| Definition | Klebsiella pneumoniae NTUH-K2044 chromosome, complete genome. |
|---|---|
| Accession | NC_012731 |
| Length | 5,248,520 |
Click here to switch to the map view.
The map label for this gene is kduD [H]
Identifier: 238896374
GI number: 238896374
Start: 4357083
End: 4357844
Strand: Reverse
Name: kduD [H]
Synonym: KP1_4541
Alternate gene names: 238896374
Gene position: 4357844-4357083 (Counterclockwise)
Preceding gene: 238896377
Following gene: 238896373
Centisome position: 83.03
GC content: 60.76
Gene sequence:
>762_bases ATGATTCTTGATGCATTCTCCCTGCAGGGAAAAGTGGCCGTCGTGAGCGGATGCGATACCGGTTTAGGTCAGGGGATGGC CCTCGGGCTGGCGGAAGCGGGCTGCGATATTGTCGGTATCAATATCGTCGAACCGGTGGAGACTATCGAGCGGGTAACCG CGCTGGGACGCCGTTTTCTCAGCCTGACCGCCGACCTGCGCCAGATCGACGGTATTCCTCAGCTTCTGGAGCGGGCGGTG GCGGAGTTCGGCCATATTGATATTCTGGTCAACAATGCCGGCCTGATTCGCCGCGAGGACGCGCTGGCGTTCAGCGAAAA AGACTGGGACGACGTGATGAACCTCAACATCAAGAGCGTATTTTTTATGTCCCAGGCGGCGGCGAAACACTTTATCGCCC AGGGCAGTGGCGGGAAGATCATTAACATCGCCTCCATGCTGTCGTTCCAGGGGGGGATCCGCGTGCCGTCGTATACCGCA TCCAAAAGCGCGGTGATGGGCGTCACCCGCCTGCTGGCCAACGAGTGGGCCAAACACAACATCAACGTCAACGCCATCGC CCCGGGGTATATGGCGACCAACAACACCCAGCAGCTGCGCGCCGACGAGCAGCGTAGCAGCGAAATCCTCGATCGCATTC CCGCCGGGCGCTGGGGGCTACCGGCCGATCTGATGGGGCCAGTCGTGTTCCTTGCCTCCTCAGCCTCCGATTACATCAAT GGCTACACGGTGGCGGTGGACGGCGGCTGGCTGGCGCGCTAA
Upstream 100 bases:
>100_bases CCCGAGAGTTCGCCCCACGCTCAGTCGCGCCGCCGGCGCGGACCGGGCCGAGAGAACCTTGCCTGCAAACAGCAGGCTCT GAACGACTAAGGAACATAAT
Downstream 100 bases:
>100_bases CCGTCCGCGATGGCCGGGGTCTGTGGTATCGCTCCGGCCTTCTGAGCAATTATTGTCCATACGCAAAAGTGCGGATCGTC CATACTCCGGAACACGGGTA
Product: 2-deoxy-D-gluconate 3-dehydrogenase
Products: NA
Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]
Number of amino acids: Translated: 253; Mature: 253
Protein sequence:
>253_residues MILDAFSLQGKVAVVSGCDTGLGQGMALGLAEAGCDIVGINIVEPVETIERVTALGRRFLSLTADLRQIDGIPQLLERAV AEFGHIDILVNNAGLIRREDALAFSEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGSGGKIINIASMLSFQGGIRVPSYTA SKSAVMGVTRLLANEWAKHNINVNAIAPGYMATNNTQQLRADEQRSSEILDRIPAGRWGLPADLMGPVVFLASSASDYIN GYTVAVDGGWLAR
Sequences:
>Translated_253_residues MILDAFSLQGKVAVVSGCDTGLGQGMALGLAEAGCDIVGINIVEPVETIERVTALGRRFLSLTADLRQIDGIPQLLERAV AEFGHIDILVNNAGLIRREDALAFSEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGSGGKIINIASMLSFQGGIRVPSYTA SKSAVMGVTRLLANEWAKHNINVNAIAPGYMATNNTQQLRADEQRSSEILDRIPAGRWGLPADLMGPVVFLASSASDYIN GYTVAVDGGWLAR >Mature_253_residues MILDAFSLQGKVAVVSGCDTGLGQGMALGLAEAGCDIVGINIVEPVETIERVTALGRRFLSLTADLRQIDGIPQLLERAV AEFGHIDILVNNAGLIRREDALAFSEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGSGGKIINIASMLSFQGGIRVPSYTA SKSAVMGVTRLLANEWAKHNINVNAIAPGYMATNNTQQLRADEQRSSEILDRIPAGRWGLPADLMGPVVFLASSASDYIN GYTVAVDGGWLAR
Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=254, Percent_Identity=32.6771653543307, Blast_Score=132, Evalue=4e-31, Organism=Homo sapiens, GI66933014, Length=249, Percent_Identity=32.9317269076305, Blast_Score=118, Evalue=4e-27, Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=31.2, Blast_Score=110, Evalue=1e-24, Organism=Homo sapiens, GI7705925, Length=254, Percent_Identity=28.3464566929134, Blast_Score=108, Evalue=5e-24, Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=29.1828793774319, Blast_Score=106, Evalue=2e-23, Organism=Homo sapiens, GI10190704, Length=249, Percent_Identity=32.5301204819277, Blast_Score=102, Evalue=3e-22, Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=31.3008130081301, Blast_Score=100, Evalue=9e-22, Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=28.3400809716599, Blast_Score=91, Evalue=1e-18, Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=29.2490118577075, Blast_Score=90, Evalue=2e-18, Organism=Homo sapiens, GI4504505, Length=254, Percent_Identity=27.1653543307087, Blast_Score=88, Evalue=8e-18, Organism=Homo sapiens, GI4503301, Length=253, Percent_Identity=28.8537549407115, Blast_Score=83, Evalue=2e-16, Organism=Homo sapiens, GI59889578, Length=194, Percent_Identity=30.4123711340206, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI31542939, Length=213, Percent_Identity=29.1079812206573, Blast_Score=74, Evalue=9e-14, Organism=Homo sapiens, GI33667109, Length=198, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI209862901, Length=210, Percent_Identity=29.0476190476191, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI19923983, Length=210, Percent_Identity=29.0476190476191, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI109715829, Length=240, Percent_Identity=25.8333333333333, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI40254986, Length=199, Percent_Identity=28.1407035175879, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=27.0588235294118, Blast_Score=67, Evalue=1e-11, Organism=Homo sapiens, GI224922801, Length=174, Percent_Identity=29.8850574712644, Blast_Score=64, Evalue=9e-11, Organism=Escherichia coli, GI1789208, Length=253, Percent_Identity=92.8853754940711, Blast_Score=490, Evalue=1e-140, Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=44.3579766536965, Blast_Score=205, Evalue=2e-54, Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=40.4, Blast_Score=176, Evalue=1e-45, Organism=Escherichia coli, GI1787335, Length=245, Percent_Identity=35.1020408163265, Blast_Score=141, Evalue=5e-35, Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=33.8775510204082, Blast_Score=128, Evalue=4e-31, Organism=Escherichia coli, GI87082100, Length=253, Percent_Identity=32.8063241106719, Blast_Score=120, Evalue=7e-29, Organism=Escherichia coli, GI1787905, Length=248, Percent_Identity=30.6451612903226, Blast_Score=98, Evalue=5e-22, Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=27.6, Blast_Score=91, Evalue=6e-20, Organism=Escherichia coli, GI1789378, Length=249, Percent_Identity=27.3092369477912, Blast_Score=82, Evalue=4e-17, Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=27.3809523809524, Blast_Score=72, Evalue=4e-14, Organism=Escherichia coli, GI1787526, Length=252, Percent_Identity=25.7936507936508, Blast_Score=67, Evalue=9e-13, Organism=Escherichia coli, GI2367365, Length=176, Percent_Identity=29.5454545454545, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI1789057, Length=188, Percent_Identity=26.5957446808511, Blast_Score=65, Evalue=5e-12, Organism=Caenorhabditis elegans, GI17555706, Length=242, Percent_Identity=30.9917355371901, Blast_Score=120, Evalue=5e-28, Organism=Caenorhabditis elegans, GI25147288, Length=245, Percent_Identity=31.4285714285714, Blast_Score=116, Evalue=9e-27, Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=33.9920948616601, Blast_Score=116, Evalue=1e-26, Organism=Caenorhabditis elegans, GI17560676, Length=254, Percent_Identity=30.3149606299213, Blast_Score=114, Evalue=5e-26, Organism=Caenorhabditis elegans, GI17559104, Length=257, Percent_Identity=31.5175097276265, Blast_Score=110, Evalue=8e-25, Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=30.6513409961686, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=29.8039215686275, Blast_Score=103, Evalue=6e-23, Organism=Caenorhabditis elegans, GI115534694, Length=247, Percent_Identity=26.7206477732794, Blast_Score=103, Evalue=9e-23, Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17560150, Length=259, Percent_Identity=28.957528957529, Blast_Score=100, Evalue=9e-22, Organism=Caenorhabditis elegans, GI17560220, Length=260, Percent_Identity=29.6153846153846, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17562906, Length=260, Percent_Identity=30, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=30.7692307692308, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=29.6992481203008, Blast_Score=96, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17544670, Length=265, Percent_Identity=28.6792452830189, Blast_Score=96, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17551412, Length=258, Percent_Identity=29.8449612403101, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17563726, Length=258, Percent_Identity=29.8449612403101, Blast_Score=94, Evalue=5e-20, Organism=Caenorhabditis elegans, GI17562990, Length=259, Percent_Identity=27.7992277992278, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17560332, Length=258, Percent_Identity=30.6201550387597, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17568967, Length=192, Percent_Identity=29.1666666666667, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17562904, Length=258, Percent_Identity=29.0697674418605, Blast_Score=91, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17538480, Length=266, Percent_Identity=27.8195488721804, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=29.277566539924, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI72000259, Length=258, Percent_Identity=27.1317829457364, Blast_Score=86, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17565030, Length=258, Percent_Identity=30.2325581395349, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI17538486, Length=258, Percent_Identity=28.6821705426357, Blast_Score=81, Evalue=4e-16, Organism=Caenorhabditis elegans, GI17536025, Length=257, Percent_Identity=26.0700389105058, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI17536651, Length=253, Percent_Identity=25.296442687747, Blast_Score=77, Evalue=8e-15, Organism=Caenorhabditis elegans, GI17561272, Length=254, Percent_Identity=27.9527559055118, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI17538182, Length=258, Percent_Identity=28.6821705426357, Blast_Score=75, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17564282, Length=200, Percent_Identity=27, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI193203117, Length=195, Percent_Identity=27.6923076923077, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI193203115, Length=193, Percent_Identity=27.979274611399, Blast_Score=72, Evalue=2e-13, Organism=Caenorhabditis elegans, GI17555612, Length=224, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI71982365, Length=193, Percent_Identity=26.9430051813472, Blast_Score=65, Evalue=5e-11, Organism=Caenorhabditis elegans, GI17508651, Length=209, Percent_Identity=26.7942583732057, Blast_Score=64, Evalue=6e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=200, Percent_Identity=31, Blast_Score=84, Evalue=3e-17, Organism=Saccharomyces cerevisiae, GI6324126, Length=250, Percent_Identity=25.2, Blast_Score=70, Evalue=4e-13, Organism=Saccharomyces cerevisiae, GI6323882, Length=237, Percent_Identity=28.6919831223629, Blast_Score=64, Evalue=2e-11, Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=31.5789473684211, Blast_Score=125, Evalue=2e-29, Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=30.1204819277108, Blast_Score=111, Evalue=4e-25, Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=30.8300395256917, Blast_Score=110, Evalue=1e-24, Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=30.0395256916996, Blast_Score=105, Evalue=3e-23, Organism=Drosophila melanogaster, GI23397609, Length=251, Percent_Identity=29.4820717131474, Blast_Score=105, Evalue=4e-23, Organism=Drosophila melanogaster, GI24643142, Length=244, Percent_Identity=27.8688524590164, Blast_Score=93, Evalue=2e-19, Organism=Drosophila melanogaster, GI24644339, Length=258, Percent_Identity=25.968992248062, Blast_Score=90, Evalue=2e-18, Organism=Drosophila melanogaster, GI18859837, Length=257, Percent_Identity=30.3501945525292, Blast_Score=86, Evalue=2e-17, Organism=Drosophila melanogaster, GI21358495, Length=202, Percent_Identity=31.1881188118812, Blast_Score=85, Evalue=4e-17, Organism=Drosophila melanogaster, GI24644337, Length=206, Percent_Identity=27.1844660194175, Blast_Score=84, Evalue=6e-17, Organism=Drosophila melanogaster, GI24649181, Length=198, Percent_Identity=28.7878787878788, Blast_Score=75, Evalue=6e-14, Organism=Drosophila melanogaster, GI17737361, Length=256, Percent_Identity=26.953125, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI221331218, Length=221, Percent_Identity=27.1493212669683, Blast_Score=71, Evalue=7e-13, Organism=Drosophila melanogaster, GI24665243, Length=221, Percent_Identity=27.1493212669683, Blast_Score=70, Evalue=9e-13, Organism=Drosophila melanogaster, GI221331216, Length=224, Percent_Identity=28.125, Blast_Score=68, Evalue=6e-12, Organism=Drosophila melanogaster, GI21357673, Length=198, Percent_Identity=26.2626262626263, Blast_Score=68, Evalue=7e-12, Organism=Drosophila melanogaster, GI24665247, Length=224, Percent_Identity=28.125, Blast_Score=68, Evalue=7e-12, Organism=Drosophila melanogaster, GI24580925, Length=201, Percent_Identity=27.363184079602, Blast_Score=67, Evalue=9e-12, Organism=Drosophila melanogaster, GI24640492, Length=214, Percent_Identity=25.2336448598131, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI24648944, Length=201, Percent_Identity=28.3582089552239, Blast_Score=66, Evalue=3e-11, Organism=Drosophila melanogaster, GI281364892, Length=173, Percent_Identity=28.3236994219653, Blast_Score=65, Evalue=5e-11, Organism=Drosophila melanogaster, GI24584748, Length=191, Percent_Identity=28.2722513089005, Blast_Score=64, Evalue=7e-11, Organism=Drosophila melanogaster, GI161076933, Length=191, Percent_Identity=28.2722513089005, Blast_Score=64, Evalue=8e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011286 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.127 [H]
Molecular weight: Translated: 27078; Mature: 27078
Theoretical pI: Translated: 5.06; Mature: 5.06
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.2 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MILDAFSLQGKVAVVSGCDTGLGQGMALGLAEAGCDIVGINIVEPVETIERVTALGRRFL CEECCEECCCCEEEEECCCCCCCCCCEEEHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH SLTADLRQIDGIPQLLERAVAEFGHIDILVNNAGLIRREDALAFSEKDWDDVMNLNIKSV HHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCCCCEEECCCHHCCCCCHHHHHCCCHHHH FFMSQAAAKHFIAQGSGGKIINIASMLSFQGGIRVPSYTASKSAVMGVTRLLANEWAKHN HHHHHHHHHHHHHCCCCCCEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC INVNAIAPGYMATNNTQQLRADEQRSSEILDRIPAGRWGLPADLMGPVVFLASSASDYIN CCEEEECCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHC GYTVAVDGGWLAR CEEEEECCCCCCC >Mature Secondary Structure MILDAFSLQGKVAVVSGCDTGLGQGMALGLAEAGCDIVGINIVEPVETIERVTALGRRFL CEECCEECCCCEEEEECCCCCCCCCCEEEHHHCCCCEEEEECCCHHHHHHHHHHHHHHHH SLTADLRQIDGIPQLLERAVAEFGHIDILVNNAGLIRREDALAFSEKDWDDVMNLNIKSV HHHHHHHHHCCHHHHHHHHHHHCCCEEEEECCCCCEEECCCHHCCCCCHHHHHCCCHHHH FFMSQAAAKHFIAQGSGGKIINIASMLSFQGGIRVPSYTASKSAVMGVTRLLANEWAKHN HHHHHHHHHHHHHCCCCCCEEEHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC INVNAIAPGYMATNNTQQLRADEQRSSEILDRIPAGRWGLPADLMGPVVFLASSASDYIN CCEEEECCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHC GYTVAVDGGWLAR CEEEEECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9278503; 2836407; 1766386 [H]