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The map label for this gene is hom [H]

Identifier: 238916336

GI number: 238916336

Start: 400796

End: 402013

Strand: Direct

Name: hom [H]

Synonym: EUBELI_00370

Alternate gene names: 238916336

Gene position: 400796-402013 (Clockwise)

Preceding gene: 238916335

Following gene: 238916337

Centisome position: 18.69

GC content: 39.16

Gene sequence:

>1218_bases
ATGGCAAAGATTGCAGTGTTAGGTTATGGAACAGTAGGATCAGGAGTGGTTGAGGTATTAAATACCAATGGTGCTTCAAT
TGCAAAGAGAGCAGGAGATACTATTGAGGTTAAGAGTGTACTTGATTTAAGAGATTTTCCTGGAGATCCAATTCAGGATA
AAATCGTTCATGATATAGATCTTATAATTAATGACCCTGAGATAGAGGTTGTTGTTGAGGTTATGGGTGGTGTAGAGCCG
GCATTTACATTTGTTAAGAAGGCACTTGAAGCAGGAAAGAGTGTGTGTACATCTAATAAGGCACTTGTTGCTGCACACGG
TCCGGAGCTTCTTGAGATGGCTAAAGAAAGAAAACTTAATTTCATGTTTGAGGCATCAGTAGGCGGTGGAATTCCAATTA
TCAGACCGCTTAACCAGTCTCTTACAGCAGATGAGATTACTAAGATTACAGGTATTCTTAATGGAACAACTAACTATATT
CTTACTAAGATGAGCAGAGAAGGAATCTCATATCAGGAGGTTCTTAAAGAGGCACAGGCACTCGGATATGCAGAAAGAAA
TCCGGAGGCTGATGTTGAAGGTTACGATGCATGCAGAAAAATAGCAATTCTTACATCACTTGCATTTGGAAATACAGTGA
AATTCGAGGAAGTGTATACAGAGGGAATAACAAAGATTTCTAATGAAGATTTTGCATATGCTAAAGAACTTGGATGCGTT
ATCAAACTTCTTGCAACAAGCTACAGCAAGGATGGCAAGGTATATGCAATAACAGCACCATTCATGATTGACAGCACACA
TCCATTATATAATGTTAATGACGTTCTTAACGGAATCTATGTACACGGCAATGTATTAGGAGATGTAATGTTCTTCGGAG
CAGGAGCAGGAAAGCTTCCAACAGCAAGTGCTGTAGTATCAGATGTAGTTGACTGTGTTAAGCATAAGGGTAAAAATGTT
ATGACAATCTGGAGTTCAGTAAAGCAGGAGCTTGGTGATACATTTGACGAGACAAGAAGATTCTTTGTAAGAATTAAGGG
CGATGATGTCCAGGCAGCCAAGGCAGCATTTGGTGAAGGACAGGTTGTTAAGGTTGATGGAATTAACGGAGAGTTCGGAT
TTGTTACAGAGCCTATGACAGAGAGAGCATTTGAAGATGCTAAGGATAAGGTTTCTGTTATAAGCAGAATCAGAATAGAT
GATACTAAATTACAGTAA

Upstream 100 bases:

>100_bases
TAGAGCAGATAGAAAGACTTAAAGGGGTAAGATATCTTAAGATATTAAGCAGTGATGCATCTATCTGATATATAAGCAAT
TAAAGAAAACGGAGGCAGAT

Downstream 100 bases:

>100_bases
TAATATAAGGGAGTAAGAGTAATGGTTAAAGTAGTTAAATTTGGTGGAAGTTCACTTGCAAGCGCAGAGCAGTTTAAGAA
GGTTGGTAATATTATCCGTG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MAKIAVLGYGTVGSGVVEVLNTNGASIAKRAGDTIEVKSVLDLRDFPGDPIQDKIVHDIDLIINDPEIEVVVEVMGGVEP
AFTFVKKALEAGKSVCTSNKALVAAHGPELLEMAKERKLNFMFEASVGGGIPIIRPLNQSLTADEITKITGILNGTTNYI
LTKMSREGISYQEVLKEAQALGYAERNPEADVEGYDACRKIAILTSLAFGNTVKFEEVYTEGITKISNEDFAYAKELGCV
IKLLATSYSKDGKVYAITAPFMIDSTHPLYNVNDVLNGIYVHGNVLGDVMFFGAGAGKLPTASAVVSDVVDCVKHKGKNV
MTIWSSVKQELGDTFDETRRFFVRIKGDDVQAAKAAFGEGQVVKVDGINGEFGFVTEPMTERAFEDAKDKVSVISRIRID
DTKLQ

Sequences:

>Translated_405_residues
MAKIAVLGYGTVGSGVVEVLNTNGASIAKRAGDTIEVKSVLDLRDFPGDPIQDKIVHDIDLIINDPEIEVVVEVMGGVEP
AFTFVKKALEAGKSVCTSNKALVAAHGPELLEMAKERKLNFMFEASVGGGIPIIRPLNQSLTADEITKITGILNGTTNYI
LTKMSREGISYQEVLKEAQALGYAERNPEADVEGYDACRKIAILTSLAFGNTVKFEEVYTEGITKISNEDFAYAKELGCV
IKLLATSYSKDGKVYAITAPFMIDSTHPLYNVNDVLNGIYVHGNVLGDVMFFGAGAGKLPTASAVVSDVVDCVKHKGKNV
MTIWSSVKQELGDTFDETRRFFVRIKGDDVQAAKAAFGEGQVVKVDGINGEFGFVTEPMTERAFEDAKDKVSVISRIRID
DTKLQ
>Mature_404_residues
AKIAVLGYGTVGSGVVEVLNTNGASIAKRAGDTIEVKSVLDLRDFPGDPIQDKIVHDIDLIINDPEIEVVVEVMGGVEPA
FTFVKKALEAGKSVCTSNKALVAAHGPELLEMAKERKLNFMFEASVGGGIPIIRPLNQSLTADEITKITGILNGTTNYIL
TKMSREGISYQEVLKEAQALGYAERNPEADVEGYDACRKIAILTSLAFGNTVKFEEVYTEGITKISNEDFAYAKELGCVI
KLLATSYSKDGKVYAITAPFMIDSTHPLYNVNDVLNGIYVHGNVLGDVMFFGAGAGKLPTASAVVSDVVDCVKHKGKNVM
TIWSSVKQELGDTFDETRRFFVRIKGDDVQAAKAAFGEGQVVKVDGINGEFGFVTEPMTERAFEDAKDKVSVISRIRIDD
TKLQ

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=252, Percent_Identity=27.3809523809524, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322599, Length=225, Percent_Identity=29.3333333333333, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 43808; Mature: 43676

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIAVLGYGTVGSGVVEVLNTNGASIAKRAGDTIEVKSVLDLRDFPGDPIQDKIVHDID
CCEEEEEECCCCCHHHHHHHCCCCHHHHHHCCCEEEEHHHHHHHCCCCCCHHHHHHHEEE
LIINDPEIEVVVEVMGGVEPAFTFVKKALEAGKSVCTSNKALVAAHGPELLEMAKERKLN
EEECCCCCEEHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCE
FMFEASVGGGIPIIRPLNQSLTADEITKITGILNGTTNYILTKMSREGISYQEVLKEAQA
EEEEECCCCCCCEECCCCCCCCHHHHHHHHHHHCCCHHHEEEHHHHCCCCHHHHHHHHHH
LGYAERNPEADVEGYDACRKIAILTSLAFGNTVKFEEVYTEGITKISNEDFAYAKELGCV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHH
IKLLATSYSKDGKVYAITAPFMIDSTHPLYNVNDVLNGIYVHGNVLGDVMFFGAGAGKLP
HHHHHHCCCCCCEEEEEECCEEECCCCCCEEHHHHHCCEEEECHHHHHHHHCCCCCCCCC
TASAVVSDVVDCVKHKGKNVMTIWSSVKQELGDTFDETRRFFVRIKGDDVQAAKAAFGEG
HHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCHHHHCEEEEEECCCCHHHHHHHCCCC
QVVKVDGINGEFGFVTEPMTERAFEDAKDKVSVISRIRIDDTKLQ
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AKIAVLGYGTVGSGVVEVLNTNGASIAKRAGDTIEVKSVLDLRDFPGDPIQDKIVHDID
CEEEEEECCCCCHHHHHHHCCCCHHHHHHCCCEEEEHHHHHHHCCCCCCHHHHHHHEEE
LIINDPEIEVVVEVMGGVEPAFTFVKKALEAGKSVCTSNKALVAAHGPELLEMAKERKLN
EEECCCCCEEHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCE
FMFEASVGGGIPIIRPLNQSLTADEITKITGILNGTTNYILTKMSREGISYQEVLKEAQA
EEEEECCCCCCCEECCCCCCCCHHHHHHHHHHHCCCHHHEEEHHHHCCCCHHHHHHHHHH
LGYAERNPEADVEGYDACRKIAILTSLAFGNTVKFEEVYTEGITKISNEDFAYAKELGCV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCHHHHHHHHHH
IKLLATSYSKDGKVYAITAPFMIDSTHPLYNVNDVLNGIYVHGNVLGDVMFFGAGAGKLP
HHHHHHCCCCCCEEEEEECCEEECCCCCCEEHHHHHCCEEEECHHHHHHHHCCCCCCCCC
TASAVVSDVVDCVKHKGKNVMTIWSSVKQELGDTFDETRRFFVRIKGDDVQAAKAAFGEG
HHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHCCCHHHHCEEEEEECCCCHHHHHHHCCCC
QVVKVDGINGEFGFVTEPMTERAFEDAKDKVSVISRIRIDDTKLQ
CEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]