Click here to switch to the map view.

The map label for this gene is yicE [H]

Identifier: 238897115

GI number: 238897115

Start: 5110386

End: 5111792

Strand: Direct

Name: yicE [H]

Synonym: KP1_5373

Alternate gene names: 238897115

Gene position: 5110386-5111792 (Clockwise)

Preceding gene: 238897113

Following gene: 238897116

Centisome position: 97.37

GC content: 61.55

Gene sequence:

>1407_bases
TTGGGATTGCTTGTGATGTCCGTTAACACCGCAGAGTCAGAAAATGCGCAACCGGTTGCGCATAAACCAGCCAGCGAATT
AATCTACCGCCTCGAAGATCGCCCGCCGCTACCGCAAACCCTGTTCGCCGCCTTCCAGCACCTGCTGGCGATGTTTGTCG
CGGTGATCACCCCGGCGCTGTTAATCTGCCAGGCTCTCGGTCTCCCGGCGCAAGATACCCAACATATCATCAGCATGTCG
CTGTTCGCCTCCGGCGTCGCCTCTATTATTCAGATCAAAGCCTGGGGCCCGGTCGGCTCCGGACTGCTCTCCATCCAGGG
CACCAGCTTCAACTTTGTCGCCCCGCTGATCATGGGCGGTACCGCCTTGAAAACCGGCGGCGCCGACGTCCCCACCATGA
TGGCCGCCCTCTTCGGCACCCTGATGCTGGCCAGCTGCACCGAAATGGTCCTCTCCCGGATCCTGCACCTGGCGCGCCGT
ATCATTACCCCGCTGGTTTCCGGCGTGGTGGTGATGATTATCGGCCTGTCGCTGATTCAGGTCGGACTGACCTCCATCGG
CGGCGGCTACGCGGCGATGGCCGACCACACCTTTGGTGCGCCGAAAAATCTGCTGCTGGCGGGTATCGTGCTGGCGCTGA
TTATTATCCTCAACCGCCAGCGCAACCCGTACCTGCGCATCGCCTCGCTAGTGATTGCCATGGCTGCCGGTTATCTGGCG
GCGTGGTTCCTCGATATGCTGCCAGCCAACACCGCCCCGACCAACAGCAGCCTCATCACCGTCCCGACGCCGCTCTATTA
TGGCCTCGGCATCGACTGGAGTCTGCTGCTGCCCCTGATGCTGGTGTTTATGATCACCTCCCTGGAAACCATCGGCGATA
TCACCGCCACCTCCGACGTCTCCGAACAGCCGGTTTCGGGTCCGCTGTATATGAAGCGCCTGAAAGGCGGCGTGCTGGCT
AACGGCCTGAACTCCTTCGTTTCCGCGGTCTTCAACACCTTCCCGAACTCCTGCTTCGGCCAGAACAACGGCGTGATCCA
GCTGACCGGGGTCGCCAGCCGCTACGTCGGCTTTGTGGTTGCCCTGATGCTGATCGTCCTCGGCCTGTTCCCGGCGGTGA
GCGGCTTTGTCCAGCATATCCCTGAGCCAGTGCTCGGCGGCGCCACGCTGGTGATGTTCGGCACCATCGCCGCGTCCGGC
GTGCGCATCGTCTCCCGTGAACCGCTGAACCGTCGGGCAATCCTGATTATCGCTCTGTCGCTGGCGGTAGGCCTCGGCGT
GTCGCAGCAGCCGCTGATCCTGCAGTTCGCCCCGGACTGGCTGAAAAACCTGCTTTCCTCCGGGATTGCCGCCGGCGGTA
TCACGGCGATTGTTCTGAATTTAATTTTCCCGCCAGAAAAGGCGTGA

Upstream 100 bases:

>100_bases
TTATCTCGTTGCGCATATTCACGGTATAAATTTTTATGAGCAAACGCTGGCAAACGTTTGCTTTTGGTCTACAGTCCGAT
AAAATTCCCGCTTTGCCACC

Downstream 100 bases:

>100_bases
TCTCATGCGTTCCCGGTCGCGCATCGGCCGGGACGTCCTCCAACCACCAGCCCCATCACGGAAATAAACCACGCCTGCCT
TGAGAAGTGCGCCTAAATCG

Product: putative purine/xanthine transport protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MGLLVMSVNTAESENAQPVAHKPASELIYRLEDRPPLPQTLFAAFQHLLAMFVAVITPALLICQALGLPAQDTQHIISMS
LFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVLSRILHLARR
IITPLVSGVVVMIIGLSLIQVGLTSIGGGYAAMADHTFGAPKNLLLAGIVLALIIILNRQRNPYLRIASLVIAMAAGYLA
AWFLDMLPANTAPTNSSLITVPTPLYYGLGIDWSLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLA
NGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASG
VRIVSREPLNRRAILIIALSLAVGLGVSQQPLILQFAPDWLKNLLSSGIAAGGITAIVLNLIFPPEKA

Sequences:

>Translated_468_residues
MGLLVMSVNTAESENAQPVAHKPASELIYRLEDRPPLPQTLFAAFQHLLAMFVAVITPALLICQALGLPAQDTQHIISMS
LFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVLSRILHLARR
IITPLVSGVVVMIIGLSLIQVGLTSIGGGYAAMADHTFGAPKNLLLAGIVLALIIILNRQRNPYLRIASLVIAMAAGYLA
AWFLDMLPANTAPTNSSLITVPTPLYYGLGIDWSLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLA
NGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASG
VRIVSREPLNRRAILIIALSLAVGLGVSQQPLILQFAPDWLKNLLSSGIAAGGITAIVLNLIFPPEKA
>Mature_467_residues
GLLVMSVNTAESENAQPVAHKPASELIYRLEDRPPLPQTLFAAFQHLLAMFVAVITPALLICQALGLPAQDTQHIISMSL
FASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGGTALKTGGADVPTMMAALFGTLMLASCTEMVLSRILHLARRI
ITPLVSGVVVMIIGLSLIQVGLTSIGGGYAAMADHTFGAPKNLLLAGIVLALIIILNRQRNPYLRIASLVIAMAAGYLAA
WFLDMLPANTAPTNSSLITVPTPLYYGLGIDWSLLLPLMLVFMITSLETIGDITATSDVSEQPVSGPLYMKRLKGGVLAN
GLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVVALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGV
RIVSREPLNRRAILIIALSLAVGLGVSQQPLILQFAPDWLKNLLSSGIAAGGITAIVLNLIFPPEKA

Specific function: Specific, proton motive force-dependent high-affinity transporter for xanthine [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=527, Percent_Identity=22.7703984819734, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI40316845, Length=527, Percent_Identity=22.7703984819734, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1790087, Length=462, Percent_Identity=93.7229437229437, Blast_Score=839, Evalue=0.0,
Organism=Escherichia coli, GI87082178, Length=444, Percent_Identity=45.045045045045, Blast_Score=354, Evalue=5e-99,
Organism=Escherichia coli, GI87082181, Length=447, Percent_Identity=29.5302013422819, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1788843, Length=445, Percent_Identity=25.8426966292135, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87081818, Length=410, Percent_Identity=25.1219512195122, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17558856, Length=489, Percent_Identity=24.5398773006135, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17541904, Length=496, Percent_Identity=22.7822580645161, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 49145; Mature: 49014

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLLVMSVNTAESENAQPVAHKPASELIYRLEDRPPLPQTLFAAFQHLLAMFVAVITPAL
CCEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LICQALGLPAQDTQHIISMSLFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGG
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCCHHHHHHHHCC
TALKTGGADVPTMMAALFGTLMLASCTEMVLSRILHLARRIITPLVSGVVVMIIGLSLIQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGLTSIGGGYAAMADHTFGAPKNLLLAGIVLALIIILNRQRNPYLRIASLVIAMAAGYLA
HHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
AWFLDMLPANTAPTNSSLITVPTPLYYGLGIDWSLLLPLMLVFMITSLETIGDITATSDV
HHHHHHHCCCCCCCCCCEEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SEQPVSGPLYMKRLKGGVLANGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVV
CCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHH
ALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSREPLNRRAILIIALS
HHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHH
LAVGLGVSQQPLILQFAPDWLKNLLSSGIAAGGITAIVLNLIFPPEKA
HHHHCCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
GLLVMSVNTAESENAQPVAHKPASELIYRLEDRPPLPQTLFAAFQHLLAMFVAVITPAL
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LICQALGLPAQDTQHIISMSLFASGVASIIQIKAWGPVGSGLLSIQGTSFNFVAPLIMGG
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEEECCCCHHHHHHHHCC
TALKTGGADVPTMMAALFGTLMLASCTEMVLSRILHLARRIITPLVSGVVVMIIGLSLIQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGLTSIGGGYAAMADHTFGAPKNLLLAGIVLALIIILNRQRNPYLRIASLVIAMAAGYLA
HHHHHCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
AWFLDMLPANTAPTNSSLITVPTPLYYGLGIDWSLLLPLMLVFMITSLETIGDITATSDV
HHHHHHHCCCCCCCCCCEEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SEQPVSGPLYMKRLKGGVLANGLNSFVSAVFNTFPNSCFGQNNGVIQLTGVASRYVGFVV
CCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHHH
ALMLIVLGLFPAVSGFVQHIPEPVLGGATLVMFGTIAASGVRIVSREPLNRRAILIIALS
HHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHH
LAVGLGVSQQPLILQFAPDWLKNLLSSGIAAGGITAIVLNLIFPPEKA
HHHHCCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]