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The map label for this gene is yoeA [H]

Identifier: 238916122

GI number: 238916122

Start: 184502

End: 185884

Strand: Reverse

Name: yoeA [H]

Synonym: EUBELI_00156

Alternate gene names: 238916122

Gene position: 185884-184502 (Counterclockwise)

Preceding gene: 238916123

Following gene: 238916121

Centisome position: 8.67

GC content: 39.48

Gene sequence:

>1383_bases
ATGGCAAAACCAATAAGTGAAGATAAAAGAAATATGATTCTTAATGGTAATCTCTTTCATGCAATTCTCATGCTTGCAAT
TCCTGTTATGATCAATAGTTTTATCCAGTCAATGTACAATCTTACAGATACTTTCTGGCTTGGAAGAATAGGTACTGAGA
ACCAGTCGGCTATCACGCTTGTTTCACCTTTCCAGAATATCCTGATTAATTTCGGTAACGGCATAACAACTGCAGGTGCA
ATTCTTATATCACAGTACCTCGGTGCAAGAGAGGATGAACAGGCTAATTCAATGGCTAACCACATCTGCCTTACTTCACT
TGCATTTTCAGTATTATGCGCACTTATATGCTGGCTTGTCTCTCCGGGACTTGTGAAATGGCTCGGTGCTGAAGGAAGTA
TATATAAATACGGACTTACATACATAAGAATTGTAGTACTTGATCTGCCTTTTCTGTTTACCATTAACCTTTTCACATCA
GTCAAACAGTCTCAGGGCGACACAGTAAAACCAATGCTTCTTAATATGTTTGGCGTTGTTATTAATCTTATATTAGACCC
GTTATTCCTTATGGTTTTCAAATGGGGTATCGGTGGTGCTGCCCTTGCAACTCTCATTGCCAAAATTCCATGTGCAGTTA
TTGCACTTATTGTACTTACAAGACCAGGACAGCTTATCAGAATTGATTTCAGGGGATTTAAGTTTGATAAAAGCAAGATG
GGTTCGATTGTAAAAATCGGACTTCCTACCGCAATCGGAGGAAGCACTATGCAGCTTGGTTTCCTTCTTATGACTAAAAA
TGTTAATGCTTACGGATTTATTGCAACAAGCGCTTATGGTATCGGAAACAAAATAAACAGCATCATTACAATGCCTGCAA
ATGGTATCGGCTCTGCCATATCAACTATCGTAGGGCAAAATATTGGTGCCAGACAGAAAGACAGAGCAGACAAAGCTTAC
CATTACGCACTCCGTATGGGTGCACTGTTTCTGTTATTCTTTGGTTTGATTCTGTCAAGAAGATTTATATCGCAGACTAT
GGTAACATTTTTCTCAACTGATGAAAGAGTTATTCCGCTGGCAACAGATTTCCTATCACTTATGGCATTCTGGTGCTGGA
GCAACGCATTTTACAATGTCACCCAGGGACTTTTTCAAGGAAGCGGTCACACCATGATAACCATGATTGTCGACGCTTCA
AGAATCTGGATATTCCGTCTGCTAACCCTCTGGGTATGTGCCAATGTGCTTAATATGGGGGTTGAATCTGTATGGTACGC
TGTTGTTATCAGTAATGGAACTTCTGCTGCCATACTTTATGGTCTCTATTGGACAGGAATATGGAAGAAATCTACTATAA
AAATTGAAAAAACAGAAGGTTAA

Upstream 100 bases:

>100_bases
ATAAAAGACTTTGAAATGTCAACAAAAAATCAGTATTTTAATTATTTTTCTGTATTAAAGAAGCATTTTCAACACGTTTA
TTAAGATAAGGGGGCTTATC

Downstream 100 bases:

>100_bases
TTAAAGAAATACATTTACCGATATACACTATAGAAATACTACAATAAAAGTCCAAGGAGGGATATCATGTCATTAAACGG
AGTTAATTCAAATTATCAGG

Product: MATE family multidrug resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MAKPISEDKRNMILNGNLFHAILMLAIPVMINSFIQSMYNLTDTFWLGRIGTENQSAITLVSPFQNILINFGNGITTAGA
ILISQYLGAREDEQANSMANHICLTSLAFSVLCALICWLVSPGLVKWLGAEGSIYKYGLTYIRIVVLDLPFLFTINLFTS
VKQSQGDTVKPMLLNMFGVVINLILDPLFLMVFKWGIGGAALATLIAKIPCAVIALIVLTRPGQLIRIDFRGFKFDKSKM
GSIVKIGLPTAIGGSTMQLGFLLMTKNVNAYGFIATSAYGIGNKINSIITMPANGIGSAISTIVGQNIGARQKDRADKAY
HYALRMGALFLLFFGLILSRRFISQTMVTFFSTDERVIPLATDFLSLMAFWCWSNAFYNVTQGLFQGSGHTMITMIVDAS
RIWIFRLLTLWVCANVLNMGVESVWYAVVISNGTSAAILYGLYWTGIWKKSTIKIEKTEG

Sequences:

>Translated_460_residues
MAKPISEDKRNMILNGNLFHAILMLAIPVMINSFIQSMYNLTDTFWLGRIGTENQSAITLVSPFQNILINFGNGITTAGA
ILISQYLGAREDEQANSMANHICLTSLAFSVLCALICWLVSPGLVKWLGAEGSIYKYGLTYIRIVVLDLPFLFTINLFTS
VKQSQGDTVKPMLLNMFGVVINLILDPLFLMVFKWGIGGAALATLIAKIPCAVIALIVLTRPGQLIRIDFRGFKFDKSKM
GSIVKIGLPTAIGGSTMQLGFLLMTKNVNAYGFIATSAYGIGNKINSIITMPANGIGSAISTIVGQNIGARQKDRADKAY
HYALRMGALFLLFFGLILSRRFISQTMVTFFSTDERVIPLATDFLSLMAFWCWSNAFYNVTQGLFQGSGHTMITMIVDAS
RIWIFRLLTLWVCANVLNMGVESVWYAVVISNGTSAAILYGLYWTGIWKKSTIKIEKTEG
>Mature_459_residues
AKPISEDKRNMILNGNLFHAILMLAIPVMINSFIQSMYNLTDTFWLGRIGTENQSAITLVSPFQNILINFGNGITTAGAI
LISQYLGAREDEQANSMANHICLTSLAFSVLCALICWLVSPGLVKWLGAEGSIYKYGLTYIRIVVLDLPFLFTINLFTSV
KQSQGDTVKPMLLNMFGVVINLILDPLFLMVFKWGIGGAALATLIAKIPCAVIALIVLTRPGQLIRIDFRGFKFDKSKMG
SIVKIGLPTAIGGSTMQLGFLLMTKNVNAYGFIATSAYGIGNKINSIITMPANGIGSAISTIVGQNIGARQKDRADKAYH
YALRMGALFLLFFGLILSRRFISQTMVTFFSTDERVIPLATDFLSLMAFWCWSNAFYNVTQGLFQGSGHTMITMIVDASR
IWIFRLLTLWVCANVLNMGVESVWYAVVISNGTSAAILYGLYWTGIWKKSTIKIEKTEG

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=449, Percent_Identity=21.6035634743875, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI226510954, Length=456, Percent_Identity=21.9298245614035, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 50650; Mature: 50519

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKPISEDKRNMILNGNLFHAILMLAIPVMINSFIQSMYNLTDTFWLGRIGTENQSAITL
CCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEE
VSPFQNILINFGNGITTAGAILISQYLGAREDEQANSMANHICLTSLAFSVLCALICWLV
ECHHHHHHEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SPGLVKWLGAEGSIYKYGLTYIRIVVLDLPFLFTINLFTSVKQSQGDTVKPMLLNMFGVV
CCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
INLILDPLFLMVFKWGIGGAALATLIAKIPCAVIALIVLTRPGQLIRIDFRGFKFDKSKM
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEECHHHC
GSIVKIGLPTAIGGSTMQLGFLLMTKNVNAYGFIATSAYGIGNKINSIITMPANGIGSAI
CCEEEECCCCCCCCCHHEEEEEEEECCCCEEEEEEECCCCCCCCCCCEEEECCCCHHHHH
STIVGQNIGARQKDRADKAYHYALRMGALFLLFFGLILSRRFISQTMVTFFSTDERVIPL
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHH
ATDFLSLMAFWCWSNAFYNVTQGLFQGSGHTMITMIVDASRIWIFRLLTLWVCANVLNMG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHC
VESVWYAVVISNGTSAAILYGLYWTGIWKKSTIKIEKTEG
HHHEEEEEEEECCCCHHHHHHHHHHCEEECCEEEEEECCC
>Mature Secondary Structure 
AKPISEDKRNMILNGNLFHAILMLAIPVMINSFIQSMYNLTDTFWLGRIGTENQSAITL
CCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEEE
VSPFQNILINFGNGITTAGAILISQYLGAREDEQANSMANHICLTSLAFSVLCALICWLV
ECHHHHHHEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SPGLVKWLGAEGSIYKYGLTYIRIVVLDLPFLFTINLFTSVKQSQGDTVKPMLLNMFGVV
CCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
INLILDPLFLMVFKWGIGGAALATLIAKIPCAVIALIVLTRPGQLIRIDFRGFKFDKSKM
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEECHHHC
GSIVKIGLPTAIGGSTMQLGFLLMTKNVNAYGFIATSAYGIGNKINSIITMPANGIGSAI
CCEEEECCCCCCCCCHHEEEEEEEECCCCEEEEEEECCCCCCCCCCCEEEECCCCHHHHH
STIVGQNIGARQKDRADKAYHYALRMGALFLLFFGLILSRRFISQTMVTFFSTDERVIPL
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHH
ATDFLSLMAFWCWSNAFYNVTQGLFQGSGHTMITMIVDASRIWIFRLLTLWVCANVLNMG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHC
VESVWYAVVISNGTSAAILYGLYWTGIWKKSTIKIEKTEG
HHHEEEEEEEECCCCHHHHHHHHHHCEEECCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]