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The map label for this gene is dnaA [H]

Identifier: 238897212

GI number: 238897212

Start: 5212742

End: 5214145

Strand: Reverse

Name: dnaA [H]

Synonym: KP1_5483

Alternate gene names: 238897212

Gene position: 5214145-5212742 (Counterclockwise)

Preceding gene: 238897213

Following gene: 238897211

Centisome position: 99.35

GC content: 57.83

Gene sequence:

>1404_bases
GTGTCACTTTCGCTTTGGCAGCAGTGTCTTGCCCGATTGCAGGATGAGTTACCAGCCACAGAATTCAGCATGTGGATCCG
CCCATTGCAGGCGGAACTGAGCGATAACACGCTGGCACTGTATGCGCCAAACCGTTTTGTGCTCGACTGGGTAAGGGACA
AATACCTCAATAATATCAATGGACTCCTCAATGATTTTTGCGGTGCGGACGCCCCGCAGCTGCGTTTTGAGGTGGGCGCT
AAGCCCGCCAGCTCGCTGCAGAAAGGGGCGGTAAGCCCGGCTGCGGCGGCCATTCCGGCGGCGCAGGTGCAGACCGCGCG
CGCGGCGCCGACGATCGTGCGCCCTGGCTGGGATAATGTCCCGGCGCCGGCGGAGCCGACCTACCGCTCTAACGTTAACG
TGAAACACACGTTTGATAACTTCGTCGAAGGTAAATCTAACCAGCTGGCCCGCGCGGCGGCGCGTCAGGTGGCGGATAAC
CCGGGCGGCGCCTACAACCCCCTGTTCCTCTATGGCGGGACGGGTCTGGGTAAAACTCACCTGCTGCACGCGGTGGGCAA
CGGCATTGTGGCGCGTAAGCCGAACGCGAAAGTGGTCTATATGCACTCCGAGCGTTTCGTTCAGGACATGGTTAAAGCGC
TGCAGAACAACGCCATCGAAGAGTTTAAGCGTTACTACCGCTCCGTTGACGCCCTGCTGATCGATGACATTCAGTTCTTT
GCCAATAAAGAACGATCCCAGGAAGAGTTTTTCCACACCTTCAATGCGCTGCTGGAAGGTAATCAGCAGATCATCCTGAC
GTCGGATCGTTATCCAAAAGAGATCAACGGCGTTGAGGATCGTCTAAAATCCCGCTTCGGCTGGGGGCTGACGGTGGCGA
TCGAGCCGCCGGAGCTGGAAACCCGCGTCGCGATCCTGATGAAAAAAGCCGACGAGAACGACATCCGCCTGCCGGGCGAA
GTGGCGTTCTTTATTGCCAAGCGTCTGCGCTCGAACGTGCGTGAGCTGGAGGGGGCGCTGAATCGCGTTATCGCCAACGC
CAACTTCACCGGCCGGGCGATCACCATCGATTTCGTGCGCGAAGCGCTGCGCGATCTGCTGGCGCTGCAGGAAAAACTGG
TCACCATCGACAATATTCAAAAGACGGTGGCGGAGTACTACAAGATTAAGGTAGCGGATCTGCTGTCCAAACGCCGCTCC
CGTTCGGTGGCGCGTCCTCGCCAGATGGCGATGGCGCTGGCCAAAGAGCTGACCAACCACAGCCTGCCGGAAATCGGCGA
TGCGTTTGGCGGCCGAGACCATACCACCGTGCTGCACGCCTGCCGCAAGATTGAGCAGCTGCGTGAAGAAAGCCACGACA
TTAAAGAAGATTTTTCCAATTTAATCAGAACATTATCCTCGTGA

Upstream 100 bases:

>100_bases
GGGCTTTTCGGCTAATGCAGGGTCTTGTCGACGTGTGCCAACAATCACGATTGTTTCAGTTTTTCTTTGATATCGATTTT
ATGTTCGAGTGGAGTCCGCC

Downstream 100 bases:

>100_bases
CGCTATGAAATTTACCGTAGAACGTGAACATTTATTAAAACCGCTGCAACAGGTGAGCGGTCCGTTAGGTGGTCGTCCGA
CGCTGCCCATTCTCGGTAAC

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLNDFCGADAPQLRFEVGA
KPASSLQKGAVSPAAAAIPAAQVQTARAAPTIVRPGWDNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADN
PGGAYNPLFLYGGTGLGKTHLLHAVGNGIVARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFF
ANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGE
VAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRS
RSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS

Sequences:

>Translated_467_residues
MSLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLNDFCGADAPQLRFEVGA
KPASSLQKGAVSPAAAAIPAAQVQTARAAPTIVRPGWDNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADN
PGGAYNPLFLYGGTGLGKTHLLHAVGNGIVARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFF
ANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGE
VAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRS
RSVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS
>Mature_466_residues
SLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNINGLLNDFCGADAPQLRFEVGAK
PASSLQKGAVSPAAAAIPAAQVQTARAAPTIVRPGWDNVPAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNP
GGAYNPLFLYGGTGLGKTHLLHAVGNGIVARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFFA
NKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELETRVAILMKKADENDIRLPGEV
AFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVREALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSR
SVARPRQMAMALAKELTNHSLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=468, Percent_Identity=94.6581196581197, Blast_Score=906, Evalue=0.0,
Organism=Escherichia coli, GI226510964, Length=246, Percent_Identity=26.8292682926829, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 52367; Mature: 52236

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNIN
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
GLLNDFCGADAPQLRFEVGAKPASSLQKGAVSPAAAAIPAAQVQTARAAPTIVRPGWDNV
HHHHHHHCCCCCCEEEECCCCCHHHHHHCCCCCHHHHCCHHHHHHHHCCCCEECCCCCCC
PAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTH
CCCCCCCCCCCCCEEECHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHH
LLHAVGNGIVARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFF
HHHHHCCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELE
HCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHCCCHHHHHHHHCCCCEEEEECCCCHH
TRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVR
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHH
EALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCC
SLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS
CCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLSLWQQCLARLQDELPATEFSMWIRPLQAELSDNTLALYAPNRFVLDWVRDKYLNNIN
CHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH
GLLNDFCGADAPQLRFEVGAKPASSLQKGAVSPAAAAIPAAQVQTARAAPTIVRPGWDNV
HHHHHHHCCCCCCEEEECCCCCHHHHHHCCCCCHHHHCCHHHHHHHHCCCCEECCCCCCC
PAPAEPTYRSNVNVKHTFDNFVEGKSNQLARAAARQVADNPGGAYNPLFLYGGTGLGKTH
CCCCCCCCCCCCCEEECHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCHHH
LLHAVGNGIVARKPNAKVVYMHSERFVQDMVKALQNNAIEEFKRYYRSVDALLIDDIQFF
HHHHHCCCCEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANKERSQEEFFHTFNALLEGNQQIILTSDRYPKEINGVEDRLKSRFGWGLTVAIEPPELE
HCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHCCCHHHHHHHHCCCCEEEEECCCCHH
TRVAILMKKADENDIRLPGEVAFFIAKRLRSNVRELEGALNRVIANANFTGRAITIDFVR
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHH
EALRDLLALQEKLVTIDNIQKTVAEYYKIKVADLLSKRRSRSVARPRQMAMALAKELTNH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCC
SLPEIGDAFGGRDHTTVLHACRKIEQLREESHDIKEDFSNLIRTLSS
CCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA