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The map label for this gene is pncB [H]

Identifier: 238916129

GI number: 238916129

Start: 189878

End: 191365

Strand: Direct

Name: pncB [H]

Synonym: EUBELI_00163

Alternate gene names: 238916129

Gene position: 189878-191365 (Clockwise)

Preceding gene: 238916128

Following gene: 238916130

Centisome position: 8.86

GC content: 39.92

Gene sequence:

>1488_bases
ATGAATAGTACATTTTTCTTTGAAAAAGGAGTAGTTATGAAGAAACAGTTTGATGAGAGAAATCTTACAATGGTAATGGA
TTTTTATGAACTTACAATGGCTAATGGTTATTTTAAGGATGAGGACAAGGAAAGAAAGGTTGCATTTGATGTGTTCTACA
GAAAGAATCCTGATAATGCCGGATATGCTATATTTGCAGGTCTTGAACAGATTATTGAATATATAGAGAATCTGCATTTT
GATGAAGATGATATTGAATACTTAAGAGGTCAGGGGCTTTTTGGGGAAGAATTCCTTGCATACCTTGCTGATTTTAAGTT
CAGGGGAGATATTTATTCATTCCCGGAAGGAACTATTATGTATCCTAATGAACCTGTAATTACTGTTGTTGCACCATTAC
TTGATGCACAGCTTGTTGAGACTGCAATTCTTCTTCAGGTTAACCACCAGTCACTTATTGCAACTAAGACAAGAAGAATC
GTGCGTTCAGCTAAGGGACGTGCTGTATCAGATTTCGGCGCGAGACGTGCACATAACATGGATGCAGCAGTATATGGTGC
AAGGGCAGCTTATATAGGTGGTGCGGTTGGAACAGCTACTGTTCTTGCCGGTCAGATGTTTAATATTCCAATCAGTGGAA
CAATGGCACACAGCTGGGTAATGTTCTATCGTGATGAATTTGAAGCATTTAAGCATTATGCAGAGAATTACCCGGATGCA
ACTGTGCTTCTTGTAGATACTTATGATGTTGTTAAATCAGGTATTCCTAATGCCATCAGATGTGCAAAGGAAGTGCTTGA
GCCAATGGGCAAGCGTCTTAAGGGCATCCGTCTTGACAGTGGTGACCTTGCATACCTATCTAAGAAGGTAAGAAAAATGC
TTGATGATGCGGGGCTTACTGACTGCAAGATAGTTGTTTCCAACAGTCTTGATGAATGGACTATTATGTCAATCTTAGAG
CAGGGCGGCTGCATTGACAGCTTTGGTGTAGGTGAGAGACTTATAACAGCAAAGTCTGATCCTGTATTTGGAGCTGTGTA
CAAGATTGCAGCAGTAGAGGAGAATGGAGTATTCCAGCCAAGAATTAAGATTTCTGAAAATGTTGAGAAGATAACGAACC
CGGGACTTAAGAAGGTTTACAGAATATATGACGAGAATAAAAAGGCAATAGCAGACCTTATAGCAGGTGCTGATGAGGTT
GTTGACCTTTCAAAGCCTTACCGCTATGTAGACCCTGTAAAGCCTTGGAAGAACAGATACTTTGAAAACTGCACAGCAGT
AGAGTTACAGCAGCTTGTTGTAAAGAACGGCAAGCGTGTAATGGACAGAGTATCTATTGATGAGATTAAGAAGTATGTTC
AGGATCAGCTCACTGATAATATATGGGAAGAAGAGCAGAGATTTGAGAATCCTCATAACCATTATCTTGACATGAGCCCG
GCATATTATGATATGAAGATGTCACTTCTTCATAAGTTGACAGACTAG

Upstream 100 bases:

>100_bases
ACAATAAGTATATATCTTGTGTATGGAATGGAAGTGAATTGTGAACATCTTTCAGATTGTGATATGCAGATAACAATAAC
AACCAGAGAACTTAGAATTG

Downstream 100 bases:

>100_bases
GGGAGAAGTGGCAGACGGACGGGCGCATAGTGTGTATATGTTGCATCGTAAGACACGCTTCCGCTCGTGGAAAGGCGTAG
CGGTACTAGGCGCACTGCCT

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MNSTFFFEKGVVMKKQFDERNLTMVMDFYELTMANGYFKDEDKERKVAFDVFYRKNPDNAGYAIFAGLEQIIEYIENLHF
DEDDIEYLRGQGLFGEEFLAYLADFKFRGDIYSFPEGTIMYPNEPVITVVAPLLDAQLVETAILLQVNHQSLIATKTRRI
VRSAKGRAVSDFGARRAHNMDAAVYGARAAYIGGAVGTATVLAGQMFNIPISGTMAHSWVMFYRDEFEAFKHYAENYPDA
TVLLVDTYDVVKSGIPNAIRCAKEVLEPMGKRLKGIRLDSGDLAYLSKKVRKMLDDAGLTDCKIVVSNSLDEWTIMSILE
QGGCIDSFGVGERLITAKSDPVFGAVYKIAAVEENGVFQPRIKISENVEKITNPGLKKVYRIYDENKKAIADLIAGADEV
VDLSKPYRYVDPVKPWKNRYFENCTAVELQQLVVKNGKRVMDRVSIDEIKKYVQDQLTDNIWEEEQRFENPHNHYLDMSP
AYYDMKMSLLHKLTD

Sequences:

>Translated_495_residues
MNSTFFFEKGVVMKKQFDERNLTMVMDFYELTMANGYFKDEDKERKVAFDVFYRKNPDNAGYAIFAGLEQIIEYIENLHF
DEDDIEYLRGQGLFGEEFLAYLADFKFRGDIYSFPEGTIMYPNEPVITVVAPLLDAQLVETAILLQVNHQSLIATKTRRI
VRSAKGRAVSDFGARRAHNMDAAVYGARAAYIGGAVGTATVLAGQMFNIPISGTMAHSWVMFYRDEFEAFKHYAENYPDA
TVLLVDTYDVVKSGIPNAIRCAKEVLEPMGKRLKGIRLDSGDLAYLSKKVRKMLDDAGLTDCKIVVSNSLDEWTIMSILE
QGGCIDSFGVGERLITAKSDPVFGAVYKIAAVEENGVFQPRIKISENVEKITNPGLKKVYRIYDENKKAIADLIAGADEV
VDLSKPYRYVDPVKPWKNRYFENCTAVELQQLVVKNGKRVMDRVSIDEIKKYVQDQLTDNIWEEEQRFENPHNHYLDMSP
AYYDMKMSLLHKLTD
>Mature_495_residues
MNSTFFFEKGVVMKKQFDERNLTMVMDFYELTMANGYFKDEDKERKVAFDVFYRKNPDNAGYAIFAGLEQIIEYIENLHF
DEDDIEYLRGQGLFGEEFLAYLADFKFRGDIYSFPEGTIMYPNEPVITVVAPLLDAQLVETAILLQVNHQSLIATKTRRI
VRSAKGRAVSDFGARRAHNMDAAVYGARAAYIGGAVGTATVLAGQMFNIPISGTMAHSWVMFYRDEFEAFKHYAENYPDA
TVLLVDTYDVVKSGIPNAIRCAKEVLEPMGKRLKGIRLDSGDLAYLSKKVRKMLDDAGLTDCKIVVSNSLDEWTIMSILE
QGGCIDSFGVGERLITAKSDPVFGAVYKIAAVEENGVFQPRIKISENVEKITNPGLKKVYRIYDENKKAIADLIAGADEV
VDLSKPYRYVDPVKPWKNRYFENCTAVELQQLVVKNGKRVMDRVSIDEIKKYVQDQLTDNIWEEEQRFENPHNHYLDMSP
AYYDMKMSLLHKLTD

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=522, Percent_Identity=27.2030651340996, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71997952, Length=532, Percent_Identity=31.9548872180451, Blast_Score=270, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI71997947, Length=532, Percent_Identity=31.9548872180451, Blast_Score=270, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI71997955, Length=217, Percent_Identity=36.405529953917, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24581587, Length=519, Percent_Identity=32.9479768786127, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI161076680, Length=277, Percent_Identity=32.8519855595668, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24581595, Length=277, Percent_Identity=32.8519855595668, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI28574709, Length=277, Percent_Identity=32.8519855595668, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24581593, Length=277, Percent_Identity=32.8519855595668, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24581591, Length=277, Percent_Identity=32.8519855595668, Blast_Score=149, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 56354; Mature: 56354

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSTFFFEKGVVMKKQFDERNLTMVMDFYELTMANGYFKDEDKERKVAFDVFYRKNPDNA
CCCCEEEECCCHHHHHCCCCCCEEEEHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCC
GYAIFAGLEQIIEYIENLHFDEDDIEYLRGQGLFGEEFLAYLADFKFRGDIYSFPEGTIM
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEECCCCEEE
YPNEPVITVVAPLLDAQLVETAILLQVNHQSLIATKTRRIVRSAKGRAVSDFGARRAHNM
CCCCCHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
DAAVYGARAAYIGGAVGTATVLAGQMFNIPISGTMAHSWVMFYRDEFEAFKHYAENYPDA
CHHHHCCHHHHHCCHHHHHHHHHCHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
TVLLVDTYDVVKSGIPNAIRCAKEVLEPMGKRLKGIRLDSGDLAYLSKKVRKMLDDAGLT
EEEEEECHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
DCKIVVSNSLDEWTIMSILEQGGCIDSFGVGERLITAKSDPVFGAVYKIAAVEENGVFQP
EEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHEEEEEECCCCCCCC
RIKISENVEKITNPGLKKVYRIYDENKKAIADLIAGADEVVDLSKPYRYVDPVKPWKNRY
CEEHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHH
FENCTAVELQQLVVKNGKRVMDRVSIDEIKKYVQDQLTDNIWEEEQRFENPHNHYLDMSP
HCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCC
AYYDMKMSLLHKLTD
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MNSTFFFEKGVVMKKQFDERNLTMVMDFYELTMANGYFKDEDKERKVAFDVFYRKNPDNA
CCCCEEEECCCHHHHHCCCCCCEEEEHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCCC
GYAIFAGLEQIIEYIENLHFDEDDIEYLRGQGLFGEEFLAYLADFKFRGDIYSFPEGTIM
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEECCCCEEE
YPNEPVITVVAPLLDAQLVETAILLQVNHQSLIATKTRRIVRSAKGRAVSDFGARRAHNM
CCCCCHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
DAAVYGARAAYIGGAVGTATVLAGQMFNIPISGTMAHSWVMFYRDEFEAFKHYAENYPDA
CHHHHCCHHHHHCCHHHHHHHHHCHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
TVLLVDTYDVVKSGIPNAIRCAKEVLEPMGKRLKGIRLDSGDLAYLSKKVRKMLDDAGLT
EEEEEECHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
DCKIVVSNSLDEWTIMSILEQGGCIDSFGVGERLITAKSDPVFGAVYKIAAVEENGVFQP
EEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHEEEEEECCCCCCCC
RIKISENVEKITNPGLKKVYRIYDENKKAIADLIAGADEVVDLSKPYRYVDPVKPWKNRY
CEEHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHCCHHHHHCCCCCCCCCCCCHHHHHH
FENCTAVELQQLVVKNGKRVMDRVSIDEIKKYVQDQLTDNIWEEEQRFENPHNHYLDMSP
HCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCC
AYYDMKMSLLHKLTD
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]