Click here to switch to the map view.

The map label for this gene is fucO [H]

Identifier: 238896271

GI number: 238896271

Start: 4253271

End: 4254419

Strand: Reverse

Name: fucO [H]

Synonym: KP1_4430

Alternate gene names: 238896271

Gene position: 4254419-4253271 (Counterclockwise)

Preceding gene: 238896272

Following gene: 238896268

Centisome position: 81.06

GC content: 63.36

Gene sequence:

>1149_bases
ATGGCAAACAGAATGATCCTCAATGAAACGGCATGGTTTGGCCGGGGGGCGATAAACGCATTAACCGATGAAGCGGTGCG
GCGCGGCTATCGTAAAGCATTGATCGTCACCGACAGCACTCTCGCCCGCTGCGGCGTGGCGGCGAAAGTCACCGACAAAC
TGGATGCCGCCGGGCTGGCATGGGATATGTTCAGCGACGTGATCCCTAACCCGACCATCGCCGTGGTCCAGCAGGGGCTG
CAGGCCTTTCAACGCAGCGGGGCGGATTACCTGATCGCCATCGGCGGCGGTTCGCCGCAGGATACCTGTAAGGCGATCGG
TATTATTCAGCGTAACCCGGAATTCGCCGATGTCCGTAGCCTCGAGGGGCTGTCGCCCACCCGTCAGCCCAGCGTGCCGA
TCTTCGCGGTGCCGACCACCGCGGGTACCGCGGCGGAGGTGACGATTAACTATGTCATCACCGATGAAGAACAGCGGCGC
AAATTCGTCTGCGTCGATCCGCATGATATCCCGCAGGTGGCCTTTATCGATGCCGATATGATGGACGCTATGCCGCCGGC
GCTGAAGGCGGCTACCGGCGTGGACGCCCTGACGCATGCTATCGAAGGGTACCTCACTCGCGGCGCCTGGGCTTTGACCG
ATGCTCTGCACCTCAAGGCCATCGAGATCATCGCCGGCGCGCTGCGCGGCTCGGTTGCCGGAGACGCCGGCGCGGGGGAA
GCTATGGCGCTCGGCCAGTATGTGGCGGGGATGGGATTTTCCAACGTTGGGCTTGGCCTGGTACACGGTATGGCGCATCC
GCTCGGCGCTTTTTACAACACGCCGCACGGCGTGGCGAATGCCATCCTGCTGCCGCACGTGATGCGCTTTAATGCTGAGG
CGACCGGGGAAAAATATCGCGACATCGCCCGGGCGATGGGCGTTAGGGTGGAAGCGTTAAGCCTGACCGCCGCGCGCGAG
GCGGCAGTAGAGGCGGTCTGCCAGCTTAACCGCGATGTCGGTATTCCCGGCCATCTGCGTGAGGTGGGCGTCAGGAAAGA
GGATATTCCGGCGCTGGCCCAGGCGGCGCTGGCGGATGTGTGTACCGGCGGCAACCCGCGCGAGGCGAGCCTGGCGGATA
TCGTCGGGTTATATCAGGCGGCCTGGTGA

Upstream 100 bases:

>100_bases
GGTGCTGGATGACGAGGCGATCGCCATCGTGCTGGAGAAGTTCAAAACCTACGGATTACGCATTGAAGAGTGATGCCGCA
ACGCTAACAGGAGAGCCACG

Downstream 100 bases:

>100_bases
TTGCCTGGCCCGGGTAAAGCAGGCAGTTACCCTGCACCGGCGCACCTCTTAACGATGGTCAGCGCGTCAGCCGCAGCTGC
TGCAGATTGCCGTCCAGCTG

Product: L-1,2-propanediol oxidoreductase

Products: NA

Alternate protein names: Propanediol oxidoreductase [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MANRMILNETAWFGRGAINALTDEAVRRGYRKALIVTDSTLARCGVAAKVTDKLDAAGLAWDMFSDVIPNPTIAVVQQGL
QAFQRSGADYLIAIGGGSPQDTCKAIGIIQRNPEFADVRSLEGLSPTRQPSVPIFAVPTTAGTAAEVTINYVITDEEQRR
KFVCVDPHDIPQVAFIDADMMDAMPPALKAATGVDALTHAIEGYLTRGAWALTDALHLKAIEIIAGALRGSVAGDAGAGE
AMALGQYVAGMGFSNVGLGLVHGMAHPLGAFYNTPHGVANAILLPHVMRFNAEATGEKYRDIARAMGVRVEALSLTAARE
AAVEAVCQLNRDVGIPGHLREVGVRKEDIPALAQAALADVCTGGNPREASLADIVGLYQAAW

Sequences:

>Translated_382_residues
MANRMILNETAWFGRGAINALTDEAVRRGYRKALIVTDSTLARCGVAAKVTDKLDAAGLAWDMFSDVIPNPTIAVVQQGL
QAFQRSGADYLIAIGGGSPQDTCKAIGIIQRNPEFADVRSLEGLSPTRQPSVPIFAVPTTAGTAAEVTINYVITDEEQRR
KFVCVDPHDIPQVAFIDADMMDAMPPALKAATGVDALTHAIEGYLTRGAWALTDALHLKAIEIIAGALRGSVAGDAGAGE
AMALGQYVAGMGFSNVGLGLVHGMAHPLGAFYNTPHGVANAILLPHVMRFNAEATGEKYRDIARAMGVRVEALSLTAARE
AAVEAVCQLNRDVGIPGHLREVGVRKEDIPALAQAALADVCTGGNPREASLADIVGLYQAAW
>Mature_381_residues
ANRMILNETAWFGRGAINALTDEAVRRGYRKALIVTDSTLARCGVAAKVTDKLDAAGLAWDMFSDVIPNPTIAVVQQGLQ
AFQRSGADYLIAIGGGSPQDTCKAIGIIQRNPEFADVRSLEGLSPTRQPSVPIFAVPTTAGTAAEVTINYVITDEEQRRK
FVCVDPHDIPQVAFIDADMMDAMPPALKAATGVDALTHAIEGYLTRGAWALTDALHLKAIEIIAGALRGSVAGDAGAGEA
MALGQYVAGMGFSNVGLGLVHGMAHPLGAFYNTPHGVANAILLPHVMRFNAEATGEKYRDIARAMGVRVEALSLTAAREA
AVEAVCQLNRDVGIPGHLREVGVRKEDIPALAQAALADVCTGGNPREASLADIVGLYQAAW

Specific function: Fucose metabolism; fourth step. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=392, Percent_Identity=27.0408163265306, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1789163, Length=382, Percent_Identity=85.6020942408377, Blast_Score=674, Evalue=0.0,
Organism=Escherichia coli, GI48994951, Length=368, Percent_Identity=42.3913043478261, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI87082107, Length=372, Percent_Identity=39.5161290322581, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1787493, Length=399, Percent_Identity=32.5814536340852, Blast_Score=205, Evalue=3e-54,
Organism=Escherichia coli, GI1789386, Length=360, Percent_Identity=26.3888888888889, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17537053, Length=421, Percent_Identity=25.6532066508314, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321181, Length=376, Percent_Identity=37.7659574468085, Blast_Score=260, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24657991, Length=412, Percent_Identity=24.5145631067961, Blast_Score=92, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211
- InterPro:   IPR013460 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.77 [H]

Molecular weight: Translated: 40205; Mature: 40074

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANRMILNETAWFGRGAINALTDEAVRRGYRKALIVTDSTLARCGVAAKVTDKLDAAGLA
CCCCEEEECCCCCCCCHHHHHHHHHHHCCHHEEEEEECCHHHHCCCHHHHHHHHHHCHHH
WDMFSDVIPNPTIAVVQQGLQAFQRSGADYLIAIGGGSPQDTCKAIGIIQRNPEFADVRS
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHEECCCCHHHHHH
LEGLSPTRQPSVPIFAVPTTAGTAAEVTINYVITDEEQRRKFVCVDPHDIPQVAFIDADM
CCCCCCCCCCCCCEEEECCCCCCEEEEEEEEEECCHHHCCCEEEECCCCCCCEEEECCHH
MDAMPPALKAATGVDALTHAIEGYLTRGAWALTDALHLKAIEIIAGALRGSVAGDAGAGE
HHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
AMALGQYVAGMGFSNVGLGLVHGMAHPLGAFYNTPHGVANAILLPHVMRFNAEATGEKYR
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHH
DIARAMGVRVEALSLTAAREAAVEAVCQLNRDVGIPGHLREVGVRKEDIPALAQAALADV
HHHHHHCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHH
CTGGNPREASLADIVGLYQAAW
HCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
ANRMILNETAWFGRGAINALTDEAVRRGYRKALIVTDSTLARCGVAAKVTDKLDAAGLA
CCCEEEECCCCCCCCHHHHHHHHHHHCCHHEEEEEECCHHHHCCCHHHHHHHHHHCHHH
WDMFSDVIPNPTIAVVQQGLQAFQRSGADYLIAIGGGSPQDTCKAIGIIQRNPEFADVRS
HHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHEECCCCHHHHHH
LEGLSPTRQPSVPIFAVPTTAGTAAEVTINYVITDEEQRRKFVCVDPHDIPQVAFIDADM
CCCCCCCCCCCCCEEEECCCCCCEEEEEEEEEECCHHHCCCEEEECCCCCCCEEEECCHH
MDAMPPALKAATGVDALTHAIEGYLTRGAWALTDALHLKAIEIIAGALRGSVAGDAGAGE
HHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCH
AMALGQYVAGMGFSNVGLGLVHGMAHPLGAFYNTPHGVANAILLPHVMRFNAEATGEKYR
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHH
DIARAMGVRVEALSLTAAREAAVEAVCQLNRDVGIPGHLREVGVRKEDIPALAQAALADV
HHHHHHCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHH
CTGGNPREASLADIVGLYQAAW
HCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]