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The map label for this gene is selB [H]

Identifier: 238897039

GI number: 238897039

Start: 5033389

End: 5035230

Strand: Reverse

Name: selB [H]

Synonym: KP1_5286

Alternate gene names: 238897039

Gene position: 5035230-5033389 (Counterclockwise)

Preceding gene: 238897040

Following gene: 238897038

Centisome position: 95.94

GC content: 64.17

Gene sequence:

>1842_bases
ATGATTATTGCCACCGCTGGACATGTTGACCACGGCAAAACGACGCTGCTGCAGGCGATAACCGGCGTGAATGCCGATCG
TTTGCCGGAGGAGAAAGCGCGGGGAATGACGATCGATCTCGGCTATGCCTACTGGCCGCAGCCGGACGGGCGGGTGCTGG
GATTTATTGACGTTCCCGGGCACGAAAAGTTTTTGTCCAACATGCTGGCGGGGGTGGGCGGTATTGACCATGCGCTGCTG
GTGGTAGCCTGCGATGACGGGGTGATGGCGCAAACCCGCGAACACCTGGCGATCCTGCAGCTGACCGGAAAGCCGACGCT
GACCGTGGCGCTGACCAAAACGGACCGCGTGGCGGCCGCCAGGGTGGCGGAGGTTCAGGCAGAGGTCGAGCAGACCCTGG
GCGAGCTGGGCTTTGACGCCGTCGCTTTCTTTCCCACCGCGGCGGCGGAAAACATCGGTATTGCGGAACTGCGCAGCCAT
CTGCTGCAGCTTGCGGAGCGCCCCCGCCCGCAGCAGCAGCGGTTTCGCCTGGCGCTGGATCGCGCTTTTACCGTCAAAGG
CGCGGGGCTGGTGGTCACCGGGACGGCGCTCTCCGGCGAAGTACGGGTCGGGGATACCCTATGGCTTACCGGCGTCAACA
CGCCGATGCGCGTCCGCGGCCTGCATGCCCAGAATCAAGCGGTTGAGCAGGCGCACGCCGGACAGCGCATTGCGCTGAAT
ATTGTCGGCGATGCGCAAAAAGAGGCAGTGCACCGCGGCGACTGGCTGCTCTCCTCACCACCGCCGGAGCCAGCAGAACG
GGTGATTGTCGAGCTGCAGTGCCATACGCCGCTCAGCCAGTGGCAGCCGCTGCATATTCACCATGCTGCCAGCCACATTA
CCGGCCGGGTGTCGCTTCTTGAGGGCAACCTGGCGGAGCTGGTGCTGGATACTCCGCTGTGGCTGGCGGATAACGACCGG
CTGGTGCTCCGCGATATCTCTGCTCGCTTGACGCTGGCGGGCGCACGGGTGGTGACGCTGGATCCTCCGCGTCGCGGCAA
ACGTAAACCGGAATATCTGCAGTGGCTGCACGCCCTGGCAGCGGTCGGCGCTGACGATGCGCAGGCGCTGGAGCTGCATC
TGCAGCGGGATGCCGTCCGGCTTGAGCACTTCGCTTGGGCGCGGCAGCTCAGCGAAGCCGGAATGGCGGCCCTGATCCAG
CGACCGGACTATCTGCAGGCCGGACAGCGCCTGCTTAGCGCGCCGCTTGCCGCCCGCTGGCAGCGAAAATTGCTGGATGC
CCTTGCGCGCTACCATGAGCAGCATCGAGACGAGCCGGGCCCTGGCCGGGAGCGCCTGCGCCGCATCGCGCTGCCGATGG
AAGATGAAGCGCTGGTGCTGCTGCTGATTGAGCAGATGCGCGAGAGCGGCTTAGTCCACAGTCATCACGGCTGGCTGCAT
TTGCCGGAGCATAAAGCCGGGTTTACCGACGAGCAGCAGGCGGTCTGGCATAAGGTGGAGACTCTGTTCGGCGACGATCC
GTGGTGGGTGCGCGATCTTGCGCGCGAAGTCCATGTTGAAGAGTCCCTGATGCGCGCGGTGCTGCGCCAGGCGGCGCAGC
AGGGGATGATTACCGCGATCGTCAAGGATCGTTACTACCGCAACGATCGCATTGTGCAGTTCGCCCAGCGGGTGCGCGAG
CTGGATCGGCTGCGCGGTTCAACCTGCGCGGCGGATTTCCGCGATACCTTAAACGTAGGGCGGAAGCTGGCGATCCAGAT
CCTGGAGTATTTCGATCGGATTGGCTTCACCCGCCGTCGCGGTAACGATCATATCCTGCGCGATAAGGCATTGTTCCGGT
AA

Upstream 100 bases:

>100_bases
CGCTGCCGTGTCCGGTGATTGGCCGCATTTATGACGGTCGGCTCTGGTTGGACCTGCGCTGTCTGGAAGATGAAACCCGC
TTTATGGAGATGTTGTTACG

Downstream 100 bases:

>100_bases
TCATTAACGTCGGCTCCCCGGCGGACTTCGTGCCGGGGAGCTGGCGAAAAGAACTTGTTAAAACCACTACGTGAGACCGC
CGAAGCAATTTCGCGTGAGC

Product: selenocysteinyl-tRNA-specific translation factor

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 613; Mature: 613

Protein sequence:

>613_residues
MIIATAGHVDHGKTTLLQAITGVNADRLPEEKARGMTIDLGYAYWPQPDGRVLGFIDVPGHEKFLSNMLAGVGGIDHALL
VVACDDGVMAQTREHLAILQLTGKPTLTVALTKTDRVAAARVAEVQAEVEQTLGELGFDAVAFFPTAAAENIGIAELRSH
LLQLAERPRPQQQRFRLALDRAFTVKGAGLVVTGTALSGEVRVGDTLWLTGVNTPMRVRGLHAQNQAVEQAHAGQRIALN
IVGDAQKEAVHRGDWLLSSPPPEPAERVIVELQCHTPLSQWQPLHIHHAASHITGRVSLLEGNLAELVLDTPLWLADNDR
LVLRDISARLTLAGARVVTLDPPRRGKRKPEYLQWLHALAAVGADDAQALELHLQRDAVRLEHFAWARQLSEAGMAALIQ
RPDYLQAGQRLLSAPLAARWQRKLLDALARYHEQHRDEPGPGRERLRRIALPMEDEALVLLLIEQMRESGLVHSHHGWLH
LPEHKAGFTDEQQAVWHKVETLFGDDPWWVRDLAREVHVEESLMRAVLRQAAQQGMITAIVKDRYYRNDRIVQFAQRVRE
LDRLRGSTCAADFRDTLNVGRKLAIQILEYFDRIGFTRRRGNDHILRDKALFR

Sequences:

>Translated_613_residues
MIIATAGHVDHGKTTLLQAITGVNADRLPEEKARGMTIDLGYAYWPQPDGRVLGFIDVPGHEKFLSNMLAGVGGIDHALL
VVACDDGVMAQTREHLAILQLTGKPTLTVALTKTDRVAAARVAEVQAEVEQTLGELGFDAVAFFPTAAAENIGIAELRSH
LLQLAERPRPQQQRFRLALDRAFTVKGAGLVVTGTALSGEVRVGDTLWLTGVNTPMRVRGLHAQNQAVEQAHAGQRIALN
IVGDAQKEAVHRGDWLLSSPPPEPAERVIVELQCHTPLSQWQPLHIHHAASHITGRVSLLEGNLAELVLDTPLWLADNDR
LVLRDISARLTLAGARVVTLDPPRRGKRKPEYLQWLHALAAVGADDAQALELHLQRDAVRLEHFAWARQLSEAGMAALIQ
RPDYLQAGQRLLSAPLAARWQRKLLDALARYHEQHRDEPGPGRERLRRIALPMEDEALVLLLIEQMRESGLVHSHHGWLH
LPEHKAGFTDEQQAVWHKVETLFGDDPWWVRDLAREVHVEESLMRAVLRQAAQQGMITAIVKDRYYRNDRIVQFAQRVRE
LDRLRGSTCAADFRDTLNVGRKLAIQILEYFDRIGFTRRRGNDHILRDKALFR
>Mature_613_residues
MIIATAGHVDHGKTTLLQAITGVNADRLPEEKARGMTIDLGYAYWPQPDGRVLGFIDVPGHEKFLSNMLAGVGGIDHALL
VVACDDGVMAQTREHLAILQLTGKPTLTVALTKTDRVAAARVAEVQAEVEQTLGELGFDAVAFFPTAAAENIGIAELRSH
LLQLAERPRPQQQRFRLALDRAFTVKGAGLVVTGTALSGEVRVGDTLWLTGVNTPMRVRGLHAQNQAVEQAHAGQRIALN
IVGDAQKEAVHRGDWLLSSPPPEPAERVIVELQCHTPLSQWQPLHIHHAASHITGRVSLLEGNLAELVLDTPLWLADNDR
LVLRDISARLTLAGARVVTLDPPRRGKRKPEYLQWLHALAAVGADDAQALELHLQRDAVRLEHFAWARQLSEAGMAALIQ
RPDYLQAGQRLLSAPLAARWQRKLLDALARYHEQHRDEPGPGRERLRRIALPMEDEALVLLLIEQMRESGLVHSHHGWLH
LPEHKAGFTDEQQAVWHKVETLFGDDPWWVRDLAREVHVEESLMRAVLRQAAQQGMITAIVKDRYYRNDRIVQFAQRVRE
LDRLRGSTCAADFRDTLNVGRKLAIQILEYFDRIGFTRRRGNDHILRDKALFR

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=370, Percent_Identity=28.9189189189189, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI5729864, Length=374, Percent_Identity=26.4705882352941, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI223555963, Length=374, Percent_Identity=26.4705882352941, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI54607086, Length=283, Percent_Identity=24.7349823321555, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI53729339, Length=217, Percent_Identity=30.4147465437788, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI53729337, Length=217, Percent_Identity=30.4147465437788, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI2367247, Length=612, Percent_Identity=78.921568627451, Blast_Score=977, Evalue=0.0,
Organism=Escherichia coli, GI1790412, Length=367, Percent_Identity=29.4277929155313, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1789737, Length=367, Percent_Identity=29.4277929155313, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1789108, Length=292, Percent_Identity=27.7397260273973, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1789559, Length=95, Percent_Identity=40, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17556456, Length=410, Percent_Identity=27.3170731707317, Blast_Score=118, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25141371, Length=293, Percent_Identity=30.7167235494881, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17506081, Length=272, Percent_Identity=28.6764705882353, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17552884, Length=404, Percent_Identity=24.2574257425743, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17569207, Length=404, Percent_Identity=24.2574257425743, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI115532067, Length=305, Percent_Identity=28.1967213114754, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI115532065, Length=305, Percent_Identity=28.1967213114754, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI32566303, Length=393, Percent_Identity=22.1374045801527, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994658, Length=239, Percent_Identity=28.8702928870293, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212656558, Length=267, Percent_Identity=26.2172284644195, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324761, Length=288, Percent_Identity=32.2916666666667, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6325337, Length=400, Percent_Identity=24.25, Blast_Score=85, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319594, Length=400, Percent_Identity=24.25, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19921738, Length=285, Percent_Identity=33.3333333333333, Blast_Score=131, Evalue=2e-30,
Organism=Drosophila melanogaster, GI281363316, Length=388, Percent_Identity=29.1237113402062, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI17864358, Length=388, Percent_Identity=29.1237113402062, Blast_Score=130, Evalue=3e-30,
Organism=Drosophila melanogaster, GI19922690, Length=257, Percent_Identity=31.5175097276265, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24652838, Length=405, Percent_Identity=23.2098765432099, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17137572, Length=405, Percent_Identity=23.2098765432099, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28572034, Length=252, Percent_Identity=31.3492063492063, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI45550900, Length=377, Percent_Identity=23.6074270557029, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17137380, Length=350, Percent_Identity=24, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 68537; Mature: 68537

Theoretical pI: Translated: 7.52; Mature: 7.52

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIATAGHVDHGKTTLLQAITGVNADRLPEEKARGMTIDLGYAYWPQPDGRVLGFIDVPG
CEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHCCCEEEECEEECCCCCCCEEEEEECCC
HEKFLSNMLAGVGGIDHALLVVACDDGVMAQTREHLAILQLTGKPTLTVALTKTDRVAAA
HHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHCCEEEEEECCCCEEEEEEECCCHHHHH
RVAEVQAEVEQTLGELGFDAVAFFPTAAAENIGIAELRSHLLQLAERPRPQQQRFRLALD
HHHHHHHHHHHHHHHCCCHHHHHCCCHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
RAFTVKGAGLVVTGTALSGEVRVGDTLWLTGVNTPMRVRGLHAQNQAVEQAHAGQRIALN
HHEEEECCCEEEEECEECCCEEECCEEEEEECCCCCEEECCCHHHHHHHHHHCCCEEEEE
IVGDAQKEAVHRGDWLLSSPPPEPAERVIVELQCHTPLSQWQPLHIHHAASHITGRVSLL
EECCHHHHHHHCCCCCCCCCCCCCHHEEEEEEEECCCHHHCCCEEEEHHHHHHHCEEEEE
EGNLAELVLDTPLWLADNDRLVLRDISARLTLAGARVVTLDPPRRGKRKPEYLQWLHALA
CCCHHHHHCCCCEEEECCCEEEEEECCCEEEEECCEEEEECCCCCCCCCHHHHHHHHHHH
AVGADDAQALELHLQRDAVRLEHFAWARQLSEAGMAALIQRPDYLQAGQRLLSAPLAARW
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHH
QRKLLDALARYHEQHRDEPGPGRERLRRIALPMEDEALVLLLIEQMRESGLVHSHHGWLH
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEECCCCEEE
LPEHKAGFTDEQQAVWHKVETLFGDDPWWVRDLAREVHVEESLMRAVLRQAAQQGMITAI
CCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
VKDRYYRNDRIVQFAQRVRELDRLRGSTCAADFRDTLNVGRKLAIQILEYFDRIGFTRRR
HHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECC
GNDHILRDKALFR
CCCCEECCHHHCC
>Mature Secondary Structure
MIIATAGHVDHGKTTLLQAITGVNADRLPEEKARGMTIDLGYAYWPQPDGRVLGFIDVPG
CEEEECCCCCCCHHHHHHHHHCCCCCCCCHHHHCCCEEEECEEECCCCCCCEEEEEECCC
HEKFLSNMLAGVGGIDHALLVVACDDGVMAQTREHLAILQLTGKPTLTVALTKTDRVAAA
HHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHCCEEEEEECCCCEEEEEEECCCHHHHH
RVAEVQAEVEQTLGELGFDAVAFFPTAAAENIGIAELRSHLLQLAERPRPQQQRFRLALD
HHHHHHHHHHHHHHHCCCHHHHHCCCHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
RAFTVKGAGLVVTGTALSGEVRVGDTLWLTGVNTPMRVRGLHAQNQAVEQAHAGQRIALN
HHEEEECCCEEEEECEECCCEEECCEEEEEECCCCCEEECCCHHHHHHHHHHCCCEEEEE
IVGDAQKEAVHRGDWLLSSPPPEPAERVIVELQCHTPLSQWQPLHIHHAASHITGRVSLL
EECCHHHHHHHCCCCCCCCCCCCCHHEEEEEEEECCCHHHCCCEEEEHHHHHHHCEEEEE
EGNLAELVLDTPLWLADNDRLVLRDISARLTLAGARVVTLDPPRRGKRKPEYLQWLHALA
CCCHHHHHCCCCEEEECCCEEEEEECCCEEEEECCEEEEECCCCCCCCCHHHHHHHHHHH
AVGADDAQALELHLQRDAVRLEHFAWARQLSEAGMAALIQRPDYLQAGQRLLSAPLAARW
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHH
QRKLLDALARYHEQHRDEPGPGRERLRRIALPMEDEALVLLLIEQMRESGLVHSHHGWLH
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEECCCCEEE
LPEHKAGFTDEQQAVWHKVETLFGDDPWWVRDLAREVHVEESLMRAVLRQAAQQGMITAI
CCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
VKDRYYRNDRIVQFAQRVRELDRLRGSTCAADFRDTLNVGRKLAIQILEYFDRIGFTRRR
HHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECC
GNDHILRDKALFR
CCCCEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2531290; 8041620; 9278503; 2140572 [H]