Click here to switch to the map view.

The map label for this gene is acrE [H]

Identifier: 238896771

GI number: 238896771

Start: 4749932

End: 4751071

Strand: Direct

Name: acrE [H]

Synonym: KP1_4991

Alternate gene names: 238896771

Gene position: 4749932-4751071 (Clockwise)

Preceding gene: 238896769

Following gene: 238896772

Centisome position: 90.5

GC content: 58.25

Gene sequence:

>1140_bases
ATGACGACTCACGCCAGAGTGACACTTTTATCCGGTTTAATTATCTCGGCCTTATTGCTAACCGGTTGCGATAATTCTGA
CAACCAGCAACCCCATGCGCAGGCGCCGCAGGTGACGGTCCATGTCGTGAACAGCGCGCCGCTATCAGTCACCACCGAAC
TGCCGGGCCGAACCTCTGCTTTTCGCGTAGCGGAAGTCCGCCCCCAGGTGAGCGGTATCATCCTGAAGCGTAACTTTGTT
GAAGGAAGTGATGTCGAAGCAGGCCAGTCGCTCTATCAGATCGATCCGGCGACCTACCAGGCGGCGTGGAACAGCGCCAA
AGGCGATGAGGCCAAAGCCGAAGCTGCGGCCGCTATCGCCCATTTGACGGTGAAACGCTACGTTCCACTGCTGGGTACTA
AATATATCAGCCAGCAGGAATACGATCAGGCAGTGGCCACCGCCCGCCAGGCCGATGCCGATGTCATCGCCACCAAAGCT
GCCGTGGAAACGGCCCGTATCAACCTGGCCTACACCAAAGTAACCTCCCCCATTAGCGGGCGCATCGGTAAATCGAGCGT
CACCGAAGGGGCGCTGGTCACCAACGGCCAGTCGGATGCCCTGGCTACCGTCCAGCAGCTCGATCCCATCTATGTTGACG
TGACGGAGTCCAGTAATGACTTCATGCGCCTTAAGCAGGAAAGCCTGCAGCGCGGCGGTGATACCAAAAGCGTTGAGCTG
GTCATGGAGAACGGCCAGGCCTATCCGCTCAAAGGTTCACTGCAGTTTTCTGACGTCACTGTTGATGAAACTACGGGCTC
AATTACTCTGCGCGCTATCTTCCCTAACCCGCAGCATGTCCTGCTGCCAGGGATGTTCGTCCGCGCCCGCATAGACGAAG
GCGTCGATCCGCAGGCTATCCTGGTACCGCAGCAAGGGGTGACCCGCACGCCGCGTGGTGATGCCTCCGTGATGCTGGTG
AATGACAAAAACCAGGTTGAAACCCGGGAAGTGGTCGCGACTCAGGCCGTTGGCGATAAGTGGCTTATCACCAGTGGGCT
GAAGCCGGGCGATAAAGTGATTGTCAGCGGCTTACAGAAAGTCCGTCCAGGCGTCACTGTCAAAGCGGAAGCGGAGCGTG
CGGCGCCGGCCGTGCAATAA

Upstream 100 bases:

>100_bases
CCAACGGCGTTTATTTGTAGGATGGCAAACTGCTTTTTGATTCCCTCTTTCTTTCACAGATTCGCCGCCTGATTGGGTAC
GTAATCTATAAGGAACCGCC

Downstream 100 bases:

>100_bases
GGATACCCAGCCATGTCTAAGTTTTTTATTCATCGACCGGTCTTCGCCTGGGTGCTGGCTATCATTATGATGATTGCCGG
CGGCCTGGCCATCCTGCAGC

Product: transmembrane protein affecting septum formation and cell membrane permeability

Products: NA

Alternate protein names: Protein envC [H]

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MTTHARVTLLSGLIISALLLTGCDNSDNQQPHAQAPQVTVHVVNSAPLSVTTELPGRTSAFRVAEVRPQVSGIILKRNFV
EGSDVEAGQSLYQIDPATYQAAWNSAKGDEAKAEAAAAIAHLTVKRYVPLLGTKYISQQEYDQAVATARQADADVIATKA
AVETARINLAYTKVTSPISGRIGKSSVTEGALVTNGQSDALATVQQLDPIYVDVTESSNDFMRLKQESLQRGGDTKSVEL
VMENGQAYPLKGSLQFSDVTVDETTGSITLRAIFPNPQHVLLPGMFVRARIDEGVDPQAILVPQQGVTRTPRGDASVMLV
NDKNQVETREVVATQAVGDKWLITSGLKPGDKVIVSGLQKVRPGVTVKAEAERAAPAVQ

Sequences:

>Translated_379_residues
MTTHARVTLLSGLIISALLLTGCDNSDNQQPHAQAPQVTVHVVNSAPLSVTTELPGRTSAFRVAEVRPQVSGIILKRNFV
EGSDVEAGQSLYQIDPATYQAAWNSAKGDEAKAEAAAAIAHLTVKRYVPLLGTKYISQQEYDQAVATARQADADVIATKA
AVETARINLAYTKVTSPISGRIGKSSVTEGALVTNGQSDALATVQQLDPIYVDVTESSNDFMRLKQESLQRGGDTKSVEL
VMENGQAYPLKGSLQFSDVTVDETTGSITLRAIFPNPQHVLLPGMFVRARIDEGVDPQAILVPQQGVTRTPRGDASVMLV
NDKNQVETREVVATQAVGDKWLITSGLKPGDKVIVSGLQKVRPGVTVKAEAERAAPAVQ
>Mature_378_residues
TTHARVTLLSGLIISALLLTGCDNSDNQQPHAQAPQVTVHVVNSAPLSVTTELPGRTSAFRVAEVRPQVSGIILKRNFVE
GSDVEAGQSLYQIDPATYQAAWNSAKGDEAKAEAAAAIAHLTVKRYVPLLGTKYISQQEYDQAVATARQADADVIATKAA
VETARINLAYTKVTSPISGRIGKSSVTEGALVTNGQSDALATVQQLDPIYVDVTESSNDFMRLKQESLQRGGDTKSVELV
MENGQAYPLKGSLQFSDVTVDETTGSITLRAIFPNPQHVLLPGMFVRARIDEGVDPQAILVPQQGVTRTPRGDASVMLVN
DKNQVETREVVATQAVGDKWLITSGLKPGDKVIVSGLQKVRPGVTVKAEAERAAPAVQ

Specific function: May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789665, Length=380, Percent_Identity=75.2631578947368, Blast_Score=559, Evalue=1e-160,
Organism=Escherichia coli, GI1786668, Length=374, Percent_Identity=70.0534759358289, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1789929, Length=370, Percent_Identity=51.3513513513513, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI87082036, Length=313, Percent_Identity=28.7539936102236, Blast_Score=129, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40418; Mature: 40287

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTHARVTLLSGLIISALLLTGCDNSDNQQPHAQAPQVTVHVVNSAPLSVTTELPGRTSA
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCE
FRVAEVRPQVSGIILKRNFVEGSDVEAGQSLYQIDPATYQAAWNSAKGDEAKAEAAAAIA
EEEEECCCCCCEEEEEECCCCCCCCCCCCCEEEECCHHHHHHCCCCCCCHHHHHHHHHHH
HLTVKRYVPLLGTKYISQQEYDQAVATARQADADVIATKAAVETARINLAYTKVTSPISG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHHEEEEEEEEEEEECCCCCC
RIGKSSVTEGALVTNGQSDALATVQQLDPIYVDVTESSNDFMRLKQESLQRGGDTKSVEL
CCCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCCCEEEE
VMENGQAYPLKGSLQFSDVTVDETTGSITLRAIFPNPQHVLLPGMFVRARIDEGVDPQAI
EEECCCEEEECCCEEEEEEEEECCCCCEEEEEECCCCCEEEECCEEEEEECCCCCCCCEE
LVPQQGVTRTPRGDASVMLVNDKNQVETREVVATQAVGDKWLITSGLKPGDKVIVSGLQK
EECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHH
VRPGVTVKAEAERAAPAVQ
HCCCCEEEECHHCCCCCCC
>Mature Secondary Structure 
TTHARVTLLSGLIISALLLTGCDNSDNQQPHAQAPQVTVHVVNSAPLSVTTELPGRTSA
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCE
FRVAEVRPQVSGIILKRNFVEGSDVEAGQSLYQIDPATYQAAWNSAKGDEAKAEAAAAIA
EEEEECCCCCCEEEEEECCCCCCCCCCCCCEEEECCHHHHHHCCCCCCCHHHHHHHHHHH
HLTVKRYVPLLGTKYISQQEYDQAVATARQADADVIATKAAVETARINLAYTKVTSPISG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEHHHHHEEEEEEEEEEEECCCCCC
RIGKSSVTEGALVTNGQSDALATVQQLDPIYVDVTESSNDFMRLKQESLQRGGDTKSVEL
CCCCCCCCCCEEEECCCCHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCCCEEEE
VMENGQAYPLKGSLQFSDVTVDETTGSITLRAIFPNPQHVLLPGMFVRARIDEGVDPQAI
EEECCCEEEECCCEEEEEEEEECCCCCEEEEEECCCCCEEEECCEEEEEECCCCCCCCEE
LVPQQGVTRTPRGDASVMLVNDKNQVETREVVATQAVGDKWLITSGLKPGDKVIVSGLQK
EECCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHH
VRPGVTVKAEAERAAPAVQ
HCCCCEEEECHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1720861; 9278503 [H]