAAGAGGCAATGGAACATTTTAAGGATATTGGTACTGTGGTTTATCTTGAACTTCCACC
AGAATCGCTCGAGGAAAGACTTGGAAGCCTTAAAGAGCGAGGCGTTGTGTCTAATGGAAAGACAACTGTAGAAGATATAT
ATGCTGACAGGGTTGCACTTTATAAGAAATATGCAGATATTACGCTTAATGAGCAGGGAAAGCAGATAAGAGAAACTGTG
GAGATGCTGTATGATATTATAATGAATAAAGACCAGTATAATTAA

Upstream 100 bases:

>100_bases
CAATTGAGGTTAACTGTCACTTCTGTAATTCACATTATACATTTACAGTTGATGAGCTTAAGGAAATGTACGACTGCTGT
ACAAGATAAATCTCAGGCAT

Downstream 100 bases:

>100_bases
ACAACTGGTTGAACTATGTAAGAATTTAGGGTAAAATAATTTTTACCCTTTTAAATACGAAAACAAGGAGGAAAAATCCT
CTCCTCACCAGAGGAGAATG

Product: shikimate kinase

Products: NA

Alternate protein names: SK [H]

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MEVHMNNIILIGMPGSGKSSLGVVLAKKIGFGFIDSDLVIQQREGMTLERIIEKHGDAGFIQIENEVNCSISPHHTVIAT
GGSAVYGKEAMEHFKDIGTVVYLELPPESLEERLGSLKERGVVSNGKTTVEDIYADRVALYKKYADITLNEQGKQIRETV
EMLYDIIMNKDQYN

Sequences:

>Translated_174_residues
MEVHMNNIILIGMPGSGKSSLGVVLAKKIGFGFIDSDLVIQQREGMTLERIIEKHGDAGFIQIENEVNCSISPHHTVIAT
GGSAVYGKEAMEHFKDIGTVVYLELPPESLEERLGSLKERGVVSNGKTTVEDIYADRVALYKKYADITLNEQGKQIRETV
EMLYDIIMNKDQYN
>Mature_174_residues
MEVHMNNIILIGMPGSGKSSLGVVLAKKIGFGFIDSDLVIQQREGMTLERIIEKHGDAGFIQIENEVNCSISPHHTVIAT
GGSAVYGKEAMEHFKDIGTVVYLELPPESLEERLGSLKERGVVSNGKTTVEDIYADRVALYKKYADITLNEQGKQIRETV
EMLYDIIMNKDQYN

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate [H]

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=164, Percent_Identity=30.4878048780488, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI87082255, Length=147, Percent_Identity=32.6530612244898, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI1786587, Length=168, Percent_Identity=31.547619047619, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000623
- InterPro:   IPR023000 [H]

Pfam domain/function: PF01202 SKI [H]

EC number: =2.7.1.71 [H]

Molecular weight: Translated: 19346; Mature: 19346

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVHMNNIILIGMPGSGKSSLGVVLAKKIGFGFIDSDLVIQQREGMTLERIIEKHGDAGF
CEEECCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHCCCCCE
IQIENEVNCSISPHHTVIATGGSAVYGKEAMEHFKDIGTVVYLELPPESLEERLGSLKER
EEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHC
GVVSNGKTTVEDIYADRVALYKKYADITLNEQGKQIRETVEMLYDIIMNKDQYN
CCCCCCCHHHHHHHHHHHHHHHHHHCEEECCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEVHMNNIILIGMPGSGKSSLGVVLAKKIGFGFIDSDLVIQQREGMTLERIIEKHGDAGF
CEEECCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHCCCCCE
IQIENEVNCSISPHHTVIATGGSAVYGKEAMEHFKDIGTVVYLELPPESLEERLGSLKER
EEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHC
GVVSNGKTTVEDIYADRVALYKKYADITLNEQGKQIRETVEMLYDIIMNKDQYN
CCCCCCCHHHHHHHHHHHHHHHHHHCEEECCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA