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The map label for this gene is rspB [H]

Identifier: 238896718

GI number: 238896718

Start: 4693616

End: 4694647

Strand: Direct

Name: rspB [H]

Synonym: KP1_4933

Alternate gene names: 238896718

Gene position: 4693616-4694647 (Clockwise)

Preceding gene: 238896713

Following gene: 238896719

Centisome position: 89.43

GC content: 57.85

Gene sequence:

>1032_bases
ATGGAAGGAATCAAAATGAGAAGCGTCGTCGTCAAAGAGCCAGGCCAACTGAACATTGAATCACGTCCGGTTCCAGTTCC
GGGCGCCCATGAAGTACGGGTGAAAATTGCTTTTGCCGGGATCTGTGGTTCCGATGTACACATCTATCACGGCCACAACC
CTTTCGCGAAATATCCCCGCGTCATCGGCCATGAATTCTATGGCATCATCGACGCCGTCGGCGAGCAGGTATCTCCGGCA
CGCATCGGCGAGCGTGTCGCGGTGGACCCCGTTGTCAGCTGCGGCCATTGTTATCCTTGCTCGGTAGGAAGGCCGAATGT
CTGTACGCAGCTCCAGGTCATAGGAGTTCACCGCGACGGGGGATTTAGCGACTATGCCTGCGTGCCGGCGAAAAATGCCT
GGCGCATCCCCGAGGCTATCAGCGACCGTCAGGCAACGATGGTTGAGCCTTTTACCATCGCGGCAAATATTACCGCCCAG
CTGCAGCCCACGGCGCAAGATATTGCCCTGGTTTACGGCGCTGGCCCGATGGGGCTGACAATCATTCAGGCGCTAAAGGG
GGTATATGGCGTTAAGCAGGTGATCGTCGTGGATCGCATTGCCGAACGTCTGCAGATGGCCCGGGAAAACGGCGCCGATC
TGACGCTCGATAACACTGACCAGCCGCTCGCGGAACAGCTGGCGCAGCGGCAGCTTGCCCCCACGCTGGTCATTGATGCC
GCCTGCCACCCGGCGATCCTGCAGGAAGCCATTCTCCTCGCCTCCCCCGCCGCCCGCATCGGTATACTCGGTTTCTCCGG
CGAGGCCTCGACCCTCACTCAGCAAAGCATCACCAGTAAAGAAATTTCTATTTTCTCCTCCCGGCTGAACAGCGGGCGTT
TTCCGCTGGTCATCGACTGGATGGAGAAAGGCCTTATTCGTCCGGAGGCGTTAATCACCCATTGTATGCCGCTGGAGCAG
GTGAAAGAGGCCATGGAGATTTTTGCTAACGACCGTAAGACCTGCTGCAAAGTGCTGCTGCAGCTGGGTTAA

Upstream 100 bases:

>100_bases
TTTTCTGCCGAGCTTTCTCAAATGTGATCCAGGCCTGATTATGATCTTTTGCATACTTGTATGGTAATAAAAGTAGCGTA
ATTTGTTCAGAAAAAAGACA

Downstream 100 bases:

>100_bases
ACCGGCATCGTATAGAATAACGGCCGACGGATATCTGCGTATCCGCCGCGCCTGATATAAATAATATAATGAGCATGGTG
TTATCATGGGAAAAAATATC

Product: putative NAD(P)-binding and starvation-sensing dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MEGIKMRSVVVKEPGQLNIESRPVPVPGAHEVRVKIAFAGICGSDVHIYHGHNPFAKYPRVIGHEFYGIIDAVGEQVSPA
RIGERVAVDPVVSCGHCYPCSVGRPNVCTQLQVIGVHRDGGFSDYACVPAKNAWRIPEAISDRQATMVEPFTIAANITAQ
LQPTAQDIALVYGAGPMGLTIIQALKGVYGVKQVIVVDRIAERLQMARENGADLTLDNTDQPLAEQLAQRQLAPTLVIDA
ACHPAILQEAILLASPAARIGILGFSGEASTLTQQSITSKEISIFSSRLNSGRFPLVIDWMEKGLIRPEALITHCMPLEQ
VKEAMEIFANDRKTCCKVLLQLG

Sequences:

>Translated_343_residues
MEGIKMRSVVVKEPGQLNIESRPVPVPGAHEVRVKIAFAGICGSDVHIYHGHNPFAKYPRVIGHEFYGIIDAVGEQVSPA
RIGERVAVDPVVSCGHCYPCSVGRPNVCTQLQVIGVHRDGGFSDYACVPAKNAWRIPEAISDRQATMVEPFTIAANITAQ
LQPTAQDIALVYGAGPMGLTIIQALKGVYGVKQVIVVDRIAERLQMARENGADLTLDNTDQPLAEQLAQRQLAPTLVIDA
ACHPAILQEAILLASPAARIGILGFSGEASTLTQQSITSKEISIFSSRLNSGRFPLVIDWMEKGLIRPEALITHCMPLEQ
VKEAMEIFANDRKTCCKVLLQLG
>Mature_343_residues
MEGIKMRSVVVKEPGQLNIESRPVPVPGAHEVRVKIAFAGICGSDVHIYHGHNPFAKYPRVIGHEFYGIIDAVGEQVSPA
RIGERVAVDPVVSCGHCYPCSVGRPNVCTQLQVIGVHRDGGFSDYACVPAKNAWRIPEAISDRQATMVEPFTIAANITAQ
LQPTAQDIALVYGAGPMGLTIIQALKGVYGVKQVIVVDRIAERLQMARENGADLTLDNTDQPLAEQLAQRQLAPTLVIDA
ACHPAILQEAILLASPAARIGILGFSGEASTLTQQSITSKEISIFSSRLNSGRFPLVIDWMEKGLIRPEALITHCMPLEQ
VKEAMEIFANDRKTCCKVLLQLG

Specific function: Not known; probable catabolic enzyme [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=329, Percent_Identity=29.483282674772, Blast_Score=141, Evalue=7e-34,
Organism=Homo sapiens, GI156523966, Length=377, Percent_Identity=26.525198938992, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4501939, Length=369, Percent_Identity=26.2872628726287, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI71565154, Length=370, Percent_Identity=25.4054054054054, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI4501929, Length=371, Percent_Identity=25.6064690026954, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI262073058, Length=370, Percent_Identity=24.3243243243243, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI71743840, Length=370, Percent_Identity=24.3243243243243, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI34577061, Length=374, Percent_Identity=25.9358288770053, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4501933, Length=369, Percent_Identity=25.2032520325203, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1787863, Length=337, Percent_Identity=65.2818991097923, Blast_Score=487, Evalue=1e-139,
Organism=Escherichia coli, GI226510992, Length=335, Percent_Identity=32.8358208955224, Blast_Score=160, Evalue=8e-41,
Organism=Escherichia coli, GI1788073, Length=350, Percent_Identity=28, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI1790045, Length=247, Percent_Identity=31.9838056680162, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1788407, Length=292, Percent_Identity=31.1643835616438, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1790718, Length=315, Percent_Identity=26.3492063492064, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1786825, Length=395, Percent_Identity=26.8354430379747, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI87082125, Length=350, Percent_Identity=28.8571428571429, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788075, Length=337, Percent_Identity=27.5964391691395, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI87081918, Length=229, Percent_Identity=27.5109170305677, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786552, Length=360, Percent_Identity=25.8333333333333, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786518, Length=86, Percent_Identity=39.5348837209302, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI87082401, Length=128, Percent_Identity=33.59375, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=332, Percent_Identity=27.710843373494, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17562878, Length=216, Percent_Identity=33.7962962962963, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI25146526, Length=351, Percent_Identity=25.3561253561254, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=253, Percent_Identity=26.8774703557312, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=353, Percent_Identity=25.2124645892351, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562584, Length=215, Percent_Identity=28.3720930232558, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562582, Length=124, Percent_Identity=32.258064516129, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322619, Length=335, Percent_Identity=26.2686567164179, Blast_Score=115, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6319955, Length=335, Percent_Identity=25.9701492537313, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6323099, Length=224, Percent_Identity=30.3571428571429, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6320033, Length=368, Percent_Identity=26.6304347826087, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319258, Length=240, Percent_Identity=31.25, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324486, Length=328, Percent_Identity=23.780487804878, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319621, Length=346, Percent_Identity=25.4335260115607, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319257, Length=212, Percent_Identity=26.8867924528302, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=326, Percent_Identity=22.0858895705521, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=326, Percent_Identity=21.7791411042945, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17137530, Length=328, Percent_Identity=25.609756097561, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI17737897, Length=337, Percent_Identity=25.5192878338279, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45550770, Length=331, Percent_Identity=22.9607250755287, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI45551930, Length=331, Percent_Identity=22.9607250755287, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI221457811, Length=331, Percent_Identity=22.9607250755287, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17737895, Length=353, Percent_Identity=25.4957507082153, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 37117; Mature: 37117

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGIKMRSVVVKEPGQLNIESRPVPVPGAHEVRVKIAFAGICGSDVHIYHGHNPFAKYPR
CCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCEEEEECCCCHHHHHH
VIGHEFYGIIDAVGEQVSPARIGERVAVDPVVSCGHCYPCSVGRPNVCTQLQVIGVHRDG
HHHHHHHHHHHHHCCCCCHHHHCCCEEECHHHHCCCCCCCCCCCCCCCCEEEEEEEECCC
GFSDYACVPAKNAWRIPEAISDRQATMVEPFTIAANITAQLQPTAQDIALVYGAGPMGLT
CCCCEEECCCCCCCCCCHHHCCCCCEEECCEEEEEEEEEEECCCHHHEEEEECCCCHHHH
IIQALKGVYGVKQVIVVDRIAERLQMARENGADLTLDNTDQPLAEQLAQRQLAPTLVIDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCEEEEEC
ACHPAILQEAILLASPAARIGILGFSGEASTLTQQSITSKEISIFSSRLNSGRFPLVIDW
CCCHHHHHHHHHHCCCCHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEH
MEKGLIRPEALITHCMPLEQVKEAMEIFANDRKTCCKVLLQLG
HHCCCCCHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MEGIKMRSVVVKEPGQLNIESRPVPVPGAHEVRVKIAFAGICGSDVHIYHGHNPFAKYPR
CCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCEEEEECCCCHHHHHH
VIGHEFYGIIDAVGEQVSPARIGERVAVDPVVSCGHCYPCSVGRPNVCTQLQVIGVHRDG
HHHHHHHHHHHHHCCCCCHHHHCCCEEECHHHHCCCCCCCCCCCCCCCCEEEEEEEECCC
GFSDYACVPAKNAWRIPEAISDRQATMVEPFTIAANITAQLQPTAQDIALVYGAGPMGLT
CCCCEEECCCCCCCCCCHHHCCCCCEEECCEEEEEEEEEEECCCHHHEEEEECCCCHHHH
IIQALKGVYGVKQVIVVDRIAERLQMARENGADLTLDNTDQPLAEQLAQRQLAPTLVIDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCEEEEEC
ACHPAILQEAILLASPAARIGILGFSGEASTLTQQSITSKEISIFSSRLNSGRFPLVIDW
CCCHHHHHHHHHHCCCCHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEH
MEKGLIRPEALITHCMPLEQVKEAMEIFANDRKTCCKVLLQLG
HHCCCCCHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7545940; 9097039; 9278503 [H]