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The map label for this gene is trpS [H]

Identifier: 238896852

GI number: 238896852

Start: 4816326

End: 4817330

Strand: Reverse

Name: trpS [H]

Synonym: KP1_5085

Alternate gene names: 238896852

Gene position: 4817330-4816326 (Counterclockwise)

Preceding gene: 238896853

Following gene: 238896848

Centisome position: 91.78

GC content: 55.52

Gene sequence:

>1005_bases
ATGACTAAGCCCATCGTTTTTAGTGGCGCACAGCCCTCAGGTGAACTGACCATTGGCAACTATATGGGTGCGCTGCGTCA
GTGGGTAAACATGCAGGACGATTACCACTGCATCTATTGCATCGTGGACCAGCACGCCATCACCGTGCGCCAGGATCCGC
AGCAGCTGCGCAAGGCGACGCTGGACACCCTGGCGCTGTATCTGGCCTGCGGCATCGACCCGCAGAAAAGCACTATCTTC
GTGCAGTCGCACGTGCCGGAACATGCCCAGCTAGGCTGGGCGCTGAACTGCTACACCTATTTCGGCGAACTGAGCCGCAT
GACTCAGTTTAAAGACAAGTCAGCGCGCTACGCGGAGAACATCAACGCCGGTCTGTTTGATTATCCGGTACTGATGGCCG
CTGACATTCTGCTGTACCAGACCAACCAGGTTCCGGTGGGCGAAGATCAGAAACAGCACCTTGAGCTAAGCCGCGATATC
GCCCAGCGTTTTAACGCCATCTACGGCGATATTTTTAAAGTGCCTGAGCCGTTTATCCCTAAATCCGGCGCGCGCGTGAT
GTCGCTGCTGGAGCCGACGAAAAAGATGTCCAAGTCCGACGACAACCGCAACAACGTCATCGGCCTGCTGGAAGATCCGA
AATCGGTGGTCAAGAAGATTAAACGTGCGGTCACCGACTCCGACGAGCCGCCGGTAGTGCGTTACGATCTGAAAGAGAAA
GCGGGCGTCTCCAACCTGCTGGATATCCTCTCCGCGGTTACCGGGAAAACTATTCCTGAGCTGGAACAGCATTTTGAAGG
CAAAATGTATGGCCACCTGAAAGGCGAAGTCGCCGAAGCGGTATCGGGCATGCTGATTGATCTGCAGGAGCGCTATCACC
GTTTCCGTAACGACGAAGCGTTTCTCAATCAGGTGATGAAAGACGGCGCGGAAAAGGCCAGCGCGCGGGCTTCTCAAACC
CTGAAAGCGGTATACGAAGCGATTGGCTTTGTCGCCAAGCCGTAA

Upstream 100 bases:

>100_bases
GAACCGCTTGCGCTGAGCGAGCCGGACTATCTCTTCGACCAGTTTAACGAACTCTTACCCGCTCTCGGGTTACCGCACAG
TGAAACTCAGGAATTGAAAC

Downstream 100 bases:

>100_bases
GCGACGCAACAGCTAAAAGGGCGGGATGATATCCCGCCCTTTTTTATGCCTGTCGCTTTATGGGAGGCAAGGTTAATGGT
TCGAAAACCAGTTCAGTTTA

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTKPIVFSGAQPSGELTIGNYMGALRQWVNMQDDYHCIYCIVDQHAITVRQDPQQLRKATLDTLALYLACGIDPQKSTIF
VQSHVPEHAQLGWALNCYTYFGELSRMTQFKDKSARYAENINAGLFDYPVLMAADILLYQTNQVPVGEDQKQHLELSRDI
AQRFNAIYGDIFKVPEPFIPKSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKSVVKKIKRAVTDSDEPPVVRYDLKEK
AGVSNLLDILSAVTGKTIPELEQHFEGKMYGHLKGEVAEAVSGMLIDLQERYHRFRNDEAFLNQVMKDGAEKASARASQT
LKAVYEAIGFVAKP

Sequences:

>Translated_334_residues
MTKPIVFSGAQPSGELTIGNYMGALRQWVNMQDDYHCIYCIVDQHAITVRQDPQQLRKATLDTLALYLACGIDPQKSTIF
VQSHVPEHAQLGWALNCYTYFGELSRMTQFKDKSARYAENINAGLFDYPVLMAADILLYQTNQVPVGEDQKQHLELSRDI
AQRFNAIYGDIFKVPEPFIPKSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKSVVKKIKRAVTDSDEPPVVRYDLKEK
AGVSNLLDILSAVTGKTIPELEQHFEGKMYGHLKGEVAEAVSGMLIDLQERYHRFRNDEAFLNQVMKDGAEKASARASQT
LKAVYEAIGFVAKP
>Mature_333_residues
TKPIVFSGAQPSGELTIGNYMGALRQWVNMQDDYHCIYCIVDQHAITVRQDPQQLRKATLDTLALYLACGIDPQKSTIFV
QSHVPEHAQLGWALNCYTYFGELSRMTQFKDKSARYAENINAGLFDYPVLMAADILLYQTNQVPVGEDQKQHLELSRDIA
QRFNAIYGDIFKVPEPFIPKSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKSVVKKIKRAVTDSDEPPVVRYDLKEKA
GVSNLLDILSAVTGKTIPELEQHFEGKMYGHLKGEVAEAVSGMLIDLQERYHRFRNDEAFLNQVMKDGAEKASARASQTL
KAVYEAIGFVAKP

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=331, Percent_Identity=42.2960725075529, Blast_Score=266, Evalue=2e-71,
Organism=Homo sapiens, GI41352700, Length=179, Percent_Identity=51.9553072625698, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1789786, Length=334, Percent_Identity=94.311377245509, Blast_Score=665, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71982800, Length=334, Percent_Identity=35.9281437125749, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI71982793, Length=334, Percent_Identity=35.9281437125749, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6320474, Length=345, Percent_Identity=38.8405797101449, Blast_Score=229, Evalue=5e-61,
Organism=Drosophila melanogaster, GI24666151, Length=334, Percent_Identity=43.7125748502994, Blast_Score=249, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 37505; Mature: 37374

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPIVFSGAQPSGELTIGNYMGALRQWVNMQDDYHCIYCIVDQHAITVRQDPQQLRKAT
CCCCEEEECCCCCCCEEHHHHHHHHHHHHCCCCCCEEEEEEEECCEEEECCCHHHHHHHH
LDTLALYLACGIDPQKSTIFVQSHVPEHAQLGWALNCYTYFGELSRMTQFKDKSARYAEN
HHHHHHHHHHCCCCCCCEEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
INAGLFDYPVLMAADILLYQTNQVPVGEDQKQHLELSRDIAQRFNAIYGDIFKVPEPFIP
CCCCCHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKSVVKKIKRAVTDSDEPPVVRYDLKEK
CCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEECCHHH
AGVSNLLDILSAVTGKTIPELEQHFEGKMYGHLKGEVAEAVSGMLIDLQERYHRFRNDEA
CCHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
FLNQVMKDGAEKASARASQTLKAVYEAIGFVAKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKPIVFSGAQPSGELTIGNYMGALRQWVNMQDDYHCIYCIVDQHAITVRQDPQQLRKAT
CCCEEEECCCCCCCEEHHHHHHHHHHHHCCCCCCEEEEEEEECCEEEECCCHHHHHHHH
LDTLALYLACGIDPQKSTIFVQSHVPEHAQLGWALNCYTYFGELSRMTQFKDKSARYAEN
HHHHHHHHHHCCCCCCCEEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
INAGLFDYPVLMAADILLYQTNQVPVGEDQKQHLELSRDIAQRFNAIYGDIFKVPEPFIP
CCCCCHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKSVVKKIKRAVTDSDEPPVVRYDLKEK
CCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEECCHHH
AGVSNLLDILSAVTGKTIPELEQHFEGKMYGHLKGEVAEAVSGMLIDLQERYHRFRNDEA
CCHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
FLNQVMKDGAEKASARASQTLKAVYEAIGFVAKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]