Click here to switch to the map view.

The map label for this gene is emrD [H]

Identifier: 238897185

GI number: 238897185

Start: 5183442

End: 5184626

Strand: Direct

Name: emrD [H]

Synonym: KP1_5455

Alternate gene names: 238897185

Gene position: 5183442-5184626 (Clockwise)

Preceding gene: 238897184

Following gene: 238897187

Centisome position: 98.76

GC content: 63.71

Gene sequence:

>1185_bases
ATGAAACGGCATAAGAACTTCAATTTGTTGTTGATGCTGGTACTGCTGGTGGCCGTCGGCCAGATGGCGCAGACCATTTA
TATTCCGGCCATCGCCGACATGGCGGTCGCGCTGAACGTCCGCGAAGGGGCGGTACAAAGCGTGATGGCGGCCTACCTGC
TGACCTACGGTATTTCACAGCTATTCTACGGCCCGCTCTCTGACCGCGTCGGTCGCCGCCCGGTGATCCTCGTCGGGATG
TCGATTTTTATGCTGGCGACGCTGGTAGCTATTACCACCCATAGCCTGCCGGTGCTGATCGCCGCCAGCGCCATGCAGGG
GATGGGCACCGGGGTCGGCGGCGTGATGGCGCGTACCCTGCCCCGCGACCTGTACGAAGGCGCTCAGCTGCGTCATGCCA
ATAGCCTGTTAAATATGGGTATTCTGGTCAGCCCGCTGATTGCGCCGCTGCTCGGCGGCATCCTCGACACCCTGTGGAGC
TGGCGCGCCTGCTACGCTTTCCTGCTGGTCCTGTGCGCCGGGGTGACCTTCAGCATGGCGAAGTGGATGCCGGAAACGCG
TCCGGAAGGGGCGCCGCGCACCAAACTTCTGGCCAGCTACAAAACGCTGTTCGGCACCGGCGCCTTTAACTGCTATCTGC
TGATGCTGATCGGCGGCCTGGCGGGGATTGCGGTATTCGAAGCCTGCTCCGGGGTGCTGATGGGCGCGGTGCTCGGCCTG
AGCAGCATGGCGGTGAGTATTCTGTTTATTCTGCCGATCCCGGCGGCGTTCTTCGGGGCGTGGTTTGCCGGCCGGCCGAA
CAAGCGTTTCCCGACCCTGATGTGGCAGTCGGTGATCTGCTGCCTGCTGGCGGGTCTGATGATGTGGATCCCAGGGCTGC
TGGGCATCATGACCGTCTGGACCCTGCTGGTGCCTGCGGCGCTGTTCTTCTTCGGCGCCGGGATGTTGTTCCCGCTGGCC
ACCAGCGGCGCGATGGAGCCGTTCCCGTTCCTCGCCGGAACCGCCGGGGCGCTGGTGGGCGGCTTGCAGAATATCGGCTC
CGGCGTGCTGGCCTGGCTGTCGGCGATGATGCCGCAAACCGGTCAGGGCAGCCTCGGCCTGCTGATGATGCTGATGGGCC
TGTTGATTCTGCTGTGCTGGCTGCCGCTGGCCTCGCGCTTCACCCACCATCAGCAGCCGGTATAA

Upstream 100 bases:

>100_bases
AGTTGTTCTGTCATTTTAATATGGTAGATTCCTCCATCGTTTACGGGATGTGCCAGTCACATATTCTTCATTTCTCTTTA
CTCACAAAGTATTCATCGAC

Downstream 100 bases:

>100_bases
GCGCGGCGGTGGTTCCCCGGATGGCGGCTGACGCCTTATCCGGGCTACCGGACTGGTCGTCTGCCGGCCCGCGCAAGCGC
AGTGCCGTCATTTTGCCGGG

Product: multidrug resistance protein D

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MKRHKNFNLLLMLVLLVAVGQMAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGM
SIFMLATLVAITTHSLPVLIAASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWS
WRACYAFLLVLCAGVTFSMAKWMPETRPEGAPRTKLLASYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGL
SSMAVSILFILPIPAAFFGAWFAGRPNKRFPTLMWQSVICCLLAGLMMWIPGLLGIMTVWTLLVPAALFFFGAGMLFPLA
TSGAMEPFPFLAGTAGALVGGLQNIGSGVLAWLSAMMPQTGQGSLGLLMMLMGLLILLCWLPLASRFTHHQQPV

Sequences:

>Translated_394_residues
MKRHKNFNLLLMLVLLVAVGQMAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGM
SIFMLATLVAITTHSLPVLIAASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWS
WRACYAFLLVLCAGVTFSMAKWMPETRPEGAPRTKLLASYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGL
SSMAVSILFILPIPAAFFGAWFAGRPNKRFPTLMWQSVICCLLAGLMMWIPGLLGIMTVWTLLVPAALFFFGAGMLFPLA
TSGAMEPFPFLAGTAGALVGGLQNIGSGVLAWLSAMMPQTGQGSLGLLMMLMGLLILLCWLPLASRFTHHQQPV
>Mature_394_residues
MKRHKNFNLLLMLVLLVAVGQMAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGM
SIFMLATLVAITTHSLPVLIAASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWS
WRACYAFLLVLCAGVTFSMAKWMPETRPEGAPRTKLLASYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGL
SSMAVSILFILPIPAAFFGAWFAGRPNKRFPTLMWQSVICCLLAGLMMWIPGLLGIMTVWTLLVPAALFFFGAGMLFPLA
TSGAMEPFPFLAGTAGALVGGLQNIGSGVLAWLSAMMPQTGQGSLGLLMMLMGLLILLCWLPLASRFTHHQQPV

Specific function: Multidrug resistance pump that participates in a low energy shock adaptative response [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI87082312, Length=394, Percent_Identity=88.5786802030457, Blast_Score=627, Evalue=0.0,
Organism=Escherichia coli, GI48994889, Length=363, Percent_Identity=25.6198347107438, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788509, Length=361, Percent_Identity=25.7617728531856, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790146, Length=365, Percent_Identity=24.6575342465753, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790794, Length=301, Percent_Identity=25.5813953488372, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787065, Length=168, Percent_Identity=27.9761904761905, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324264, Length=170, Percent_Identity=30.5882352941176, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41993; Mature: 41993

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
6.9 %Met     (Translated Protein)
8.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
6.9 %Met     (Mature Protein)
8.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure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CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8240355; 7686882; 9278503 [H]