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The map label for this gene is fusA [H]

Identifier: 238896822

GI number: 238896822

Start: 4787767

End: 4789881

Strand: Reverse

Name: fusA [H]

Synonym: KP1_5050

Alternate gene names: 238896822

Gene position: 4789881-4787767 (Counterclockwise)

Preceding gene: 238896823

Following gene: 238896821

Centisome position: 91.26

GC content: 52.1

Gene sequence:

>2115_bases
ATGGCTCGTACAACACCCATCGCACGCTACCGTAACATCGGTATCAGTGCGCACATCGACGCCGGTAAAACCACTACTAC
CGAACGTATTCTGTTCTACACCGGTGTAAACCACAAAATCGGTGAAGTTCATGACGGCGCCGCTACCATGGACTGGATGG
AGCAGGAGCAGGAACGTGGTATCACCATCACTTCCGCTGCGACTACTGCATTCTGGTCTGGTATGGCCAAACAGTATGAA
CCGCACCGCGTAAACATCATCGACACCCCGGGGCACGTTGACTTCACTATCGAAGTAGAACGTTCCATGCGTGTTCTTGA
TGGTGCGGTAATGGTTTACTGCGCAGTTGGTGGTGTTCAGCCGCAGTCTGAAACCGTATGGCGTCAGGCAAACAAATATA
AAGTTCCGCGCATCGCGTTCGTTAACAAAATGGACCGCATGGGCGCTAACTTCCTGAAAGTTGTTGGTCAGATCAAAACC
CGTCTGGGCGCGAACCCGGTTCCGCTGCAGCTGGCAATTGGTGCTGAAGAAGGTTTCACCGGCGTTGTTGACCTGGTGAA
AATGAAAGCCATCAACTGGAACGATGCAGACCAGGGGGTAACCTTCGAATACGAAGATATCCCGGCTGACATGCAGGACC
TGGCTGATGAATGGCACCAGAACCTGATCGAATCCGCAGCTGAAGCTTCTGAAGAGCTGATGGAAAAATACCTGGGTGGT
GAAGAACTGACTGAAGAAGAGATCAAAAAAGCTCTGCGTCAGCGCGTTCTGAACAACGAAATCATCCTGGTAACCTGTGG
TTCTGCGTTCAAGAACAAAGGCGTTCAGGCGATGCTGGATGCGGTAATTGATTACCTGCCATCCCCGGTTGACGTACCTG
CGATCAACGGTATCCTGGACGACGGTAAAGATACCCCGGCTGAGCGTCACGCAAGCGACGACGAGCCGTTCTCTGCACTG
GCGTTCAAAATCGCTACCGACCCGTTCGTGGGTAACCTGACCTTCTTCCGCGTGTACTCCGGTGTGGTTAACTCTGGTGA
TACCGTACTGAACTCCGTGAAAGCTGCACGTGAGCGTTTCGGTCGTATCGTTCAGATGCACGCTAACAAACGTGAAGAGA
TCAAAGAAGTTCGCGCGGGCGATATCGCTGCTGCTATCGGTCTGAAAGACGTAACTACTGGTGACACCCTGTGTGACCCG
GATGCGCCGATCATTCTGGAGCGTATGGAATTCCCTGAGCCGGTAATCTCCATCGCCGTTGAGCCGAAAACCAAAGCTGA
CCAGGAAAAAATGGGTCTGGCTCTGGGTCGTCTGGCTAAAGAAGACCCGTCTTTCCGCGTATGGACTGACGAAGAGTCTA
ACCAGACCATTATCGCCGGTATGGGTGAGCTGCACCTCGACATCATCGTTGACCGTATGAAGCGTGAATTCAACGTTGAA
GCGAACGTCGGTAAACCTCAGGTTGCTTACCGTGAAGCGATTCGCGCGAAAGTTACCGATATCGAAGGTAAACACGCCAA
GCAGTCTGGTGGTCGTGGTCAGTACGGTCACGTTGTGATCGACATGTACCCGCTGGAGCCGGGCTCTAACCCGAAAGGTT
ACGAGTTCATCAACGACATCAAAGGTGGTGTAATTCCTGGCGAATACATCCCGGCCGTTGATAAAGGCATCCAGGAACAG
CTGAAAGCTGGTCCGCTGGCAGGTTACCCGGTAGTTGATATGGGTATCCGTCTGCACTTCGGTTCTTACCACGACGTTGA
CTCCTCTGAGCTGGCGTTTAAACTGGCTGCGTCTATTGCCTTTAAAGAAGGCTTTAAGAAAGCAAAACCAGTTCTGCTTG
AGCCGATCATGAAGGTTGAAGTAGAAACTCCGGAAGAGAACACTGGTGACGTTATCGGTGACTTGAGCCGTCGTCGCGGT
ATGCTGCGCGGTCAGGAATCCGAAGTAACCGGCGTTAAGATCCACGCTGAAGTACCGCTGTCCGAAATGTTCGGTTATGC
AACTCAGCTGCGTTCTCTGACCAAAGGTCGTGCATCATACACCATGGAATTCCTGAAGTATGATGATGCGCCGAACAACG
TTGCTCAGGCCGTTATTGAAGCCCGTGGTAAATAA

Upstream 100 bases:

>100_bases
GTAATCCCTTCGGAGTCATAGTCACCAGGCGGGCGCTTCAGATGAGTCGCCCGCTCTGGATAACTTAACTGAACGCCTAA
AGAAATAAACGAGGAATCAA

Downstream 100 bases:

>100_bases
TCCACAGGATTAAAACCTAAGTCCCGTGCTCTCTCCGAAGGGGAGAGCACTATAGTAAGGAATATAGCCGTGTCTAAAGA
AAAATTTGAACGTACAAAAC

Product: elongation factor G

Products: GDP; phosphate

Alternate protein names: EF-G [H]

Number of amino acids: Translated: 704; Mature: 703

Protein sequence:

>704_residues
MARTTPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWSGMAKQYE
PHRVNIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYKVPRIAFVNKMDRMGANFLKVVGQIKT
RLGANPVPLQLAIGAEEGFTGVVDLVKMKAINWNDADQGVTFEYEDIPADMQDLADEWHQNLIESAAEASEELMEKYLGG
EELTEEEIKKALRQRVLNNEIILVTCGSAFKNKGVQAMLDAVIDYLPSPVDVPAINGILDDGKDTPAERHASDDEPFSAL
AFKIATDPFVGNLTFFRVYSGVVNSGDTVLNSVKAARERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDP
DAPIILERMEFPEPVISIAVEPKTKADQEKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGELHLDIIVDRMKREFNVE
ANVGKPQVAYREAIRAKVTDIEGKHAKQSGGRGQYGHVVIDMYPLEPGSNPKGYEFINDIKGGVIPGEYIPAVDKGIQEQ
LKAGPLAGYPVVDMGIRLHFGSYHDVDSSELAFKLAASIAFKEGFKKAKPVLLEPIMKVEVETPEENTGDVIGDLSRRRG
MLRGQESEVTGVKIHAEVPLSEMFGYATQLRSLTKGRASYTMEFLKYDDAPNNVAQAVIEARGK

Sequences:

>Translated_704_residues
MARTTPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWSGMAKQYE
PHRVNIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYKVPRIAFVNKMDRMGANFLKVVGQIKT
RLGANPVPLQLAIGAEEGFTGVVDLVKMKAINWNDADQGVTFEYEDIPADMQDLADEWHQNLIESAAEASEELMEKYLGG
EELTEEEIKKALRQRVLNNEIILVTCGSAFKNKGVQAMLDAVIDYLPSPVDVPAINGILDDGKDTPAERHASDDEPFSAL
AFKIATDPFVGNLTFFRVYSGVVNSGDTVLNSVKAARERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDP
DAPIILERMEFPEPVISIAVEPKTKADQEKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGELHLDIIVDRMKREFNVE
ANVGKPQVAYREAIRAKVTDIEGKHAKQSGGRGQYGHVVIDMYPLEPGSNPKGYEFINDIKGGVIPGEYIPAVDKGIQEQ
LKAGPLAGYPVVDMGIRLHFGSYHDVDSSELAFKLAASIAFKEGFKKAKPVLLEPIMKVEVETPEENTGDVIGDLSRRRG
MLRGQESEVTGVKIHAEVPLSEMFGYATQLRSLTKGRASYTMEFLKYDDAPNNVAQAVIEARGK
>Mature_703_residues
ARTTPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWSGMAKQYEP
HRVNIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQPQSETVWRQANKYKVPRIAFVNKMDRMGANFLKVVGQIKTR
LGANPVPLQLAIGAEEGFTGVVDLVKMKAINWNDADQGVTFEYEDIPADMQDLADEWHQNLIESAAEASEELMEKYLGGE
ELTEEEIKKALRQRVLNNEIILVTCGSAFKNKGVQAMLDAVIDYLPSPVDVPAINGILDDGKDTPAERHASDDEPFSALA
FKIATDPFVGNLTFFRVYSGVVNSGDTVLNSVKAARERFGRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDPD
APIILERMEFPEPVISIAVEPKTKADQEKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGELHLDIIVDRMKREFNVEA
NVGKPQVAYREAIRAKVTDIEGKHAKQSGGRGQYGHVVIDMYPLEPGSNPKGYEFINDIKGGVIPGEYIPAVDKGIQEQL
KAGPLAGYPVVDMGIRLHFGSYHDVDSSELAFKLAASIAFKEGFKKAKPVLLEPIMKVEVETPEENTGDVIGDLSRRRGM
LRGQESEVTGVKIHAEVPLSEMFGYATQLRSLTKGRASYTMEFLKYDDAPNNVAQAVIEARGK

Specific function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=703, Percent_Identity=44.5234708392603, Blast_Score=568, Evalue=1e-162,
Organism=Homo sapiens, GI19923640, Length=721, Percent_Identity=38.4188626907073, Blast_Score=441, Evalue=1e-123,
Organism=Homo sapiens, GI25306287, Length=721, Percent_Identity=36.754507628294, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI25306283, Length=460, Percent_Identity=41.0869565217391, Blast_Score=300, Evalue=3e-81,
Organism=Homo sapiens, GI157426893, Length=154, Percent_Identity=35.7142857142857, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI94966754, Length=140, Percent_Identity=37.8571428571429, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI4503483, Length=150, Percent_Identity=38, Blast_Score=96, Evalue=2e-19,
Organism=Homo sapiens, GI310132016, Length=123, Percent_Identity=39.0243902439024, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI310110807, Length=123, Percent_Identity=39.0243902439024, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI310123363, Length=123, Percent_Identity=39.0243902439024, Blast_Score=82, Evalue=2e-15,
Organism=Escherichia coli, GI1789738, Length=704, Percent_Identity=98.0113636363636, Blast_Score=1422, Evalue=0.0,
Organism=Escherichia coli, GI1790835, Length=493, Percent_Identity=26.1663286004057, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI48994988, Length=152, Percent_Identity=39.4736842105263, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1788922, Length=155, Percent_Identity=35.4838709677419, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17533571, Length=709, Percent_Identity=43.0183356840621, Blast_Score=531, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17556745, Length=713, Percent_Identity=29.7335203366059, Blast_Score=292, Evalue=4e-79,
Organism=Caenorhabditis elegans, GI17506493, Length=426, Percent_Identity=26.9953051643192, Blast_Score=105, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17557151, Length=172, Percent_Identity=37.7906976744186, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71988819, Length=147, Percent_Identity=34.6938775510204, Blast_Score=84, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71988811, Length=147, Percent_Identity=34.6938775510204, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6323098, Length=695, Percent_Identity=42.7338129496403, Blast_Score=551, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6322359, Length=799, Percent_Identity=30.162703379224, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6324707, Length=480, Percent_Identity=25.625, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320593, Length=480, Percent_Identity=25.625, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323320, Length=162, Percent_Identity=35.8024691358025, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324166, Length=145, Percent_Identity=40, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24582462, Length=707, Percent_Identity=44.6958981612447, Blast_Score=588, Evalue=1e-168,
Organism=Drosophila melanogaster, GI221458488, Length=744, Percent_Identity=32.1236559139785, Blast_Score=364, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24585709, Length=812, Percent_Identity=26.7241379310345, Blast_Score=169, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24585711, Length=812, Percent_Identity=26.7241379310345, Blast_Score=169, Evalue=7e-42,
Organism=Drosophila melanogaster, GI24585713, Length=812, Percent_Identity=26.7241379310345, Blast_Score=169, Evalue=7e-42,
Organism=Drosophila melanogaster, GI78706572, Length=186, Percent_Identity=34.4086021505376, Blast_Score=104, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28574573, Length=141, Percent_Identity=36.8794326241135, Blast_Score=83, Evalue=6e-16,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR004540
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 77544; Mature: 77413

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTTPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERG
CCCCCCCHHHHCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCC
ITITSAATTAFWSGMAKQYEPHRVNIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQ
EEEEEHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECHHHHHHHHHEEEEEECCCCC
PQSETVWRQANKYKVPRIAFVNKMDRMGANFLKVVGQIKTRLGANPVPLQLAIGAEEGFT
CCHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCH
GVVDLVKMKAINWNDADQGVTFEYEDIPADMQDLADEWHQNLIESAAEASEELMEKYLGG
HHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EELTEEEIKKALRQRVLNNEIILVTCGSAFKNKGVQAMLDAVIDYLPSPVDVPAINGILD
CCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHCCHHHHHHHHHHHCCCCCCCCHHCCCCC
DGKDTPAERHASDDEPFSALAFKIATDPFVGNLTFFRVYSGVVNSGDTVLNSVKAARERF
CCCCCCHHHCCCCCCCHHHEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
GRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDPDAPIILERMEFPEPVISIAV
HHHHHHHCCCHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCEEEHHHCCCCCEEEEEE
EPKTKADQEKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGELHLDIIVDRMKREFNVE
CCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHCCCC
ANVGKPQVAYREAIRAKVTDIEGKHAKQSGGRGQYGHVVIDMYPLEPGSNPKGYEFINDI
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHC
KGGVIPGEYIPAVDKGIQEQLKAGPLAGYPVVDMGIRLHFGSYHDVDSSELAFKLAASIA
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEECCEEEEECCCCCCCCHHHHHHHHHHHH
FKEGFKKAKPVLLEPIMKVEVETPEENTGDVIGDLSRRRGMLRGQESEVTGVKIHAEVPL
HHHHHHHCCCHHHCCHHEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCH
SEMFGYATQLRSLTKGRASYTMEFLKYDDAPNNVAQAVIEARGK
HHHHHHHHHHHHHHCCHHHHEEHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
ARTTPIARYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERG
CCCCCCHHHHCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCC
ITITSAATTAFWSGMAKQYEPHRVNIIDTPGHVDFTIEVERSMRVLDGAVMVYCAVGGVQ
EEEEEHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECHHHHHHHHHEEEEEECCCCC
PQSETVWRQANKYKVPRIAFVNKMDRMGANFLKVVGQIKTRLGANPVPLQLAIGAEEGFT
CCHHHHHHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCH
GVVDLVKMKAINWNDADQGVTFEYEDIPADMQDLADEWHQNLIESAAEASEELMEKYLGG
HHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EELTEEEIKKALRQRVLNNEIILVTCGSAFKNKGVQAMLDAVIDYLPSPVDVPAINGILD
CCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHCCHHHHHHHHHHHCCCCCCCCHHCCCCC
DGKDTPAERHASDDEPFSALAFKIATDPFVGNLTFFRVYSGVVNSGDTVLNSVKAARERF
CCCCCCHHHCCCCCCCHHHEEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
GRIVQMHANKREEIKEVRAGDIAAAIGLKDVTTGDTLCDPDAPIILERMEFPEPVISIAV
HHHHHHHCCCHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCEEEHHHCCCCCEEEEEE
EPKTKADQEKMGLALGRLAKEDPSFRVWTDEESNQTIIAGMGELHLDIIVDRMKREFNVE
CCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCHHHHHHHHHHHHHHCCCC
ANVGKPQVAYREAIRAKVTDIEGKHAKQSGGRGQYGHVVIDMYPLEPGSNPKGYEFINDI
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHC
KGGVIPGEYIPAVDKGIQEQLKAGPLAGYPVVDMGIRLHFGSYHDVDSSELAFKLAASIA
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEECCEEEEECCCCCCCCHHHHHHHHHHHH
FKEGFKKAKPVLLEPIMKVEVETPEENTGDVIGDLSRRRGMLRGQESEVTGVKIHAEVPL
HHHHHHHCCCHHHCCHHEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEEECCCH
SEMFGYATQLRSLTKGRASYTMEFLKYDDAPNNVAQAVIEARGK
HHHHHHHHHHHHHHCCHHHHEEHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA