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The map label for this gene is ydgK [H]

Identifier: 238897146

GI number: 238897146

Start: 5146358

End: 5147521

Strand: Direct

Name: ydgK [H]

Synonym: KP1_5409

Alternate gene names: 238897146

Gene position: 5146358-5147521 (Clockwise)

Preceding gene: 238897145

Following gene: 238897147

Centisome position: 98.05

GC content: 64.35

Gene sequence:

>1164_bases
ATGGCACGTGTTTCCCTCTCCTGGGCGCTGATCCTCGGCCTGCTGTCGGGTATCGGCCCGCTGTGCACGGATTTTTATCT
GCCGGCGCTGCCGGAGATCACTCAGCAGCTGCAGGCCACCAGCACCCAGACCCAGCTGTCGTTGACCGCCGCGCTGATTG
GTCTCGGCCTGGGTCAGCTGTTTTTCGGCCCGCTGAGCGACCGCATTGGCCGCCTGAAACCGCTGGCGCTGTCGCTGCTG
CTGTTTATCTTCTCTTCGGCGATGTGCGCCCTGACCCGCGATATCAACATGCTGATTGTCTGGCGCTTTTTACAAGGCTT
TGCCGGCGCCGGCGGCTCGGTGCTGTCGCGATCCATTGCCCGCGATAAATACCAGGGCACCCTGCTGACCCAGTTTTTCG
CCCTGCTGATGACCGTGAACGGCATTGCGCCGGTGCTGTCCCCGGTGCTGGGCGGCTACGTTATCACCGCCTTCGACTGG
CGAATTCTCTTCTGGACGATGGCCGCCATTGGCGGCGTGCTGCTGGTGATGAGCCTGGCGATCCTGCGGGAAACGCGCCC
GGCCACAGCGGCGCATGCCAGCCGCCAACGGCCCGGCCAGCCGGTGCTGAAAAATCGCCGCTTTCTGCGCTTCTGCCTGA
TCCAGGCCTTTATGATGGCCGGGCTGTTCTCCTACATCGGCTCTTCTTCCTTCGTGATGCAGAGCGAATACGGCATGAGC
GCCATGCAGTTCAGTCTGCTGTTCGGTCTGAACGGTATCGGGCTGATCATCGCCGCGATGATCTTTTCCCGTCTGGCGCG
CCGCTTTAGCGCCGAAAGCCTGCTGCGCGGCGGCCTGACGCTGGCCGTGAGCTGTGCGGCGATCATGCTGCTGTTTGCCT
GGCTGCATCTGCCGGTGCTGGCGCTGGTCGGCCTGTTCTTTACCGTGTCGCTGATGAGCGGCATCAGCACCGTCGCCGGC
GCGGAGGCGATGAGCGCCGTCGACGCCGCGCAGTCCGGGACCGCGTCCGCGCTGATGGGCACCCTGATGTTTGTCTTCGG
CGGCATCGCCGCGCCGCTGGCGGGTCTCGGCGGCGAAACGATGCTGAAAATGAGCCTCGCGATGGCCATCTGCTACCTGC
TGGCGCTGCTGCTGGGCCTCAGCAAACCGCGCGACGCACGCTAA

Upstream 100 bases:

>100_bases
CGACCTCAATAACCGGATCACCCTCTGGCAGTCGCTGGGCGGCGGCGCCAGTTAAACTTACCCGCCGGGCGACCGAGCCC
GGCCTCTACAAGGAATCGTT

Downstream 100 bases:

>100_bases
TCTCCTGCTGCGGTAATAAAATATTCCAGATTTATTACCGCACTATTTCCCGCCATATCTACCATTCTCGTATTATTCTC
CACGTACTAATCGTGATACT

Product: putative general substrate transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MARVSLSWALILGLLSGIGPLCTDFYLPALPEITQQLQATSTQTQLSLTAALIGLGLGQLFFGPLSDRIGRLKPLALSLL
LFIFSSAMCALTRDINMLIVWRFLQGFAGAGGSVLSRSIARDKYQGTLLTQFFALLMTVNGIAPVLSPVLGGYVITAFDW
RILFWTMAAIGGVLLVMSLAILRETRPATAAHASRQRPGQPVLKNRRFLRFCLIQAFMMAGLFSYIGSSSFVMQSEYGMS
AMQFSLLFGLNGIGLIIAAMIFSRLARRFSAESLLRGGLTLAVSCAAIMLLFAWLHLPVLALVGLFFTVSLMSGISTVAG
AEAMSAVDAAQSGTASALMGTLMFVFGGIAAPLAGLGGETMLKMSLAMAICYLLALLLGLSKPRDAR

Sequences:

>Translated_387_residues
MARVSLSWALILGLLSGIGPLCTDFYLPALPEITQQLQATSTQTQLSLTAALIGLGLGQLFFGPLSDRIGRLKPLALSLL
LFIFSSAMCALTRDINMLIVWRFLQGFAGAGGSVLSRSIARDKYQGTLLTQFFALLMTVNGIAPVLSPVLGGYVITAFDW
RILFWTMAAIGGVLLVMSLAILRETRPATAAHASRQRPGQPVLKNRRFLRFCLIQAFMMAGLFSYIGSSSFVMQSEYGMS
AMQFSLLFGLNGIGLIIAAMIFSRLARRFSAESLLRGGLTLAVSCAAIMLLFAWLHLPVLALVGLFFTVSLMSGISTVAG
AEAMSAVDAAQSGTASALMGTLMFVFGGIAAPLAGLGGETMLKMSLAMAICYLLALLLGLSKPRDAR
>Mature_386_residues
ARVSLSWALILGLLSGIGPLCTDFYLPALPEITQQLQATSTQTQLSLTAALIGLGLGQLFFGPLSDRIGRLKPLALSLLL
FIFSSAMCALTRDINMLIVWRFLQGFAGAGGSVLSRSIARDKYQGTLLTQFFALLMTVNGIAPVLSPVLGGYVITAFDWR
ILFWTMAAIGGVLLVMSLAILRETRPATAAHASRQRPGQPVLKNRRFLRFCLIQAFMMAGLFSYIGSSSFVMQSEYGMSA
MQFSLLFGLNGIGLIIAAMIFSRLARRFSAESLLRGGLTLAVSCAAIMLLFAWLHLPVLALVGLFFTVSLMSGISTVAGA
EAMSAVDAAQSGTASALMGTLMFVFGGIAAPLAGLGGETMLKMSLAMAICYLLALLLGLSKPRDAR

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=403, Percent_Identity=31.5136476426799, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1790146, Length=295, Percent_Identity=32.2033898305085, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI48994889, Length=332, Percent_Identity=29.2168674698795, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI87082312, Length=253, Percent_Identity=27.6679841897233, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1787065, Length=278, Percent_Identity=26.978417266187, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789042, Length=154, Percent_Identity=27.2727272727273, Blast_Score=62, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6319480, Length=181, Percent_Identity=27.0718232044199, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41219; Mature: 41088

Theoretical pI: Translated: 10.65; Mature: 10.65

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ARVSLSWALILGLLSGIGPLCTDFYLPALPEITQQLQATSTQTQLSLTAALIGLGLGQL
CCCHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFGPLSDRIGRLKPLALSLLLFIFSSAMCALTRDINMLIVWRFLQGFAGAGGSVLSRSIA
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RDKYQGTLLTQFFALLMTVNGIAPVLSPVLGGYVITAFDWRILFWTMAAIGGVLLVMSLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILRETRPATAAHASRQRPGQPVLKNRRFLRFCLIQAFMMAGLFSYIGSSSFVMQSEYGMS
HHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCHH
AMQFSLLFGLNGIGLIIAAMIFSRLARRFSAESLLRGGLTLAVSCAAIMLLFAWLHLPVL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
ALVGLFFTVSLMSGISTVAGAEAMSAVDAAQSGTASALMGTLMFVFGGIAAPLAGLGGET
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHH
MLKMSLAMAICYLLALLLGLSKPRDAR
HHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]