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The map label for this gene is yahK [H]

Identifier: 238897129

GI number: 238897129

Start: 5128299

End: 5129348

Strand: Direct

Name: yahK [H]

Synonym: KP1_5388

Alternate gene names: 238897129

Gene position: 5128299-5129348 (Clockwise)

Preceding gene: 238897127

Following gene: 238897132

Centisome position: 97.71

GC content: 62.57

Gene sequence:

>1050_bases
ATGCTGATCAACGCTATTGGTACCTACTCCGCCAGCCAGCCGCTGGAATCAATGGCCATCACCCGCCGCGACCCGGGGCC
GCAGGATGTACAGATCGCCATCGCTTACTGCGGCGTCTGCCACTCCGATCTCCACCAGGCGCGATCGGAATGGGCAGGAA
CGCTGTATCCCTGCGTGCCGGGGCATGAAATTGTGGGTCGGGTGACCGCGGTCGGCAACGCCGTCTCGCGCTACGCCGTC
GGCGATCTGGTGGGCGTCGGCTGTATGGTCGATAGCTGTCAACAGTGCGAAGAGTGCGCCGAGGGGCTGGAAAACTACTG
CGACCACATGGTGCTGACCTATAACGGGCCGACCCAGGACGCGCCGGGACACACGCTTGGCGGTTATTCACAGCAGATCG
TGGTCAATGAACGCTACGTGCTGCGGATAACCCATCCCGAAGCGCAGCTGGCCGCCGTCGCGCCGCTGCTGTGCGCCGGG
ATCACGACATACTCGCCGCTGCGCCACTGGCACGTCGGGCCGGGTAAAAAAGTCGGCGTGGTCGGCATCGGCGGCCTCGG
GCATATGGGGATCAAGTTGGCCCACGCCATGGGGGCCCACGTGGTGGCCTTTACCACCTCCGAATCCAAGCGTAATGCGG
CCAGAGCGCTGGGCGCCGATGACGTAGTGGTGTCGCGCAATGAAGACGAAATGGCGGCCCACGTCAAAAGCTTCGATTTC
ATCCTCAACACCGTGGCGGCGCCGCACAATCTCGATGCCTTCACCACGCTGCTGAAACGCGATGGCACCATGACGCTGGT
TGGCGCCCCGACCACGCCGCATCCGTCGCCGGAAGTGTTCAATCTGATCTTCCGCCGCCGGTCGATTGCCGGCTCGATGA
TCGGCGGTATTCCGGAAACTCAGGAGATGCTCGACTTCTGCGCCGAACACGGCATCGTCGCCGATATCGAACTGATCCGC
GGCGATGAGATCAACGAAGCCTGGGAAAGAATGGTCAAGGGTGACGTGAAATACCGCTTCGTGATCGACAGTGCGACCCT
CGCCGGCTAA

Upstream 100 bases:

>100_bases
CTCGCATCTCGGCCAGTCCAGGCTACGCTTATCGATGCCACTGACCACCCGCATTCCCCTCCCGTTCTATTGAGTCCATT
CATCAAGAAGAGGTTTCGCT

Downstream 100 bases:

>100_bases
GCGCCGCGACGAAAGGTACGCCGCCATTCCGTCGGGCTGACGCCAAAGCGCGCTTTAAACTGCTGGCGCCAGGTGACCGC
TGAAAGATAGCCCACCGCCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MLINAIGTYSASQPLESMAITRRDPGPQDVQIAIAYCGVCHSDLHQARSEWAGTLYPCVPGHEIVGRVTAVGNAVSRYAV
GDLVGVGCMVDSCQQCEECAEGLENYCDHMVLTYNGPTQDAPGHTLGGYSQQIVVNERYVLRITHPEAQLAAVAPLLCAG
ITTYSPLRHWHVGPGKKVGVVGIGGLGHMGIKLAHAMGAHVVAFTTSESKRNAARALGADDVVVSRNEDEMAAHVKSFDF
ILNTVAAPHNLDAFTTLLKRDGTMTLVGAPTTPHPSPEVFNLIFRRRSIAGSMIGGIPETQEMLDFCAEHGIVADIELIR
GDEINEAWERMVKGDVKYRFVIDSATLAG

Sequences:

>Translated_349_residues
MLINAIGTYSASQPLESMAITRRDPGPQDVQIAIAYCGVCHSDLHQARSEWAGTLYPCVPGHEIVGRVTAVGNAVSRYAV
GDLVGVGCMVDSCQQCEECAEGLENYCDHMVLTYNGPTQDAPGHTLGGYSQQIVVNERYVLRITHPEAQLAAVAPLLCAG
ITTYSPLRHWHVGPGKKVGVVGIGGLGHMGIKLAHAMGAHVVAFTTSESKRNAARALGADDVVVSRNEDEMAAHVKSFDF
ILNTVAAPHNLDAFTTLLKRDGTMTLVGAPTTPHPSPEVFNLIFRRRSIAGSMIGGIPETQEMLDFCAEHGIVADIELIR
GDEINEAWERMVKGDVKYRFVIDSATLAG
>Mature_349_residues
MLINAIGTYSASQPLESMAITRRDPGPQDVQIAIAYCGVCHSDLHQARSEWAGTLYPCVPGHEIVGRVTAVGNAVSRYAV
GDLVGVGCMVDSCQQCEECAEGLENYCDHMVLTYNGPTQDAPGHTLGGYSQQIVVNERYVLRITHPEAQLAAVAPLLCAG
ITTYSPLRHWHVGPGKKVGVVGIGGLGHMGIKLAHAMGAHVVAFTTSESKRNAARALGADDVVVSRNEDEMAAHVKSFDF
ILNTVAAPHNLDAFTTLLKRDGTMTLVGAPTTPHPSPEVFNLIFRRRSIAGSMIGGIPETQEMLDFCAEHGIVADIELIR
GDEINEAWERMVKGDVKYRFVIDSATLAG

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565152, Length=239, Percent_Identity=26.7782426778243, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI156523966, Length=344, Percent_Identity=25, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4501939, Length=344, Percent_Identity=25, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4501933, Length=359, Percent_Identity=25.3481894150418, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI71743840, Length=330, Percent_Identity=24.2424242424242, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI262073058, Length=329, Percent_Identity=24.3161094224924, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI34577061, Length=359, Percent_Identity=25.3481894150418, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI71565154, Length=232, Percent_Identity=27.1551724137931, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1786518, Length=347, Percent_Identity=83.8616714697406, Blast_Score=587, Evalue=1e-169,
Organism=Escherichia coli, GI87082401, Length=348, Percent_Identity=35.632183908046, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI87081918, Length=312, Percent_Identity=26.9230769230769, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788407, Length=275, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786552, Length=363, Percent_Identity=26.7217630853994, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI226510992, Length=269, Percent_Identity=28.6245353159851, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562584, Length=337, Percent_Identity=28.7833827893175, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17562582, Length=341, Percent_Identity=28.4457478005865, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71988145, Length=337, Percent_Identity=28.486646884273, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI25146526, Length=361, Percent_Identity=27.4238227146814, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=363, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=231, Percent_Identity=29.004329004329, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=268, Percent_Identity=27.2388059701493, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565904, Length=205, Percent_Identity=31.219512195122, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=349, Percent_Identity=32.0916905444126, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6323980, Length=336, Percent_Identity=38.0952380952381, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6323961, Length=349, Percent_Identity=32.0916905444126, Blast_Score=166, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6324486, Length=344, Percent_Identity=31.1046511627907, Blast_Score=163, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6323729, Length=344, Percent_Identity=29.6511627906977, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319949, Length=332, Percent_Identity=36.4457831325301, Blast_Score=152, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6320033, Length=369, Percent_Identity=28.7262872628726, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322619, Length=261, Percent_Identity=29.8850574712644, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=261, Percent_Identity=29.8850574712644, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319258, Length=340, Percent_Identity=24.7058823529412, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17737895, Length=361, Percent_Identity=24.9307479224377, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 37431; Mature: 37431

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00059 ADH_ZINC ; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLINAIGTYSASQPLESMAITRRDPGPQDVQIAIAYCGVCHSDLHQARSEWAGTLYPCVP
CEEECCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCEECCCCC
GHEIVGRVTAVGNAVSRYAVGDLVGVGCMVDSCQQCEECAEGLENYCDHMVLTYNGPTQD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCC
APGHTLGGYSQQIVVNERYVLRITHPEAQLAAVAPLLCAGITTYSPLRHWHVGPGKKVGV
CCCCCCCCCCCEEEECCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEE
VGIGGLGHMGIKLAHAMGAHVVAFTTSESKRNAARALGADDVVVSRNEDEMAAHVKSFDF
EEECCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
ILNTVAAPHNLDAFTTLLKRDGTMTLVGAPTTPHPSPEVFNLIFRRRSIAGSMIGGIPET
HHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
QEMLDFCAEHGIVADIELIRGDEINEAWERMVKGDVKYRFVIDSATLAG
HHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCC
>Mature Secondary Structure
MLINAIGTYSASQPLESMAITRRDPGPQDVQIAIAYCGVCHSDLHQARSEWAGTLYPCVP
CEEECCCCCCCCCCHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCEECCCCC
GHEIVGRVTAVGNAVSRYAVGDLVGVGCMVDSCQQCEECAEGLENYCDHMVLTYNGPTQD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCC
APGHTLGGYSQQIVVNERYVLRITHPEAQLAAVAPLLCAGITTYSPLRHWHVGPGKKVGV
CCCCCCCCCCCEEEECCEEEEEEECCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEE
VGIGGLGHMGIKLAHAMGAHVVAFTTSESKRNAARALGADDVVVSRNEDEMAAHVKSFDF
EEECCCCHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
ILNTVAAPHNLDAFTTLLKRDGTMTLVGAPTTPHPSPEVFNLIFRRRSIAGSMIGGIPET
HHHHHCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
QEMLDFCAEHGIVADIELIRGDEINEAWERMVKGDVKYRFVIDSATLAG
HHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]