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The map label for this gene is capD [H]

Identifier: 238916049

GI number: 238916049

Start: 88033

End: 89898

Strand: Direct

Name: capD [H]

Synonym: EUBELI_00082

Alternate gene names: 238916049

Gene position: 88033-89898 (Clockwise)

Preceding gene: 238916048

Following gene: 238916050

Centisome position: 4.11

GC content: 36.44

Gene sequence:

>1866_bases
ATGATGGGTGAAACTAAAAAGGACAGAATACAGCTTCTGGTAAGAAGATTTTTCTTGTTTTTAACAGATACATTTTTACT
GAATGCATGTGTATATCTGTCGCTTATTATGAGATTTGATGTAGGTATTGTATCTATTGAACCTCAATATATTAACAATT
ATGTAGACAATATGCTGTTCTATACAATAATATCGCTGCTTATATTCTGGGTGTTCAGATTATATCACAGTCTGTGGCAG
TATGCGAGTATAGCTGAGGTGTACAGGATTGCTGAAGCATGTATTACTGTAGAAGTGGTACATTTCTTAAGTAATAAGAT
GGTGGGTAATATGCTTCCTAGAAGCTGCTATTTTAATGCGGCAATATACCTTATTATTGCAATATGTGCAAGTCGTTTTA
TGTACAGAATGATAAGAACTGTTCTTAACAAATACAGAAATATTAAGACTTCCAACAATGTAATGATTATTGGTGCCGGA
GAGGCAACTAATGTCATTATGAGAGAAATACAGAATTCGAGCTATCTTGCCAATTCTAATATTGCATGTATTATTGATGA
TGACCGCCGCAAGGTTGGTAAATACATACGAGGCGTCAAGGTTATAGGAACAAGGGACAAGATTAAGGAAGCAGCAAAGC
TTTATGATATTGATGAGATTATATTTGCAATTCCATCAGCATCTAATGAAGTTAAAAGGGATATATTAAACATTTGTAAA
GAGACTGATTGTACTCTTAAGATTCTGCCAGGTGTATATCAGATGGTAGATGGAGAGATTAATGTTAATTCTATCCGTAA
TGTTGATGTGCTTGACCTTCTTGGAAGAGACCCGATTGAAGTAGATATTGAATCTATCATGGGTTATGTTAAGGATAAGG
TCATTATGGTAACAGGTGGTGGCGGTTCTATTGGTTCAGAGCTGTGCCGCCAGCTTGTAAGTCACAAGCCTAAGCAGCTC
ATTATATTTGATATATATGAGAATAATGCCTATGATATTCAGCAGGAATTAAAGATTAATTATCCTGATGCCAATGTTGT
TACTCTTATTGGTTCGATAAGAAATGTTTCAAGACTTGAAAGCGTATTTGCACAGTATAAGCCAGATATTGTATATCATG
CAGCAGCACATAAGCATGTACCGCTTATGGAAGTCAGTCCTGATGAGGCTGTTAAGAATAATGTTGTTGGTACATGGAAT
GTTGCAAGGATGGCTGATAAGTATGGGGTTAAGAAGTTTGTTATGATAAGTACAGATAAGGCTGTTAATCCAACTAATGT
AATGGGAGCAACAAAGCGTATCTGTGAGATGATTGTTCAGACATATAACGGGATATCCAAGACAGATTTCGTTGCTGTAA
GATTCGGTAATGTACTTGGAAGTAACGGCTCAGTCATTCCTCTTTTTAAGAGACAGATTGAGGCTGGCGGACCGGTTACG
GTTACAGATCCTAATATTATAAGATATTTCATGACTATACCAGAGGCGGTTTCACTTGTTCTTCAGGCAGGTGCATATGC
CAAAGGTGGAGAGATATTCATTCTTGATATGGGTGAGCCTGTTAAGATTGATGACCTCGCAAAGAACCTTATCAGATTGT
CAGGTTATACACTTGGCGTTGATATGGAGATTAAATATACGGGACTCAGACCAGGAGAAAAATTATATGAGGAACTTCTT
ATGAAAGAGGAAGGACTTCAGGAGACAGACAACAAGCTTATTCACATTGGAAAACCAATTGAGTTTGATAAAGAGAATTT
CTTTAATAACCTTGAGAAGCTTAAGGAAGAAGCTTATTCAGAAACAGGTAATATAAGAGAATCACTTAAGAAGGTGGTTG
TTACTTACCATCCGGATGAACATTAA

Upstream 100 bases:

>100_bases
TTGCATTGCCATTTTTATTTTTTCTGTTGCATATTTCTTATGGAATTGGTACAGTATGTGGGTTAGCAGCTAAAAAGCCT
GCTAAAGAAACGAGGAACTG

Downstream 100 bases:

>100_bases
TTTTATCTGGCTATAGAATGTATTTATATGGGGGAGAAGGTATATGGGGATATATCAGAAGTTAAAGTTTTTTATTGGAA
AGGTAACTGTGCTTATTATG

Product: hypothetical protein

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 621; Mature: 621

Protein sequence:

>621_residues
MMGETKKDRIQLLVRRFFLFLTDTFLLNACVYLSLIMRFDVGIVSIEPQYINNYVDNMLFYTIISLLIFWVFRLYHSLWQ
YASIAEVYRIAEACITVEVVHFLSNKMVGNMLPRSCYFNAAIYLIIAICASRFMYRMIRTVLNKYRNIKTSNNVMIIGAG
EATNVIMREIQNSSYLANSNIACIIDDDRRKVGKYIRGVKVIGTRDKIKEAAKLYDIDEIIFAIPSASNEVKRDILNICK
ETDCTLKILPGVYQMVDGEINVNSIRNVDVLDLLGRDPIEVDIESIMGYVKDKVIMVTGGGGSIGSELCRQLVSHKPKQL
IIFDIYENNAYDIQQELKINYPDANVVTLIGSIRNVSRLESVFAQYKPDIVYHAAAHKHVPLMEVSPDEAVKNNVVGTWN
VARMADKYGVKKFVMISTDKAVNPTNVMGATKRICEMIVQTYNGISKTDFVAVRFGNVLGSNGSVIPLFKRQIEAGGPVT
VTDPNIIRYFMTIPEAVSLVLQAGAYAKGGEIFILDMGEPVKIDDLAKNLIRLSGYTLGVDMEIKYTGLRPGEKLYEELL
MKEEGLQETDNKLIHIGKPIEFDKENFFNNLEKLKEEAYSETGNIRESLKKVVVTYHPDEH

Sequences:

>Translated_621_residues
MMGETKKDRIQLLVRRFFLFLTDTFLLNACVYLSLIMRFDVGIVSIEPQYINNYVDNMLFYTIISLLIFWVFRLYHSLWQ
YASIAEVYRIAEACITVEVVHFLSNKMVGNMLPRSCYFNAAIYLIIAICASRFMYRMIRTVLNKYRNIKTSNNVMIIGAG
EATNVIMREIQNSSYLANSNIACIIDDDRRKVGKYIRGVKVIGTRDKIKEAAKLYDIDEIIFAIPSASNEVKRDILNICK
ETDCTLKILPGVYQMVDGEINVNSIRNVDVLDLLGRDPIEVDIESIMGYVKDKVIMVTGGGGSIGSELCRQLVSHKPKQL
IIFDIYENNAYDIQQELKINYPDANVVTLIGSIRNVSRLESVFAQYKPDIVYHAAAHKHVPLMEVSPDEAVKNNVVGTWN
VARMADKYGVKKFVMISTDKAVNPTNVMGATKRICEMIVQTYNGISKTDFVAVRFGNVLGSNGSVIPLFKRQIEAGGPVT
VTDPNIIRYFMTIPEAVSLVLQAGAYAKGGEIFILDMGEPVKIDDLAKNLIRLSGYTLGVDMEIKYTGLRPGEKLYEELL
MKEEGLQETDNKLIHIGKPIEFDKENFFNNLEKLKEEAYSETGNIRESLKKVVVTYHPDEH
>Mature_621_residues
MMGETKKDRIQLLVRRFFLFLTDTFLLNACVYLSLIMRFDVGIVSIEPQYINNYVDNMLFYTIISLLIFWVFRLYHSLWQ
YASIAEVYRIAEACITVEVVHFLSNKMVGNMLPRSCYFNAAIYLIIAICASRFMYRMIRTVLNKYRNIKTSNNVMIIGAG
EATNVIMREIQNSSYLANSNIACIIDDDRRKVGKYIRGVKVIGTRDKIKEAAKLYDIDEIIFAIPSASNEVKRDILNICK
ETDCTLKILPGVYQMVDGEINVNSIRNVDVLDLLGRDPIEVDIESIMGYVKDKVIMVTGGGGSIGSELCRQLVSHKPKQL
IIFDIYENNAYDIQQELKINYPDANVVTLIGSIRNVSRLESVFAQYKPDIVYHAAAHKHVPLMEVSPDEAVKNNVVGTWN
VARMADKYGVKKFVMISTDKAVNPTNVMGATKRICEMIVQTYNGISKTDFVAVRFGNVLGSNGSVIPLFKRQIEAGGPVT
VTDPNIIRYFMTIPEAVSLVLQAGAYAKGGEIFILDMGEPVKIDDLAKNLIRLSGYTLGVDMEIKYTGLRPGEKLYEELL
MKEEGLQETDNKLIHIGKPIEFDKENFFNNLEKLKEEAYSETGNIRESLKKVVVTYHPDEH

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG1086

COG function: function code MG; Predicted nucleoside-diphosphate sugar epimerases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide synthase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=333, Percent_Identity=29.4294294294294, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR003869 [H]

Pfam domain/function: PF02719 Polysacc_synt_2 [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 70303; Mature: 70303

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMGETKKDRIQLLVRRFFLFLTDTFLLNACVYLSLIMRFDVGIVSIEPQYINNYVDNMLF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHH
YTIISLLIFWVFRLYHSLWQYASIAEVYRIAEACITVEVVHFLSNKMVGNMLPRSCYFNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AIYLIIAICASRFMYRMIRTVLNKYRNIKTSNNVMIIGAGEATNVIMREIQNSSYLANSN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCEEECCC
IACIIDDDRRKVGKYIRGVKVIGTRDKIKEAAKLYDIDEIIFAIPSASNEVKRDILNICK
CEEEEECHHHHHHHHHCCEEEECCHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHC
ETDCTLKILPGVYQMVDGEINVNSIRNVDVLDLLGRDPIEVDIESIMGYVKDKVIMVTGG
CCCCEEEECCHHHHHHCCCCCCCCCCCCHHHHHHCCCCCEEEHHHHHHHHCCCEEEEECC
GGSIGSELCRQLVSHKPKQLIIFDIYENNAYDIQQELKINYPDANVVTLIGSIRNVSRLE
CCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHCEECCCCCHHHHHHHHHHHHHHHH
SVFAQYKPDIVYHAAAHKHVPLMEVSPDEAVKNNVVGTWNVARMADKYGVKKFVMISTDK
HHHHHCCCCEEEEECCCCCCCEEECCCCHHHHCCCCCCCHHHHHHHHHCCEEEEEEECCC
AVNPTNVMGATKRICEMIVQTYNGISKTDFVAVRFGNVLGSNGSVIPLFKRQIEAGGPVT
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHCCCCCCEEHHHHHHHCCCCCEE
VTDPNIIRYFMTIPEAVSLVLQAGAYAKGGEIFILDMGEPVKIDDLAKNLIRLSGYTLGV
ECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEEE
DMEIKYTGLRPGEKLYEELLMKEEGLQETDNKLIHIGKPIEFDKENFFNNLEKLKEEAYS
EEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHH
ETGNIRESLKKVVVTYHPDEH
HCCHHHHHHHHEEEEECCCCC
>Mature Secondary Structure
MMGETKKDRIQLLVRRFFLFLTDTFLLNACVYLSLIMRFDVGIVSIEPQYINNYVDNMLF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHH
YTIISLLIFWVFRLYHSLWQYASIAEVYRIAEACITVEVVHFLSNKMVGNMLPRSCYFNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
AIYLIIAICASRFMYRMIRTVLNKYRNIKTSNNVMIIGAGEATNVIMREIQNSSYLANSN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCEEECCC
IACIIDDDRRKVGKYIRGVKVIGTRDKIKEAAKLYDIDEIIFAIPSASNEVKRDILNICK
CEEEEECHHHHHHHHHCCEEEECCHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHC
ETDCTLKILPGVYQMVDGEINVNSIRNVDVLDLLGRDPIEVDIESIMGYVKDKVIMVTGG
CCCCEEEECCHHHHHHCCCCCCCCCCCCHHHHHHCCCCCEEEHHHHHHHHCCCEEEEECC
GGSIGSELCRQLVSHKPKQLIIFDIYENNAYDIQQELKINYPDANVVTLIGSIRNVSRLE
CCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHCEECCCCCHHHHHHHHHHHHHHHH
SVFAQYKPDIVYHAAAHKHVPLMEVSPDEAVKNNVVGTWNVARMADKYGVKKFVMISTDK
HHHHHCCCCEEEEECCCCCCCEEECCCCHHHHCCCCCCCHHHHHHHHHCCEEEEEEECCC
AVNPTNVMGATKRICEMIVQTYNGISKTDFVAVRFGNVLGSNGSVIPLFKRQIEAGGPVT
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECHHCCCCCCEEHHHHHHHCCCCCEE
VTDPNIIRYFMTIPEAVSLVLQAGAYAKGGEIFILDMGEPVKIDDLAKNLIRLSGYTLGV
ECCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCEEEEE
DMEIKYTGLRPGEKLYEELLMKEEGLQETDNKLIHIGKPIEFDKENFFNNLEKLKEEAYS
EEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHH
ETGNIRESLKKVVVTYHPDEH
HCCHHHHHHHHEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.093 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: p-Chloromercuribenzoate; TMP [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]