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The map label for this gene is gntU [H]

Identifier: 238896897

GI number: 238896897

Start: 4871824

End: 4873164

Strand: Reverse

Name: gntU [H]

Synonym: KP1_5134

Alternate gene names: 238896897

Gene position: 4873164-4871824 (Counterclockwise)

Preceding gene: 238896898

Following gene: 238896895

Centisome position: 92.85

GC content: 60.4

Gene sequence:

>1341_bases
GTGAGTACTTTAACGCTTGTTTTAACAGCAGTCGGCTCGGTATTGCTGCTGCTGTTTTTAGTCATGAAGGCGCGAATGCA
CGCCTTCGTGGCTTTGATGGTGGTTTCTATTGGCGCCGGTCTCTTCTCCGGCATGCCGCTGGATAAAATCGCGGCGACGA
TGGAGAAAGGGATGGGCGGTACGCTGGGCTTCCTGGCGATCGTCGTCGCGCTCGGCGCGATGTTCGGTAAGATCCTGCAT
GAAACGGGGGCGGTCGATCAGATTGCCGTCAAGATGCTCAAATCCTTTGGCCACAATCGCGCGCACTATGCGATTGGTCT
CGCCGGTCTCATCTGCGCGCTGCCGCTGTTCTTCGAAGTGGCGATCGTACTGCTGATTAGCGTCGCCTTCTCGATGGCGC
GCCATACCGGTACTAACCTCGTGAAGCTGGTGATCCCGCTGTTTGCCGGCGTTGCCGCCGCCGCGGCGTTTCTGTTGCCT
GGACCGGCGCCGATGCTGCTGGCGTCGCAAATGCACGCCGACTTTGGCTGGATGATCCTGATTGGCCTGTGTGCGGCCAT
TCCGGGGATGATTATCGCCGGTCCGCTATGGGGCAACTTCATCAGCCGCTACGTCGAATTGCATATTCCTGACGACGTCA
CGGAACCGCATCTCGGGGAAGGCAAAATGCCCTCCTTCGGCTTCAGCCTGGCGCTGATCCTGCTGCCGCTGGTGCTGGTT
GGCCTGAAAACCATCGCCGCGCGCTTTGTGCCGGTGGGTTCCACTGCCTACGAATGGTTCGAGTTTATCGGCCACCCGTT
CACCGCGATCCTGGTGGCCTGCCTGGTGGCGATTTACGGTCTGGCGGTACGTCAGGGAATGGCGAAAGACCGGGTGATGG
AGATTTGCGGCCACGCGCTGCAGCCGGCCGGGATTATTCTGCTGGTGATCGGGGCTGGCGGCGTCTTCAAGCAGGTGCTG
GTTGACTCCGGCGTTGGCCCGGCGCTTGGTGAAGCGCTGACCGGAATGGGGCTGCCGATCGCTATTACCTGCTTCGTACT
GGCGGCGGCGGTGCGTATCATTCAGGGCTCTGCCACCGTGGCGTGCCTGACGGCGGTCGGCCTGGTGATGCCGGTGATTG
AGCAGCTGAACTACAGCGGCGCGCAGATGGCGGCATTGTCTATCTGTATCGCCGGCGGCTCGATTGTGGTAAGCCACGTG
AACGACGCCGGCTTCTGGCTGTTTGGTAAATTTACCGGCGCCAGTGAAGCCCAGACGCTGAAGACCTGGACCATGATGGA
AACCATCCTTGGCACCACCGGGGCGATTGTCGGTATGATCGCCTTCCAGCTGCTGAGCTAA

Upstream 100 bases:

>100_bases
CAGGCGCCGACGAGAGCGATGTGCTTATCGTCGATATCGACCAGCCGCTGGAAGGCGTGGTGGCCAGCACCATCGAGGTG
ATCAACAAAGGCAGTCACTA

Downstream 100 bases:

>100_bases
ACCCGCCCATCTCCCGCTCGCGGGAAATAAAAAGCCAGGGTAACGCTGCTTACCCTGGCTTCTTTGCAATAAGCCGCCCT
TTTTCCCTCTTTTCCTTGCC

Product: low affinity gluconate transporter

Products: Proton [Cytoplasm]; gluconate [Cytoplasm] [C]

Alternate protein names: Gluconate permease; Gnt-I system [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSTLTLVLTAVGSVLLLLFLVMKARMHAFVALMVVSIGAGLFSGMPLDKIAATMEKGMGGTLGFLAIVVALGAMFGKILH
ETGAVDQIAVKMLKSFGHNRAHYAIGLAGLICALPLFFEVAIVLLISVAFSMARHTGTNLVKLVIPLFAGVAAAAAFLLP
GPAPMLLASQMHADFGWMILIGLCAAIPGMIIAGPLWGNFISRYVELHIPDDVTEPHLGEGKMPSFGFSLALILLPLVLV
GLKTIAARFVPVGSTAYEWFEFIGHPFTAILVACLVAIYGLAVRQGMAKDRVMEICGHALQPAGIILLVIGAGGVFKQVL
VDSGVGPALGEALTGMGLPIAITCFVLAAAVRIIQGSATVACLTAVGLVMPVIEQLNYSGAQMAALSICIAGGSIVVSHV
NDAGFWLFGKFTGASEAQTLKTWTMMETILGTTGAIVGMIAFQLLS

Sequences:

>Translated_446_residues
MSTLTLVLTAVGSVLLLLFLVMKARMHAFVALMVVSIGAGLFSGMPLDKIAATMEKGMGGTLGFLAIVVALGAMFGKILH
ETGAVDQIAVKMLKSFGHNRAHYAIGLAGLICALPLFFEVAIVLLISVAFSMARHTGTNLVKLVIPLFAGVAAAAAFLLP
GPAPMLLASQMHADFGWMILIGLCAAIPGMIIAGPLWGNFISRYVELHIPDDVTEPHLGEGKMPSFGFSLALILLPLVLV
GLKTIAARFVPVGSTAYEWFEFIGHPFTAILVACLVAIYGLAVRQGMAKDRVMEICGHALQPAGIILLVIGAGGVFKQVL
VDSGVGPALGEALTGMGLPIAITCFVLAAAVRIIQGSATVACLTAVGLVMPVIEQLNYSGAQMAALSICIAGGSIVVSHV
NDAGFWLFGKFTGASEAQTLKTWTMMETILGTTGAIVGMIAFQLLS
>Mature_445_residues
STLTLVLTAVGSVLLLLFLVMKARMHAFVALMVVSIGAGLFSGMPLDKIAATMEKGMGGTLGFLAIVVALGAMFGKILHE
TGAVDQIAVKMLKSFGHNRAHYAIGLAGLICALPLFFEVAIVLLISVAFSMARHTGTNLVKLVIPLFAGVAAAAAFLLPG
PAPMLLASQMHADFGWMILIGLCAAIPGMIIAGPLWGNFISRYVELHIPDDVTEPHLGEGKMPSFGFSLALILLPLVLVG
LKTIAARFVPVGSTAYEWFEFIGHPFTAILVACLVAIYGLAVRQGMAKDRVMEICGHALQPAGIILLVIGAGGVFKQVLV
DSGVGPALGEALTGMGLPIAITCFVLAAAVRIIQGSATVACLTAVGLVMPVIEQLNYSGAQMAALSICIAGGSIVVSHVN
DAGFWLFGKFTGASEAQTLKTWTMMETILGTTGAIVGMIAFQLLS

Specific function: Part of the gluconate utilization system Gnt-I; low- affinity intake of gluconate [H]

COG id: COG2610

COG function: function code GE; H+/gluconate symporter and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gntP permease family [H]

Homologues:

Organism=Escherichia coli, GI48994939, Length=446, Percent_Identity=95.9641255605381, Blast_Score=796, Evalue=0.0,
Organism=Escherichia coli, GI1790716, Length=430, Percent_Identity=36.5116279069767, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI48994935, Length=434, Percent_Identity=35.4838709677419, Blast_Score=265, Evalue=4e-72,
Organism=Escherichia coli, GI2367370, Length=425, Percent_Identity=34.1176470588235, Blast_Score=238, Evalue=8e-64,
Organism=Escherichia coli, GI1789097, Length=450, Percent_Identity=34, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1788707, Length=426, Percent_Identity=34.9765258215962, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1790776, Length=432, Percent_Identity=31.712962962963, Blast_Score=204, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003474 [H]

Pfam domain/function: PF02447 GntP_permease [H]

EC number: NA

Molecular weight: Translated: 46374; Mature: 46242

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
STLTLVLTAVGSVLLLLFLVMKARMHAFVALMVVSIGAGLFSGMPLDKIAATMEKGMGG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
TLGFLAIVVALGAMFGKILHETGAVDQIAVKMLKSFGHNRAHYAIGLAGLICALPLFFEV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
AIVLLISVAFSMARHTGTNLVKLVIPLFAGVAAAAAFLLPGPAPMLLASQMHADFGWMIL
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHH
IGLCAAIPGMIIAGPLWGNFISRYVELHIPDDVTEPHLGEGKMPSFGFSLALILLPLVLV
HHHHHHCCHHHEECHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
GLKTIAARFVPVGSTAYEWFEFIGHPFTAILVACLVAIYGLAVRQGMAKDRVMEICGHAL
HHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
QPAGIILLVIGAGGVFKQVLVDSGVGPALGEALTGMGLPIAITCFVLAAAVRIIQGSATV
CCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHH
ACLTAVGLVMPVIEQLNYSGAQMAALSICIAGGSIVVSHVNDAGFWLFGKFTGASEAQTL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEECCCCCHHHHH
KTWTMMETILGTTGAIVGMIAFQLLS
HHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; gluconate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + gluconate [Periplasm] = Proton [Cytoplasm] + gluconate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]