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The map label for this gene is gntT [H]

Identifier: 238896882

GI number: 238896882

Start: 4847503

End: 4848819

Strand: Direct

Name: gntT [H]

Synonym: KP1_5119

Alternate gene names: 238896882

Gene position: 4847503-4848819 (Clockwise)

Preceding gene: 238896881

Following gene: 238896885

Centisome position: 92.36

GC content: 59.07

Gene sequence:

>1317_bases
ATGCCATTAGTCATCGTTGCTATCGGGGTTGCCCTGTTGTTGCTGTTAATGATCCGTTTCAAAATGAACGGCTTCATTGC
GCTGGTTCTGGTGGCGCTCGCCGTCGGATTAATGCAGGGTATGCCACTGGATAAAGTGATCGTCTCCATCAAAAACGGCG
TTGGCGGCACCCTTGGCAGCCTCGCGCTGATCATGGGCTTCGGCGCTATGCTCGGTAAGCTGCTGGCAGACTGCGGCGGC
GCCCAGCGTATCGCCACCACGCTTATCAATAAGTTCGGTAAGAAGCATATTCAGTGGGCGGTGGTCCTGACCGGCTTCAC
CGTTGGCTTCGCCCTGTTCTATGAAGTGGGCTTCGTGCTGATGCTGCCGCTGGTGTTCACCATCGCCGCCTCGGCCCGTA
TTCCGTTGCTGTACGTCGGCGTACCGATGGCAGCCGCGCTCTCCGTCACCCACGGCTTCCTGCCGCCGCATCCGGGTCCG
ACCGCGATCGCCACCATCTTCCATGCCGATATGGGCAAAACGCTGCTCTACGGCACCATTCTGGCTATCCCGACGGTTAT
CCTGGCGGGACCGGTGTTTGCGCGCTTCCTGAAAGGGATAGATAAGCCGATCCCGGAAGGCCTGCATAACCCGAAAGTGT
TCACTGAAGAAGAGATGCCAGGCTTTGGCGTCAGCGTCTGGACCTCGCTGGTTCCGGTGATCCTGATGGCGATGCGCGCC
GTGGCTGAGATGATCCTGCCGAAAGGCCACGCCTTCCTGCCAATTGCCGAGTTCTTCGGCGACCCGGTGATGGCCACCCT
GATTGCGGTACTGATTGCCCTGTTCACCTTCGGTTTGAACCGCGGCCGCTCCATGGAGCAGATCAACGATACCCTGACCT
CTTCGATCAAAATCATCGCCATGATGCTGTTGATCATCGGCGGCGGCGGTGCCTTCAAGCAGGTGCTGGTGGATAGCGGC
ATGGATAAATACATCGCCTCTATCATGCACGAATCGAACATGTCTCCGCTGTTTATGGCGTGGTCTATCGCCGCGGTGCT
GCGTATCGCGCTGGGTTCGGCGACCGTGGCCGCCATCACCGCGGGCGGGATCGCCGCGCCGCTGATCGCCACCACCGGCG
TCAGCCCGGAGCTGATGGTTATCGCCGTTGGCTCCGGCAGCGTTATCTTCTCCCATGTTAACGATCCGGGCTTCTGGCTG
TTCAAAGAGTACTTTAACCTGACCATCGGCGAGACCATCAAGTCCTGGTCGGTGCTGGAAACCATTATCTCAGTCTGCGG
CCTGGTGGGCTGTCTGCTGCTGGGGATGGTGGTGTAA

Upstream 100 bases:

>100_bases
AAGCGTTTACGGTGCCAGACTATTTTGCTCCCTGACGGAGCGGATGCTCTACAGGTTCGAACTTTGACGTTACCCATAAC
AAATTAAGGCCAGGTAAATC

Downstream 100 bases:

>100_bases
GGTCACTCCCGCCACAGAAAAAGGCCGGTCCGCGTGAAGCGGGCCGGCCTTTTTTATCGGACATGCTCTTCGCCGCGCAG
AGGAGCGCGCGGCAGGAAGT

Product: high-affinity gluconate transporter

Products: Proton [Cytoplasm]; gluconate [Cytoplasm] [C]

Alternate protein names: Gluconate permease; Gnt-I system [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MPLVIVAIGVALLLLLMIRFKMNGFIALVLVALAVGLMQGMPLDKVIVSIKNGVGGTLGSLALIMGFGAMLGKLLADCGG
AQRIATTLINKFGKKHIQWAVVLTGFTVGFALFYEVGFVLMLPLVFTIAASARIPLLYVGVPMAAALSVTHGFLPPHPGP
TAIATIFHADMGKTLLYGTILAIPTVILAGPVFARFLKGIDKPIPEGLHNPKVFTEEEMPGFGVSVWTSLVPVILMAMRA
VAEMILPKGHAFLPIAEFFGDPVMATLIAVLIALFTFGLNRGRSMEQINDTLTSSIKIIAMMLLIIGGGGAFKQVLVDSG
MDKYIASIMHESNMSPLFMAWSIAAVLRIALGSATVAAITAGGIAAPLIATTGVSPELMVIAVGSGSVIFSHVNDPGFWL
FKEYFNLTIGETIKSWSVLETIISVCGLVGCLLLGMVV

Sequences:

>Translated_438_residues
MPLVIVAIGVALLLLLMIRFKMNGFIALVLVALAVGLMQGMPLDKVIVSIKNGVGGTLGSLALIMGFGAMLGKLLADCGG
AQRIATTLINKFGKKHIQWAVVLTGFTVGFALFYEVGFVLMLPLVFTIAASARIPLLYVGVPMAAALSVTHGFLPPHPGP
TAIATIFHADMGKTLLYGTILAIPTVILAGPVFARFLKGIDKPIPEGLHNPKVFTEEEMPGFGVSVWTSLVPVILMAMRA
VAEMILPKGHAFLPIAEFFGDPVMATLIAVLIALFTFGLNRGRSMEQINDTLTSSIKIIAMMLLIIGGGGAFKQVLVDSG
MDKYIASIMHESNMSPLFMAWSIAAVLRIALGSATVAAITAGGIAAPLIATTGVSPELMVIAVGSGSVIFSHVNDPGFWL
FKEYFNLTIGETIKSWSVLETIISVCGLVGCLLLGMVV
>Mature_437_residues
PLVIVAIGVALLLLLMIRFKMNGFIALVLVALAVGLMQGMPLDKVIVSIKNGVGGTLGSLALIMGFGAMLGKLLADCGGA
QRIATTLINKFGKKHIQWAVVLTGFTVGFALFYEVGFVLMLPLVFTIAASARIPLLYVGVPMAAALSVTHGFLPPHPGPT
AIATIFHADMGKTLLYGTILAIPTVILAGPVFARFLKGIDKPIPEGLHNPKVFTEEEMPGFGVSVWTSLVPVILMAMRAV
AEMILPKGHAFLPIAEFFGDPVMATLIAVLIALFTFGLNRGRSMEQINDTLTSSIKIIAMMLLIIGGGGAFKQVLVDSGM
DKYIASIMHESNMSPLFMAWSIAAVLRIALGSATVAAITAGGIAAPLIATTGVSPELMVIAVGSGSVIFSHVNDPGFWLF
KEYFNLTIGETIKSWSVLETIISVCGLVGCLLLGMVV

Specific function: Part of the gluconate utilization system Gnt-I; high- affinity intake of gluconate [H]

COG id: COG2610

COG function: function code GE; H+/gluconate symporter and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gntP permease family [H]

Homologues:

Organism=Escherichia coli, GI48994935, Length=438, Percent_Identity=93.1506849315068, Blast_Score=786, Evalue=0.0,
Organism=Escherichia coli, GI1790716, Length=438, Percent_Identity=62.5570776255708, Blast_Score=544, Evalue=1e-156,
Organism=Escherichia coli, GI2367370, Length=449, Percent_Identity=48.9977728285078, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1790776, Length=438, Percent_Identity=39.9543378995434, Blast_Score=345, Evalue=3e-96,
Organism=Escherichia coli, GI1788707, Length=435, Percent_Identity=36.7816091954023, Blast_Score=271, Evalue=7e-74,
Organism=Escherichia coli, GI48994939, Length=434, Percent_Identity=35.0230414746544, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1789097, Length=439, Percent_Identity=33.4851936218679, Blast_Score=221, Evalue=7e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003474 [H]

Pfam domain/function: PF02447 GntP_permease [H]

EC number: NA

Molecular weight: Translated: 46137; Mature: 46005

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVIVAIGVALLLLLMIRFKMNGFIALVLVALAVGLMQGMPLDKVIVSIKNGVGGTLGS
CCEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHH
LALIMGFGAMLGKLLADCGGAQRIATTLINKFGKKHIQWAVVLTGFTVGFALFYEVGFVL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLPLVFTIAASARIPLLYVGVPMAAALSVTHGFLPPHPGPTAIATIFHADMGKTLLYGTI
HHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHH
LAIPTVILAGPVFARFLKGIDKPIPEGLHNPKVFTEEEMPGFGVSVWTSLVPVILMAMRA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHH
VAEMILPKGHAFLPIAEFFGDPVMATLIAVLIALFTFGLNRGRSMEQINDTLTSSIKIIA
HHHHHCCCCCCEEEHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
MMLLIIGGGGAFKQVLVDSGMDKYIASIMHESNMSPLFMAWSIAAVLRIALGSATVAAIT
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHH
AGGIAAPLIATTGVSPELMVIAVGSGSVIFSHVNDPGFWLFKEYFNLTIGETIKSWSVLE
HCCHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHH
TIISVCGLVGCLLLGMVV
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PLVIVAIGVALLLLLMIRFKMNGFIALVLVALAVGLMQGMPLDKVIVSIKNGVGGTLGS
CEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHH
LALIMGFGAMLGKLLADCGGAQRIATTLINKFGKKHIQWAVVLTGFTVGFALFYEVGFVL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLPLVFTIAASARIPLLYVGVPMAAALSVTHGFLPPHPGPTAIATIFHADMGKTLLYGTI
HHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHH
LAIPTVILAGPVFARFLKGIDKPIPEGLHNPKVFTEEEMPGFGVSVWTSLVPVILMAMRA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCHHHHHHHHHHHHHHHHH
VAEMILPKGHAFLPIAEFFGDPVMATLIAVLIALFTFGLNRGRSMEQINDTLTSSIKIIA
HHHHHCCCCCCEEEHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
MMLLIIGGGGAFKQVLVDSGMDKYIASIMHESNMSPLFMAWSIAAVLRIALGSATVAAIT
HHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHH
AGGIAAPLIATTGVSPELMVIAVGSGSVIFSHVNDPGFWLFKEYFNLTIGETIKSWSVLE
HCCHHHHHHHHCCCCCCEEEEEECCCCEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHH
TIISVCGLVGCLLLGMVV
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; gluconate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + gluconate [Periplasm] = Proton [Cytoplasm] + gluconate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 2845225; 7984428; 3040894; 9045817 [H]