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The map label for this gene is mutM [H]

Identifier: 238897076

GI number: 238897076

Start: 5072468

End: 5073277

Strand: Reverse

Name: mutM [H]

Synonym: KP1_5327

Alternate gene names: 238897076

Gene position: 5073277-5072468 (Counterclockwise)

Preceding gene: 238897077

Following gene: 238897068

Centisome position: 96.66

GC content: 60.49

Gene sequence:

>810_bases
ATGCCTGAATTACCAGAGGTTGAAACCAGCCGCCGCGGCATCGAGCCGCACCTGGTTGGCGCAACCATTCTGCACGCCGT
CGTGCGCAACGGACGGCTGCGCTGGCCGGTTTCCGAAGAGATCTATCGCCTGAGCGACGTTCCGGTTCTCAGCGTGCGTC
GCCGCGCCAAATACCTGCTTCTGGAGCTGCCGGACGGCTGGATCATCGTCCATCTTGGGATGTCGGGGAGCCTGCGCATC
CTGAGCGAAGAGCTGCCTGCTGAAAAACACGATCACGTTGACCTGGTCATGAGTAACGGCAAGGTGTTGCGCTACACCGA
TCCACGCCGCTTTGGCGCCTGGTTGTGGACCAGAACGCTGGAAGGCCATCCGGTACTGGCCCATCTTGGCCCGGAGCCGC
TCAGCGACGCGTTCAACGCCGACTATCTCCAGCAAAAATGCGCGAAGAAGAAAACCGCAATCAAACCCTGGCTGATGGAT
AACAAGCTGGTGGTGGGCGTGGGGAATATCTACGCCAGTGAATCGCTGTTCTCCGCCGGGATCCATCCTGACCGGCTGGC
GTCCTCGCTGTCGCGGGAAGAGTGTGAGCAGCTGGTGAAGGTGATTAAGCTGGTCCTGCTGCGTTCGATAGAGCAGGGCG
GCACCACGTTAAAGGATTTCCTGCAAAGCGATGGCAAGCCGGGCTATTTCGCCCAGGAGCTACAGGTCTATGGCCGCAAG
GGCGAACCCTGCCGGATCTGCGGCACGCCGGTCGTCGGGACCAAACATGCCCAGCGGGCGACCTTTTATTGCCGTCAGTG
CCAGAAGTAG

Upstream 100 bases:

>100_bases
GGGTTTTTTGTTTTTAAAACTCCCCCATATTGCTTTCACATACTCCCTTTTCAGTCACCTGTCCGTGAAGCACAATACGT
CGGGTAAACGGAGGAAAATC

Downstream 100 bases:

>100_bases
TTCTCAGGAACAGGAATGTTTGTCGGCCAGGTCAGCGGGCCTGCGGGTGCGCATCTGGTGGGCCGGGGGCGTTTGTAGTC
CAGGTCAGCGTAGCGCCATC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MPELPEVETSRRGIEPHLVGATILHAVVRNGRLRWPVSEEIYRLSDVPVLSVRRRAKYLLLELPDGWIIVHLGMSGSLRI
LSEELPAEKHDHVDLVMSNGKVLRYTDPRRFGAWLWTRTLEGHPVLAHLGPEPLSDAFNADYLQQKCAKKKTAIKPWLMD
NKLVVGVGNIYASESLFSAGIHPDRLASSLSREECEQLVKVIKLVLLRSIEQGGTTLKDFLQSDGKPGYFAQELQVYGRK
GEPCRICGTPVVGTKHAQRATFYCRQCQK

Sequences:

>Translated_269_residues
MPELPEVETSRRGIEPHLVGATILHAVVRNGRLRWPVSEEIYRLSDVPVLSVRRRAKYLLLELPDGWIIVHLGMSGSLRI
LSEELPAEKHDHVDLVMSNGKVLRYTDPRRFGAWLWTRTLEGHPVLAHLGPEPLSDAFNADYLQQKCAKKKTAIKPWLMD
NKLVVGVGNIYASESLFSAGIHPDRLASSLSREECEQLVKVIKLVLLRSIEQGGTTLKDFLQSDGKPGYFAQELQVYGRK
GEPCRICGTPVVGTKHAQRATFYCRQCQK
>Mature_268_residues
PELPEVETSRRGIEPHLVGATILHAVVRNGRLRWPVSEEIYRLSDVPVLSVRRRAKYLLLELPDGWIIVHLGMSGSLRIL
SEELPAEKHDHVDLVMSNGKVLRYTDPRRFGAWLWTRTLEGHPVLAHLGPEPLSDAFNADYLQQKCAKKKTAIKPWLMDN
KLVVGVGNIYASESLFSAGIHPDRLASSLSREECEQLVKVIKLVLLRSIEQGGTTLKDFLQSDGKPGYFAQELQVYGRKG
EPCRICGTPVVGTKHAQRATFYCRQCQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=269, Percent_Identity=91.0780669144982, Blast_Score=510, Evalue=1e-146,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 30285; Mature: 30154

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETSRRGIEPHLVGATILHAVVRNGRLRWPVSEEIYRLSDVPVLSVRRRAKYLL
CCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCEECCCHHHHHHHHCCCCHHHHHHCCCEEE
LELPDGWIIVHLGMSGSLRILSEELPAEKHDHVDLVMSNGKVLRYTDPRRFGAWLWTRTL
EECCCCEEEEEECCCCCEEHHHHHCCCCCCCCEEEEEECCEEEEECCCHHHHHHHHEEEC
EGHPVLAHLGPEPLSDAFNADYLQQKCAKKKTAIKPWLMDNKLVVGVGNIYASESLFSAG
CCCEEEEECCCCHHHHHCCHHHHHHHHHHHHHCCCCEEECCEEEEEECCHHHHHHHHHCC
IHPDRLASSLSREECEQLVKVIKLVLLRSIEQGGTTLKDFLQSDGKPGYFAQELQVYGRK
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHCCC
GEPCRICGTPVVGTKHAQRATFYCRQCQK
CCCEEEECCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
PELPEVETSRRGIEPHLVGATILHAVVRNGRLRWPVSEEIYRLSDVPVLSVRRRAKYLL
CCCCCCCHHHCCCCCHHHHHHHHHHHHHCCEECCCHHHHHHHHCCCCHHHHHHCCCEEE
LELPDGWIIVHLGMSGSLRILSEELPAEKHDHVDLVMSNGKVLRYTDPRRFGAWLWTRTL
EECCCCEEEEEECCCCCEEHHHHHCCCCCCCCEEEEEECCEEEEECCCHHHHHHHHEEEC
EGHPVLAHLGPEPLSDAFNADYLQQKCAKKKTAIKPWLMDNKLVVGVGNIYASESLFSAG
CCCEEEEECCCCHHHHHCCHHHHHHHHHHHHHCCCCEEECCEEEEEECCHHHHHHHHHCC
IHPDRLASSLSREECEQLVKVIKLVLLRSIEQGGTTLKDFLQSDGKPGYFAQELQVYGRK
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHCCC
GEPCRICGTPVVGTKHAQRATFYCRQCQK
CCCEEEECCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA