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The map label for this gene is qor [C]

Identifier: 238897126

GI number: 238897126

Start: 5125877

End: 5126884

Strand: Direct

Name: qor [C]

Synonym: KP1_5385

Alternate gene names: 238897126

Gene position: 5125877-5126884 (Clockwise)

Preceding gene: 238897125

Following gene: 238897127

Centisome position: 97.66

GC content: 63.79

Gene sequence:

>1008_bases
ATGAAAGCTATCGCCATTACTCAAGCCGCCGCTGACGGCAACAACATCCCTTCTTTAACCGAGATCGACCTGCCGATCCC
CACCGCCCACGGGCGTGATCTGCTGGTCGCTGTGAAGGCTATCTCGGTCAATCCGGTAGACACCAAAGTGCGCGCCGGCT
TTCAGGGTGACACGCCGCGGGTGCTGGGCTGGGACGCCGTTGGCGTGGTGCAGTCCGTCGGTGAGGAAGTGACGCTGTTC
GCGCCCGGGGACGAGGTCTGGTACGCCGGCGCGCTGGGCCGGGCCGGCAGCAACAGTGAATATCAGCTGGTGGATGAGCG
CCTGGTGGCGCACAAACCGCGCACCCTCGATAATGCCTCCGCCGCCGCGCTGCCGCTGACGGCGATCACCGCCTGGGAGC
TGCTGTTTCACCGTCTCGGCGTTGAGGAAGGCGGCAATGCGGGCGACACGCTGCTAATCGTCGGCGCGGCGGGCGGCGTG
GGGTCTATCCTGACCCAGCTGGCCAGTAAACTGACCGCCATGACGGTGATCGGCACCGCCTCGCGTCCCGAGAGCCAGCA
GTGGGTCCGCGAGGCGGGCGCGCACCATGTGATCGATCATAGCAAGCCGCTCGCCGACGAGCTGGCGCGCATTGGTATCA
CGTCGGTAACCCATGTCGCCAGCCTGACCAATACCGAGCAGCACTTCAACGCGCTGATCGACGCCCTCGCCCCGCAGGGC
AAGCTGGCGCTGATTGATGACCCGGAGACCCTGGACGTGGTGCCGCTGAAAGCGAAAAGCCTGTCCCTGCACTGGGAATT
TATGTTCACCCGTTCAATGTTTGAGACGGATGATATGATCGCCCAGCATCAGCTGCTCACCCGCGTGGCGGCGCTGATCG
ACAACCACACTATCAAAACCACCCTTGGCGAACACTACGGCGCCATCACCGCCGCCAATCTGCAGAAAGCGCATCGCCAG
CTGGAAACCGGACGCGCCGTCGGCAAGATCGTGCTGGAGGGGTTTTAA

Upstream 100 bases:

>100_bases
GCATATAACTGTTATTGCCGTTAGCCCGTTTTTCCCCTCCCGGCAGCGGTCTACGATGGCTCCATCTTTTCATTCACCCG
AATCACAGACCGGAGCAGTT

Downstream 100 bases:

>100_bases
GATGATATCGCTTATCGCCGTGCTCAAGGCGAAACCGGGCCAAACGGACGCCCTGCGTCAGGCCCTGCAGGCGCTGCTCC
TGCCGACGAGACAGGAGCCG

Product: bifunctional oxidoreductase/alginate lyase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKAIAITQAAADGNNIPSLTEIDLPIPTAHGRDLLVAVKAISVNPVDTKVRAGFQGDTPRVLGWDAVGVVQSVGEEVTLF
APGDEVWYAGALGRAGSNSEYQLVDERLVAHKPRTLDNASAAALPLTAITAWELLFHRLGVEEGGNAGDTLLIVGAAGGV
GSILTQLASKLTAMTVIGTASRPESQQWVREAGAHHVIDHSKPLADELARIGITSVTHVASLTNTEQHFNALIDALAPQG
KLALIDDPETLDVVPLKAKSLSLHWEFMFTRSMFETDDMIAQHQLLTRVAALIDNHTIKTTLGEHYGAITAANLQKAHRQ
LETGRAVGKIVLEGF

Sequences:

>Translated_335_residues
MKAIAITQAAADGNNIPSLTEIDLPIPTAHGRDLLVAVKAISVNPVDTKVRAGFQGDTPRVLGWDAVGVVQSVGEEVTLF
APGDEVWYAGALGRAGSNSEYQLVDERLVAHKPRTLDNASAAALPLTAITAWELLFHRLGVEEGGNAGDTLLIVGAAGGV
GSILTQLASKLTAMTVIGTASRPESQQWVREAGAHHVIDHSKPLADELARIGITSVTHVASLTNTEQHFNALIDALAPQG
KLALIDDPETLDVVPLKAKSLSLHWEFMFTRSMFETDDMIAQHQLLTRVAALIDNHTIKTTLGEHYGAITAANLQKAHRQ
LETGRAVGKIVLEGF
>Mature_335_residues
MKAIAITQAAADGNNIPSLTEIDLPIPTAHGRDLLVAVKAISVNPVDTKVRAGFQGDTPRVLGWDAVGVVQSVGEEVTLF
APGDEVWYAGALGRAGSNSEYQLVDERLVAHKPRTLDNASAAALPLTAITAWELLFHRLGVEEGGNAGDTLLIVGAAGGV
GSILTQLASKLTAMTVIGTASRPESQQWVREAGAHHVIDHSKPLADELARIGITSVTHVASLTNTEQHFNALIDALAPQG
KLALIDDPETLDVVPLKAKSLSLHWEFMFTRSMFETDDMIAQHQLLTRVAALIDNHTIKTTLGEHYGAITAANLQKAHRQ
LETGRAVGKIVLEGF

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=352, Percent_Identity=26.7045454545455, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI194239674, Length=184, Percent_Identity=34.2391304347826, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI13236495, Length=184, Percent_Identity=34.2391304347826, Blast_Score=101, Evalue=9e-22,
Organism=Homo sapiens, GI194239676, Length=184, Percent_Identity=34.2391304347826, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI24308257, Length=194, Percent_Identity=28.8659793814433, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17507255, Length=239, Percent_Identity=33.4728033472803, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71987554, Length=181, Percent_Identity=32.5966850828729, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35648; Mature: 35648

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS01162 QOR_ZETA_CRYSTAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIAITQAAADGNNIPSLTEIDLPIPTAHGRDLLVAVKAISVNPVDTKVRAGFQGDTPR
CCEEEEEEECCCCCCCCCCEEECCCCCCCCCCEEEEEEEEEECCCCCHHHCCCCCCCCCC
VLGWDAVGVVQSVGEEVTLFAPGDEVWYAGALGRAGSNSEYQLVDERLVAHKPRTLDNAS
EECCHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
AAALPLTAITAWELLFHRLGVEEGGNAGDTLLIVGAAGGVGSILTQLASKLTAMTVIGTA
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHEEECC
SRPESQQWVREAGAHHVIDHSKPLADELARIGITSVTHVASLTNTEQHFNALIDALAPQG
CCCCHHHHHHHCCCCEECCCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCC
KLALIDDPETLDVVPLKAKSLSLHWEFMFTRSMFETDDMIAQHQLLTRVAALIDNHTIKT
CEEEECCCCCEEEEEECCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
TLGEHYGAITAANLQKAHRQLETGRAVGKIVLEGF
HHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKAIAITQAAADGNNIPSLTEIDLPIPTAHGRDLLVAVKAISVNPVDTKVRAGFQGDTPR
CCEEEEEEECCCCCCCCCCEEECCCCCCCCCCEEEEEEEEEECCCCCHHHCCCCCCCCCC
VLGWDAVGVVQSVGEEVTLFAPGDEVWYAGALGRAGSNSEYQLVDERLVAHKPRTLDNAS
EECCHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCC
AAALPLTAITAWELLFHRLGVEEGGNAGDTLLIVGAAGGVGSILTQLASKLTAMTVIGTA
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHEEECC
SRPESQQWVREAGAHHVIDHSKPLADELARIGITSVTHVASLTNTEQHFNALIDALAPQG
CCCCHHHHHHHCCCCEECCCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHCCCC
KLALIDDPETLDVVPLKAKSLSLHWEFMFTRSMFETDDMIAQHQLLTRVAALIDNHTIKT
CEEEECCCCCEEEEEECCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
TLGEHYGAITAANLQKAHRQLETGRAVGKIVLEGF
HHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.26 {1,4-naphthoquinone}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA