Click here to switch to the map view.

The map label for this gene is yhcP [H]

Identifier: 238896746

GI number: 238896746

Start: 4723366

End: 4725333

Strand: Reverse

Name: yhcP [H]

Synonym: KP1_4965

Alternate gene names: 238896746

Gene position: 4725333-4723366 (Counterclockwise)

Preceding gene: 238896747

Following gene: 238896745

Centisome position: 90.03

GC content: 58.18

Gene sequence:

>1968_bases
ATGGGGACATATACCATTGCTCCCCGGCATCTCCGCTTTGCCATTAAGCTTGCATGCGCGGTGGTGCTGGCGCTGTTTGT
CGGTTTCCATTTTCAGCTCGAAACGCCGCGCTGGGCGGTACTGACGGCAGCGATCGTCGCCGCCGGGCCGGCCTTTGCTG
CTGGCGGCGAACCGTACTCCGGCGCGATCCGCTATCGCGGTATGTTGCGTATTGCCGGGACCTTTATTGGCTGTATTGCG
GCGCTGGTTATCATCATCCTGATGATCCGCGCGCCTCTGCTGATGATGCTGGTCTGCTGTCTGTGGGCCGGGTTTTGTAC
CTGGGTTTCGTCGCTGGTTAAGGTCGAAAACTCCTATGCCTGGGGGCTGGCCGGGTACACCGCGCTGATTATCATTATTA
CCATCCATACCAATCCGATGCTGGCGCCGCAGTTTGCTGTCGAACGCTGCAGCGAAATTGTCATCGGTATTGTCAGCGCC
ATCGTCGCCGATCTCCTGTTTTCGCCGCGTTCGATTAAAAAAGAGATCGACCTCGAGCTCGATAACCTGCTGATTGCACA
GTATAAGCTGATGCAGTTATGCGTCGCGCACGGTGAAAAAGAGGAAGTGGATCAAGCCTGGGGAGCGCTGGTACGCCGCA
CTACGGCGCTGGAAGGTATGCGTAGTAACCTGATTATGGAATCCTCACGCTGGGCAAAGGCGAATCAGCGCCTGAAGGCG
ATCAACACCCTTTCGCTAACCCTTATCACCCAGGCTTGCGAAACCTATCTGATTCAGAACTCACGCCCGGAAATGGTCAC
GGACGACTATCGCGAGCTGTTCGCCGAGCCGGTTGAGACGGTGCAGGATGTCCACCAGCAGCTGAAGCGCATGCGCCGCT
TCCTGACCTGGAAAGGCGAGCATAATACCCCGGTCACGATTTATAGCTGGGTGGGCGCCGCCACGCGTTACCTGCTGCTT
AAGCGCGGCGTGGTGGGGAATACTAAAATCAGCCGTATCGAGGATGGCGTGTTGCGCGGCGAAACGGTGGTTAAAGTGGA
GTCCGCCGAACGTCATCACGCGATGGTGAACTTCTGGCGCACCTCTGTCTCCTGTATTCTCGGAACGCTATTCTGGCTGT
GGACGGGCTGGACCTCAGGCAGCGGCGCGATGGTAATGATCGCCGTGGTTACCGCGCTGGCGATGCGCCTGCCAAACCCG
CGTATGGTGGCGATAGACTTCCTCTATGGCACCCTGGCGGCGTTACCGTTGGGCACCTTGTACTTCCTGGTGATCATGCC
GGCGACGCAGCAGAGCATGCTGTTGCTTTGCATCAGCCTGGCGGCGATGGCGTTCTTTATCGGGATCGAAGTGCAGAAAA
GGCGTCTCGGATCGCTGGGGGCGCTGGCGAGCACCATCAACATTCTGGTGCTGGATAACCCGATGCAGTTCCAGTTCAGC
CAGTTCCTCGATAGCGCGCTGGGGCAGATCGTCGGCTGTTTCCTCGCTCTGATGGTTATTCTCATTGTCAGGGATAACTC
CCGGGCCAGAACCGGTCGGGTGCTGCTGAACCAGTTTGTCTCCGCGGCGGTCTCTTCGCTGACCACCAACTCGGCGCGTC
GCAAAGAGAATCATCTGCCCGCGCTCTATCAGCAGCTGTTTTTATTACTCAATAAATTCCCGGGTGACGTCGCCCGTTTC
CGTCTGGCGTTGACGTTAATCATCGCCCATCAGCGCTTGCGCGATGCGCCCGTGCCGGTGAACGACGATCTCTCCGCCTT
CCATCGTCAGCTGCGACGTACCGCGGACCATGTGATCTCCGCCGGCAGCGATGATAAGCGTCGGCGCTATTTTACCCAGC
TGCTGGCGGAGCTTGATGTCTATCAGGAGAAGCTGCGGGTCTGGGAGGCCTCGCCGCAGGTCACCGAGCCGGTACGGCGA
CTGGTTGAGATGTTGCATAAGTATCAGCATGTGCTGACCAGCAGCTAA

Upstream 100 bases:

>100_bases
CGGCGACGGTAGTGATCACCGGTCAAGAAGATCGTGATACCAGCCAGGCCAACTTCTTCCAGAAACTGGCTATGCGCCTG
CGCGAATTTGGTTAATCGCT

Downstream 100 bases:

>100_bases
CCCATAAACCGACGCCCAGGCGTCGGTTTTTTTATCGCTATACTTAACGGCGACAGAAAGAGAAGCGGGAGGGGCTGTCA
TGACCACCTATACGTTTGAT

Product: p-hydroxybenzoic acid efflux subunit AaeB

Products: NA

Alternate protein names: pHBA efflux pump protein B [H]

Number of amino acids: Translated: 655; Mature: 654

Protein sequence:

>655_residues
MGTYTIAPRHLRFAIKLACAVVLALFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGMLRIAGTFIGCIA
ALVIIILMIRAPLLMMLVCCLWAGFCTWVSSLVKVENSYAWGLAGYTALIIIITIHTNPMLAPQFAVERCSEIVIGIVSA
IVADLLFSPRSIKKEIDLELDNLLIAQYKLMQLCVAHGEKEEVDQAWGALVRRTTALEGMRSNLIMESSRWAKANQRLKA
INTLSLTLITQACETYLIQNSRPEMVTDDYRELFAEPVETVQDVHQQLKRMRRFLTWKGEHNTPVTIYSWVGAATRYLLL
KRGVVGNTKISRIEDGVLRGETVVKVESAERHHAMVNFWRTSVSCILGTLFWLWTGWTSGSGAMVMIAVVTALAMRLPNP
RMVAIDFLYGTLAALPLGTLYFLVIMPATQQSMLLLCISLAAMAFFIGIEVQKRRLGSLGALASTINILVLDNPMQFQFS
QFLDSALGQIVGCFLALMVILIVRDNSRARTGRVLLNQFVSAAVSSLTTNSARRKENHLPALYQQLFLLLNKFPGDVARF
RLALTLIIAHQRLRDAPVPVNDDLSAFHRQLRRTADHVISAGSDDKRRRYFTQLLAELDVYQEKLRVWEASPQVTEPVRR
LVEMLHKYQHVLTSS

Sequences:

>Translated_655_residues
MGTYTIAPRHLRFAIKLACAVVLALFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGMLRIAGTFIGCIA
ALVIIILMIRAPLLMMLVCCLWAGFCTWVSSLVKVENSYAWGLAGYTALIIIITIHTNPMLAPQFAVERCSEIVIGIVSA
IVADLLFSPRSIKKEIDLELDNLLIAQYKLMQLCVAHGEKEEVDQAWGALVRRTTALEGMRSNLIMESSRWAKANQRLKA
INTLSLTLITQACETYLIQNSRPEMVTDDYRELFAEPVETVQDVHQQLKRMRRFLTWKGEHNTPVTIYSWVGAATRYLLL
KRGVVGNTKISRIEDGVLRGETVVKVESAERHHAMVNFWRTSVSCILGTLFWLWTGWTSGSGAMVMIAVVTALAMRLPNP
RMVAIDFLYGTLAALPLGTLYFLVIMPATQQSMLLLCISLAAMAFFIGIEVQKRRLGSLGALASTINILVLDNPMQFQFS
QFLDSALGQIVGCFLALMVILIVRDNSRARTGRVLLNQFVSAAVSSLTTNSARRKENHLPALYQQLFLLLNKFPGDVARF
RLALTLIIAHQRLRDAPVPVNDDLSAFHRQLRRTADHVISAGSDDKRRRYFTQLLAELDVYQEKLRVWEASPQVTEPVRR
LVEMLHKYQHVLTSS
>Mature_654_residues
GTYTIAPRHLRFAIKLACAVVLALFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYSGAIRYRGMLRIAGTFIGCIAA
LVIIILMIRAPLLMMLVCCLWAGFCTWVSSLVKVENSYAWGLAGYTALIIIITIHTNPMLAPQFAVERCSEIVIGIVSAI
VADLLFSPRSIKKEIDLELDNLLIAQYKLMQLCVAHGEKEEVDQAWGALVRRTTALEGMRSNLIMESSRWAKANQRLKAI
NTLSLTLITQACETYLIQNSRPEMVTDDYRELFAEPVETVQDVHQQLKRMRRFLTWKGEHNTPVTIYSWVGAATRYLLLK
RGVVGNTKISRIEDGVLRGETVVKVESAERHHAMVNFWRTSVSCILGTLFWLWTGWTSGSGAMVMIAVVTALAMRLPNPR
MVAIDFLYGTLAALPLGTLYFLVIMPATQQSMLLLCISLAAMAFFIGIEVQKRRLGSLGALASTINILVLDNPMQFQFSQ
FLDSALGQIVGCFLALMVILIVRDNSRARTGRVLLNQFVSAAVSSLTTNSARRKENHLPALYQQLFLLLNKFPGDVARFR
LALTLIIAHQRLRDAPVPVNDDLSAFHRQLRRTADHVISAGSDDKRRRYFTQLLAELDVYQEKLRVWEASPQVTEPVRRL
VEMLHKYQHVLTSS

Specific function: Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell [H]

COG id: COG1289

COG function: function code S; Predicted membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic acid exporter ArAE (TC 2.A.85) family [H]

Homologues:

Organism=Escherichia coli, GI1789636, Length=655, Percent_Identity=81.5267175572519, Blast_Score=1110, Evalue=0.0,
Organism=Escherichia coli, GI1787933, Length=517, Percent_Identity=23.4042553191489, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006726 [H]

Pfam domain/function: PF04632 FUSC [H]

EC number: NA

Molecular weight: Translated: 73222; Mature: 73091

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTYTIAPRHLRFAIKLACAVVLALFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYS
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCC
GAIRYRGMLRIAGTFIGCIAALVIIILMIRAPLLMMLVCCLWAGFCTWVSSLVKVENSYA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
WGLAGYTALIIIITIHTNPMLAPQFAVERCSEIVIGIVSAIVADLLFSPRSIKKEIDLEL
CHHHHHEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHH
DNLLIAQYKLMQLCVAHGEKEEVDQAWGALVRRTTALEGMRSNLIMESSRWAKANQRLKA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
INTLSLTLITQACETYLIQNSRPEMVTDDYRELFAEPVETVQDVHQQLKRMRRFLTWKGE
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
HNTPVTIYSWVGAATRYLLLKRGVVGNTKISRIEDGVLRGETVVKVESAERHHAMVNFWR
CCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHCCCEEEEECCCHHHHHHHHHHH
TSVSCILGTLFWLWTGWTSGSGAMVMIAVVTALAMRLPNPRMVAIDFLYGTLAALPLGTL
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
YFLVIMPATQQSMLLLCISLAAMAFFIGIEVQKRRLGSLGALASTINILVLDNPMQFQFS
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHH
QFLDSALGQIVGCFLALMVILIVRDNSRARTGRVLLNQFVSAAVSSLTTNSARRKENHLP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCH
ALYQQLFLLLNKFPGDVARFRLALTLIIAHQRLRDAPVPVNDDLSAFHRQLRRTADHVIS
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHC
AGSDDKRRRYFTQLLAELDVYQEKLRVWEASPQVTEPVRRLVEMLHKYQHVLTSS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GTYTIAPRHLRFAIKLACAVVLALFVGFHFQLETPRWAVLTAAIVAAGPAFAAGGEPYS
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCCC
GAIRYRGMLRIAGTFIGCIAALVIIILMIRAPLLMMLVCCLWAGFCTWVSSLVKVENSYA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
WGLAGYTALIIIITIHTNPMLAPQFAVERCSEIVIGIVSAIVADLLFSPRSIKKEIDLEL
CHHHHHEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHH
DNLLIAQYKLMQLCVAHGEKEEVDQAWGALVRRTTALEGMRSNLIMESSRWAKANQRLKA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
INTLSLTLITQACETYLIQNSRPEMVTDDYRELFAEPVETVQDVHQQLKRMRRFLTWKGE
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
HNTPVTIYSWVGAATRYLLLKRGVVGNTKISRIEDGVLRGETVVKVESAERHHAMVNFWR
CCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHCCHHCCCEEEEECCCHHHHHHHHHHH
TSVSCILGTLFWLWTGWTSGSGAMVMIAVVTALAMRLPNPRMVAIDFLYGTLAALPLGTL
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHH
YFLVIMPATQQSMLLLCISLAAMAFFIGIEVQKRRLGSLGALASTINILVLDNPMQFQFS
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHH
QFLDSALGQIVGCFLALMVILIVRDNSRARTGRVLLNQFVSAAVSSLTTNSARRKENHLP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCH
ALYQQLFLLLNKFPGDVARFRLALTLIIAHQRLRDAPVPVNDDLSAFHRQLRRTADHVIS
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHC
AGSDDKRRRYFTQLLAELDVYQEKLRVWEASPQVTEPVRRLVEMLHKYQHVLTSS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA