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The map label for this gene is garD [H]

Identifier: 238896639

GI number: 238896639

Start: 4618011

End: 4619582

Strand: Direct

Name: garD [H]

Synonym: KP1_4844

Alternate gene names: 238896639

Gene position: 4618011-4619582 (Clockwise)

Preceding gene: 238896634

Following gene: 238896642

Centisome position: 87.99

GC content: 58.97

Gene sequence:

>1572_bases
ATGGCTGACATTGCAATTCGACAACAATCGCCGACCGCGTTTTATATTAAAGTTGACCCGACAGATAATGTGGCGATTAT
TGTCAACGATCGCGGCTTAACCGCCGGAACGCGTTTCCCGGACGGCCTGACGCTCGTCGAGCATATCCCGCAGGGTCACA
AAGTTGCCCTGGTGGATATCCCCGCCCATGGTGAAATCATCCGCTACGGCGAAGTCATTGGCTATGCCGTACGCGATATC
CCGCAGGGAAGCTGGATTGACGAGTCGCTGGTGGAGCTGCCCACCGCCCCGCCGCTGAATACCCTGCCGCTGGCCACTAA
AGTGCCTGAACCGCTACCGCCGCTGGAAGGTTACACCTTCGAAGGCTACCGCAATGCTGACGGCAGCGTGGGTACCAAGA
ATCTGCTGGGTATTACTACCAGCGTGCACTGCGTCGCTGGCGTGGTCGATTACGTGGTGAAAATCATTGAACGCGACCTG
CTGCCAAACTATCCCAACGTCGATGGCGTGGTGGGTCTGAATCATCTCTACGGCTGCGGCGTGGCGATTAATGCGCCGGC
GGCGGTAGTGCCGATTCGCACCATTCATAATATCGCCCTCAACCCAAACTTCGGCGGCGAGGTGATGGTCATTGGCCTCG
GCTGTGAGAAGCTGCAGCCGGAACGCCTGCTGCAGGGCACGGAAGACGTCAAAAGTATCCCGGTGGACAGCGCCAGCATC
GTCAGCCTGCAGGATGAAAAGCATGTTGGTTTTAAATCGATGGTCGATGACATTCTGCAGGTCGCCGAGCGCCACCTGGC
GAAACTGAACCAGCGCCAGCGGGAAACCTGCCCGGCCTCTGAGCTGGTGGTCGGGATGCAGTGCGGCGGCAGCGACGCCT
TTTCAGGCGTGACCGCCAACCCGGCGGTAGGTTACGCGTCCGACCTGCTGGTGCGCTGCGGCGCGACGGTGATGTTCTCG
GAAGTGACCGAAGTACGCGACGCCATTCATCTGTTGACCCCGCGGGCGATTAACGAAGAGGTCGGTAAACGTCTGCTGGA
AGAGATGGCCTGGTACGATAACTATCTTGATATGGGCAAAACCGACCGCAGCGCCAACCCCTCCCCCGGCAACAAGAAAG
GCGGTCTGGCCAACGTGGTGGAAAAAGCGCTGGGGTCGATTGCCAAATCAGGGAAAAGCGCCATCGTTGAGGTGCTCTCT
CCGGGGCAGCGTCCGACCAAACGCGGCCTCATTTACGCCGCAACCCCCGCCAGCGATTTTGTCTGCGGCACCCAGCAGGT
AGCCTCTGGCATCACGGTGCAGGTATTCACCACCGGTCGCGGTACGCCGTACGGACTGATGGCGGTACCGGTGATAAAAA
TGGCGACCCGTACCGAGCTGGCCAACCGCTGGTATGACTTAATGGACATTAACGCCGGGACCATCGCCACTGGCGAAGAG
ACGATTGAGGATGTCGGGCGGAAGCTGTTCGAATTTATTCTCGACGTCGCCAGCGGACGCAAAAAAACCTTCTCCGATCA
ATGGGGCCTGCACAACCAGCTGGCGGTATTTAACCCGGCGCCGGTAACCTGA

Upstream 100 bases:

>100_bases
AATCAACTCAGCTGACATCCTTTATTCCATCATACTGATACGTAGCAAATGAATTAGCGTTTTATTTTATTATTAGCACC
TGTTTGGAGATGACTGGACA

Downstream 100 bases:

>100_bases
TCGAGAGCGTAAGGATTTAACCACTTTTAGCCCGGATCTATCCGGGCTTGTTGGTTAGGGATGCTGGGCGGCAAGAAAAG
CGCTGATCTCCGCCTGCGTC

Product: (D)-galactarate dehydrogenase

Products: NA

Alternate protein names: GalcD [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MADIAIRQQSPTAFYIKVDPTDNVAIIVNDRGLTAGTRFPDGLTLVEHIPQGHKVALVDIPAHGEIIRYGEVIGYAVRDI
PQGSWIDESLVELPTAPPLNTLPLATKVPEPLPPLEGYTFEGYRNADGSVGTKNLLGITTSVHCVAGVVDYVVKIIERDL
LPNYPNVDGVVGLNHLYGCGVAINAPAAVVPIRTIHNIALNPNFGGEVMVIGLGCEKLQPERLLQGTEDVKSIPVDSASI
VSLQDEKHVGFKSMVDDILQVAERHLAKLNQRQRETCPASELVVGMQCGGSDAFSGVTANPAVGYASDLLVRCGATVMFS
EVTEVRDAIHLLTPRAINEEVGKRLLEEMAWYDNYLDMGKTDRSANPSPGNKKGGLANVVEKALGSIAKSGKSAIVEVLS
PGQRPTKRGLIYAATPASDFVCGTQQVASGITVQVFTTGRGTPYGLMAVPVIKMATRTELANRWYDLMDINAGTIATGEE
TIEDVGRKLFEFILDVASGRKKTFSDQWGLHNQLAVFNPAPVT

Sequences:

>Translated_523_residues
MADIAIRQQSPTAFYIKVDPTDNVAIIVNDRGLTAGTRFPDGLTLVEHIPQGHKVALVDIPAHGEIIRYGEVIGYAVRDI
PQGSWIDESLVELPTAPPLNTLPLATKVPEPLPPLEGYTFEGYRNADGSVGTKNLLGITTSVHCVAGVVDYVVKIIERDL
LPNYPNVDGVVGLNHLYGCGVAINAPAAVVPIRTIHNIALNPNFGGEVMVIGLGCEKLQPERLLQGTEDVKSIPVDSASI
VSLQDEKHVGFKSMVDDILQVAERHLAKLNQRQRETCPASELVVGMQCGGSDAFSGVTANPAVGYASDLLVRCGATVMFS
EVTEVRDAIHLLTPRAINEEVGKRLLEEMAWYDNYLDMGKTDRSANPSPGNKKGGLANVVEKALGSIAKSGKSAIVEVLS
PGQRPTKRGLIYAATPASDFVCGTQQVASGITVQVFTTGRGTPYGLMAVPVIKMATRTELANRWYDLMDINAGTIATGEE
TIEDVGRKLFEFILDVASGRKKTFSDQWGLHNQLAVFNPAPVT
>Mature_522_residues
ADIAIRQQSPTAFYIKVDPTDNVAIIVNDRGLTAGTRFPDGLTLVEHIPQGHKVALVDIPAHGEIIRYGEVIGYAVRDIP
QGSWIDESLVELPTAPPLNTLPLATKVPEPLPPLEGYTFEGYRNADGSVGTKNLLGITTSVHCVAGVVDYVVKIIERDLL
PNYPNVDGVVGLNHLYGCGVAINAPAAVVPIRTIHNIALNPNFGGEVMVIGLGCEKLQPERLLQGTEDVKSIPVDSASIV
SLQDEKHVGFKSMVDDILQVAERHLAKLNQRQRETCPASELVVGMQCGGSDAFSGVTANPAVGYASDLLVRCGATVMFSE
VTEVRDAIHLLTPRAINEEVGKRLLEEMAWYDNYLDMGKTDRSANPSPGNKKGGLANVVEKALGSIAKSGKSAIVEVLSP
GQRPTKRGLIYAATPASDFVCGTQQVASGITVQVFTTGRGTPYGLMAVPVIKMATRTELANRWYDLMDINAGTIATGEET
IEDVGRKLFEFILDVASGRKKTFSDQWGLHNQLAVFNPAPVT

Specific function: D-galactarate metabolism; first step. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789516, Length=523, Percent_Identity=92.925430210325, Blast_Score=1004, Evalue=0.0,
Organism=Escherichia coli, GI1789475, Length=513, Percent_Identity=31.5789473684211, Blast_Score=218, Evalue=9e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR017654
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.42 [H]

Molecular weight: Translated: 56126; Mature: 55995

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIAIRQQSPTAFYIKVDPTDNVAIIVNDRGLTAGTRFPDGLTLVEHIPQGHKVALVDI
CCCCEEECCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCCEEEEEEE
PAHGEIIRYGEVIGYAVRDIPQGSWIDESLVELPTAPPLNTLPLATKVPEPLPPLEGYTF
CCCCCEEEHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEE
EGYRNADGSVGTKNLLGITTSVHCVAGVVDYVVKIIERDLLPNYPNVDGVVGLNHLYGCG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHCCC
VAINAPAAVVPIRTIHNIALNPNFGGEVMVIGLGCEKLQPERLLQGTEDVKSIPVDSASI
EEECCCCEEEEHHHHHEEEECCCCCCEEEEEECCCCCCCHHHHHCCCHHHHHCCCCCCEE
VSLQDEKHVGFKSMVDDILQVAERHLAKLNQRQRETCPASELVVGMQCGGSDAFSGVTAN
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCCCCCCCC
PAVGYASDLLVRCGATVMFSEVTEVRDAIHLLTPRAINEEVGKRLLEEMAWYDNYLDMGK
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
TDRSANPSPGNKKGGLANVVEKALGSIAKSGKSAIVEVLSPGQRPTKRGLIYAATPASDF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCEEEEECCCCCC
VCGTQQVASGITVQVFTTGRGTPYGLMAVPVIKMATRTELANRWYDLMDINAGTIATGEE
CCCHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEECCHH
TIEDVGRKLFEFILDVASGRKKTFSDQWGLHNQLAVFNPAPVT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCC
>Mature Secondary Structure 
ADIAIRQQSPTAFYIKVDPTDNVAIIVNDRGLTAGTRFPDGLTLVEHIPQGHKVALVDI
CCCEEECCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCCEEEEEEE
PAHGEIIRYGEVIGYAVRDIPQGSWIDESLVELPTAPPLNTLPLATKVPEPLPPLEGYTF
CCCCCEEEHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEE
EGYRNADGSVGTKNLLGITTSVHCVAGVVDYVVKIIERDLLPNYPNVDGVVGLNHLYGCG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHCCC
VAINAPAAVVPIRTIHNIALNPNFGGEVMVIGLGCEKLQPERLLQGTEDVKSIPVDSASI
EEECCCCEEEEHHHHHEEEECCCCCCEEEEEECCCCCCCHHHHHCCCHHHHHCCCCCCEE
VSLQDEKHVGFKSMVDDILQVAERHLAKLNQRQRETCPASELVVGMQCGGSDAFSGVTAN
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEEEECCCCCCCCCCCCC
PAVGYASDLLVRCGATVMFSEVTEVRDAIHLLTPRAINEEVGKRLLEEMAWYDNYLDMGK
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCC
TDRSANPSPGNKKGGLANVVEKALGSIAKSGKSAIVEVLSPGQRPTKRGLIYAATPASDF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCEEEEECCCCCC
VCGTQQVASGITVQVFTTGRGTPYGLMAVPVIKMATRTELANRWYDLMDINAGTIATGEE
CCCHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEECCHH
TIEDVGRKLFEFILDVASGRKKTFSDQWGLHNQLAVFNPAPVT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 2407727; 9772162; 10762278 [H]